debrisoquin and Autoimmune Diabetes studies

debrisoquin and Autoimmune Diabetes

Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Research Excerpts

Excerpt	Relevance	Reference
"Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine."	1.32	Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus. ( Barkai, L; Krikovszky, D; Madácsy, L; Sánta, A, 2004)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (50.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

2 (50.00)

18.7374

1990's

1 (25.00)

18.2507

2000's

1 (25.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Madácsy, L	1
Barkai, L	1
Sánta, A	1
Krikovszky, D	1
Kallio, J	1
Huupponen, R	1
Viikari, J	1
Hume, L	1
Bechtel, YC	1
Joanne, C	1
Grandmottet, M	1
Bechtel, PR	1

Studies

Madácsy, L

Barkai, L

Sánta, A

Krikovszky, D

Kallio, J

Huupponen, R

Viikari, J

Hume, L

Bechtel, YC

Joanne, C

Grandmottet, M

Bechtel, PR

Other Studies

4 other studies available for debrisoquin and Autoimmune Diabetes

Article	Year
Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus. Hormone research, 2004, Volume: 61, Issue:4 Topics: Case-Control Studies; Child; Child, Preschool; Cytochrome P-450 CYP2D6; Debrisoquin; Diabetes Mellit	2004
Debrisoquine hydroxylation polymorphism in diabetic patients. Diabetes research (Edinburgh, Scotland), 1990, Volume: 15, Issue:3 Topics: Adult; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Debrisoquin; Diabetes Mellitu	1990
Potentiation of hypotensive effect of debrisoquine by insulin. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:5 Topics: Adult; Antihypertensive Agents; Debrisoquin; Diabetes Mellitus, Type 1; Drug Synergism; Humans; Hype	1985
The influence of insulin-dependent diabetes on the metabolism of caffeine and the expression of the debrisoquin oxidation phenotype. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:4 Topics: Acetylation; Adult; Caffeine; Debrisoquin; Diabetes Mellitus, Type 1; Female; Humans; Isoquinolines;	1988

Article

Year

Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus.

Hormone research, 2004, Volume: 61, Issue:4

Topics: Case-Control Studies; Child; Child, Preschool; Cytochrome P-450 CYP2D6; Debrisoquin; Diabetes Mellit

2004

Debrisoquine hydroxylation polymorphism in diabetic patients.

Diabetes research (Edinburgh, Scotland), 1990, Volume: 15, Issue:3

Topics: Adult; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Debrisoquin; Diabetes Mellitu

1990

Potentiation of hypotensive effect of debrisoquine by insulin.

Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:5

Topics: Adult; Antihypertensive Agents; Debrisoquin; Diabetes Mellitus, Type 1; Drug Synergism; Humans; Hype

1985

The influence of insulin-dependent diabetes on the metabolism of caffeine and the expression of the debrisoquin oxidation phenotype.

Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:4

Topics: Acetylation; Adult; Caffeine; Debrisoquin; Diabetes Mellitus, Type 1; Female; Humans; Isoquinolines;

1988