debrisoquin has been researched along with Arthritis, Rheumatoid in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beyeler, C | 1 |
| Daly, AK | 1 |
| Armstrong, M | 1 |
| Astbury, C | 1 |
| Bird, HA | 1 |
| Idle, JR | 1 |
| Benitez, J | 1 |
| Ladero, JM | 1 |
| Andres, MP | 1 |
| Jover, JA | 1 |
| Morado, C | 1 |
| Bañares, A | 1 |
| Gustafsson, LL | 1 |
| Eriksson, LS | 1 |
| Dahl, ML | 1 |
| Eleborg, L | 1 |
| Ericzon, BG | 1 |
| Nyberg, A | 1 |
| Skeith, KJ | 1 |
| Hussain, MS | 1 |
| Coutts, RT | 1 |
| Ramos-Remus, C | 1 |
| Avina-Zubieta, JA | 1 |
| Russell, AS | 1 |
1 trial available for debrisoquin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Adverse drug reactions and debrisoquine/sparteine (P450IID6) polymorphism in patients with fibromyalgia.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Age | 1997 |
3 other studies available for debrisoquin and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity.
Topics: Adult; Aged; Alleles; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP2D6; Cyto | 1994 |
Debrisoquine oxidation polymorphism in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Debrisoquin; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Phenotyp | 1994 |
Cyclophosphamide-induced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Cytochrome P-450 CYP2D6; Debrisoquin; | 1996 |