debrisoquin has been researched along with Arrhythmias, Cardiac in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship between debrisoquine metabolic phenotype and the pharmacokinetics and pharmacodynamics of propafenone was studied in 28 patients with chronic ventricular arrhythmias (22 extensive metabolizers [EMs] and six poor metabolizers [PMs] of debrisoquine)." | 3.67 | Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences. ( McAllister, CB; Roden, DM; Siddoway, LA; Thompson, KA; Wang, T; Wilkinson, GR; Woosley, RL, 1987) |
| "A debrisoquine test was performed in 10." | 1.28 | Identification of propafenone metaboliser phenotype from plasma and urine excretion data. ( Belloni, M; Bernasconi, R; Cappiello, E; Castel, JM; Giani, P; Landolina, M; Latini, R; Leopaldi, D, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Latini, R | 1 |
| Belloni, M | 1 |
| Bernasconi, R | 1 |
| Cappiello, E | 1 |
| Giani, P | 1 |
| Landolina, M | 1 |
| Leopaldi, D | 1 |
| Castel, JM | 1 |
| Siddoway, LA | 1 |
| Thompson, KA | 1 |
| McAllister, CB | 1 |
| Wang, T | 1 |
| Wilkinson, GR | 1 |
| Roden, DM | 1 |
| Woosley, RL | 1 |
2 other studies available for debrisoquin and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Identification of propafenone metaboliser phenotype from plasma and urine excretion data.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Debrisoquin; Female; Humans; Hydroxylation; Ma | 1992 |
Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences.
Topics: Adult; Aged; Arrhythmias, Cardiac; Cytochrome P-450 CYP2D6; Debrisoquin; Dose-Response Relationship, | 1987 |