debrisoquin has been researched along with Arrhythmia in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship between debrisoquine metabolic phenotype and the pharmacokinetics and pharmacodynamics of propafenone was studied in 28 patients with chronic ventricular arrhythmias (22 extensive metabolizers [EMs] and six poor metabolizers [PMs] of debrisoquine)." | 3.67 | Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences. ( McAllister, CB; Roden, DM; Siddoway, LA; Thompson, KA; Wang, T; Wilkinson, GR; Woosley, RL, 1987) |
| "A debrisoquine test was performed in 10." | 1.28 | Identification of propafenone metaboliser phenotype from plasma and urine excretion data. ( Belloni, M; Bernasconi, R; Cappiello, E; Castel, JM; Giani, P; Landolina, M; Latini, R; Leopaldi, D, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Latini, R | 1 |
| Belloni, M | 1 |
| Bernasconi, R | 1 |
| Cappiello, E | 1 |
| Giani, P | 1 |
| Landolina, M | 1 |
| Leopaldi, D | 1 |
| Castel, JM | 1 |
| Siddoway, LA | 1 |
| Thompson, KA | 1 |
| McAllister, CB | 1 |
| Wang, T | 1 |
| Wilkinson, GR | 1 |
| Roden, DM | 1 |
| Woosley, RL | 1 |
2 other studies available for debrisoquin and Arrhythmia
| Article | Year |
|---|---|
Identification of propafenone metaboliser phenotype from plasma and urine excretion data.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Debrisoquin; Female; Humans; Hydroxylation; Ma | 1992 |
Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences.
Topics: Adult; Aged; Arrhythmias, Cardiac; Cytochrome P-450 CYP2D6; Debrisoquin; Dose-Response Relationship, | 1987 |