debrisoquin has been researched along with Angor Pectoris in 5 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a case of perhexiline maleate-induced hepatitis secondary to a long-term administration of recommended daily dosages of 300 mg." | 1.28 | Perhexiline maleate-induced hepatitis. ( Maurer, R; Satz, N; Spycher, MA; Streuli, R; Täuber, M, 1991) |
| "Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination." | 1.27 | Impaired oxidation of debrisoquine in patients with perhexiline liver injury. ( Morgan, MY; Oates, NS; Reshef, R; Shah, RR; Sherlock, S; Smith, RL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, RR | 3 |
| Oates, NS | 3 |
| Idle, JR | 2 |
| Smith, RL | 3 |
| Lockhart, JD | 2 |
| Morgan, MY | 1 |
| Reshef, R | 1 |
| Sherlock, S | 1 |
| Talbot, S | 1 |
| Satz, N | 1 |
| Täuber, M | 1 |
| Streuli, R | 1 |
| Spycher, MA | 1 |
| Maurer, R | 1 |
5 other studies available for debrisoquin and Angor Pectoris
| Article | Year |
|---|---|
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
Topics: Adult; Aged; Alcohol Drinking; Angina Pectoris; Debrisoquin; Female; Humans; Isoquinolines; Liver Fu | 1982 |
Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.
Topics: Angina Pectoris; Debrisoquin; Electromyography; Humans; Hydroxylation; Isoquinolines; Male; Middle A | 1983 |
Impaired oxidation of debrisoquine in patients with perhexiline liver injury.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Chronic Disease; D | 1984 |
Angina in hypertensive patients. With particular reference to the negative chronotropic effects of sympatholytic therapy.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Bethanidine; Blood Pressure; Debrisoquin; Drug Therapy | 1976 |
Perhexiline maleate-induced hepatitis.
Topics: Angina Pectoris; Biopsy; Chemical and Drug Induced Liver Injury; Debrisoquin; Humans; Liver; Male; M | 1991 |