debrisoquin has been researched along with Alzheimer Disease in 3 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benítez, J | 1 |
| Barquero, MS | 1 |
| Coria, F | 1 |
| Molina, JA | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Ladero, JM | 1 |
| Liu, TY | 1 |
| Chi, CW | 1 |
| Yang, JC | 1 |
| Cheung, SC | 1 |
| Liu, HC | 1 |
| Steventon, GB | 1 |
| Heafield, MT | 1 |
| Sturman, S | 1 |
| Waring, RH | 1 |
| Williams, AC | 1 |
3 other studies available for debrisoquin and Alzheimer Disease
| Article | Year |
|---|---|
Oxidative polymorphism of debrisoquine is not related to the risk of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Femal | 1993 |
Debrisoquine metabolism in Chinese patients with Alzheimer's and Parkinson's diseases.
Topics: Aged; Alzheimer Disease; China; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Parkinson Di | 1992 |
Xenobiotic metabolism in Alzheimer's disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Carbocysteine; Debriso | 1990 |