debrisoquin has been researched along with Alcoholic Cirrhosis in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A comparison between the single and the "cocktail" dosage did not reveal any significant differences in the pharmacokinetic parameters." | 1.28 | [Simultaneous administration of various model substances for characterizing in vivo biotransformation in chronic liver diseases]. ( Henschel, L; Hoffmann, A; Huster, A; Jorke, D; Kraul, H; Reinhardt, M; Töpfer, R; Truckenbrodt, J, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Truckenbrodt, J | 1 |
| Kraul, H | 1 |
| Huster, A | 1 |
| Töpfer, R | 1 |
| Henschel, L | 1 |
| Hoffmann, A | 1 |
| Reinhardt, M | 1 |
| Jorke, D | 1 |
| Debruyne, D | 1 |
| Gram, LF | 1 |
| Grollier, G | 1 |
| Camsonne, R | 1 |
| Agron, L | 1 |
| Dao, MT | 1 |
| Lacotte, J | 1 |
| Bigot, MC | 1 |
| Moulin, M | 1 |
2 other studies available for debrisoquin and Alcoholic Cirrhosis
| Article | Year |
|---|---|
[Simultaneous administration of various model substances for characterizing in vivo biotransformation in chronic liver diseases].
Topics: Biotransformation; Caffeine; Debrisoquin; Dipyrone; Fatty Liver, Alcoholic; Female; Hepatitis, Chron | 1990 |
Quinidine disposition in relation to antipyrine elimination and debrisoquine phenotype in alcoholic patients with and without cirrhosis.
Topics: Adult; Aged; Alcoholism; Antipyrine; Chromatography, Liquid; Debrisoquin; Female; Half-Life; Humans; | 1989 |