debrisoquin has been researched along with Agranulocytosis in 1 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " These same two sisters had previously developed agranulocytosis in association with carbimazole therapy." | 7.67 | The metabolism of debrisoquine in man: (1) regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis. ( Crothers, MJ; Idle, JR; Ritchie, JC; Shah, RR; Smith, RL, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ritchie, JC | 1 |
| Crothers, MJ | 1 |
| Shah, RR | 1 |
| Idle, JR | 1 |
| Smith, RL | 1 |
1 other study available for debrisoquin and Agranulocytosis
| Article | Year |
|---|---|
The metabolism of debrisoquine in man: (1) regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Carbimazole; Child; Debrisoquin; Female; Humans; Hydroxyla | 1986 |