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debrisoquin and Aging

debrisoquin has been researched along with Aging in 7 studies

Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing."1.27Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. ( Barbeau, A; Cloutier, T; Paris, S; Plasse, L; Poirier, J; Roy, M, 1985)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's4 (57.14)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dorne, JL1
Walton, K1
Slob, W1
Renwick, AG1
Danhof, M1
Idle, JR1
Teunissen, MW1
Sloan, TP1
Breimer, DD1
Smith, RL1
Hoshi, H1
Masuda, M2
Yamamoto, Y1
Suimamoto, Y1
Kazusaka, A2
Fujita, S2
Morita, K1
Maeda, Y1
Imaoka, S1
Funae, Y1
Pollock, BG1
Perel, JM1
Altieri, LP1
Kirshner, M1
Fasiczka, AL1
Houck, PR1
Reynolds, CF1
Siegmund, W1
Hanke, W1
Zschiesche, M1
Franke, G1
Biebler, KE1
Wilke, A1
Barbeau, A1
Cloutier, T1
Roy, M1
Plasse, L1
Paris, S1
Poirier, J1

Other Studies

7 other studies available for debrisoquin and Aging

ArticleYear
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:11

    Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoqu

2002
Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation.
    Pharmacology, 1981, Volume: 22, Issue:6

    Topics: Aging; Antipyrine; Body Weight; Debrisoquin; Female; Half-Life; Humans; Hydroxylation; Isoquinolines

1981
Debrisoquine/sparteine-type polymorphic drug metabolism in wild Clethrionomys rufocanus.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:11

    Topics: Aging; Animals; Arvicolinae; Debrisoquin; Female; In Vitro Techniques; Male; Microsomes, Liver; Poly

1995
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
    Biochemical pharmacology, 1998, May-01, Volume: 55, Issue:9

    Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En

1998
Debrisoquine hydroxylation phenotyping in geriatric psychopharmacology.
    Psychopharmacology bulletin, 1992, Volume: 28, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Debrisoquin; Female; Humans; Hydroxylation; Male; Middle Aged; Pheno

1992
N-acetylation and debrisoquine type oxidation polymorphism in Caucasians--with reference to age and sex.
    International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:12

    Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Debrisoquin; Female; Humans; Male; Middle Aged;

1990
Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine.
    Lancet (London, England), 1985, Nov-30, Volume: 2, Issue:8466

    Topics: Adult; Aging; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Liver; Middle Aged; Parkins

1985