debrisoquin has been researched along with Aging in 7 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing." | 1.27 | Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. ( Barbeau, A; Cloutier, T; Paris, S; Plasse, L; Poirier, J; Roy, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dorne, JL | 1 |
| Walton, K | 1 |
| Slob, W | 1 |
| Renwick, AG | 1 |
| Danhof, M | 1 |
| Idle, JR | 1 |
| Teunissen, MW | 1 |
| Sloan, TP | 1 |
| Breimer, DD | 1 |
| Smith, RL | 1 |
| Hoshi, H | 1 |
| Masuda, M | 2 |
| Yamamoto, Y | 1 |
| Suimamoto, Y | 1 |
| Kazusaka, A | 2 |
| Fujita, S | 2 |
| Morita, K | 1 |
| Maeda, Y | 1 |
| Imaoka, S | 1 |
| Funae, Y | 1 |
| Pollock, BG | 1 |
| Perel, JM | 1 |
| Altieri, LP | 1 |
| Kirshner, M | 1 |
| Fasiczka, AL | 1 |
| Houck, PR | 1 |
| Reynolds, CF | 1 |
| Siegmund, W | 1 |
| Hanke, W | 1 |
| Zschiesche, M | 1 |
| Franke, G | 1 |
| Biebler, KE | 1 |
| Wilke, A | 1 |
| Barbeau, A | 1 |
| Cloutier, T | 1 |
| Roy, M | 1 |
| Plasse, L | 1 |
| Paris, S | 1 |
| Poirier, J | 1 |
7 other studies available for debrisoquin and Aging
| Article | Year |
|---|---|
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoqu | 2002 |
Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation.
Topics: Aging; Antipyrine; Body Weight; Debrisoquin; Female; Half-Life; Humans; Hydroxylation; Isoquinolines | 1981 |
Debrisoquine/sparteine-type polymorphic drug metabolism in wild Clethrionomys rufocanus.
Topics: Aging; Animals; Arvicolinae; Debrisoquin; Female; In Vitro Techniques; Male; Microsomes, Liver; Poly | 1995 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En | 1998 |
Debrisoquine hydroxylation phenotyping in geriatric psychopharmacology.
Topics: Aged; Aged, 80 and over; Aging; Debrisoquin; Female; Humans; Hydroxylation; Male; Middle Aged; Pheno | 1992 |
N-acetylation and debrisoquine type oxidation polymorphism in Caucasians--with reference to age and sex.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Debrisoquin; Female; Humans; Male; Middle Aged; | 1990 |
Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine.
Topics: Adult; Aging; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Liver; Middle Aged; Parkins | 1985 |