debrisoquin has been researched along with Ache in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The variation in plasma morphine concentrations was higher than that of oxycodone, consistent with the lower bioavailability of morphine." | 6.69 | Morphine or oxycodone in cancer pain? ( Heiskanen, TE; Kalso, EA; Ruismäki, PM; Seppälä, TA, 2000) |
| "Codeine is an old drug that is still widely used to treat mild and moderate pain." | 4.79 | The pharmacogenetics of codeine hypoalgesia. ( Brøsen, K; Sindrup, SH, 1995) |
| " The variation in plasma morphine concentrations was higher than that of oxycodone, consistent with the lower bioavailability of morphine." | 2.69 | Morphine or oxycodone in cancer pain? ( Heiskanen, TE; Kalso, EA; Ruismäki, PM; Seppälä, TA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sindrup, SH | 2 |
| Poulsen, L | 1 |
| Brøsen, K | 2 |
| Arendt-Nielsen, L | 1 |
| Gram, LF | 1 |
| Gleason, PP | 1 |
| Frye, RF | 1 |
| O'Toole, T | 1 |
| Heiskanen, TE | 1 |
| Ruismäki, PM | 1 |
| Seppälä, TA | 1 |
| Kalso, EA | 1 |
1 review available for debrisoquin and Ache
| Article | Year |
|---|---|
The pharmacogenetics of codeine hypoalgesia.
Topics: Analgesics, Opioid; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome | 1995 |
1 trial available for debrisoquin and Ache
| Article | Year |
|---|---|
Morphine or oxycodone in cancer pain?
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Cytochrome P-450 CYP2D6; | 2000 |
2 other studies available for debrisoquin and Ache
| Article | Year |
|---|---|
Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?
Topics: Adult; Brain; Codeine; Cold Temperature; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; De | 1993 |
Debilitating reaction following the initial dose of tramadol.
Topics: Adult; Akathisia, Drug-Induced; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Debrisoquin; Humans; Ma | 1997 |