debrisoquin has been researched along with Abdominal Migraine in 2 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 37 migraine sufferers and 26 controls age- and sex-matched to 26 of these patients, debrisoquine hydroxylation following an oral dose of 10 mg was employed as a marker of oxidation status, determined by calculating the metabolic ratio (MR): urinary debrisoquine/urinary 4-hydroxydebrisoquine." | 1.27 | Hepatic cytochrome P450-mediated oxidation function in migraine. ( Amery, WK; Caers, LI; Davies, PT; Heykants, J; Rose, FC; Steiner, TJ; Woestenborghs, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dahlöf, C | 1 |
| Alm, C | 1 |
| Bertling, I | 1 |
| Barret, L | 1 |
| Amery, WK | 1 |
| Davies, PT | 1 |
| Caers, LI | 1 |
| Heykants, J | 1 |
| Steiner, TJ | 1 |
| Woestenborghs, R | 1 |
| Rose, FC | 1 |
2 other studies available for debrisoquin and Abdominal Migraine
| Article | Year |
|---|---|
Cytochrome P-450-dependent hydroxylation in migraine.
Topics: Chromatography, Gas; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Mal | 1992 |
Hepatic cytochrome P450-mediated oxidation function in migraine.
Topics: Adult; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Liver; Male; Midd | 1988 |