deamino-arginine-vasopressin and Myocardial-Bridging

To illustrate the effect of myocardial bridges on coronary vascular tone, we describe the cases of 2 patients with different clinical presentations in the context of reproducible increased spasticity at the site of myocardial bridging. One had an episode of takotsubo cardiomyopathy, and one developed typical Prinzmetal angina while receiving desmopressin treatment for pituitary insufficiency. In both patients, acetylcholine challenge clearly revealed both the presence and the severity of myocardial bridging while producing several recognizable degrees of abnormal spastic tendency.Both baseline functional states and responses to different medications correlate with spastic tendency and enable the characterization of individual cases. Understanding the spectrum of spastic conditions might help to clarify the causes of atypical ischemic events, especially in patients with myocardial bridging.

Topics: Acetylcholine; Angina Pectoris, Variant; Antidiuretic Agents; Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Deamino Arginine Vasopressin; Echocardiography; Female; Humans; Hypopituitarism; Male; Middle Aged; Myocardial Bridging; Predictive Value of Tests; Takotsubo Cardiomyopathy; Treatment Outcome; Vasodilator Agents