deamino-arginine-vasopressin and Fetal-Death

Topics: Adult; Deamino Arginine Vasopressin; Diabetes Insipidus; Diabetes, Gestational; Female; Fetal Death; Humans; Liver Function Tests; Pregnancy

Gestational diabetes insipidus is a rare, transient complication of pregnancy typically characterized by polyuria and polydipsia that may lead to mild electrolyte abnormalities. More severe sequelae of gestational diabetes insipidus are uncommon.. We present a case of a 25-year-old woman at 23 weeks of gestation in a dichorionic-diamniotic twin pregnancy who developed severe symptomatic gestational diabetes insipidus complicated by rhabdomyolysis and death of both fetuses.. Maternal rhabdomyolysis caused by gestational diabetes insipidus is extremely rare. Early recognition and treatment of gestational diabetes insipidus is necessary to prevent maternal and fetal morbidity and mortality.

Topics: Adult; Antidiuretic Agents; Deamino Arginine Vasopressin; Diabetes Insipidus; Female; Fetal Death; Humans; Hypernatremia; Polyuria; Pregnancy; Pregnancy Complications; Pregnancy, Twin; Rhabdomyolysis

Diabetes insipidus in pregnancy has different causes. The association of diabetes insipidus with disturbances of liver function has been reported, however, diabetes insipidus has rarely been reported in HELLP syndrome. We present a 23-year-old primigravida with a singleton gestation complicated by HELLP syndrome who developed postpartum diabetes insipidus. Labor was induced promptly to terminate pregnancy because of intrauterine fetal death and liver dysfunction. 1-deamino-8-D-arginine-vasopressin was administered. Diabetes insipidus and liver dysfunction resolved within 2 weeks. Development of diabetes insipidus may result from increased vasopressinase activity mainly caused by deterioration of liver functions caused by HELLP syndrome. In pregnant women with liver disease as a result of any cause, the development of diabetes insipidus should be assessed with particular attention.

Topics: Adult; Antidiuretic Agents; Deamino Arginine Vasopressin; Diabetes Insipidus; Female; Fetal Death; Glucocorticoids; HELLP Syndrome; Humans; Liver Diseases; Plasma Exchange; Postpartum Period; Pregnancy

This report is on six pregnancies of a woman with idiopathic diabetes insipidus detected after previous stillbirth, during the second pregnancy. On treatment with the only then available injectable substitute, an eutrophic child developed. Since the end of the second pregnancy, the patient has been treated with DDAVP. During the other five pregnancies dystrophic children were delivered due to placental insufficiencies. In the last pregnancy, after cessation of foetal growth a new growth phase could be initiated by improvement of placenta flow by haemodilution.

Topics: Adult; Cardiotocography; Cesarean Section; Deamino Arginine Vasopressin; Diabetes Insipidus; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Growth Retardation; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complications; Ultrasonography, Prenatal