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ddt and Tremor

ddt has been researched along with Tremor in 23 studies

1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane: structure in first source

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment of rats with phenoxybenzamine (5 mg/kg; SC), an alpha adrenergic antagonist, decreased the peak tremor power and startle magnitude of rats subsequently given DDT (75 mg/kg; PO) or chlordecone (60 mg/kg; IP), without having a significant effect on control animals."7.67Pharmacological modification of tremor and enhanced acoustic startle by chlordecone and p,p'-DDT. ( Gallus, JA; Herr, DW; Tilson, HA, 1987)
"Male, Fischer strain 344 adult rats were given various doses (25-100 mg/kg) of p,p'-DDT by oral gavage, and levels of biogenic amines, their metabolites, and amino acid neurotransmitters, tremor activity, and rectal temperature were measured at several intervals (2, 5, 12, and 24 h) after dosing."7.67Effects of p,p'-DDT on the rat brain concentrations of biogenic amine and amino acid neurotransmitters and their association with p,p'-DDT-induced tremor and hyperthermia. ( Chen, PH; Hong, JS; Hudson, PM; Tilson, HA, 1985)
"Rats given a tremorigenic dose of DDT (75 mg/kg, PO) were treated with pharmacological agents either 30 min prior to DDT or 1-2 h prior to testing at the time of peak effect (12 h postdosing)."7.67DDT-induced tremor in rats: effects of pharmacological agents. ( Herr, DW; Hong, JS; Tilson, HA, 1985)
"Tremor was quantified 8 hr later by spectral analysis of whole body movements."5.27Modulation of p,p'-DDT-induced tremor by catecholaminergic agents. ( Herr, DW; Tilson, HA, 1987)
"p,p'-DDT and related agents act to hold the sodium channel open once opened and this effect is believed to be responsible for neurological effects of tremor and hyperexcitability in vivo."3.67Neurochemical effects of DDT in rat brain in vivo. ( Herr, DW; Hong, JS; Hudson, PM; Tilson, HA, 1986)
"Pretreatment of rats with phenoxybenzamine (5 mg/kg; SC), an alpha adrenergic antagonist, decreased the peak tremor power and startle magnitude of rats subsequently given DDT (75 mg/kg; PO) or chlordecone (60 mg/kg; IP), without having a significant effect on control animals."3.67Pharmacological modification of tremor and enhanced acoustic startle by chlordecone and p,p'-DDT. ( Gallus, JA; Herr, DW; Tilson, HA, 1987)
"Male, Fischer strain 344 adult rats were given various doses (25-100 mg/kg) of p,p'-DDT by oral gavage, and levels of biogenic amines, their metabolites, and amino acid neurotransmitters, tremor activity, and rectal temperature were measured at several intervals (2, 5, 12, and 24 h) after dosing."3.67Effects of p,p'-DDT on the rat brain concentrations of biogenic amine and amino acid neurotransmitters and their association with p,p'-DDT-induced tremor and hyperthermia. ( Chen, PH; Hong, JS; Hudson, PM; Tilson, HA, 1985)
"Rats given a tremorigenic dose of DDT (75 mg/kg, PO) were treated with pharmacological agents either 30 min prior to DDT or 1-2 h prior to testing at the time of peak effect (12 h postdosing)."3.67DDT-induced tremor in rats: effects of pharmacological agents. ( Herr, DW; Hong, JS; Tilson, HA, 1985)
" The rats received a continuous intravenous infusion of DDT (10 mg/h) until onset of a predefined pharmacodynamic endpoint (facial muscle tremor)."1.34The effect of a high-fat meal on the pharmacodynamics of a model lipophilic compound that binds extensively to triglyceride-rich lipoproteins. ( Gershkovich, P; Hoffman, A; Shtainer, D, 2007)
"Tremors were observed in the majority of hatchlings in the 150 ppm group and at lower incidences in the 30 ppm group."1.33Reassessment of ecotoxicities of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane in Japanese quail under the OECD draft new avian one-generation reproduction test guideline. ( Chiba, Y; Ebino, K; Fujie, H; Harada, T; Hayashi, K; Koma, Y; Nagata, T; Nakashima, N; Odanaka, Y; Saka, M; Satoh, M; Teramoto, S; Ueda, H, 2005)
"Pretreatment with phenytoin significantly attenuated the tremor produced by p,p'-DDT but enhanced that produced by chlordecone."1.275,5-Diphenylhydantoin antagonizes neurochemical and behavioral effects of p,p'-DDT but not of chlordecone. ( Hong, JS; Hudson, PM; Tilson, HA, 1986)
"Tremor was quantified 8 hr later by spectral analysis of whole body movements."1.27Modulation of p,p'-DDT-induced tremor by catecholaminergic agents. ( Herr, DW; Tilson, HA, 1987)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199021 (91.30)18.7374
1990's0 (0.00)18.2507
2000's2 (8.70)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LUCKENS, MM1
DAVIS, WH1
Ueda, H1
Ebino, K1
Fujie, H1
Hayashi, K1
Satoh, M1
Nakashima, N1
Chiba, Y1
Harada, T1
Saka, M1
Koma, Y1
Nagata, T1
Odanaka, Y1
Teramoto, S1
Gershkovich, P1
Shtainer, D1
Hoffman, A1
BROMILEY, RB1
BARD, P1
Britton, WM1
Tilson, HA8
Hudson, PM3
Hong, JS5
Herr, DW6
Gallus, JA1
Uphouse, L1
Williams, J1
Mailman, RB1
Chen, PH1
Chen, P1
Harry, GJ1
Morio, Y1
Imanishi, T1
Nishimura, M1
Yagasaki, O1
Kar, PP1
Matin, MA1
Peters, DA2
Hrdina, PD3
Singhal, RL3
Ling, GM2
Stern, P1
Svendsen, O1
Henderson, GL1
Woolley, DE1
Black, WD1
Ecobichon, DJ1

Other Studies

23 other studies available for ddt and Tremor

ArticleYear
BATS: SENSITIVITY TO DDT.
    Science (New York, N.Y.), 1964, Nov-13, Volume: 146, Issue:3646

    Topics: Animals; Body Weight; Chiroptera; DDT; Pharmacology; Research; Seizures; Toxicology; Tremor

1964
Reassessment of ecotoxicities of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane in Japanese quail under the OECD draft new avian one-generation reproduction test guideline.
    Regulatory toxicology and pharmacology : RTP, 2005, Volume: 41, Issue:3

    Topics: Administration, Oral; Animals; Animals, Newborn; Coturnix; DDT; Embryo, Nonmammalian; Environmental

2005
The effect of a high-fat meal on the pharmacodynamics of a model lipophilic compound that binds extensively to triglyceride-rich lipoproteins.
    International journal of pharmaceutics, 2007, Mar-21, Volume: 333, Issue:1-2

    Topics: Administration, Oral; Animals; Brain; Chylomicrons; DDT; Dietary Fats; Facial Muscles; Food-Drug Int

2007
Tremor and changes in reflex status produced by DDT in decerebrate, decerebrate-decerebellate and spinal animals.
    Bulletin of the Johns Hopkins Hospital, 1949, Volume: 84, Issue:5

    Topics: Animals; DDT; Nervous System Physiological Phenomena; Reflex; Tremor

1949
Toxicity of high dietary levels of DDT in laying hens.
    Bulletin of environmental contamination and toxicology, 1975, Volume: 13, Issue:6

    Topics: Analysis of Variance; Animals; Chickens; DDT; Diet; Egg Shell; Eggs; Female; Tremor

1975
5,5-Diphenylhydantoin antagonizes neurochemical and behavioral effects of p,p'-DDT but not of chlordecone.
    Journal of neurochemistry, 1986, Volume: 47, Issue:6

    Topics: Animals; Brain Chemistry; Brain Stem; Caudate Nucleus; Chlordecone; DDT; Hippocampus; Hydroxyindolea

1986
Neurochemical effects of DDT in rat brain in vivo.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1986, Volume: 9

    Topics: Amino Acids; Animals; Biogenic Amines; Brain; DDT; Dose-Response Relationship, Drug; Hydantoins; Ion

1986
Pharmacological modification of tremor and enhanced acoustic startle by chlordecone and p,p'-DDT.
    Psychopharmacology, 1987, Volume: 91, Issue:3

    Topics: Acoustic Stimulation; Animals; Calcium; Chlordecone; DDT; Injections, Intraventricular; Insecticides

1987
Sexual behavior of intact female rats after treatment with o,p'-DDT or p,p'-DDT.
    Reproductive toxicology (Elmsford, N.Y.), 1989, Volume: 3, Issue:1

    Topics: Animals; Binding, Competitive; DDT; Diestrus; Estradiol; Female; Isomerism; Pesticide Residues; Post

1989
Blockade of only spinal alpha 1 adrenoceptors is insufficient to attenuate DDT-induced alterations in motor function.
    Toxicology and applied pharmacology, 1989, Volume: 101, Issue:1

    Topics: Analysis of Variance; Animals; Cerebral Cortex; DDT; Infusions, Parenteral; Male; Movement; Prazosin

1989
Effects of p,p'-DDT on the rat brain concentrations of biogenic amine and amino acid neurotransmitters and their association with p,p'-DDT-induced tremor and hyperthermia.
    Journal of neurochemistry, 1985, Volume: 45, Issue:5

    Topics: Amino Acids; Animals; Biogenic Amines; Body Temperature; Brain; DDT; Fever; Kinetics; Male; Neurotra

1985
Pharmacological modification of DDT-induced tremor and hyperthermia in rats: distributional factors.
    Psychopharmacology, 1986, Volume: 89, Issue:3

    Topics: Animals; Brain Chemistry; DDT; Drug Interactions; Fever; Hydantoins; Male; Piperonyl Butoxide; Rats;

1986
Characteristics of neuronal effects of DDT and dieldrin in mice.
    Nihon juigaku zasshi. The Japanese journal of veterinary science, 1987, Volume: 49, Issue:6

    Topics: Animals; DDT; Dieldrin; Male; Mice; Nervous System; Seizures; Tremor

1987
Modulation of p,p'-DDT-induced tremor by catecholaminergic agents.
    Toxicology and applied pharmacology, 1987, Volume: 91, Issue:2

    Topics: Animals; Apomorphine; Clonidine; DDT; Dopamine; Haloperidol; Male; Norepinephrine; Phenoxybenzamine;

1987
DDT-induced tremor in rats: effects of pharmacological agents.
    Psychopharmacology, 1985, Volume: 86, Issue:4

    Topics: Analysis of Variance; Animals; DDT; Dose-Response Relationship, Drug; Male; Mephenesin; Phenytoin; P

1985
Possible role of cerebral amino acids in acute neurotoxic effects of DDT in mice.
    European journal of pharmacology, 1974, Volume: 25, Issue:1

    Topics: Amino Acids; Animals; Behavior, Animal; Brain; Brain Chemistry; DDT; gamma-Aminobutyric Acid; Glycin

1974
The role of brain serotonin in DDT-induced hyperpyrexia.
    Journal of neurochemistry, 1972, Volume: 19, Issue:4

    Topics: Animals; Brain; Brain Stem; DDT; Fenclonine; Fever; Fluorine; Hydroxyindoleacetic Acid; Male; Pargyl

1972
Neurotoxic effects of DDT: protection by cycloheximide.
    The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:2

    Topics: Acetylcholine; Animals; Body Temperature; Brain Chemistry; Cyclophosphamide; Dactinomycin; DDT; Feve

1972
The effect of DDT on muscle dystrophy and its role in producing rest tremor.
    Arhiv za higijenu rada i toksikologiju, 1973, Volume: 24, Issue:4

    Topics: Animals; Corpus Striatum; DDT; Muscular Dystrophies; Rats; Tremor

1973
The ultrastructure of livers from chickens embryogenically injected with DDT.
    Acta pharmacologica et toxicologica, 1973, Volume: 33, Issue:2

    Topics: Animals; Cell Division; Chick Embryo; Chickens; Culture Media; DDT; Endoplasmic Reticulum; Female; G

1973
Role of brain acetylcholine and dopamine in acute neurotoxic effects of DDT.
    European journal of pharmacology, 1971, Volume: 15, Issue:3

    Topics: Acetylcholine; Animals; Basal Ganglia; Central Nervous System; DDT; Dopamine; Female; Male; Rats; Se

1971
Ontogenesis of drug-induced tremor in the rat.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:1

    Topics: Age Factors; Alkaloids; Animals; Brain; DDT; Hallucinogens; Indoles; Rats; Spinal Cord; Tremor; Trem

1970
A pharmacodynamic study of DDT in rabbits following acute intravenous administration.
    Canadian journal of physiology and pharmacology, 1971, Volume: 49, Issue:1

    Topics: Adipose Tissue; Animals; Brain; Brain Chemistry; DDT; Female; Kidney; Liver; Lung; Muscles; Myocardi

1971