dasatinib has been researched along with Leukemia* in 2 studies
2 other study(ies) available for dasatinib and Leukemia
| Article | Year |
|---|---|
Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells.
We used the concept of bioisosteres to design and synthesize a novel series of dasatinib derivatives for the treatment of leukemia. Unfortunately, most of the dasatinib derivatives did not show appreciable inhibition against leukemia cell lines K562 and HL60. However, acrylamide compound 2c had comparable inhibitory activity with dasatinib against K562 cells (IC Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Dasatinib; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia; Mice; Neoplastic Stem Cells; Oxadiazoles; Triazoles | 2018 |
Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line.
Some novel 6-substituted pyrazolo[3,4-d]pyrimidines 4, 5, 6a-d, 7a-c, 8 and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidines 9a-c, 10a-c, 11, 12a,b, 13a-c and 14 were synthesized and characterized by spectral and elemental analyses. They were screened for their biological activity in vitro against Abl and Src kinases. Compounds 7a and 7b revealed the highest activity against both wild and mutant Abl kinases as well as the Src kinase and the leukemia K-562 cell line. They can be considered as new hits for further structural optimization to obtain better activity. Topics: Antineoplastic Agents; Humans; K562 Cells; Leukemia; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines; src-Family Kinases; Structure-Activity Relationship | 2016 |