darapladib has been researched along with Malaria* in 1 studies
1 other study(ies) available for darapladib and Malaria
| Article | Year |
|---|---|
Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.
The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate that Plasmodium falciparum imports a host antioxidant enzyme, peroxiredoxin 6 (PRDX6), during hemoglobin uptake from the red blood cell cytosol. PRDX6 is a lipid-peroxidation repair enzyme with phospholipase A Topics: Animals; Antimalarials; Artemisinins; Benzaldehydes; Drug Resistance; Hemoglobins; Humans; Lipids; Malaria; Malaria, Falciparum; Mice; Oximes; Peroxiredoxin VI; Plasmodium falciparum | 2022 |