dapsone has been researched along with Plasmodium falciparum Malaria in 51 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria." | 9.14 | Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. ( Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG, 2009) |
| " This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients." | 9.14 | Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. ( Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA, 2009) |
| "Artemether-Lumefantrine and Chlorproguanil-Dapsone have high and comparable cure rates and similar safety profiles when used for treatment of uncomplicated malaria in pregnancy." | 9.13 | A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda. ( Kaye, DK; Mutyaba, TS; Ndeezi, G; Nshemerirwe, R, 2008) |
| "We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda." | 9.13 | A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. ( Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C, 2008) |
| " Mild degrees of haemolysis consistently occur with continued therapy, although adverse effects may be less likely with intermittent treatment, as most reported adverse effects have occurred with long-term use of dapsone." | 6.42 | Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes. ( Brabin, BJ; Eggelte, TA; Parise, M; Verhoeff, F, 2004) |
| "falciparum malaria was known for many years, there was no report about the incidence of P." | 5.32 | Malaria, leprosy and dapsone. ( Arora, VM; Chattopadhya, D; Kapoor, L; Saha, K, 2003) |
| "Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria." | 5.14 | Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. ( Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG, 2009) |
| " This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients." | 5.14 | Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. ( Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA, 2009) |
| "Artemether-Lumefantrine and Chlorproguanil-Dapsone have high and comparable cure rates and similar safety profiles when used for treatment of uncomplicated malaria in pregnancy." | 5.13 | A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda. ( Kaye, DK; Mutyaba, TS; Ndeezi, G; Nshemerirwe, R, 2008) |
| "We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda." | 5.13 | A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. ( Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C, 2008) |
| " Since prophylaxis with amodiaquine at 5 mg/kg weekly had failed, amodiaquine at a dose of 10mg/kg weekly and Maloprim (half a tablet or one tablet depending on body weight, which gave ranges of dapsone of 1." | 5.07 | Chemoprophylaxis against malaria in Papua New Guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine. ( Alpers, MP; Gibney, S; Gibson, FD; Heywood, PF; Jolley, D; Stace, J; Trenholme, KR; Vrbova, H, 1992) |
| "Plasmodium falciparum malaria has no effect on the pharmacokinetic parameters for chlorproguanil, dapsone or chlorcycloguanil." | 3.73 | Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. ( Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P, 2006) |
| "G6PD deficiency is common in African patients with malaria and until a reliable and simple G6PD test is available, the use of 8-aminoquinolines will remain problematic." | 2.76 | Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials. ( Carter, N; Duparc, S; Pamba, A; Waitumbi, JN, 2011) |
| "falciparum malaria was evaluated according to G6PD deficiency in a secondary analysis of an open-label, randomized clinical trial." | 2.73 | High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. ( Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A, 2008) |
| "In a randomized controlled study of malaria prophylaxis, dapsone-pyrimethamine at a weekly dosage of dapsone 50-100 mg with pyrimethamine 6." | 2.67 | Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique. ( Pividal, J; Schapira, A; Streat, E; Viktinski, V, 1992) |
| " Mild degrees of haemolysis consistently occur with continued therapy, although adverse effects may be less likely with intermittent treatment, as most reported adverse effects have occurred with long-term use of dapsone." | 2.42 | Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes. ( Brabin, BJ; Eggelte, TA; Parise, M; Verhoeff, F, 2004) |
| " Drug-induced acute hemolytic anemia in G6PD A- subjects can be life-threatening, depending on the nature and dosage of the drug trigger." | 1.38 | Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. ( Carter, N; Duparc, S; Luzzatto, L; Pamba, A; Premji, Z; Richardson, ND; Tiono, AB, 2012) |
| "Eleven of these had a recrudescence of their infection." | 1.33 | Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response. ( Imwong, M; Krudsood, S; Looareesuwan, S; Nonprasert, A; Pukrittayakamee, S; Snounou, G; White, NJ; Wilairatana, P, 2005) |
| "falciparum malaria was known for many years, there was no report about the incidence of P." | 1.32 | Malaria, leprosy and dapsone. ( Arora, VM; Chattopadhya, D; Kapoor, L; Saha, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (35.29) | 18.2507 |
| 2000's | 28 (54.90) | 29.6817 |
| 2010's | 5 (9.80) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Talawanich, Y | 1 |
| Kamchonwongpaisan, S | 1 |
| Sirawaraporn, W | 1 |
| Yuthavong, Y | 1 |
| Fanello, CI | 2 |
| Karema, C | 2 |
| Avellino, P | 1 |
| Bancone, G | 1 |
| Uwimana, A | 2 |
| Lee, SJ | 1 |
| d'Alessandro, U | 2 |
| Modiano, D | 1 |
| Ogunfowokan, O | 1 |
| Dankyau, M | 1 |
| Madaki, AJ | 1 |
| Thacher, TD | 1 |
| Miller, AK | 1 |
| Bandyopadhyay, N | 1 |
| Wootton, DG | 2 |
| Duparc, S | 6 |
| Kirby, PL | 3 |
| Winstanley, PA | 9 |
| Ward, SA | 4 |
| Premji, Z | 4 |
| Umeh, RE | 1 |
| Owusu-Agyei, S | 1 |
| Esamai, F | 1 |
| Ezedinachi, EU | 1 |
| Oguche, S | 1 |
| Borrmann, S | 1 |
| Sowunmi, A | 2 |
| Pamba, A | 4 |
| Kellam, L | 1 |
| Guiguemdé, R | 1 |
| Greenwood, B | 4 |
| Kaye, DK | 1 |
| Nshemerirwe, R | 1 |
| Mutyaba, TS | 1 |
| Ndeezi, G | 1 |
| Gosling, RD | 1 |
| Gesase, S | 1 |
| Mosha, JF | 1 |
| Carneiro, I | 1 |
| Hashim, R | 1 |
| Lemnge, M | 1 |
| Mosha, FW | 1 |
| Chandramohan, D | 1 |
| Tiono, AB | 2 |
| Dicko, A | 1 |
| Ndububa, DA | 1 |
| Agbenyega, T | 1 |
| Pitmang, S | 1 |
| Awobusuyi, J | 1 |
| Goh, LE | 1 |
| Harrell, E | 1 |
| Carter, N | 3 |
| Luzzatto, L | 2 |
| Bardsley, B | 1 |
| Barry, SJ | 1 |
| Drozdz, MA | 1 |
| Hancock, SA | 1 |
| Okafo, GN | 1 |
| Szafran, MM | 1 |
| Waitumbi, JN | 1 |
| Richardson, ND | 1 |
| Sulo, J | 1 |
| Chimpeni, P | 3 |
| Hatcher, J | 2 |
| Kublin, JG | 4 |
| Plowe, CV | 2 |
| Molyneux, ME | 2 |
| Marsh, K | 2 |
| Taylor, TE | 2 |
| Watkins, WM | 5 |
| Curtis, J | 4 |
| Maxwell, CA | 3 |
| Msuya, FH | 1 |
| Mkongewa, S | 1 |
| Alloueche, A | 3 |
| Warhurst, DC | 2 |
| Lang, T | 2 |
| Pincock, S | 1 |
| Chambo, W | 1 |
| Mwaimu, M | 1 |
| Magogo, F | 1 |
| Carneiro, IA | 1 |
| Curtis, CF | 2 |
| Zimmerman, PA | 1 |
| Saha, K | 1 |
| Kapoor, L | 1 |
| Arora, VM | 1 |
| Chattopadhya, D | 1 |
| Looareesuwan, S | 3 |
| Imwong, M | 2 |
| Wilairatana, P | 3 |
| Bailey, W | 1 |
| Barton, S | 1 |
| Bwika, J | 2 |
| Falade, CO | 1 |
| Fehintola, FA | 1 |
| Horton, J | 1 |
| Jaffar, S | 1 |
| Kanyok, T | 2 |
| Kremsner, PG | 2 |
| Missinou, MA | 1 |
| Mkandala, C | 1 |
| Oduola, AM | 1 |
| Robertson, L | 1 |
| Brabin, BJ | 1 |
| Eggelte, TA | 1 |
| Parise, M | 1 |
| Verhoeff, F | 1 |
| Bates, SJ | 1 |
| Happi, TC | 1 |
| Sibley, CH | 1 |
| Krudsood, S | 1 |
| Pukrittayakamee, S | 1 |
| Nonprasert, A | 1 |
| Snounou, G | 1 |
| White, NJ | 2 |
| Stewart, LB | 1 |
| Peters, W | 1 |
| Robinson, BL | 1 |
| Taylor-Robinson, D | 1 |
| Jones, K | 1 |
| Garner, P | 1 |
| Simpson, JA | 1 |
| Hughes, D | 1 |
| Manyando, C | 1 |
| Bojang, K | 1 |
| Aarons, L | 1 |
| Winstanley, P | 3 |
| Edwards, G | 1 |
| Watkins, WA | 1 |
| Ward, S | 2 |
| Aponte, JJ | 2 |
| Menendez, C | 3 |
| Schellenberg, D | 1 |
| Kahigwa, E | 2 |
| Mshinda, H | 2 |
| Vountasou, P | 1 |
| Tanner, M | 2 |
| Alonso, PL | 2 |
| Opara, H | 1 |
| Biagini, GA | 1 |
| Kanjala, MK | 1 |
| Woessner, M | 1 |
| Neate, C | 1 |
| Nyirenda, M | 1 |
| Blencowe, H | 1 |
| Dube-Mbeye, Q | 1 |
| Molyneux, M | 1 |
| Dunyo, S | 1 |
| Ngamije, D | 1 |
| Ndahindwa, V | 1 |
| Van Overmeir, C | 1 |
| Van Doren, W | 1 |
| Hogh, B | 1 |
| Thompson, R | 1 |
| Lobo, V | 1 |
| Dgedge, M | 1 |
| Dziegiel, M | 1 |
| Borre, M | 1 |
| Gottschau, A | 1 |
| Streat, E | 2 |
| Schapira, A | 2 |
| Barreto, J | 1 |
| Moncrieff, J | 1 |
| Rieckmann, KH | 3 |
| Yeo, AE | 5 |
| Davis, DR | 1 |
| Hutton, DC | 1 |
| Wheatley, PF | 1 |
| Simpson, R | 1 |
| Font, F | 2 |
| Hirt, R | 2 |
| Mashaka, M | 1 |
| Ascaso, C | 1 |
| Trigg, JK | 1 |
| Mbwana, H | 1 |
| Chambo, O | 1 |
| Hills, E | 2 |
| Watkins, W | 2 |
| Edstein, MD | 4 |
| Shanks, GD | 3 |
| Kyle, DE | 1 |
| Chinwongprom, K | 1 |
| Amradee, S | 1 |
| Vounatsou, P | 1 |
| Acosta, CJ | 1 |
| Schellenberg, DM | 1 |
| Galindo, CM | 1 |
| Kimario, J | 1 |
| Urassa, H | 1 |
| Brabin, B | 1 |
| Smith, TA | 1 |
| Kitua, AY | 1 |
| Amukoye, E | 1 |
| Snow, RW | 1 |
| Mosobo, M | 1 |
| Ngumbao, E | 1 |
| Lowe, B | 1 |
| Ton, M | 1 |
| Minyiri, G | 1 |
| Marbiah, NT | 1 |
| Petersen, E | 1 |
| David, K | 1 |
| Magbity, E | 1 |
| Lines, J | 1 |
| Bradley, DJ | 1 |
| Duraisingh, MT | 1 |
| Ortelli, F | 1 |
| Mutabingwa, T | 1 |
| Nzila, A | 1 |
| Mberu, E | 1 |
| Nduati, E | 1 |
| Dzinjalamala, FK | 1 |
| Kamwendo, DD | 1 |
| Malkin, EM | 1 |
| Cortese, JF | 1 |
| Martino, LM | 1 |
| Mukadam, RA | 1 |
| Rogerson, SJ | 1 |
| Lescano, AG | 1 |
| Vrbova, H | 1 |
| Gibney, S | 1 |
| Gibson, FD | 1 |
| Jolley, D | 1 |
| Heywood, PF | 1 |
| Stace, J | 1 |
| Trenholme, KR | 1 |
| Alpers, MP | 1 |
| Pividal, J | 1 |
| Viktinski, V | 1 |
| Suriyamongkol, V | 1 |
| Timsaad, S | 1 |
| Webster, HK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Study on the Tolerability and Efficacy of the Combination Chlorproguanil-Dapsone+Artesunate Compared to Amodiaquine+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria in Rwandan Children[NCT00461578] | 800 participants | Interventional | 2005-04-30 | Completed | |||
| An Open, Randomised, Multi-centre Dose Ranging Phase II Study to Evaluate LAPDAP in Combination With Three Different Doses of Artesunate[NCT00519467] | Phase 2 | 120 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| A Multi-centre, Randomised, Double-blind, Double Dummy Study Comparing the Efficacy and Safety of Chlorproguanil-dapsone-artesunate Versus Artemether-lumefantrine in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria in Children and Adoles[NCT00344006] | Phase 3 | 1,395 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Zambia[NCT06166498] | Phase 3 | 600 participants (Anticipated) | Interventional | 2024-02-15 | Not yet recruiting | ||
| Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Cameroon[NCT06173206] | Phase 3 | 900 participants (Anticipated) | Interventional | 2024-03-15 | Not yet recruiting | ||
| Drug Options for Intermittent Preventive Treatment for Malaria in Infants in an Area With High Resistance to Sulfadoxine/Pyrimethamine: an Evaluation of Short and Long-acting Antimalarial Drugs[NCT00158574] | Phase 2/Phase 3 | 2,419 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| A Multi-centre, Randomised, Double-blind Study to Compare the Efficacy and Safety of Chlorproguanil-dapsone-artesunate Versus Chlorproguanil-dapsone in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria in Children, Adolescents and Adults [NCT00371735] | Phase 3 | 900 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Short Course of Quinine Plus a Single Dose of Sulphadoxine-Pyrimethamine for Plasmodium Falciparum Malaria[NCT00167739] | Phase 4 | 50 participants | Interventional | 2003-04-30 | Completed | ||
| Intermittent Treatment With Sulfadoxine-Pyrimethamine for Malaria Control in Children: A Randomised, Double Blind, and Placebo-Controlled Clinical Trial[NCT00168948] | Phase 4 | 1,200 participants | Interventional | 2003-03-31 | Active, not recruiting | ||
| A Longitudinal Study Assessing the Infectious Status and Immunity of Mothers and Their Children in Lambaréné, Including Intermittent Treatment of Children With Sulfadoxine-pyrimethamine for Malaria Control and Its Impact on Long-term Health[NCT00167843] | Phase 4 | 1,189 participants | Interventional | 2002-12-31 | Completed | ||
| Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infant: a Randomized, Double-blind, and Placebo-controlled Clinical Trial[NCT00206739] | Phase 4 | 1,070 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| The Prevention of Anaemia and Malaria in Infants in an Area of Intense and Perennial Malaria Transmission[NCT00497471] | 832 participants (Actual) | Interventional | 1995-02-28 | Terminated (stopped due to Follow-up end in 1999) | |||
| Pharmacokinetics of Chlorproguanil-Dapsone in Pregnant Women With Plasmodium Falciparum Infection, and Reinfection With P. Falciparum During Pregnancy Following Treatment[NCT00126971] | Phase 1 | 132 participants | Interventional | 2005-07-31 | Suspended | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dapsone and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes.
Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Dapsone; Drug Resistance; Female; Humans; Infan | 2004 |
Malaria: uncomplicated, caused by Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combina | 2005 |
Studies on anti-folate antimalarials in east Africa.
Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; | 1999 |
26 trials available for dapsone and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combina | 2008 |
Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Com | 2009 |
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationshi | 2009 |
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Dapsone; Double-Blind Method; Et | 2009 |
A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda.
Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Dapsone; | 2008 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Africa South of the Sahara; Animals; Antimalarials; Artemisinins; Artesunate; Chi | 2009 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.
Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; D | 2002 |
Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment.
Topics: Animals; Antimalarials; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Drug Therapy, Co | 2002 |
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.
Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinat | 2004 |
Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation.
Topics: Age Factors; Anemia; Animals; Antigens, Protozoan; Child, Preschool; Dapsone; Drug Therapy, Combinat | 2007 |
Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisia; Artemisinins; Artesunate; Child; Child, Presch | 2008 |
A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Dapsone; Drug Administration Sch | 2008 |
The influence of Maloprim chemoprophylaxis on cellular and humoral immune responses to Plasmodium falciparum asexual blood stage antigens in schoolchildren living in a malaria endemic area of Mozambique.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Child; Cohort Studies; Cross-Sec | 1994 |
Recent military experience with malaria chemoprophylaxis.
Topics: Antimalarials; Australia; Chloroquine; Dapsone; Doxycycline; Drug Administration Schedule; Drug Comb | 1993 |
A comparative study of the efficacies of chloroquine and a pyrimethamine-dapsone combination in clearing Plasmodium falciparum parasitaemia in school children in Tanzania.
Topics: Antimalarials; Child; Chloroquine; Dapsone; Drug Combinations; Female; Humans; Malaria, Falciparum; | 1996 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria.
Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resist | 1997 |
A controlled trial of lambda-cyhalothrin-impregnated bed nets and/or dapsone/pyrimethamine for malaria control in Sierra Leone.
Topics: Anti-Infective Agents; Bedding and Linens; Child; Child, Preschool; Dapsone; Humans; Infant; Insecti | 1998 |
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.
Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate S | 1998 |
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind | 2002 |
Chemoprophylaxis against malaria in Papua New Guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine.
Topics: Antimalarials; Body Weight; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Fe | 1992 |
Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique.
Topics: Child; Dapsone; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mozambique; Pyrimethamine | 1992 |
Proguanil combined with dapsone chemoprophylaxis for malaria.
Topics: Adult; Australia; Dapsone; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Military Pe | 1992 |
Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border.
Topics: Blood Cells; Cambodia; Dapsone; Doxycycline; Drug Therapy, Combination; Drug Tolerance; Glucosephosp | 1992 |
22 other studies available for dapsone and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase.
Topics: Antimalarials; Dapsone; Dihydropteroate Synthase; Drug Interactions; Drug Resistance; Drug Synergism | 2015 |
The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.
Topics: Anemia, Hemolytic; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Glucosephosphate Dehy | 2010 |
Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Liqui | 2011 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
The development of Lapdap, an affordable new treatment for malaria.
Topics: Animals; Antimalarials; Child; Clinical Trials as Topic; Dapsone; Drug Approval; Drug Combinations; | 2003 |
Drug company to offer new malaria drug cheaply in Africa.
Topics: Africa; Antimalarials; Dapsone; Drug Combinations; Drug Costs; Drug Industry; Humans; International | 2003 |
Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets.
Topics: Altitude; Animals; Anopheles; Antigens, Protozoan; Child; Child, Preschool; Dapsone; Drug Therapy, C | 2003 |
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets.
Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; | 2003 |
Malaria, leprosy and dapsone.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Dapsone; Female; Humans; Incidence; India; Leprostati | 2003 |
Chlorproguanil-dapsone for malaria in Africa.
Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falcip | 2004 |
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.
Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Pr | 2004 |
Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Dihydropteroate Syntha | 2005 |
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combinatio | 2004 |
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria | 2006 |
Determination of dapsone in serum and saliva using reversed-phase high-performance liquid chromatography with ultraviolet or electrochemical detection.
Topics: Chromatography, High Pressure Liquid; Dapsone; Electrochemistry; Humans; Leprosy; Malaria, Falciparu | 1994 |
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone.
Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; | 1997 |
Direct comparison of antimalarial activity among PS-15 combination therapies by bioassay of serum samples from treated Saimiri sciureus.
Topics: Animals; Antimalarials; Atovaquone; Biological Assay; Dapsone; Disease Models, Animal; Drug Synergis | 1997 |
Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant Plasmodium falciparum isolates.
Topics: Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falcip | 1997 |
Antimalaria activity of the triple combination of proguanil, atovaquone and dapsone.
Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Resistance, Multiple; Drug Synergism; Drug Therapy | 1997 |
Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Fema | 1997 |
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug | 2001 |
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria.
Topics: Antimalarials; Artemisinins; Clinical Trials, Phase III as Topic; Dapsone; Drug Approval; Drug Combi | 2001 |