dapsone and Methemoglobinemia studies

Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"V methylene blue therapy causes significant decline in MetHb level and is more effective in treatment of methemoglobinemia as compared to intermittent regimen."	9.13	Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy. ( Mishra, OP; Pandey, M; Prasad, R; Singh, R, 2008)
"To present a comprehensive review of dapsone-induced methemoglobinemia and its management."	8.87	Dapsone-induced methemoglobinemia: a primer for clinicians. ( Barclay, JA; Ibrahim, RB; Ziemba, SE, 2011)
"To report a case of methemoglobinemia in a patient receiving dapsone for prophylaxis of Pneumocystis carinii pneumonia (PCP)."	8.80	Dapsone-induced methemoglobinemia. ( McCarthy, MW; Ward, KE, 1998)
"The appearance of bite cells associated with methemoglobinemia can be caused by oxidizing drugs such as dapsone in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or high drug serum levels."	8.12	Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. ( Awan, M; Brown, LE; Gandelman, JS; Geere, M; Hu, Y; Kogan, SC; Leavitt, AD; Pearson, HJ, 2022)
"Methemoglobinemia is a common complication of dapsone poisoning."	8.12	Acute dapsone poisoning with methemoglobinemia: a case report. ( Alilou, M; Benhalima, A; Chajai, I; El Arfaoui, M; El Hamzaoui, H; El Ouazzani, MC, 2022)
" CASE REPORT A 22-year-old woman, who was diagnosed with multibacillary leprosy, developed dapsone-induced methemoglobinemia and hemolytic anemia, complicated by melioidosis."	8.02	Challenges in Managing a Lepromatous Leprosy Patient Complicated with Melioidosis Infection, Dapsone-Induced Methemoglobinemia, Hemolytic Anemia, and Lepra Reaction. ( Chew, LP; Chua, HH; Fam, TL; Lee, JTH; Muniandy, P; Tang, ASO; Ting, IPL; Wong, QY; Yeo, ST, 2021)
" We report a case of an 83-year-old female with stage III chronic kidney disease, who was started on high-dose prednisone for nephrotic syndrome and dapsone for pneumocystis jirovecii pneumonia prophylaxis."	8.02	Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia. ( Ali, R; Kadhem, S; Mannemuddhu, SS; Ruchi, R, 2021)
"Dapsone gel is a topical treatment for facial acne in adolescents and adults, and while systemic dapsone therapy is known to be associated with methemoglobinemia, once-daily topical dapsone has been well tolerated with few side effects in large randomized controlled trials."	7.96	Severe methemoglobinemia due to topical dapsone misuse in a teenage girl. ( McCarthy, J; McCarthy, P; McFadden, V; Stefanko, N; Yale, S, 2020)
"Dapsone intoxication can be a life-threatening condition due its enterohepatic recirculation pharmacokinetics, and therefore, persistent methemoglobinemia development."	7.96	Whole bowel irrigation in dapsone intoxication with persistent methemoglobinemia. ( Barrios, C; Carboni Bisso, I; Cordero, MP; Gemelli, N; Pina, D, 2020)
" Numerous testing modalities are performed in the ED focused on an infectious versus pulmonary etiology prior to coming to the conclusion that the source is methemoglobinemia induced by dapsone therapy."	7.91	Neutropenia, Hypoxia, and the Complexities of Emergency Medicine: A Case of Dapsone-Induced Methemoglobinemia. ( Blomkalns, A; Iams, A; Vu, S, 2019)
"This case shows that dapsone-induced mania severity is correlated with methemoglobinemia level, leading for the first time to the hypothesis of a physiopathological mechanism by which dapsone could induce mania."	7.91	Methemoglobinemia as a biomarker of dapsone-induced mania severity. ( Ait Tayeb, AEK; Becquemont, L; Colle, R; Corruble, E; David, DJ; de Menthon, M; Lambotte, O; Mesdom, P; Verstuyft, C, 2019)
" de Martínez Hospital, with cyanosis in face and limb, in poor condition, that consumed dapsone accidentally."	7.88	[Methemoglobinemia due to Dapsone: a pediatric case report]. ( Capurso, C; Larroca, MC; Matsuda, M; Paccor, A; Rizzo, E, 2018)
"We attempted to clarify this issue by comparing the clinical course of methemoglobinemia caused by dapsone and that caused by other toxic agents."	7.83	Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. ( Ahn, S; Kim, WY; Kim, YJ; Lee, JH; Lee, YS; Lim, KS; Oh, BJ; Ryoo, SM; Seo, DW; Sohn, CH, 2016)
"While methemoglobinemia is a possible complication of chronic dapsone therapy or of acute overdose, serious adverse manifestations related to methemoglobin formation remain rare."	7.81	Acute visual loss following dapsone-induced methemoglobinemia and hemolysis. ( Hantson, P; Hanuschk, D; Kozyreff, A; Saint-Marcoux, F; Tafzi, N; Tennstedt, D, 2015)
"Diaphenylsulfone (DDS: Dapsone) is used for Pneumocystis pneumonia (PCP) prophylaxis, and methemoglobinemia has rarely been reported as a side effect of DDS."	7.81	Identifying the Cause of the "Saturation Gap": Two Cases of Dapsone-induced Methemoglobinemia. ( Arita, M; Furuta, K; Hashimoto, T; Ikeda, S; Ikeo, S; Ishida, T; Ito, A; Nishiyama, A; Tachibana, H; Takaiwa, T; Tanaka, M; Tokioka, F; Yokoyama, T; Yoshioka, H, 2015)
"Among 167 pediatric patients treated for hematologic malignancies or aplastic anemia who received dapsone for PCP prophylaxis, demographic and dapsone treatment data were retrospectively collected."	7.77	Dapsone-induced methemoglobinemia: a dose-related occurrence? ( Esbenshade, AJ; Friedman, DL; Ho, RH; Shintani, A; Smith, LA; Zhao, Z, 2011)
"The curcumin's effect given orally by gavage in single- or multiple-dose regimens on methemoglobinemia induced by dapsone (DDS) was investigated in male Wistar rats."	7.77	Curcumin could prevent methemoglobinemia induced by dapsone in rats. ( Alcantara, GK; Bergamaschi, MM; Queiroz, RH; Valério, DA, 2011)
"Dapsone induces methemoglobinemia by oxidant stress; ethyl pyruvate (EP) is an antioxidant and radical oxygen species scavenger."	7.74	The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats. ( Jo, YH; Kang, YJ; Kim, K; Kwon, WY; Lee, JH; Shin, SD; Suh, GJ, 2008)
"This report describes a case of methemoglobinemia in association with dapsone therapy."	7.73	Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura. ( Roberts, WD; Schiff, DE; Sue, YJ, 2006)
"We studied 15 children with acute lymphoblastic leukemia (ALL) receiving dapsone for PCP prophylaxis to determine the frequency of methemoglobinemia, and correlate its occurrence with cytochrome b5 reductase (Cb5R) enzyme levels."	7.73	Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels. ( Athale, UH; Barr, RD; Hoyer, JD; MacDonald, P; Williams, S, 2005)
"The treatment of two common adverse effects of dapsone (methemoglobinemia and hemolytic anemia) is discussed, and a case of acute dapsone intoxication is described."	7.68	Dapsone-induced methemoglobinemia and hemolytic anemia. ( Erstad, BL, 1992)
" We have attempted to reduce dapsone-dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co-administration of cimetidine."	7.68	The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. ( Breckenridge, AM; Coleman, MD; Friedmann, PS; Park, BK; Rhodes, LE; Scott, AK; Verbov, JL, 1992)
"The authors report 8 cases of Horton's disease and/or polymyalgia rheumatica treated with prednisone with an initially favourable result."	7.67	[Role of dapsone in the treatment of Horton's disease and polymyalgia rheumatica]. ( Celton, H; Doury, P; Eulry, F; Fabresse, FX; Larroque, P; Pattin, S, 1984)
"Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone)."	7.66	Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency. ( Fryd, CH; Ganer, A; Knobel, B; Rachmilewitz, EA, 1981)
"Twenty patients with dermatitis herpetiformis treated with di(4-aminophenyl)-sulphone (Dapsone) were analyzed with respect to serum hemopexin concentration as well as some other haematological parameters."	7.65	Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone). ( Kastrup, W; Lindstedt, G; Lundberg, PA; Mobacken, H, 1975)
"Dapsone has been utilized for the prevention of Pneumocystis jirovecii pneumonia in immunosuppressed patients including pediatric kidney transplant recipients, in whom trimethoprim-sulfamethoxazole (TMP-SMX) is contraindicated."	5.62	Dapsone-induced methemoglobinemia in pediatrics post-renal transplant. ( Hindka, A; Huynh, D; Verghese, PS, 2021)
" Though these drugs are generally well tolerated, they can result in potentially severe adverse effects."	5.56	Murphy's law in force: sequential adverse events encountered during the treatment of Pneumocystis pneumonia (cotrimoxazole-induced acute peripheral neuropathy and primaquine-induced methemoglobinemia). ( Agarwal, R; Dhooria, S; Muthu, V; Prasad, KT; Saxena, P; Sehgal, IS, 2020)
"Dapsone (75 mg/day) was begun as adjunctive treatment, and new blister formation ceased."	5.56	A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis. ( Hayama, Y; Imanishi, H; Sugawara, K; Tsuruta, D; Yoshimoto, N, 2020)
"Dapsone was suspended and one week later, her methemoglobinemia was absent."	5.56	[Methemoglobinemia caused by dapsone. Report of one case]. ( Barnafi, E; Jara, A; Rojas, V; Sepúlveda, RA, 2020)
"Methylene blue is the first-choice treatment of methemoglobinemia, but it is not readily available in most Korean emergency departments because of an import suspension."	5.40	High-dose vitamin C management in dapsone-induced methemoglobinemia. ( Kang, TS; Lee, KW; Park, SY, 2014)
"Acquired methemoglobinemia is a common, potentially fatal syndrome that can occur as a result of exposure to numerous xenobiotics."	5.37	Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure. ( Canning, J; Levine, M, 2011)
"Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis."	5.36	Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. ( Ashurst, JV; Fritz, WT; Hauger, W; Wasson, MN, 2010)
"Methylene blue was administered (2 mg/kg intravenously) and the patient rapidly improved."	5.30	A case of methemoglobinemia after ingestion of an aphrodisiac, later proven as dapsone. ( Kim, M; Kim, MJ; Lee, JY; Lee, KJ; Lee, SW, 1999)
"It is the drug of choice for the treatment of leprosy and prophylaxis of malaria."	5.30	Haematological and biochemical alterations in leprosy patients already treated with dapsone and MDT. ( Barbosa, JC; de Carvalho, D; de Souza, AM; Gouveia, E; Melchior Júnior, E; Queiroz, RH, 1997)
"Intraoperative cyanosis is most commonly caused by hypoxaemia."	5.27	Intraoperative cyanosis: a case of dapsone-induced methaemoglobinaemia. ( Leighton, K; Mayo, W; Robertson, B; Ruedy, J, 1987)
"A case of methemoglobinemia is reported in one such patient treated with dapsone."	5.27	Methemoglobinemia from dapsone therapy for a suspected brown spider bite. ( Iserson, KV, 1985)
"To present a comprehensive review of dapsone-induced methemoglobinemia and its management."	4.87	Dapsone-induced methemoglobinemia: a primer for clinicians. ( Barclay, JA; Ibrahim, RB; Ziemba, SE, 2011)
"To report a case of methemoglobinemia in a patient receiving dapsone for prophylaxis of Pneumocystis carinii pneumonia (PCP)."	4.80	Dapsone-induced methemoglobinemia. ( McCarthy, MW; Ward, KE, 1998)
"Methemoglobinemia is a common complication of dapsone poisoning."	4.12	Acute dapsone poisoning with methemoglobinemia: a case report. ( Alilou, M; Benhalima, A; Chajai, I; El Arfaoui, M; El Hamzaoui, H; El Ouazzani, MC, 2022)
"The appearance of bite cells associated with methemoglobinemia can be caused by oxidizing drugs such as dapsone in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or high drug serum levels."	4.12	Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. ( Awan, M; Brown, LE; Gandelman, JS; Geere, M; Hu, Y; Kogan, SC; Leavitt, AD; Pearson, HJ, 2022)
" CASE REPORT A 22-year-old woman, who was diagnosed with multibacillary leprosy, developed dapsone-induced methemoglobinemia and hemolytic anemia, complicated by melioidosis."	4.02	Challenges in Managing a Lepromatous Leprosy Patient Complicated with Melioidosis Infection, Dapsone-Induced Methemoglobinemia, Hemolytic Anemia, and Lepra Reaction. ( Chew, LP; Chua, HH; Fam, TL; Lee, JTH; Muniandy, P; Tang, ASO; Ting, IPL; Wong, QY; Yeo, ST, 2021)
" We report a case of an 83-year-old female with stage III chronic kidney disease, who was started on high-dose prednisone for nephrotic syndrome and dapsone for pneumocystis jirovecii pneumonia prophylaxis."	4.02	Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia. ( Ali, R; Kadhem, S; Mannemuddhu, SS; Ruchi, R, 2021)
"Dapsone gel is a topical treatment for facial acne in adolescents and adults, and while systemic dapsone therapy is known to be associated with methemoglobinemia, once-daily topical dapsone has been well tolerated with few side effects in large randomized controlled trials."	3.96	Severe methemoglobinemia due to topical dapsone misuse in a teenage girl. ( McCarthy, J; McCarthy, P; McFadden, V; Stefanko, N; Yale, S, 2020)
"Dapsone intoxication can be a life-threatening condition due its enterohepatic recirculation pharmacokinetics, and therefore, persistent methemoglobinemia development."	3.96	Whole bowel irrigation in dapsone intoxication with persistent methemoglobinemia. ( Barrios, C; Carboni Bisso, I; Cordero, MP; Gemelli, N; Pina, D, 2020)
"This case shows that dapsone-induced mania severity is correlated with methemoglobinemia level, leading for the first time to the hypothesis of a physiopathological mechanism by which dapsone could induce mania."	3.91	Methemoglobinemia as a biomarker of dapsone-induced mania severity. ( Ait Tayeb, AEK; Becquemont, L; Colle, R; Corruble, E; David, DJ; de Menthon, M; Lambotte, O; Mesdom, P; Verstuyft, C, 2019)
" Numerous testing modalities are performed in the ED focused on an infectious versus pulmonary etiology prior to coming to the conclusion that the source is methemoglobinemia induced by dapsone therapy."	3.91	Neutropenia, Hypoxia, and the Complexities of Emergency Medicine: A Case of Dapsone-Induced Methemoglobinemia. ( Blomkalns, A; Iams, A; Vu, S, 2019)
" de Martínez Hospital, with cyanosis in face and limb, in poor condition, that consumed dapsone accidentally."	3.88	[Methemoglobinemia due to Dapsone: a pediatric case report]. ( Capurso, C; Larroca, MC; Matsuda, M; Paccor, A; Rizzo, E, 2018)
"We attempted to clarify this issue by comparing the clinical course of methemoglobinemia caused by dapsone and that caused by other toxic agents."	3.83	Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. ( Ahn, S; Kim, WY; Kim, YJ; Lee, JH; Lee, YS; Lim, KS; Oh, BJ; Ryoo, SM; Seo, DW; Sohn, CH, 2016)
"Dapsone is an extensively Used drug for the treatment of leprosy as well as'some other clinical problems worldwide: Its use has been predicted to increase further, especially in non leprosy conditions."	3.83	Dapsone: An Update. ( Aruna, B; Kallappa, H; Karjigi, S; Kusuma, MR; Murthy, SC; Reddy, YN, 2016)
"While methemoglobinemia is a possible complication of chronic dapsone therapy or of acute overdose, serious adverse manifestations related to methemoglobin formation remain rare."	3.81	Acute visual loss following dapsone-induced methemoglobinemia and hemolysis. ( Hantson, P; Hanuschk, D; Kozyreff, A; Saint-Marcoux, F; Tafzi, N; Tennstedt, D, 2015)
"Diaphenylsulfone (DDS: Dapsone) is used for Pneumocystis pneumonia (PCP) prophylaxis, and methemoglobinemia has rarely been reported as a side effect of DDS."	3.81	Identifying the Cause of the "Saturation Gap": Two Cases of Dapsone-induced Methemoglobinemia. ( Arita, M; Furuta, K; Hashimoto, T; Ikeda, S; Ikeo, S; Ishida, T; Ito, A; Nishiyama, A; Tachibana, H; Takaiwa, T; Tanaka, M; Tokioka, F; Yokoyama, T; Yoshioka, H, 2015)
"Among 167 pediatric patients treated for hematologic malignancies or aplastic anemia who received dapsone for PCP prophylaxis, demographic and dapsone treatment data were retrospectively collected."	3.77	Dapsone-induced methemoglobinemia: a dose-related occurrence? ( Esbenshade, AJ; Friedman, DL; Ho, RH; Shintani, A; Smith, LA; Zhao, Z, 2011)
" The resulting methaemoglobinaemia and lactic acidosis persisted despite treatment with methylene blue, multiple-dose activated charcoal and ascorbic acid."	3.77	Acute dapsone overdose: the effects of continuous veno-venous haemofiltration on the elimination of dapsone. ( Anstey, CM; Edstein, MD; Gorton, CJ; Masurkar, VA, 2011)
"Dapsone is used as an antibiotic for leprosy and for dermatological disorders and may cause methemoglobinemia."	3.76	Dapsone intoxication: clinical course and characteristics. ( Cha, KC; Do, HH; Hwang, SO; Ji, HJ; Kim, H; Lee, CC; Lee, KH; Park, KH; Park, SM; Singer, AJ, 2010)
"We studied 15 children with acute lymphoblastic leukemia (ALL) receiving dapsone for PCP prophylaxis to determine the frequency of methemoglobinemia, and correlate its occurrence with cytochrome b5 reductase (Cb5R) enzyme levels."	3.73	Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels. ( Athale, UH; Barr, RD; Hoyer, JD; MacDonald, P; Williams, S, 2005)
"Dapsone, used for prevention of Pneumocystis jirovecii infections, has been reported to cause hemolytic anemia and methemoglobinemia; its tolerability in solid organ transplant recipients is not well described."	3.73	Complications related to dapsone use for Pneumocystis jirovecii pneumonia prophylaxis in solid organ transplant recipients. ( Barton, TD; Bloom, RD; Blumberg, EA; Chojnowski, D; Doyle, AM; Goral, S; Korenda, K; Lee, I, 2005)
"This report describes a case of methemoglobinemia in association with dapsone therapy."	3.73	Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura. ( Roberts, WD; Schiff, DE; Sue, YJ, 2006)
"We report the case of a 26 year-old female who was treated on numerous occasions for methemoglobinemia believed secondary to surreptitious abuse of dapsone as part of a factitious disorder."	3.70	Factitious methemoglobinemia. ( Carr, KM; Caruana, LC; Elias, L; Rabinowitz, I, 1999)
" Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp)."	3.70	Clinical and laboratory parameters in dapsone acute intoxication. ( Carrazza, FR; Carrazza, MZ; Oga, S, 2000)
"There are many case reports of dapsone overdose in adults but only a few reports of dapsone-induced methemoglobinemia in children."	3.69	Acute dapsone intoxication: a pediatric case report. ( MacDonald, RD; McGuigan, MA, 1997)
"Acute poisoning from excessive dapsone (4,4-diaminodiphenylsulfone) intake in uncommon in the United States; no cases were reported during 1992."	3.69	Severe accidental dapsone overdose. ( Bailie, GR; McGoldrick, MD, 1995)
"The treatment of two common adverse effects of dapsone (methemoglobinemia and hemolytic anemia) is discussed, and a case of acute dapsone intoxication is described."	3.68	Dapsone-induced methemoglobinemia and hemolytic anemia. ( Erstad, BL, 1992)
" We have attempted to reduce dapsone-dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co-administration of cimetidine."	3.68	The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. ( Breckenridge, AM; Coleman, MD; Friedmann, PS; Park, BK; Rhodes, LE; Scott, AK; Verbov, JL, 1992)
"The authors report 8 cases of Horton's disease and/or polymyalgia rheumatica treated with prednisone with an initially favourable result."	3.67	[Role of dapsone in the treatment of Horton's disease and polymyalgia rheumatica]. ( Celton, H; Doury, P; Eulry, F; Fabresse, FX; Larroque, P; Pattin, S, 1984)
"Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone)."	3.66	Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency. ( Fryd, CH; Ganer, A; Knobel, B; Rachmilewitz, EA, 1981)
"5 g of 4,4'-diamino, diphenyl sulphone (dapsone) taken as a suicide attempt in a patient on long-term therapy for tuberculoid leprosy resulted in permanent bilateral retinal necrosis, previously unreported side effect of this drug."	3.66	Permanent retinal damage following massive dapsone overdose. ( Agnello, R; Chester, GH; Holt, K; Kenner, DJ, 1980)
"Twenty patients with dermatitis herpetiformis treated with di(4-aminophenyl)-sulphone (Dapsone) were analyzed with respect to serum hemopexin concentration as well as some other haematological parameters."	3.65	Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone). ( Kastrup, W; Lindstedt, G; Lundberg, PA; Mobacken, H, 1975)
"Dapsone is an antibacterial sulfonamide with anti-inflammatory property, which showed therapeutic activity in patients with immune thrombocytopenia (ITP); the activity in patients who showed refractoriness to rituximab is unknown."	2.77	Dapsone salvage therapy for adult patients with immune thrombocytopenia relapsed or refractory to steroid and rituximab. ( Chiozzotto, M; Fanin, R; Marin, L; Puglisi, S; Volpetti, S; Zaja, F, 2012)
"1."	2.39	Dapsone toxicity: some current perspectives. ( Coleman, MD, 1995)
"Dapsone has been utilized for the prevention of Pneumocystis jirovecii pneumonia in immunosuppressed patients including pediatric kidney transplant recipients, in whom trimethoprim-sulfamethoxazole (TMP-SMX) is contraindicated."	1.62	Dapsone-induced methemoglobinemia in pediatrics post-renal transplant. ( Hindka, A; Huynh, D; Verghese, PS, 2021)
" Though these drugs are generally well tolerated, they can result in potentially severe adverse effects."	1.56	Murphy's law in force: sequential adverse events encountered during the treatment of Pneumocystis pneumonia (cotrimoxazole-induced acute peripheral neuropathy and primaquine-induced methemoglobinemia). ( Agarwal, R; Dhooria, S; Muthu, V; Prasad, KT; Saxena, P; Sehgal, IS, 2020)
"Dapsone (75 mg/day) was begun as adjunctive treatment, and new blister formation ceased."	1.56	A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis. ( Hayama, Y; Imanishi, H; Sugawara, K; Tsuruta, D; Yoshimoto, N, 2020)
"Dapsone was suspended and one week later, her methemoglobinemia was absent."	1.56	[Methemoglobinemia caused by dapsone. Report of one case]. ( Barnafi, E; Jara, A; Rojas, V; Sepúlveda, RA, 2020)
"Dapsone clearance was enhanced by ECTR, especially by IHD-HP."	1.43	Extracorporeal treatments in a dapsone overdose: a case report. ( Bernier-Jean, A; Bouchard, J; Brindamour, D; Cormier, M; Déziel, C; Ghannoum, M, 2016)
"Methylene blue is the first-choice treatment of methemoglobinemia, but it is not readily available in most Korean emergency departments because of an import suspension."	1.40	High-dose vitamin C management in dapsone-induced methemoglobinemia. ( Kang, TS; Lee, KW; Park, SY, 2014)
"Methylene blue was administered and the methaemoglobin level dropped to 5% within three days."	1.39	[Dapsone-induced methaemoglobinaemia]. ( Mrgan, M; Rytter, D, 2013)
"Methemoglobinemia is a rare pathology that results from the oxidation of iron in the hemoglobin molecule."	1.38	Two cases of acquired methemoglobinemia. ( Bergmans, D; Hall, A; Schnabel, R; Stessel, B, 2012)
"Acquired methemoglobinemia is a common, potentially fatal syndrome that can occur as a result of exposure to numerous xenobiotics."	1.37	Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure. ( Canning, J; Levine, M, 2011)
"Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis."	1.36	Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. ( Ashurst, JV; Fritz, WT; Hauger, W; Wasson, MN, 2010)
"Dapsone is a leprostatic agent commonly prescribed for the management of leprosy, malaria, and the immunosuppression-induced infections of Pneumocystis carinii and Toxoplasma gondii."	1.34	The recognition, physiology, and treatment of medication-induced methemoglobinemia: a case report. ( Glickman, RS; Karlis, V; Turner, MD, 2007)
"Dapsone was the most common etiology of acquired methemoglobinemia, accounting for 42% of all cases."	1.32	Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. ( Ash-Bernal, R; Wise, R; Wright, SM, 2004)
"It is the drug of choice for the treatment of leprosy and prophylaxis of malaria."	1.30	Haematological and biochemical alterations in leprosy patients already treated with dapsone and MDT. ( Barbosa, JC; de Carvalho, D; de Souza, AM; Gouveia, E; Melchior Júnior, E; Queiroz, RH, 1997)
"Methylene blue was administered (2 mg/kg intravenously) and the patient rapidly improved."	1.30	A case of methemoglobinemia after ingestion of an aphrodisiac, later proven as dapsone. ( Kim, M; Kim, MJ; Lee, JY; Lee, KJ; Lee, SW, 1999)
" Daily dosing of mice with dapsone (50 mg kg-1, p."	1.29	A dapsone-induced blood dyscrasia in the mouse: evidence for the role of an active metabolite. ( Ahmadi, M; Khalaf, LF; Nicholls, PJ; Smith, HJ, 1996)
"Methemoglobinemia is caused by many factors, both congenital and acquired."	1.29	Chronic methemoglobinemia: improving hemoglobin saturation monitoring during anesthesia. ( Bourke, DL; Mackenzie, CF; Sprung, J; Thomas, P, 1994)
" The 3,3'DDS and MADDT derivatives were both significantly less toxic compared with DDS."	1.28	An investigation into the haematological toxicity of structural analogues of dapsone in-vivo and in-vitro. ( Coleman, MD; Hussain, F; Park, BK; Storr, RC; Tingle, MD, 1991)
"Intraoperative cyanosis is most commonly caused by hypoxaemia."	1.27	Intraoperative cyanosis: a case of dapsone-induced methaemoglobinaemia. ( Leighton, K; Mayo, W; Robertson, B; Ruedy, J, 1987)
"A case of methemoglobinemia is reported in one such patient treated with dapsone."	1.27	Methemoglobinemia from dapsone therapy for a suspected brown spider bite. ( Iserson, KV, 1985)
"It was concluded that haemolytic anaemia after dapsone therapy is not due to a functional impairment of the enzyme."	1.26	Studies on dapsone induced haemolytic anaemia. I. Methaemoglobin production and G-6-PD activity in correlation with dapsone dosage. ( Allegra, F; De Panfilis, G; Manfredi, G; Zampetti, M, 1979)
"A description of the clinical and biochemical course is given for a patient who developed haemolysis and methaemoglobinaemia following dapsone therapy in high dosage for 2 weeks."	1.26	High dose dapsone toxicity. ( Goldwein, MI; Shelley, WB, 1976)

Research

Studies (187)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Delta Methemoglobin Blood Level

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (22.46)	18.7374
1990's	40 (21.39)	18.2507
2000's	35 (18.72)	29.6817
2010's	42 (22.46)	24.3611
2020's	28 (14.97)	2.80

Authors	Studies
Cook, A	1
Grant, S	1
Kapeluk, S	1
Steele, P	1
Sriperumbuduri, S	1
Hesketh, C	1
Clark, EG	1
Sapra, D	1
Singh, GK	1
Bahuguna, A	1
Das, P	1
Gupta, A	1
Jacob, G	1
Schorr, M	1
Moist, LM	1
Yoshida, M	1
Nambu, R	1
Yasuda, R	1
Sakaguchi, H	1
Hara, T	1
Iwama, I	1
Mizuochi, T	1
Yoshida, T	1
Nishimura, K	1
Murabe, H	1
Yokota, T	1
Zia, S	1
Kazim, SN	1
Yousif, AOM	1
Kuthbudeen, MW	1
Hu, Y	3
Geere, M	3
Awan, M	3
Leavitt, AD	3
Brown, LE	3
Pearson, HJ	3
Gandelman, JS	3
Kogan, SC	3
El Hamzaoui, H	3
Chajai, I	3
El Ouazzani, MC	3
Benhalima, A	3
El Arfaoui, M	3
Alilou, M	3
Vandermeersch, D	1
Sansen, PY	1
Pothen, L	1
Condren, J	1
Fitzgerald, D	1
Ezhilarasan, D	1
Yale, S	1
Stefanko, N	1
McCarthy, P	1
McFadden, V	1
McCarthy, J	1
Sahu, KK	2
Lal, A	2
Mishra, AK	2
George, SV	2
Saxena, P	1
Muthu, V	1
Dhooria, S	1
Sehgal, IS	1
Prasad, KT	1
Agarwal, R	1
Siddiqui, AD	1
Bailey, NJ	1
Kraft, RM	1
Schouten, WM	1
Carboni Bisso, I	1
Gemelli, N	1
Cordero, MP	1
Barrios, C	1
Pina, D	1
Lewis, JS	1
Jacobs, ZG	1
Tan, YA	1
Ng, KC	1
Cheo, SW	1
Khoo, TT	1
Low, QJ	1
Jonkers, BRP	1
Cobanoglu, G	1
Blok, EJ	1
Köbben, JJ	1
van der Helm, MW	1
van Hoof, IJAM	1
Tintu, AN	1
Bethlehem, C	2
Versmissen, J	1
Hindka, A	1
Huynh, D	1
Verghese, PS	1
Mannemuddhu, SS	1
Ali, R	1
Kadhem, S	1
Ruchi, R	1
Gallardo, CA	1
Fan, BE	1
Lim, KGE	1
Kuperan, P	1
Hayama, Y	1
Imanishi, H	1
Yoshimoto, N	1
Sugawara, K	1
Tsuruta, D	1
Sepúlveda, RA	1
Barnafi, E	1
Rojas, V	1
Jara, A	1
Tripathi, T	1
Singh, AR	1
Kapoor, R	1
Sinha, A	1
Ghosh, S	1
Kaur, K	1
Pokhariya, D	1
Maity, S	1
Tapadar, A	1
Chandra, A	1
Tang, ASO	1
Wong, QY	1
Yeo, ST	1
Ting, IPL	1
Lee, JTH	1
Fam, TL	1
Chew, LP	1
Chua, HH	1
Muniandy, P	1
Mack, J	1
Mian, A	1
Salim, SA	1
Ramachandran Nair, L	1
Palabindala, V	1
Craici, I	1
Karjigi, S	1
Murthy, SC	1
Kallappa, H	1
Kusuma, MR	1
Aruna, B	1
Reddy, YN	1
Mahapatra, MK	1
Giri, PP	1
Paccor, A	1
Matsuda, M	1
Capurso, C	1
Rizzo, E	1
Larroca, MC	1
Colle, R	1
Ait Tayeb, AEK	1
Mesdom, P	1
de Menthon, M	1
Becquemont, L	1
Verstuyft, C	1
David, DJ	1
Lambotte, O	1
Corruble, E	1
Vu, S	1
Iams, A	1
Blomkalns, A	1
Torabi, J	1
Campbell, A	1
Nair, G	1
Patel, GL	1
Miura, Y	1
Graham, JA	1
Chang, YJ	1
Ali, H	1
Draper, A	1
Chua, F	1
Burke, P	1
Jahangir, K	1
Kolber, MR	1
Mitsides, N	1
Green, D	1
Middleton, R	1
New, D	1
Lamerton, E	1
Allen, J	1
Redshaw, J	1
Chadwick, PR	1
Subudhi, CP	1
Wood, G	1
Wieringa, A	1
Hoogendoorn, M	1
van der Maten, J	1
van Roon, EN	1
Park, SY	1
Lee, KW	1
Kang, TS	1
Rytter, D	1
Mrgan, M	1
Senthilkumaran, S	1
Benita, F	1
Ananth, C	1
Thirumalaikolundusubramanian, P	2
Malasingam, R	1
Ranganathan, D	1
Jeyaseelan, L	1
Ramanathan, K	1
Jacks, M	1
Owens, J	1
John, GT	1
Watton, C	1
Smith, K	1
Carter, E	1
Swartzentruber, GS	1
Yanta, JH	1
Pizon, AF	1
Hanuschk, D	1
Kozyreff, A	1
Tafzi, N	1
Tennstedt, D	1
Hantson, P	1
Saint-Marcoux, F	1
Furuta, K	1
Ikeo, S	1
Takaiwa, T	1
Ikeda, S	1
Nishiyama, A	1
Yokoyama, T	1
Ito, A	1
Tokioka, F	1
Tanaka, M	1
Yoshioka, H	1
Tachibana, H	1
Arita, M	1
Hashimoto, T	1
Ishida, T	1
Albuquerque, RV	1
Malcher, NS	1
Amado, LL	1
Coleman, MD	10
Dos Santos, DC	1
Borges, RS	1
Valente, SA	1
Valente, VC	1
Monteiro, MC	1
Graff, DM	1
Bosse, GM	1
Sullivan, J	1
Kim, YJ	1
Sohn, CH	1
Ryoo, SM	1
Ahn, S	1
Seo, DW	1
Lee, YS	1
Lee, JH	2
Oh, BJ	1
Lim, KS	1
Kim, WY	1
Ghannoum, M	1
Cormier, M	1
Bernier-Jean, A	1
Brindamour, D	1
Déziel, C	1
Bouchard, J	1
O'Dwyer, D	1
McElvaney, NG	1
Jo, YH	1
Kwon, WY	1
Kim, K	1
Shin, SD	1
Kang, YJ	1
Suh, GJ	1
Commondoor, R	1
Murray, MJ	1
Walker, JG	1
Kadia, T	1
Brown, L	1
Juneja, HS	1
de Groot, JF	1
Ashurst, JV	1
Wasson, MN	1
Hauger, W	1
Fritz, WT	1
Moulis, G	1
Bagheri, H	1
Saint Martory, J	1
Bernard, P	1
Montastruc, JL	1
Park, KH	1
Kim, H	1
Lee, CC	1
Cha, KC	1
Park, SM	1
Ji, HJ	1
Do, HH	1
Lee, KH	1
Hwang, SO	1
Singer, AJ	1
Nessim, SJ	1
Lipman, ML	1
Narayanan, N	1
Conlon, N	1
Seigne, P	1
Subramaniam, A	1
Corallo, C	1
Nagappan, R	1
Esbenshade, AJ	1
Ho, RH	1
Shintani, A	1
Zhao, Z	1
Smith, LA	1
Friedman, DL	1
Pallais, JC	1
Mackool, BT	1
Pitman, MB	1
Abouraya, M	1
Sacco, JC	1
Hayes, K	1
Thomas, S	1
Kitchens, CS	1
Trepanier, LA	1
Bergamaschi, MM	1
Alcantara, GK	1
Valério, DA	1
Queiroz, RH	3
Canning, J	1
Levine, M	1
Barclay, JA	1
Ziemba, SE	1
Ibrahim, RB	1
Masurkar, VA	1
Edstein, MD	1
Gorton, CJ	1
Anstey, CM	1
Spoon, KC	1
Ramar, K	1
Zaja, F	1
Marin, L	1
Chiozzotto, M	1
Puglisi, S	1
Volpetti, S	1
Fanin, R	1
Piette, EW	1
Werth, VP	1
Stichtenoth, D	1
Hall, A	1
Stessel, B	1
Bergmans, D	1
Schnabel, R	1
Bryant, SM	1
Pittman, LM	1
Groeper, K	1
Katcher, K	1
Tobias, JD	1
Salamat, A	1
Watson, HG	1
ALEXANDER, JO	1
FISHER, I	2
ORKIN, M	2
Sharif, F	1
Hussey, S	1
Gill, D	1
Asrress, KN	1
Wathen, CG	1
Gorard, DA	1
Ash-Bernal, R	1
Wise, R	1
Wright, SM	1
Williams, S	1
MacDonald, P	1
Hoyer, JD	1
Barr, RD	1
Athale, UH	1
Lee, I	1
Barton, TD	1
Goral, S	1
Doyle, AM	1
Bloom, RD	1
Chojnowski, D	1
Korenda, K	1
Blumberg, EA	1
Talarico, JF	1
Metro, DG	1
Dunford, LM	1
Roy, DM	1
Hahn, TE	1
Padmanabhan, S	1
Segal, BH	1
Almyroudis, N	1
McCarthy, PL	1
Battiwalla, M	1
Shadnia, S	1
Rahimi, M	1
Moeinsadat, M	1
Vesal, G	1
Donyavi, M	1
Abdollahi, M	1
Hohenhaus, M	1
Schiff, DE	1
Roberts, WD	1
Sue, YJ	1
Matisoff, AJ	1
Panni, MK	1
Sener, O	1
Doganci, L	1
Safali, M	1
Besirbellioglu, B	1
Bulucu, F	1
Pahsa, A	1
Choi, A	1
Sarang, A	1
Turner, MD	1
Karlis, V	1
Glickman, RS	1
Mehta, M	3
Prasad, R	1
Singh, R	1
Mishra, OP	1
Pandey, M	1
Endre, ZH	1
Charlesworth, JA	1
Macdonald, GJ	1
Woodbridge, L	1
Revuz, J	2
Hornac, P	2
Magna, LA	1
Beiguelman, B	1
Doury, P	1
Fabresse, FX	1
Pattin, S	1
Eulry, F	1
Celton, H	1
Larroque, P	1
Ganer, A	1
Knobel, B	1
Fryd, CH	1
Rachmilewitz, EA	1
Bernstein, JE	1
Lorincz, AL	1
Lambert, M	1
Sonnet, J	1
Mahieu, P	1
Hassoun, A	1
De Prost, Y	1
Galacteros, F	1
Penev, M	1
Touraine, R	1
Subramanyam, V	1
Subbiah, B	1
Chiranjeevi, V	1
Selvaraj, B	1
Chelliah, T	1
Subramaniam, R	1
Kenner, DJ	1
Holt, K	1
Agnello, R	1
Chester, GH	1
Szeremeta, W	1
Dohar, JE	1
McGoldrick, MD	1
Bailie, GR	1
Rydzewski, B	1
Davis, R	1
Gomber, S	1
Singh, RP	1
Chawla, R	3
Gupta, R	1
Sharma, S	1
Sprung, J	1
Bourke, DL	1
Mackenzie, CF	1
Thomas, P	1
Gurnani, A	1
Bhattacharya, A	2
Sheela, A	1
Thachil, RT	1
Sridhar, CB	1
Mathews, LM	1
Mathews, PJ	1
Wagner, A	1
Marosi, C	1
Binder, M	1
Röggla, G	1
Staudinger, T	1
Keil, F	1
Locker, GJ	1
Frass, M	1
Pirmohamed, M	1
Williams, D	1
Tingle, MD	4
Barry, M	1
Khoo, SH	1
O'Mahony, C	1
Wilkins, EG	1
Breckenridge, AM	6
Park, BK	9
Sin, DD	1
Shafran, SD	1
Driver, JA	1
Lynn, J	1
Dhanjal, US	1
Hoetelmans, RM	1
Otten, JM	1
Koks, CH	1
Soesan, M	1
Beijnen, JH	1
Ahmadi, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients[NCT01836614]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2015-01-31	Withdrawn (stopped due to Study was closed due to recommendations of performing a PK study first.)
Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869]		91 participants (Actual)	Interventional	2011-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours

Peak Methemoglobin Blood Levels

Intervention	percentage of methemoglobin in blood (Mean)
Prilocaine	2.73
Lidocaine	0.78
No Local Anesthetic	0.76

The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours

Time to Peak Methemoglobin Blood Levels

Intervention	percentage of methemoglobin in blood (Mean)
Prilocaine	3.55
Lidocaine	1.63
No Local Anesthetic	1.60

The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours

Article	Year
Dapsone-induced hepatic complications: it's time to think beyond methemoglobinemia. Drug and chemical toxicology, 2021, Volume: 44, Issue:3 Topics: Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Dapsone; Dose-Response Relat	2021
A patient with leukaemia turns blue. Archives of disease in childhood. Education and practice edition, 2009, Volume: 94, Issue:1 Topics: Anti-Infective Agents; Child; Cyanosis; Dapsone; Female; Humans; Methemoglobinemia; Neutropenia; Pre	2009
Dapsone-induced methemoglobinemia: a primer for clinicians. The Annals of pharmacotherapy, 2011, Volume: 45, Issue:9 Topics: Anemia, Hemolytic; Anti-Infective Agents; Dapsone; Enzyme Inhibitors; Humans; Methemoglobinemia; Met	2011
Dapsone in the management of autoimmune bullous diseases. Immunology and allergy clinics of North America, 2012, Volume: 32, Issue:2 Topics: Agranulocytosis; Animals; Autoimmune Diseases; Dapsone; Disease Management; Drug Hypersensitivity; H	2012
[Side effects of treatment with sulfones]. LARC medical, 1981, Volume: 1, Issue:3 Topics: Adult; Agranulocytosis; Chemical and Drug Induced Liver Injury; Child; Dapsone; Drug Eruptions; Drug	1981
Sulfonamides and sulfones in dermatologic therapy. International journal of dermatology, 1981, Volume: 20, Issue:2 Topics: Animals; Chancroid; Conjunctivitis, Inclusion; Dapsone; Dermatitis Herpetiformis; Erythrocytes; Gluc	1981
Dapsone toxicity: some current perspectives. General pharmacology, 1995, Volume: 26, Issue:7 Topics: Agranulocytosis; Anti-Infective Agents; Dapsone; Humans; Liver; Methemoglobinemia	1995
Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1997, Volume: 3, Issue:2 Topics: Aged; Dapsone; Female; Humans; Kidney Transplantation; Liver Transplantation; Methemoglobinemia; Mid	1997
Dapsone-induced methemoglobinemia. The Annals of pharmacotherapy, 1998, Volume: 32, Issue:5 Topics: Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Dapsone; Female; Humans; Methemoglobinemia; Pne	1998
Methaemoglobinaemia and poisoning. Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2001, Volume: 9, Issue:5 Topics: Adult; Child, Preschool; Chlorates; Cyanosis; Dapsone; Emergency Medical Services; Emergency Nursing	2001
Adverse effects of dapsone. International journal of dermatology, 1975, Volume: 14, Issue:7 Topics: Agranulocytosis; Anemia, Hemolytic; Dapsone; Erythrocytes; Humans; Leukocytes; Leukopenia; Methemogl	1975

Article	Year
Dapsone salvage therapy for adult patients with immune thrombocytopenia relapsed or refractory to steroid and rituximab. American journal of hematology, 2012, Volume: 87, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Contraindications; Dan	2012
Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy. Indian journal of pediatrics, 2008, Volume: 75, Issue:3 Topics: Anti-Infective Agents; Child, Preschool; Dapsone; Enzyme Inhibitors; Female; Humans; Infusions, Intr	2008
Diformyl diaminodiphenyl sufone (DFD) as an antimalarial in man. Military medicine, 1970, Volume: 135, Issue:7 Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Formates; Humans; Malaria; Mal	1970

Article	Year
Methaemoglobinaemia in the perioperative period with regional block. BMJ case reports, 2021, Sep-07, Volume: 14, Issue:9 Topics: Benzocaine; Dapsone; Humans; Methemoglobin; Methemoglobinemia; Perioperative Period	2021
A Transplant Patient with Blue Lips, Tongue, and Fingertips. Kidney360, 2021, 02-25, Volume: 2, Issue:2 Topics: Dapsone; Humans; Lip; Methemoglobinemia; Tongue	2021
Three doses of dapsone causing methemoglobinemia in leprosy: A report of two cases. Dermatologic therapy, 2022, Volume: 35, Issue:7 Topics: Dapsone; Humans; Leprostatic Agents; Leprosy; Methemoglobinemia	2022
Methemoglobinemia in a 28-year-old woman treated with dapsone. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2022, 08-08, Volume: 194, Issue:30 Topics: Adult; Dapsone; Female; Humans; Methemoglobinemia	2022
Dapsone for Refractory Gastrointestinal Symptoms in Children With Immunoglobulin A Vasculitis. Pediatrics, 2022, 09-01, Volume: 150, Issue:3 Topics: Abdominal Pain; Adrenal Cortex Hormones; Child; Dapsone; Gastrointestinal Diseases; Humans; IgA Vasc	2022
Dapsone-induced methaemoglobinaemia in relapsing polychondritis. BMJ case reports, 2022, 09-15, Volume: 15, Issue:9 Topics: Dapsone; Humans; Methemoglobinemia; Polychondritis, Relapsing	2022
Intentional dapsone overdose: a rare cause of acquired methaemoglobinaemia in the emergency department. BMJ case reports, 2022, Sep-20, Volume: 15, Issue:9 Topics: Anti-Infective Agents; Charcoal; Dapsone; Drug Overdose; Emergency Service, Hospital; Female; Humans	2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1 Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur	2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1 Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur	2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1 Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur	2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1 Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur	2022
Acute dapsone poisoning with methemoglobinemia: a case report. The Pan African medical journal, 2022, Volume: 43 Topics: Adolescent; Ascorbic Acid; Charcoal; Dapsone; Female; Humans; Methemoglobinemia; Tachypnea	2022
Acute dapsone poisoning with methemoglobinemia: a case report. The Pan African medical journal, 2022, Volume: 43 Topics: Adolescent; Ascorbic Acid; Charcoal; Dapsone; Female; Humans; Methemoglobinemia; Tachypnea	2022
Acute dapsone poisoning with methemoglobinemia: a case report. The Pan African medical journal, 2022, Volume: 43 Topics: Adolescent; Ascorbic Acid; Charcoal; Dapsone; Female; Humans; Methemoglobinemia; Tachypnea	2022
Acute dapsone poisoning with methemoglobinemia: a case report. The Pan African medical journal, 2022, Volume: 43 Topics: Adolescent; Ascorbic Acid; Charcoal; Dapsone; Female; Humans; Methemoglobinemia; Tachypnea	2022
Bad luck comes in threes. European journal of internal medicine, 2023, Volume: 115 Topics: Anemia, Hemolytic; Dapsone; Humans; Methemoglobinemia; Pneumonia, Pneumocystis	2023
Dapsone Induced Methaemoglobinaemia A reminder the iatrogenic causes of cyanosis. Irish medical journal, 2023, 03-23, Volume: 116, Issue:3 Topics: Cyanosis; Dapsone; Humans; Iatrogenic Disease; Methemoglobinemia	2023
Severe methemoglobinemia due to topical dapsone misuse in a teenage girl. Pediatric dermatology, 2020, Volume: 37, Issue:2 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Anti-Infective Agents; Dapsone; Drug Misuse; Fem	2020
Methemoglobinemia in Transplant Recipient Patients: Future of Dapsone as Progress in transplantation (Aliso Viejo, Calif.), 2020, Volume: 30, Issue:1 Topics: Anti-Infective Agents; Dapsone; Humans; Methemoglobinemia; Organ Transplantation; Pneumocystis carin	2020
Murphy's law in force: sequential adverse events encountered during the treatment of Pneumocystis pneumonia (cotrimoxazole-induced acute peripheral neuropathy and primaquine-induced methemoglobinemia). The New Zealand medical journal, 2020, 01-17, Volume: 133, Issue:1508 Topics: Anti-Bacterial Agents; Antimalarials; Clindamycin; Dapsone; Drug Therapy, Combination; Female; Human	2020
Closing the saturation gap: a ten-year retrospective experience with methemoglobinemia. Internal and emergency medicine, 2020, Volume: 15, Issue:6 Topics: Adult; Aged; Antimalarials; Cyanosis; Dapsone; Dyspnea; Female; Humans; Infant, Newborn; Male; Massa	2020
27-Year-Old Woman With Fever, Headache, and Anemia. Mayo Clinic proceedings, 2020, Volume: 95, Issue:6 Topics: Adult; Anemia; Anti-Infective Agents; Blood Gas Analysis; Dapsone; Female; Fever; Headache; Humans;	2020
Whole bowel irrigation in dapsone intoxication with persistent methemoglobinemia. The American journal of emergency medicine, 2020, Volume: 38, Issue:10 Topics: Adolescent; Dapsone; Female; Gastrointestinal Tract; Humans; Methemoglobinemia; Methylene Blue; Ther	2020
Subtle case of dapsone-induced methaemoglobinaemia. BMJ case reports, 2020, Aug-24, Volume: 13, Issue:8 Topics: Aged; Anti-Infective Agents; Confusion; Dapsone; Female; Humans; Memory Disorders; Methemoglobin; Me	2020
A case of dapsone-induced methaemoglobinaemia. Clinical medicine (London, England), 2020, Volume: 20, Issue:5 Topics: Dapsone; Humans; Methemoglobinemia; Methylene Blue	2020
Symptomatic rebound methaemoglobinaemia after treatment with dapsone. The Netherlands journal of medicine, 2020, Volume: 78, Issue:5 Topics: Adult; Dapsone; Female; Folic Acid Antagonists; Humans; Methemoglobinemia; Methylene Blue	2020
Dapsone-induced methemoglobinemia in pediatrics post-renal transplant. Pediatric transplantation, 2021, Volume: 25, Issue:3 Topics: Anti-Infective Agents; Child; Dapsone; Female; Humans; Kidney Transplantation; Male; Methemoglobinem	2021
Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia. CEN case reports, 2021, Volume: 10, Issue:3 Topics: Aged, 80 and over; Dapsone; Dyspnea; Female; Humans; Methemoglobinemia; Nephrotic Syndrome	2021
Chronic dapsone use causing methemoglobinemia with oxidative hemolysis and dyserythropoiesis. American journal of hematology, 2021, 12-01, Volume: 96, Issue:12 Topics: Aged, 80 and over; Anti-Infective Agents; Dapsone; Erythrocytes; Erythropoiesis; Female; Folic Acid	2021
A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis. Acta dermatovenerologica Croatica : ADC, 2020, Volume: 28, Issue:4 Topics: Aged, 80 and over; Anti-Inflammatory Agents; Cyanosis; Dapsone; Dyspnea; Humans; Male; Methemoglobin	2020
[Methemoglobinemia caused by dapsone. Report of one case]. Revista medica de Chile, 2020, Volume: 148, Issue:12 Topics: Dapsone; Female; Humans; Methemoglobinemia; Middle Aged; Rituximab; Trimethoprim, Sulfamethoxazole D	2020
Dapsone-induced methaemoglobinaemia in leprosy: a close mimic of 'happy hypoxia' in the COVID-19 pandemic. Journal of the European Academy of Dermatology and Venereology : JEADV, 2021, Volume: 35, Issue:9 Topics: COVID-19; Dapsone; Humans; Hypoxia; Leprosy; Methemoglobinemia; Pandemics; SARS-CoV-2	2021
Challenges in Managing a Lepromatous Leprosy Patient Complicated with Melioidosis Infection, Dapsone-Induced Methemoglobinemia, Hemolytic Anemia, and Lepra Reaction. The American journal of case reports, 2021, May-26, Volume: 22 Topics: Adult; Anemia, Hemolytic; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Le	2021
Case 5: Fever and Hypoxia in a 17-year-old Boy Undergoing Cancer Chemotherapy. Pediatrics in review, 2017, Volume: 38, Issue:5 Topics: Adolescent; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Dapsone; Fever; H	2017
Upward trend of dapsone-induced methemoglobinemia in renal transplant community . Clinical nephrology, 2017, Volume: 88, Issue:9 Topics: Adult; Aged; Anti-Infective Agents; Dapsone; Female; Humans; Kidney Transplantation; Male; Methemogl	2017
Dapsone: An Update. Indian journal of leprosy, 2016, Volume: 87, Issue:4 Topics: Agranulocytosis; Dapsone; Drug Hypersensitivity Syndrome; Humans; Leprostatic Agents; Leprosy; Methe	2016
Methemoglobinemia: A Girl with 'Chocolate Brown' Colored Blood. Indian journal of pediatrics, 2018, Volume: 85, Issue:10 Topics: Blood; Child, Preschool; Color; Dapsone; Drug Overdose; Female; Humans; Methemoglobinemia	2018
[Methemoglobinemia due to Dapsone: a pediatric case report]. Archivos argentinos de pediatria, 2018, 08-01, Volume: 116, Issue:4 Topics: Child; Cyanosis; Dapsone; Enzyme Inhibitors; Female; Humans; Methemoglobinemia; Methylene Blue	2018
Methemoglobinemia as a biomarker of dapsone-induced mania severity. Journal of affective disorders, 2019, 07-01, Volume: 254 Topics: Biomarkers; Bipolar Disorder; Dapsone; Humans; Male; Methemoglobinemia; Middle Aged	2019
Neutropenia, Hypoxia, and the Complexities of Emergency Medicine: A Case of Dapsone-Induced Methemoglobinemia. The Journal of emergency medicine, 2019, Volume: 56, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Anti-Infective Agents; Dapsone; Emergency Service, Hospital; Enz	2019
Dapsone-Induced Methemoglobinemia in Two Renal Transplant Recipients. Progress in transplantation (Aliso Viejo, Calif.), 2019, Volume: 29, Issue:3 Topics: Aged; Anti-Infective Agents; Dapsone; Enzyme Inhibitors; Female; Humans; Kidney Failure, Chronic; Ki	2019
An unusual cause of cyanosis in a patient with COPD. BMJ case reports, 2013, Mar-01, Volume: 2013 Topics: Anti-Infective Agents; Cyanosis; Dapsone; Dermatitis Herpetiformis; Diagnosis, Differential; Humans;	2013
Dapsone-induced methemoglobinemia: case of the blue lady. Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:9 Topics: Anti-Infective Agents; Dapsone; Female; Humans; Methemoglobinemia; Middle Aged	2013
Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. Transplant infectious disease : an official journal of the Transplantation Society, 2014, Volume: 16, Issue:1 Topics: Adult; Aged; Anti-Infective Agents; Azathioprine; Cohort Studies; Cyclosporine; Dapsone; Female; Glo	2014
Very late recovery of dapsone-induced methemoglobinemia. Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:1 Topics: Antidotes; Charcoal; Dapsone; Enterohepatic Circulation; Female; Folic Acid Antagonists; Half-Life;	2014
High-dose vitamin C management in dapsone-induced methemoglobinemia. The American journal of emergency medicine, 2014, Volume: 32, Issue:6 Topics: Aged, 80 and over; Ascorbic Acid; Dapsone; Female; Humans; Methemoglobin; Methemoglobinemia; Vitamin	2014
[Dapsone-induced methaemoglobinaemia]. Ugeskrift for laeger, 2013, Nov-11, Volume: 175, Issue:46 Topics: Dapsone; Enzyme Inhibitors; Female; Folic Acid Antagonists; Humans; Methemoglobinemia; Methylene Blu	2013
Dapsone-induced methemoglobinemia: therapeutic alternatives and medicolegal aspects. The American journal of emergency medicine, 2014, Volume: 32, Issue:8 Topics: Ascorbic Acid; Dapsone; Female; Humans; Methemoglobinemia; Vitamins	2014
An audit of dapsone-associated methaemoglobinaemia in renal transplant recipients. Nephrology (Carlton, Vic.), 2014, Volume: 19, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Dapsone; Female; Humans; Kidney Transplantati	2014
Methemoglobinemia as a complication of topical dapsone. The New England journal of medicine, 2015, 01-29, Volume: 372, Issue:5 Topics: Dapsone; Female; Humans; Methemoglobinemia	2015
Methemoglobinemia as a complication of topical dapsone. The New England journal of medicine, 2015, 01-29, Volume: 372, Issue:5 Topics: Administration, Topical; Dapsone; Female; Humans; Methemoglobinemia; Young Adult	2015
Acute visual loss following dapsone-induced methemoglobinemia and hemolysis. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:5 Topics: Acute Disease; Adult; Dapsone; Drug Overdose; Female; Hemolysis; Humans; Ischemia; Methemoglobinemia	2015
Identifying the Cause of the "Saturation Gap": Two Cases of Dapsone-induced Methemoglobinemia. Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:13 Topics: Aged, 80 and over; Anti-Infective Agents; Antibiotic Prophylaxis; Cryptogenic Organizing Pneumonia;	2015
In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PloS one, 2015, Volume: 10, Issue:8 Topics: Adult; Antioxidants; Catalase; Cells, Cultured; Dapsone; Erythrocytes; Female; Humans; Male; Methemo	2015
Case Report of Methemoglobinemia in a Toddler Secondary to Topical Dapsone Exposure. Pediatrics, 2016, Volume: 138, Issue:2 Topics: Administration, Topical; Dapsone; Dermatologic Agents; Female; Humans; Infant; Methemoglobinemia	2016
Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Dapsone; Dose-Response Relationship, Drug; Dru	2016
Extracorporeal treatments in a dapsone overdose: a case report. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:9 Topics: Antidotes; Dapsone; Drug Overdose; Female; Half-Life; Hemofiltration; Hemoperfusion; Humans; Methemo	2016
A case of dapsone induced methaemoglobinaemia. Irish journal of medical science, 2008, Volume: 177, Issue:3 Topics: Adult; Dapsone; Enzyme Inhibitors; Female; Humans; Methemoglobinemia; Methylene Blue; Oxygen Inhalat	2008
The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats. Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:9 Topics: Animals; Anti-Infective Agents; Antioxidants; Dapsone; Free Radical Scavengers; Injections, Intraper	2008
Dapsone induced methemoglobinemia in a patient with glioblastoma. Journal of neuro-oncology, 2009, Volume: 94, Issue:1 Topics: Anti-Infective Agents; Brain Stem Neoplasms; Dapsone; Glioblastoma; Humans; Male; Methemoglobinemia;	2009
Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. The Journal of the American Osteopathic Association, 2010, Volume: 110, Issue:1 Topics: Aged; Anti-Allergic Agents; Dapsone; Dermatitis, Contact; Diphenhydramine; Female; Histamine H1 Anta	2010
Very late relapse of dapsone-induced methaemoglobinemia. European journal of clinical pharmacology, 2010, Volume: 66, Issue:6 Topics: Adult; Anti-Bacterial Agents; Dapsone; Dermatitis; Female; Humans; Immunosuppressive Agents; Lupus E	2010
Dapsone intoxication: clinical course and characteristics. Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:6 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Dapsone; Emergency Service, Hospital; Female; Humans; M	2010
The case/ cyanosis in a hemodialysis patient. Kidney international, 2010, Volume: 78, Issue:3 Topics: Adult; Anti-Infective Agents; Cyanosis; Dapsone; Female; Humans; Methemoglobinemia; Renal Dialysis;	2010
Acute methaemoglobinaemia secondary to intentional dapsone overdose. Irish medical journal, 2010, Volume: 103, Issue:9 Topics: Acute Disease; Adult; Anti-Infective Agents; Dapsone; Female; Humans; Methemoglobinemia; Methylene B	2010
Dapsone-associated methaemoglobinaemia in patients with a haematologic malignancy. Anaesthesia and intensive care, 2010, Volume: 38, Issue:6 Topics: Adult; Aged; Anti-Infective Agents; Dapsone; Female; Hematologic Neoplasms; Humans; Male; Methemoglo	2010
Dapsone-induced methemoglobinemia: a dose-related occurrence? Cancer, 2011, Aug-01, Volume: 117, Issue:15 Topics: Anemia, Aplastic; Anti-Infective Agents; Child; Child, Preschool; Cohort Studies; Cross-Sectional St	2011
Case records of the Massachusetts General Hospital: Case 7-2011: a 52-year-old man with upper respiratory symptoms and low oxygen saturation levels. The New England journal of medicine, 2011, Mar-10, Volume: 364, Issue:10 Topics: Celiac Disease; Cough; Dapsone; Dermatitis Herpetiformis; Diabetes Mellitus, Type 1; Diagnosis, Diff	2011
Dapsone-associated methemoglobinemia in a patient with slow NAT25B haplotype and impaired cytochrome b5 reductase activity. Journal of clinical pharmacology, 2012, Volume: 52, Issue:2* Topics: Aged; Anti-Infective Agents; Arylamine N-Acetyltransferase; Cytochrome P-450 CYP2C19; Cytochrome-B(5	2012
Curcumin could prevent methemoglobinemia induced by dapsone in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:7 Topics: Animals; Antioxidants; Curcumin; Dapsone; Dose-Response Relationship, Drug; Injections, Intraperiton	2011
Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:2 Topics: Anti-Infective Agents; Arizona; Cyanosis; Dapsone; Female; Humans; Infant; Infusions, Intravenous; M	2011
Acute dapsone overdose: the effects of continuous veno-venous haemofiltration on the elimination of dapsone. Anaesthesia and intensive care, 2011, Volume: 39, Issue:6 Topics: Acidosis, Lactic; Adolescent; Anti-Infective Agents; Antidotes; Antioxidants; Ascorbic Acid; Blood G	2011
Unexplained hypoxemia. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Dec-15, Volume: 7, Issue:6 Topics: Ascorbic Acid; Azathioprine; Blood Gas Analysis; Dapsone; Female; Follow-Up Studies; Humans; Hyperca	2011
[Lip cyanosis in dapsone therapy: should the dosage be reduced?]. MMW Fortschritte der Medizin, 2012, Apr-05, Volume: 154, Issue:6 Topics: Cyanosis; Dapsone; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Glucosephosphat	2012
Two cases of acquired methemoglobinemia. Acta anaesthesiologica Belgica, 2012, Volume: 63, Issue:2 Topics: Anti-Infective Agents; Antidotes; Dapsone; Female; HIV Infections; HIV-1; Humans; Male; Methemoglobi	2012
Dapsone use in Loxosceles reclusa envenomation: is there an indication? The American journal of emergency medicine, 2003, Volume: 21, Issue:1 Topics: Adult; Anti-Infective Agents; Dapsone; Humans; Male; Methemoglobinemia; Phosphoric Diester Hydrolase	2003
Anesthetic management of a patient with methemoglobinemia. Southern medical journal, 2003, Volume: 96, Issue:5 Topics: Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Dapsone; Female; Humans; Intraoper	2003
Drug-induced methaemoglobinaemia presenting with angina following the use of dapsone. Clinical and laboratory haematology, 2003, Volume: 25, Issue:5 Topics: Aged; Angina Pectoris; Dapsone; Humans; Male; Methemoglobinemia; Methylene Blue	2003
An unusual complication associated with dapsone therapy of dermatitis herpetiformis. Scottish medical journal, 1958, Volume: 3, Issue:5 Topics: Dapsone; Dermatitis Herpetiformis; Humans; Methemoglobinemia; Sulfones	1958
METHEMOGLOBINEMIA ASSOCIATED WITH THE INGESTION OF DIASONE. Archives of dermatology, 1965, Volume: 92 Topics: Dapsone; Dermatitis Herpetiformis; Drug Therapy; Humans; Methemoglobinemia; Sulfanilamide; Sulfanila	1965
The tale of a blue toddler. Irish medical journal, 2003, Volume: 96, Issue:8 Topics: Anti-Infective Agents; Child, Preschool; Cyanosis; Dapsone; Enzyme Inhibitors; Humans; Male; Methemo	2003
Methaemoglobinaemia at endoscopy. European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:9 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dapsone; Endoscopy, Gastrointestinal; Female; Humans	2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine, 2004, Volume: 83, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi	2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine, 2004, Volume: 83, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi	2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine, 2004, Volume: 83, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi	2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine, 2004, Volume: 83, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi	2004
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels. Pediatric blood & cancer, 2005, Volume: 44, Issue:1 Topics: Anti-Infective Agents; Case-Control Studies; Child; Child, Preschool; Cytochrome-B(5) Reductase; Dap	2005
Complications related to dapsone use for Pneumocystis jirovecii pneumonia prophylaxis in solid organ transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:11 Topics: Adult; Aged; Anemia, Hemolytic; Anti-Infective Agents; Antibiotic Prophylaxis; Dapsone; Female; Huma	2005
Presentation of dapsone-induced methemoglobinemia in a patient status post small bowel transplant. Journal of clinical anesthesia, 2005, Volume: 17, Issue:7 Topics: Adolescent; Anesthesia, General; Anti-Infective Agents; Dapsone; Folic Acid Antagonists; Humans; Int	2005
Dapsone-induced methemoglobinemia after hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:2 Topics: Adult; Anemia, Aplastic; Anti-Infective Agents; Dapsone; Female; Hematopoietic Stem Cell Transplanta	2006
Acute methemoglobinemia following attempted suicide by Dapson. Archives of medical research, 2006, Volume: 37, Issue:3 Topics: Acute Disease; Adolescent; Arteries; Blood Cell Count; Blood Gas Analysis; Dapsone; Female; Hospital	2006
Case of methemoglobinemia. Medicine and health, Rhode Island, 2006, Volume: 89, Issue:2 Topics: Aged; Dapsone; Female; Humans; Methemoglobinemia; Methylene Blue	2006
Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura. Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:6 Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Mur	2006
Methylene blue treatment for methemoglobinemia and subsequent dramatic bispectral index reduction. Anesthesiology, 2006, Volume: 105, Issue:1 Topics: Aged; Dapsone; Electroencephalography; Female; Humans; Methemoglobinemia; Methylene Blue	2006
Severe dapsone hypersensitivity syndrome. Journal of investigational allergology & clinical immunology, 2006, Volume: 16, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dapsone; Dermatitis Herpetiformis; Drug Eruptions; D	2006
Drug-induced methaemoglobinaemia following elective coronary artery bypass grafting. Anaesthesia, 2007, Volume: 62, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Coronary Artery Bypass; Dapson	2007
The recognition, physiology, and treatment of medication-induced methemoglobinemia: a case report. Anesthesia progress, 2007,Fall, Volume: 54, Issue:3 Topics: Anesthesia, General; Dapsone; Female; Humans; Leprostatic Agents; Mandibular Fractures; Methemoglobi	2007
Cimetidine and dapsone-mediated methaemoglobinaemia. Anaesthesia, 2007, Volume: 62, Issue:11 Topics: Anti-Infective Agents; Cimetidine; Dapsone; Histamine H2 Antagonists; Humans; Methemoglobinemia; Pos	2007
Guiding management in perioperative methemoglobinemia. Minerva anestesiologica, 2007, Volume: 73, Issue:12 Topics: Dapsone; Folic Acid Antagonists; Humans; Hypoxia; Intraoperative Complications; Methemoglobinemia; M	2007
Successful treatment of acute dapsone intoxication using charcoal hemoperfusion. Australian and New Zealand journal of medicine, 1983, Volume: 13, Issue:5 Topics: Acne Vulgaris; Adult; Charcoal; Dapsone; Female; Hemolysis; Hemoperfusion; Humans; Hypoxia; Methemog	1983
NADH-methemoglobin reductase and methemoglobinemia among leprosy patients. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1984, Volume: 52, Issue:4 Topics: Adult; Cytochrome-B(5) Reductase; Dapsone; Female; Humans; Leprosy; Male; Methemoglobinemia; NADH, N	1984
[Role of dapsone in the treatment of Horton's disease and polymyalgia rheumatica]. Annales de medecine interne, 1984, Volume: 135, Issue:1 Topics: Aged; Anemia, Hemolytic; Dapsone; Female; Follow-Up Studies; Giant Cell Arteritis; Humans; Iatrogeni	1984
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency. Israel journal of medical sciences, 1981, Volume: 17, Issue:8 Topics: Adult; Cytochrome-B(5) Reductase; Dapsone; Hemoglobinopathies; Hemoglobins, Abnormal; Hemolysis; Hum	1981
Delayed sulfhemoglobinemia after acute dapsone intoxication. Journal of toxicology. Clinical toxicology, 1982, Volume: 19, Issue:1 Topics: Adult; Dapsone; Humans; Male; Methemoglobinemia; Methylene Blue; Suicide, Attempted; Sulfhemoglobine	1982
[Methemoglobinemia and hemolytic anemia induced by Disulon]. Annales de dermatologie et de venereologie, 1982, Volume: 109, Issue:12 Topics: Acetylation; Anemia, Hemolytic; Dapsone; Humans; Methemoglobinemia; Phenotype; Time Factors	1982
Methemoglobinemia following dapsone ingestion. Indian pediatrics, 1981, Volume: 18, Issue:2 Topics: Child; Dapsone; Female; Humans; Methemoglobinemia	1981
Dapsone poisoning (a case report). The Journal of the Association of Physicians of India, 1981, Volume: 29, Issue:10 Topics: Adolescent; Athetosis; Cyanosis; Dapsone; Humans; Leprosy; Male; Methemoglobinemia	1981
Permanent retinal damage following massive dapsone overdose. The British journal of ophthalmology, 1980, Volume: 64, Issue:10 Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Dapsone; Fluorescein Angiography; Humans; Macula Lute	1980
Dapsone-induced methemoglobinemia: an anesthetic risk. International journal of pediatric otorhinolaryngology, 1995, Volume: 33, Issue:1 Topics: Adolescent; Anesthesia, General; Dapsone; Female; Humans; Lupus Erythematosus, Discoid; Methemoglobi	1995
Severe accidental dapsone overdose. The American journal of emergency medicine, 1995, Volume: 13, Issue:4 Topics: Charcoal; Cyanosis; Dapsone; Dermatitis Herpetiformis; Drug Overdose; Humans; Male; Methemoglobinemi	1995
A case of atypical cyanosis. Journal of the Tennessee Medical Association, 1995, Volume: 88, Issue:9 Topics: Adult; Cyanosis; Dapsone; Humans; Male; Methemoglobinemia; Pneumonia, Pneumocystis	1995
Accidental dapsone poisoning in children. Indian pediatrics, 1994, Volume: 31, Issue:9 Topics: Accidents, Home; Ascorbic Acid; Central Nervous System; Child, Preschool; Dapsone; Humans; Male; Met	1994
Chronic methemoglobinemia: improving hemoglobin saturation monitoring during anesthesia. Journal of clinical monitoring, 1994, Volume: 10, Issue:4 Topics: Aged; Anesthesia; Cataract Extraction; Chronic Disease; Dapsone; Hemoglobins; Humans; Intraoperative	1994
Acute dapsone poisoning. Anaesthesia and intensive care, 1993, Volume: 21, Issue:3 Topics: Acute Disease; Adult; Dapsone; Humans; Leprosy; Male; Methemoglobinemia; Suicide, Attempted; Sulfhem	1993
Dapsone poisoning. The Journal of tropical medicine and hygiene, 1993, Volume: 96, Issue:5 Topics: Adult; Combined Modality Therapy; Cyanosis; Dapsone; Female; Fluid Therapy; Humans; Infusions, Intra	1993
Actionstat. Methemoglobinemia. Nursing, 1995, Volume: 25, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Adult; Dapsone; Emergency Nursing; Humans; Male; Methemoglobinem	1995
Fatal poisoning due to dapsone in a patient with grossly elevated methaemoglobin levels. The British journal of dermatology, 1995, Volume: 133, Issue:5 Topics: Anti-Infective Agents; Dapsone; Drug Overdose; Fatal Outcome; Female; Humans; Methemoglobinemia; Mid	1995
Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency. AIDS (London, England), 1996, Volume: 10, Issue:5 Topics: Adult; Aged; CD4 Lymphocyte Count; Dapsone; Drug Hypersensitivity; Erythrocytes; Glutathione; HIV In	1996
Dapsone- and primaquine-induced methemoglobinemia in HIV-infected individuals. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Aug-15, Volume: 12, Issue:5 Topics: Adult; AIDS-Related Opportunistic Infections; Anemia, Hemolytic; Anti-Infective Agents; Clindamycin;	1996
Worsening oxygen saturation during treatment with oxidative drugs: a clinical reminder. JAMA, 1996, Oct-16, Volume: 276, Issue:15 Topics: Anti-Infective Agents; Dapsone; Humans; Methemoglobinemia; Oxidation-Reduction; Oxygen; Primaquine	1996
Combined dapsone and clofazimine intoxication. Human & experimental toxicology, 1996, Volume: 15, Issue:8 Topics: Adult; Charcoal; Clofazimine; Dapsone; Drug Overdose; Gastric Lavage; Humans; Leprostatic Agents; Ma	1996
A dapsone-induced blood dyscrasia in the mouse: evidence for the role of an active metabolite. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:2 Topics: Animals; Cimetidine; Dapsone; Enzyme Inhibitors; Female; Folic Acid Antagonists; Histamine H2 Antago	1996
Dapsone induced methaemoglobinaemia. International journal of STD & AIDS, 1996, Volume: 7, Issue:6 Topics: Adult; Dapsone; Female; HIV Seropositivity; Humans; Leprostatic Agents; Male; Methemoglobinemia	1996
Acute dapsone intoxication: a pediatric case report. Pediatric emergency care, 1997, Volume: 13, Issue:2 Topics: Antimalarials; Charcoal; Child, Preschool; Dapsone; Humans; Male; Methemoglobinemia; Methylene Blue;	1997
Deliberate self-poisoning with dapsone. A case report and summary of relevant pharmacology and treatment. Anaesthesia, 1997, Volume: 52, Issue:4 Topics: Adolescent; Antidotes; Bilirubin; Critical Care; Dapsone; Female; Humans; L-Lactate Dehydrogenase; L	1997
Methodologic problems encountered with cooximetry in methemoglobinemia. The American journal of the medical sciences, 1997, Volume: 314, Issue:3 Topics: Adult; Aged; Dapsone; Diagnostic Errors; Female; Humans; Male; Methemoglobin; Methemoglobinemia; Oxi	1997
Haematological and biochemical alterations in leprosy patients already treated with dapsone and MDT. Pharmaceutica acta Helvetiae, 1997, Volume: 72, Issue:4 Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy; Male;	1997
Dapsone methaemoglobinaemia. Anaesthesia and intensive care, 1998, Volume: 26, Issue:1 Topics: Adult; Dapsone; Female; Humans; Methemoglobinemia	1998
Asymptomatic methaemoglobinaemia and its implications. Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:6 Topics: Cyanosis; Dapsone; Humans; Intraoperative Complications; Leprostatic Agents; Male; Methemoglobinemia	1998
Neonatal methemoglobinemia due to transplacental transfer of dapsone. Indian pediatrics, 1998, Volume: 35, Issue:6 Topics: Dapsone; Diagnosis, Differential; Female; Humans; Infant, Newborn; Leprostatic Agents; Leprosy, Lepr	1998
Lessons to be learned: a case study approach: prolonged methaemoglobinaemia due to inadvertent dapsone poisoning; treatment with methylene blue and exchange transfusion. The journal of the Royal Society for the Promotion of Health, 1999, Volume: 119, Issue:1 Topics: Adult; Antidotes; Baclofen; Dapsone; Exchange Transfusion, Whole Blood; Folic Acid Antagonists; Hemo	1999
A case of methemoglobinemia after ingestion of an aphrodisiac, later proven as dapsone. Yonsei medical journal, 1999, Volume: 40, Issue:4 Topics: Administration, Oral; Adult; Antidotes; Aphrodisiacs; Cyanosis; Dapsone; Humans; Male; Methemoglobin	1999
Factitious methemoglobinemia. American journal of hematology, 1999, Volume: 62, Issue:3 Topics: Adult; Dapsone; Factitious Disorders; Female; Folic Acid Antagonists; Humans; Methemoglobinemia; Sub	1999
Blue and breathless. Hospital medicine (London, England : 1998), 1999, Volume: 60, Issue:7 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dapsone; Fatal Outcome; Female; HIV Seropositivity;	1999
Dapsone-induced methhaemoglobinaemia: a source of diagnostic confusion. International journal of clinical practice, 2000, Volume: 54, Issue:3 Topics: Adolescent; Adult; Dapsone; Diagnosis, Differential; Female; Folic Acid Antagonists; Humans; Male; M	2000
[Methemoglobinemia--causes, diagnosis and treatment]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2000, May-20, Volume: 120, Issue:13 Topics: Adolescent; Adult; Anti-Infective Agents; Dapsone; Female; Humans; Methemoglobinemia; Methylene Blue	2000
Clinical and laboratory parameters in dapsone acute intoxication. Revista de saude publica, 2000, Volume: 34, Issue:4 Topics: Adolescent; Adult; Child; Child, Preschool; Cyanosis; Dapsone; Female; Humans; Infant; Leprostatic A	2000
Unexplained acute severe methaemoglobinaemia in a young adult. British journal of anaesthesia, 2001, Volume: 86, Issue:2 Topics: Acute Disease; Adult; Dapsone; Female; Humans; Leprostatic Agents; Methemoglobinemia	2001
[Respiratory insufficiency caused by dapsone-induced methemoglobinemia]. Ugeskrift for laeger, 2001, Jan-01, Volume: 163, Issue:1 Topics: Anti-Infective Agents; Dapsone; Diagnosis, Differential; Female; Humans; Legionnaires' Disease; Meth	2001
Immunohematotoxicity studies with combinations of dapsone and zidovudine. International immunopharmacology, 2001, Volume: 1, Issue:12 Topics: AIDS-Related Opportunistic Infections; Anemia; Animals; Anti-HIV Agents; Antiprotozoal Agents; Bone	2001
Methemoglobinemia associated with the ingestion of Diasone. Archives of dermatology, 1965, Volume: 92, Issue:3 Topics: Dapsone; Dermatitis Herpetiformis; Humans; Male; Methemoglobinemia; Middle Aged	1965
Dapsone-induced methemoglobinemia in leprosy patients. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2001, Volume: 69, Issue:3 Topics: Adolescent; Adult; Child; Cytochrome Reductases; Cytochrome-B(5) Reductase; Dapsone; Female; Humans;	2001
Diagnostic confusion caused by dapsone-induced methaemoglobinaemia. British journal of anaesthesia, 2001, Volume: 87, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Dapsone; Diagnosis, Differential; Female; Humans; M	2001
Dapsone-induced cholestasis and impairment of bile salt output in the rat. Biochemical pharmacology, 2002, Apr-15, Volume: 63, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Biomarkers; Body Weight; Car	2002
Effects of H(2)-receptor antagonists on dapsone-induced methaemoglobinaemia in rats. Pharmacological research, 2002, Volume: 45, Issue:4 Topics: Animals; Biotransformation; Dapsone; Dose-Response Relationship, Drug; Drug Interactions; Famotidine	2002
Acute dapsone intoxication: a case with prolonged symptoms. Clinical toxicology, 1979, Volume: 14, Issue:1 Topics: Acetylation; Biotransformation; Dapsone; Hemolysis; Humans; Male; Methemoglobinemia; Middle Aged; Ti	1979
Studies on dapsone induced haemolytic anaemia. I. Methaemoglobin production and G-6-PD activity in correlation with dapsone dosage. The British journal of dermatology, 1979, Volume: 100, Issue:4 Topics: Anemia, Hemolytic; Dapsone; Dose-Response Relationship, Drug; Glucosephosphate Dehydrogenase; Humans	1979
[Case of iatrogenic methemoglobinemia (due to 4,4-diamino-diphenylsulfone)]. Giornale di clinica medica, 1979, Volume: 60, Issue:6 Topics: Dapsone; Dermatitis Herpetiformis; Humans; Male; Methemoglobinemia; Methylene Blue; Middle Aged; Tim	1979
Sulfones and sulfonamides in dermatology today. Journal of the American Academy of Dermatology, 1979, Volume: 1, Issue:6 Topics: Agranulocytosis; Dapsone; Drug Hypersensitivity; Hemolysis; Humans; Kidney Diseases; Methemoglobinem	1979
Hematologic side-effects of dapsone. The Ohio State medical journal, 1977, Volume: 73, Issue:8 Topics: Adult; Agranulocytosis; Dapsone; Female; Hematologic Diseases; Hematopoietic System; Hemolysis; Huma	1977
High dose dapsone toxicity. The British journal of dermatology, 1976, Volume: 95, Issue:1 Topics: Aged; Anemia, Hemolytic; Dapsone; Dermatitis Herpetiformis; Female; Foot Diseases; Gangrene; Humans;	1976
Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone). Archives for dermatological research = Archiv fur dermatologische Forschung, 1975, Dec-31, Volume: 254, Issue:3 Topics: Adult; Aged; Anemia, Hemolytic; Dapsone; Dermatitis Herpetiformis; Erythrocyte Count; Female; Haptog	1975
Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the presence of trimethoprim in the rat. The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:2 Topics: Acetylation; Animals; Cimetidine; Dapsone; Drug Interactions; Half-Life; Male; Methemoglobin; Methem	1992
The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. British journal of clinical pharmacology, 1992, Volume: 34, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Dapsone; Dermatitis Herpetiformis; Drug Therapy, Combina	1992
Dapsone-induced methemoglobinemia and pulse oximetry. Anesthesiology, 1992, Volume: 77, Issue:3 Topics: Dapsone; Female; Humans; Intraoperative Complications; Methemoglobinemia; Methylene Blue; Middle Age	1992
Dapsone-induced methemoglobinemia and hemolytic anemia. Clinical pharmacy, 1992, Volume: 11, Issue:9 Topics: Adult; Anemia, Hemolytic; Charcoal; Dapsone; Drug Monitoring; Female; Hemoperfusion; Humans; Methemo	1992
Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the rat during chronic dapsone administration. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Dapsone; Hydroxylation; Male; Methemoglob	1991
An investigation into the haematological toxicity of structural analogues of dapsone in-vivo and in-vitro. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:11 Topics: Adolescent; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dapsone; Erythrocytes;	1991
Respiratory insufficiency from dapsone-induced methemoglobinemia. AIDS (London, England), 1991, Volume: 5, Issue:11 Topics: Adult; Dapsone; HIV Infections; Humans; Male; Methemoglobinemia; Opportunistic Infections; Pneumonia	1991
Inhibition of dapsone-induced methaemoglobinaemia in the rat isolated perfused liver. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:5 Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cimetidine; Dapsone; Half-Life; Liver; Male; Me	1990
The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man. British journal of clinical pharmacology, 1990, Volume: 30, Issue:5 Topics: Adult; Cimetidine; Dapsone; Humans; Hydroxylation; Male; Methemoglobinemia	1990
Inhibition of dapsone-induced methaemoglobinaemia in the rat. Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4 Topics: Animals; Cimetidine; Dapsone; Male; Methemoglobinemia; Piperonyl Butoxide; Rats; Rats, Inbred Strain	1990
Sex-dependent sensitivity to dapsone-induced methaemoglobinaemia in the rat. Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4 Topics: Animals; Dapsone; Female; Humans; Hydroxylation; Male; Methemoglobinemia; Rats; Rats, Inbred Strains	1990
Acute dapsone poisoning. Indian pediatrics, 1989, Volume: 26, Issue:7 Topics: Child, Preschool; Dapsone; Developing Countries; Drug Overdose; Humans; India; Male; Methemoglobinem	1989
Dapsone-induced methemoglobinemia in a patient with P. carinii pneumonia and AIDS. The New England journal of medicine, 1987, Dec-31, Volume: 317, Issue:27 Topics: Acquired Immunodeficiency Syndrome; Dapsone; Humans; Male; Methemoglobinemia; Pneumonia, Pneumocysti	1987
Intraoperative cyanosis: a case of dapsone-induced methaemoglobinaemia. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1987, Volume: 34, Issue:1 Topics: Adolescent; Cyanosis; Dapsone; Humans; Intraoperative Complications; Male; Methemoglobinemia	1987
Dapsone and Heinz bodies. Archives of dermatology, 1985, Volume: 121, Issue:1 Topics: Anemia; Dapsone; Erythrocyte Count; Heinz Bodies; Humans; Methemoglobinemia	1985
[Toxic methemoglobinemia following the postoperative ingestion of 4,4-diaminodiphenylsulfone (DADPS)--on the differential diagnosis of cyanosis]. Anasthesie, Intensivtherapie, Notfallmedizin, 1985, Volume: 20, Issue:1 Topics: Adult; Cyanosis; Dapsone; Diagnosis, Differential; Female; Humans; Lupus Erythematosus, Systemic; Me	1985
Methemoglobinemia from dapsone therapy for a suspected brown spider bite. The Journal of emergency medicine, 1985, Volume: 3, Issue:4 Topics: Adult; Dapsone; Female; Humans; Methemoglobinemia; Spider Bites	1985
Exacerbation of dapsone-induced Heinz body hemolytic anemia following treatment with methylene blue. The American journal of the medical sciences, 1974, Volume: 267, Issue:5 Topics: Anemia, Hemolytic; Dapsone; Erythrocytes; Female; Glutathione; Heinz Bodies; Humans; Lupus Erythemat	1974
Biochemical effects of aromatic amines. I. Methaemoglobinaemia, haemolysis and Heinz-body formation induced by 4,4'-diaminodiphenylsulphone. Biochemical pharmacology, 1965, Volume: 14, Issue:7 Topics: Chromatography, Ion Exchange; Cytoplasm; Dapsone; Dermatitis Herpetiformis; Erythrocytes; Heinz Bodi	1965
Microsomal N-oxidation of dapson as a cause of methemoglobin formation in human red cells. The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:3 Topics: Animals; Carbon Isotopes; Chromatography, Thin Layer; Dapsone; Erythrocytes; Hemoglobins; Humans; In	1972
Haemolytic effects of DDS in leprosy patients. The Indian journal of medical research, 1972, Volume: 60, Issue:10 Topics: Adult; Anemia, Hemolytic; Dapsone; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency;	1972
[Case of severe poisoning with diamino-diphenylsulfone (DDS)--an antileprotic drug]. Polskie Archiwum Medycyny Wewnetrznej, 1972, Volume: 49, Issue:2 Topics: Adolescent; Dapsone; Diuresis; Exchange Transfusion, Whole Blood; Female; Furosemide; Humans; Methem	1972
Polymorphic acetylation of drugs in rabbits. Xenobiotica; the fate of foreign compounds in biological systems, 1973, Volume: 3, Issue:3 Topics: Acetylation; Aminobenzoates; Aminosalicylic Acids; Animals; Body Temperature; Chromatography, Thin L	1973
[Glutathione reductase deficiency in Duhring's dermatitis herpetiformis]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:8 Topics: Aged; Blood Cell Count; Child; Clinical Enzyme Tests; Dapsone; Dermatitis Herpetiformis; Erythrocyte	1973
Reduced pressure potentiation of the side effects of the antimalarial, Dapsone. Aerospace medicine, 1967, Volume: 38, Issue:11 Topics: Aerospace Medicine; Altitude; Anemia; Animals; Asia, Southeastern; Dapsone; Erythrocyte Count; Hyper	1967
Mechanism of methemoglobin formation by diphenylsulfones. Effect of 4-amino-4'-hydroxyaminodiphenylsulfone and other p-substituted derivatives. Biochemical pharmacology, 1972, May-01, Volume: 21, Issue:9 Topics: Azo Compounds; Carbon Isotopes; Dapsone; Erythrocytes; Esters; Hemoglobins; Humans; Infrared Rays; K	1972
Dapsone poisoning. The Medical journal of Australia, 1970, Jun-06, Volume: 1, Issue:23 Topics: Ascorbic Acid; Child, Preschool; Cyanosis; Dapsone; Dyspnea; Female; Heart Rate; Hemoglobins; Humans	1970
Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam. The New England journal of medicine, 1968, Nov-21, Volume: 279, Issue:21 Topics: Antimalarials; Chloroquine; Cyanosis; Dapsone; Diseases in Twins; Erythrocytes; Female; Hematocrit;	1968
The effects of dapsone on red cells. Transactions of the St. John's Hospital Dermatological Society, 1968, Volume: 54, Issue:2 Topics: Cell Membrane; Dapsone; Erythrocytes; Female; Humans; Male; Methemoglobinemia	1968
[Hematological changes in acute accidental poisoning with sulfones]. Revista do Hospital das Clinicas, 1966, Volume: 21, Issue:1 Topics: Anemia, Hemolytic; Blood; Child; Child, Preschool; Dapsone; Female; Glucosephosphate Dehydrogenase;	1966

dapsone and Methemoglobinemia