dapsone has been researched along with Malaria, Falciparum in 51 studies
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria." | 9.14 | Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. ( Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG, 2009) |
| " This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients." | 9.14 | Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. ( Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA, 2009) |
| "Artemether-Lumefantrine and Chlorproguanil-Dapsone have high and comparable cure rates and similar safety profiles when used for treatment of uncomplicated malaria in pregnancy." | 9.13 | A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda. ( Kaye, DK; Mutyaba, TS; Ndeezi, G; Nshemerirwe, R, 2008) |
| "We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda." | 9.13 | A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. ( Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C, 2008) |
| " Mild degrees of haemolysis consistently occur with continued therapy, although adverse effects may be less likely with intermittent treatment, as most reported adverse effects have occurred with long-term use of dapsone." | 6.42 | Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes. ( Brabin, BJ; Eggelte, TA; Parise, M; Verhoeff, F, 2004) |
| "falciparum malaria was known for many years, there was no report about the incidence of P." | 5.32 | Malaria, leprosy and dapsone. ( Arora, VM; Chattopadhya, D; Kapoor, L; Saha, K, 2003) |
| "Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria." | 5.14 | Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. ( Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG, 2009) |
| " This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients." | 5.14 | Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. ( Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA, 2009) |
| "Artemether-Lumefantrine and Chlorproguanil-Dapsone have high and comparable cure rates and similar safety profiles when used for treatment of uncomplicated malaria in pregnancy." | 5.13 | A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda. ( Kaye, DK; Mutyaba, TS; Ndeezi, G; Nshemerirwe, R, 2008) |
| "We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda." | 5.13 | A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. ( Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C, 2008) |
| " Since prophylaxis with amodiaquine at 5 mg/kg weekly had failed, amodiaquine at a dose of 10mg/kg weekly and Maloprim (half a tablet or one tablet depending on body weight, which gave ranges of dapsone of 1." | 5.07 | Chemoprophylaxis against malaria in Papua New Guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine. ( Alpers, MP; Gibney, S; Gibson, FD; Heywood, PF; Jolley, D; Stace, J; Trenholme, KR; Vrbova, H, 1992) |
| "Plasmodium falciparum malaria has no effect on the pharmacokinetic parameters for chlorproguanil, dapsone or chlorcycloguanil." | 3.73 | Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. ( Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P, 2006) |
| "G6PD deficiency is common in African patients with malaria and until a reliable and simple G6PD test is available, the use of 8-aminoquinolines will remain problematic." | 2.76 | Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials. ( Carter, N; Duparc, S; Pamba, A; Waitumbi, JN, 2011) |
| "falciparum malaria was evaluated according to G6PD deficiency in a secondary analysis of an open-label, randomized clinical trial." | 2.73 | High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. ( Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A, 2008) |
| "In a randomized controlled study of malaria prophylaxis, dapsone-pyrimethamine at a weekly dosage of dapsone 50-100 mg with pyrimethamine 6." | 2.67 | Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique. ( Pividal, J; Schapira, A; Streat, E; Viktinski, V, 1992) |
| " Mild degrees of haemolysis consistently occur with continued therapy, although adverse effects may be less likely with intermittent treatment, as most reported adverse effects have occurred with long-term use of dapsone." | 2.42 | Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes. ( Brabin, BJ; Eggelte, TA; Parise, M; Verhoeff, F, 2004) |
| " Drug-induced acute hemolytic anemia in G6PD A- subjects can be life-threatening, depending on the nature and dosage of the drug trigger." | 1.38 | Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. ( Carter, N; Duparc, S; Luzzatto, L; Pamba, A; Premji, Z; Richardson, ND; Tiono, AB, 2012) |
| "Eleven of these had a recrudescence of their infection." | 1.33 | Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response. ( Imwong, M; Krudsood, S; Looareesuwan, S; Nonprasert, A; Pukrittayakamee, S; Snounou, G; White, NJ; Wilairatana, P, 2005) |
| "falciparum malaria was known for many years, there was no report about the incidence of P." | 1.32 | Malaria, leprosy and dapsone. ( Arora, VM; Chattopadhya, D; Kapoor, L; Saha, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (35.29) | 18.2507 |
| 2000's | 28 (54.90) | 29.6817 |
| 2010's | 5 (9.80) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Talawanich, Y | 1 |
| Kamchonwongpaisan, S | 1 |
| Sirawaraporn, W | 1 |
| Yuthavong, Y | 1 |
| Fanello, CI | 2 |
| Karema, C | 2 |
| Avellino, P | 1 |
| Bancone, G | 1 |
| Uwimana, A | 2 |
| Lee, SJ | 1 |
| d'Alessandro, U | 2 |
| Modiano, D | 1 |
| Ogunfowokan, O | 1 |
| Dankyau, M | 1 |
| Madaki, AJ | 1 |
| Thacher, TD | 1 |
| Miller, AK | 1 |
| Bandyopadhyay, N | 1 |
| Wootton, DG | 2 |
| Duparc, S | 6 |
| Kirby, PL | 3 |
| Winstanley, PA | 9 |
| Ward, SA | 4 |
| Premji, Z | 4 |
| Umeh, RE | 1 |
| Owusu-Agyei, S | 1 |
| Esamai, F | 1 |
| Ezedinachi, EU | 1 |
| Oguche, S | 1 |
| Borrmann, S | 1 |
| Sowunmi, A | 2 |
| Pamba, A | 4 |
| Kellam, L | 1 |
| Guiguemdé, R | 1 |
| Greenwood, B | 4 |
| Kaye, DK | 1 |
| Nshemerirwe, R | 1 |
| Mutyaba, TS | 1 |
| Ndeezi, G | 1 |
| Gosling, RD | 1 |
| Gesase, S | 1 |
| Mosha, JF | 1 |
| Carneiro, I | 1 |
| Hashim, R | 1 |
| Lemnge, M | 1 |
| Mosha, FW | 1 |
| Chandramohan, D | 1 |
| Tiono, AB | 2 |
| Dicko, A | 1 |
| Ndububa, DA | 1 |
| Agbenyega, T | 1 |
| Pitmang, S | 1 |
| Awobusuyi, J | 1 |
| Goh, LE | 1 |
| Harrell, E | 1 |
| Carter, N | 3 |
| Luzzatto, L | 2 |
| Bardsley, B | 1 |
| Barry, SJ | 1 |
| Drozdz, MA | 1 |
| Hancock, SA | 1 |
| Okafo, GN | 1 |
| Szafran, MM | 1 |
| Waitumbi, JN | 1 |
| Richardson, ND | 1 |
| Sulo, J | 1 |
| Chimpeni, P | 3 |
| Hatcher, J | 2 |
| Kublin, JG | 4 |
| Plowe, CV | 2 |
| Molyneux, ME | 2 |
| Marsh, K | 2 |
| Taylor, TE | 2 |
| Watkins, WM | 5 |
| Curtis, J | 4 |
| Maxwell, CA | 3 |
| Msuya, FH | 1 |
| Mkongewa, S | 1 |
| Alloueche, A | 3 |
| Warhurst, DC | 2 |
| Lang, T | 2 |
| Pincock, S | 1 |
| Chambo, W | 1 |
| Mwaimu, M | 1 |
| Magogo, F | 1 |
| Carneiro, IA | 1 |
| Curtis, CF | 2 |
| Zimmerman, PA | 1 |
| Saha, K | 1 |
| Kapoor, L | 1 |
| Arora, VM | 1 |
| Chattopadhya, D | 1 |
| Looareesuwan, S | 3 |
| Imwong, M | 2 |
| Wilairatana, P | 3 |
| Bailey, W | 1 |
| Barton, S | 1 |
| Bwika, J | 2 |
| Falade, CO | 1 |
| Fehintola, FA | 1 |
| Horton, J | 1 |
| Jaffar, S | 1 |
| Kanyok, T | 2 |
| Kremsner, PG | 2 |
| Missinou, MA | 1 |
| Mkandala, C | 1 |
| Oduola, AM | 1 |
| Robertson, L | 1 |
| Brabin, BJ | 1 |
| Eggelte, TA | 1 |
| Parise, M | 1 |
| Verhoeff, F | 1 |
| Bates, SJ | 1 |
| Happi, TC | 1 |
| Sibley, CH | 1 |
| Krudsood, S | 1 |
| Pukrittayakamee, S | 1 |
| Nonprasert, A | 1 |
| Snounou, G | 1 |
| White, NJ | 2 |
| Stewart, LB | 1 |
| Peters, W | 1 |
| Robinson, BL | 1 |
| Taylor-Robinson, D | 1 |
| Jones, K | 1 |
| Garner, P | 1 |
| Simpson, JA | 1 |
| Hughes, D | 1 |
| Manyando, C | 1 |
| Bojang, K | 1 |
| Aarons, L | 1 |
| Winstanley, P | 3 |
| Edwards, G | 1 |
| Watkins, WA | 1 |
| Ward, S | 2 |
| Aponte, JJ | 2 |
| Menendez, C | 3 |
| Schellenberg, D | 1 |
| Kahigwa, E | 2 |
| Mshinda, H | 2 |
| Vountasou, P | 1 |
| Tanner, M | 2 |
| Alonso, PL | 2 |
| Opara, H | 1 |
| Biagini, GA | 1 |
| Kanjala, MK | 1 |
| Woessner, M | 1 |
| Neate, C | 1 |
| Nyirenda, M | 1 |
| Blencowe, H | 1 |
| Dube-Mbeye, Q | 1 |
| Molyneux, M | 1 |
| Dunyo, S | 1 |
| Ngamije, D | 1 |
| Ndahindwa, V | 1 |
| Van Overmeir, C | 1 |
| Van Doren, W | 1 |
| Hogh, B | 1 |
| Thompson, R | 1 |
| Lobo, V | 1 |
| Dgedge, M | 1 |
| Dziegiel, M | 1 |
| Borre, M | 1 |
| Gottschau, A | 1 |
| Streat, E | 2 |
| Schapira, A | 2 |
| Barreto, J | 1 |
| Moncrieff, J | 1 |
| Rieckmann, KH | 3 |
| Yeo, AE | 5 |
| Davis, DR | 1 |
| Hutton, DC | 1 |
| Wheatley, PF | 1 |
| Simpson, R | 1 |
| Font, F | 2 |
| Hirt, R | 2 |
| Mashaka, M | 1 |
| Ascaso, C | 1 |
| Trigg, JK | 1 |
| Mbwana, H | 1 |
| Chambo, O | 1 |
| Hills, E | 2 |
| Watkins, W | 2 |
| Edstein, MD | 4 |
| Shanks, GD | 3 |
| Kyle, DE | 1 |
| Chinwongprom, K | 1 |
| Amradee, S | 1 |
| Vounatsou, P | 1 |
| Acosta, CJ | 1 |
| Schellenberg, DM | 1 |
| Galindo, CM | 1 |
| Kimario, J | 1 |
| Urassa, H | 1 |
| Brabin, B | 1 |
| Smith, TA | 1 |
| Kitua, AY | 1 |
| Amukoye, E | 1 |
| Snow, RW | 1 |
| Mosobo, M | 1 |
| Ngumbao, E | 1 |
| Lowe, B | 1 |
| Ton, M | 1 |
| Minyiri, G | 1 |
| Marbiah, NT | 1 |
| Petersen, E | 1 |
| David, K | 1 |
| Magbity, E | 1 |
| Lines, J | 1 |
| Bradley, DJ | 1 |
| Duraisingh, MT | 1 |
| Ortelli, F | 1 |
| Mutabingwa, T | 1 |
| Nzila, A | 1 |
| Mberu, E | 1 |
| Nduati, E | 1 |
| Dzinjalamala, FK | 1 |
| Kamwendo, DD | 1 |
| Malkin, EM | 1 |
| Cortese, JF | 1 |
| Martino, LM | 1 |
| Mukadam, RA | 1 |
| Rogerson, SJ | 1 |
| Lescano, AG | 1 |
| Vrbova, H | 1 |
| Gibney, S | 1 |
| Gibson, FD | 1 |
| Jolley, D | 1 |
| Heywood, PF | 1 |
| Stace, J | 1 |
| Trenholme, KR | 1 |
| Alpers, MP | 1 |
| Pividal, J | 1 |
| Viktinski, V | 1 |
| Suriyamongkol, V | 1 |
| Timsaad, S | 1 |
| Webster, HK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Study on the Tolerability and Efficacy of the Combination Chlorproguanil-Dapsone+Artesunate Compared to Amodiaquine+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria in Rwandan Children[NCT00461578] | 800 participants | Interventional | 2005-04-30 | Completed | |||
| An Open, Randomised, Multi-centre Dose Ranging Phase II Study to Evaluate LAPDAP in Combination With Three Different Doses of Artesunate[NCT00519467] | Phase 2 | 120 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| A Multi-centre, Randomised, Double-blind, Double Dummy Study Comparing the Efficacy and Safety of Chlorproguanil-dapsone-artesunate Versus Artemether-lumefantrine in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria in Children and Adoles[NCT00344006] | Phase 3 | 1,395 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Zambia[NCT06166498] | Phase 3 | 600 participants (Anticipated) | Interventional | 2024-02-15 | Not yet recruiting | ||
| Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Cameroon[NCT06173206] | Phase 3 | 900 participants (Anticipated) | Interventional | 2024-03-15 | Not yet recruiting | ||
| Drug Options for Intermittent Preventive Treatment for Malaria in Infants in an Area With High Resistance to Sulfadoxine/Pyrimethamine: an Evaluation of Short and Long-acting Antimalarial Drugs[NCT00158574] | Phase 2/Phase 3 | 2,419 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| A Multi-centre, Randomised, Double-blind Study to Compare the Efficacy and Safety of Chlorproguanil-dapsone-artesunate Versus Chlorproguanil-dapsone in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria in Children, Adolescents and Adults [NCT00371735] | Phase 3 | 900 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Short Course of Quinine Plus a Single Dose of Sulphadoxine-Pyrimethamine for Plasmodium Falciparum Malaria[NCT00167739] | Phase 4 | 50 participants | Interventional | 2003-04-30 | Completed | ||
| Intermittent Treatment With Sulfadoxine-Pyrimethamine for Malaria Control in Children: A Randomised, Double Blind, and Placebo-Controlled Clinical Trial[NCT00168948] | Phase 4 | 1,200 participants | Interventional | 2003-03-31 | Active, not recruiting | ||
| A Longitudinal Study Assessing the Infectious Status and Immunity of Mothers and Their Children in Lambaréné, Including Intermittent Treatment of Children With Sulfadoxine-pyrimethamine for Malaria Control and Its Impact on Long-term Health[NCT00167843] | Phase 4 | 1,189 participants | Interventional | 2002-12-31 | Completed | ||
| Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infant: a Randomized, Double-blind, and Placebo-controlled Clinical Trial[NCT00206739] | Phase 4 | 1,070 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| The Prevention of Anaemia and Malaria in Infants in an Area of Intense and Perennial Malaria Transmission[NCT00497471] | 832 participants (Actual) | Interventional | 1995-02-28 | Terminated (stopped due to Follow-up end in 1999) | |||
| Pharmacokinetics of Chlorproguanil-Dapsone in Pregnant Women With Plasmodium Falciparum Infection, and Reinfection With P. Falciparum During Pregnancy Following Treatment[NCT00126971] | Phase 1 | 132 participants | Interventional | 2005-07-31 | Suspended | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dapsone and Malaria, Falciparum
| Article | Year |
|---|---|
Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes.
Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Dapsone; Drug Resistance; Female; Humans; Infan | 2004 |
Malaria: uncomplicated, caused by Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combina | 2005 |
Studies on anti-folate antimalarials in east Africa.
Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; | 1999 |
26 trials available for dapsone and Malaria, Falciparum
| Article | Year |
|---|---|
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combina | 2008 |
Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Com | 2009 |
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationshi | 2009 |
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Dapsone; Double-Blind Method; Et | 2009 |
A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda.
Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Dapsone; | 2008 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug R | 2009 |
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Africa South of the Sahara; Animals; Antimalarials; Artemisinins; Artesunate; Chi | 2009 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug | 2011 |
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.
Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; D | 2002 |
Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment.
Topics: Animals; Antimalarials; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Drug Therapy, Co | 2002 |
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.
Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinat | 2004 |
Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation.
Topics: Age Factors; Anemia; Animals; Antigens, Protozoan; Child, Preschool; Dapsone; Drug Therapy, Combinat | 2007 |
Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisia; Artemisinins; Artesunate; Child; Child, Presch | 2008 |
A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Dapsone; Drug Administration Sch | 2008 |
The influence of Maloprim chemoprophylaxis on cellular and humoral immune responses to Plasmodium falciparum asexual blood stage antigens in schoolchildren living in a malaria endemic area of Mozambique.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Child; Cohort Studies; Cross-Sec | 1994 |
Recent military experience with malaria chemoprophylaxis.
Topics: Antimalarials; Australia; Chloroquine; Dapsone; Doxycycline; Drug Administration Schedule; Drug Comb | 1993 |
A comparative study of the efficacies of chloroquine and a pyrimethamine-dapsone combination in clearing Plasmodium falciparum parasitaemia in school children in Tanzania.
Topics: Antimalarials; Child; Chloroquine; Dapsone; Drug Combinations; Female; Humans; Malaria, Falciparum; | 1996 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants.
Topics: Adult; Anemia, Iron-Deficiency; Antimalarials; Dapsone; Delayed-Action Preparations; Double-Blind Me | 1997 |
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria.
Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resist | 1997 |
A controlled trial of lambda-cyhalothrin-impregnated bed nets and/or dapsone/pyrimethamine for malaria control in Sierra Leone.
Topics: Anti-Infective Agents; Bedding and Linens; Child; Child, Preschool; Dapsone; Humans; Infant; Insecti | 1998 |
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.
Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate S | 1998 |
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind | 2002 |
Chemoprophylaxis against malaria in Papua New Guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine.
Topics: Antimalarials; Body Weight; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Fe | 1992 |
Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique.
Topics: Child; Dapsone; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mozambique; Pyrimethamine | 1992 |
Proguanil combined with dapsone chemoprophylaxis for malaria.
Topics: Adult; Australia; Dapsone; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Military Pe | 1992 |
Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border.
Topics: Blood Cells; Cambodia; Dapsone; Doxycycline; Drug Therapy, Combination; Drug Tolerance; Glucosephosp | 1992 |
22 other studies available for dapsone and Malaria, Falciparum
| Article | Year |
|---|---|
Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase.
Topics: Antimalarials; Dapsone; Dihydropteroate Synthase; Drug Interactions; Drug Resistance; Drug Synergism | 2015 |
The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.
Topics: Anemia, Hemolytic; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Glucosephosphate Dehy | 2010 |
Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Liqui | 2011 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child | 2012 |
The development of Lapdap, an affordable new treatment for malaria.
Topics: Animals; Antimalarials; Child; Clinical Trials as Topic; Dapsone; Drug Approval; Drug Combinations; | 2003 |
Drug company to offer new malaria drug cheaply in Africa.
Topics: Africa; Antimalarials; Dapsone; Drug Combinations; Drug Costs; Drug Industry; Humans; International | 2003 |
Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets.
Topics: Altitude; Animals; Anopheles; Antigens, Protozoan; Child; Child, Preschool; Dapsone; Drug Therapy, C | 2003 |
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets.
Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; | 2003 |
Malaria, leprosy and dapsone.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Dapsone; Female; Humans; Incidence; India; Leprostati | 2003 |
Chlorproguanil-dapsone for malaria in Africa.
Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falcip | 2004 |
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.
Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Pr | 2004 |
Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Dihydropteroate Syntha | 2005 |
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combinatio | 2004 |
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria | 2006 |
Determination of dapsone in serum and saliva using reversed-phase high-performance liquid chromatography with ultraviolet or electrochemical detection.
Topics: Chromatography, High Pressure Liquid; Dapsone; Electrochemistry; Humans; Leprosy; Malaria, Falciparu | 1994 |
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone.
Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; | 1997 |
Direct comparison of antimalarial activity among PS-15 combination therapies by bioassay of serum samples from treated Saimiri sciureus.
Topics: Animals; Antimalarials; Atovaquone; Biological Assay; Dapsone; Disease Models, Animal; Drug Synergis | 1997 |
Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant Plasmodium falciparum isolates.
Topics: Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falcip | 1997 |
Antimalaria activity of the triple combination of proguanil, atovaquone and dapsone.
Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Resistance, Multiple; Drug Synergism; Drug Therapy | 1997 |
Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Fema | 1997 |
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug | 2001 |
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria.
Topics: Antimalarials; Artemisinins; Clinical Trials, Phase III as Topic; Dapsone; Drug Approval; Drug Combi | 2001 |