dapsone has been researched along with Kernicterus in 3 studies
Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kernicterus is probably caused by precipitation of insoluble bilirubin acid in brain cells." | 4.76 | Drug-induced displacement of bilirubin from albumin in the newborn. ( Brodersen, R; Friis-Hansen, B; Stern, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brodersen, R | 2 |
| Friis-Hansen, B | 1 |
| Stern, L | 1 |
| Larsen, FG | 1 |
| Larsen, CG | 1 |
| Ebbesen, F | 1 |
| Knudsen, A | 1 |
1 review available for dapsone and Kernicterus
| Article | Year |
|---|---|
Drug-induced displacement of bilirubin from albumin in the newborn.
Topics: Bilirubin; Binding, Competitive; Dapsone; Dialysis; Horseradish Peroxidase; Humans; Infant, Newborn; | 1983 |
2 other studies available for dapsone and Kernicterus
| Article | Year |
|---|---|
[Prevention of kernicterus. Current methods of determining drug-induced bilirubin displacement].
Topics: Albumins; Bilirubin; Dapsone; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infan | 1983 |
The possible risk of bilirubin encephalopathy as predicted by plasma parameters in neonates with previous severe asphyxia.
Topics: Asphyxia Neonatorum; Birth Weight; Dapsone; Gestational Age; Humans; Infant, Newborn; Kernicterus; L | 1992 |