Page last updated: 2024-10-25

dapsone and Glucosephosphate Dehydrogenase Deficiency

dapsone has been researched along with Glucosephosphate Dehydrogenase Deficiency in 41 studies

Glucosephosphate Dehydrogenase Deficiency: A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.

Research Excerpts

ExcerptRelevanceReference
"Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children."9.20Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. ( Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E, 2015)
"The appearance of bite cells associated with methemoglobinemia can be caused by oxidizing drugs such as dapsone in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or high drug serum levels."8.12Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. ( Awan, M; Brown, LE; Gandelman, JS; Geere, M; Hu, Y; Kogan, SC; Leavitt, AD; Pearson, HJ, 2022)
"Haemolysis and frank anaemia from dapsone therapy of leprosy has been long recognized."7.68Effect of dapsone on haemoglobin concentration in patients with leprosy. ( Byrd, SR; Gelber, RH, 1991)
"Malaria is a leading cause of mortality, particularly in sub-Saharan African children."6.77Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria. ( Bassat, Q; D' Alessandro, U; Daniel, A; Forret, P; González, R; Machevo, S; Nabasumba, C; Piola, P; Robert, A; Talisuna, A; Turyakira, E; Van Geertruyden, JP; van Loen, H; Van Malderen, C; Van Overmeir, C; Yeka, A, 2012)
"Dapsone is a highly useful drug for treating a variety of pathologies but oral dapsone is contraindicated in patients with G6PDd due to oxidative stress-induced anemia."5.91Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model. ( D'Alessandro, A; Dziewulska, KH; Hay, AM; Reisz, JA; Zimring, JC, 2023)
"Oxidant hemolysis is a known complication of dapsone, but its frequency in adult patients who have undergone a SCT for hematological malignancies is not well established."5.38High prevalence of Dapsone-induced oxidant hemolysis in North American SCT recipients without glucose-6-phosphate-dehydrogenase deficiency. ( Bredeson, C; George, B; Hari, PN; Harrington, AM; Kroft, SH; Olteanu, H, 2012)
"Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children."5.20Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. ( Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E, 2015)
"The appearance of bite cells associated with methemoglobinemia can be caused by oxidizing drugs such as dapsone in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or high drug serum levels."4.12Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. ( Awan, M; Brown, LE; Gandelman, JS; Geere, M; Hu, Y; Kogan, SC; Leavitt, AD; Pearson, HJ, 2022)
"Haemolysis and frank anaemia from dapsone therapy of leprosy has been long recognized."3.68Effect of dapsone on haemoglobin concentration in patients with leprosy. ( Byrd, SR; Gelber, RH, 1991)
"Malaria is a leading cause of mortality, particularly in sub-Saharan African children."2.77Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria. ( Bassat, Q; D' Alessandro, U; Daniel, A; Forret, P; González, R; Machevo, S; Nabasumba, C; Piola, P; Robert, A; Talisuna, A; Turyakira, E; Van Geertruyden, JP; van Loen, H; Van Malderen, C; Van Overmeir, C; Yeka, A, 2012)
"G6PD deficiency is common in African patients with malaria and until a reliable and simple G6PD test is available, the use of 8-aminoquinolines will remain problematic."2.76Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials. ( Carter, N; Duparc, S; Pamba, A; Waitumbi, JN, 2011)
"falciparum malaria was evaluated according to G6PD deficiency in a secondary analysis of an open-label, randomized clinical trial."2.73High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. ( Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A, 2008)
"Panniculitis is a recognized, but rare complication of α1-antitrypsin (A1AT) deficiency."2.50Alpha-1-antitrypsin deficiency-associated panniculitis: a case report. ( Cardoso, J; Carvalho, R; Chaveiro, A; Laureano, A, 2014)
"Dapsone is a highly useful drug for treating a variety of pathologies but oral dapsone is contraindicated in patients with G6PDd due to oxidative stress-induced anemia."1.91Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model. ( D'Alessandro, A; Dziewulska, KH; Hay, AM; Reisz, JA; Zimring, JC, 2023)
"Oxidant hemolysis is a known complication of dapsone, but its frequency in adult patients who have undergone a SCT for hematological malignancies is not well established."1.38High prevalence of Dapsone-induced oxidant hemolysis in North American SCT recipients without glucose-6-phosphate-dehydrogenase deficiency. ( Bredeson, C; George, B; Hari, PN; Harrington, AM; Kroft, SH; Olteanu, H, 2012)
" Drug-induced acute hemolytic anemia in G6PD A- subjects can be life-threatening, depending on the nature and dosage of the drug trigger."1.38Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. ( Carter, N; Duparc, S; Luzzatto, L; Pamba, A; Premji, Z; Richardson, ND; Tiono, AB, 2012)
"Here we determined the prevalence of G6PD deficiency and the occurrence of G6PD-related hemolytic events in a large cohort of patients."1.36Prevalence of G6PD deficiency in a large cohort of HIV-infected patients. ( Giordano, TP; Serpa, JA; Villarreal-Williams, E, 2010)
"Dapsone was the most common etiology of acquired methemoglobinemia, accounting for 42% of all cases."1.32Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. ( Ash-Bernal, R; Wise, R; Wright, SM, 2004)
"Twenty-one cases of agranulocytosis following dosage with one tablet of Maloprim given once or twice weekly are reviewed."1.27Agranulocytosis associated with maloprim: review of cases. ( Farquhar, JA; Hutchinson, DB; Whiteman, PD, 1986)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199019 (46.34)18.7374
1990's5 (12.20)18.2507
2000's2 (4.88)29.6817
2010's13 (31.71)24.3611
2020's2 (4.88)2.80

Authors

AuthorsStudies
Hu, Y3
Geere, M3
Awan, M3
Leavitt, AD3
Brown, LE3
Pearson, HJ3
Gandelman, JS3
Kogan, SC3
Dziewulska, KH1
Reisz, JA1
Hay, AM1
D'Alessandro, A1
Zimring, JC1
Rochford, R1
Ohrt, C1
Baresel, PC1
Campo, B1
Sampath, A1
Magill, AJ1
Tekwani, BL1
Walker, LA1
Luzzatto, L3
Seneca, E1
Laureano, A1
Carvalho, R1
Chaveiro, A1
Cardoso, J1
Poirot, E1
Vittinghoff, E1
Ishengoma, D1
Alifrangis, M1
Carneiro, I1
Hashim, R1
Baraka, V1
Mosha, J1
Gesase, S1
Chandramohan, D1
Gosling, R1
Schulkes, KJ1
Tervaert, JW1
Rijken, F1
Haas, LE1
Fanello, CI1
Karema, C1
Avellino, P1
Bancone, G1
Uwimana, A1
Lee, SJ1
d'Alessandro, U1
Modiano, D1
Serpa, JA1
Villarreal-Williams, E1
Giordano, TP1
Olteanu, H1
Harrington, AM1
George, B1
Hari, PN1
Bredeson, C1
Kroft, SH1
Carter, N2
Pamba, A2
Duparc, S2
Waitumbi, JN1
Van Malderen, C1
Van Geertruyden, JP1
Machevo, S1
González, R1
Bassat, Q1
Talisuna, A1
Yeka, A1
Nabasumba, C1
Piola, P1
Daniel, A1
Turyakira, E1
Forret, P1
Van Overmeir, C1
van Loen, H1
Robert, A1
D' Alessandro, U1
Stichtenoth, D1
Greenfield, NP1
Maibach, H1
Richardson, ND1
Premji, Z1
Tiono, AB1
Ash-Bernal, R1
Wise, R1
Wright, SM1
Bernstein, JE1
Lorincz, AL1
Pettit, JH1
Magon, AM1
Leipzig, RM2
Zannoni, VG1
Brewer, GJ2
Magon, A1
Bloom, K1
Ponnampalam, JT1
Todd, P1
Samaratunga, IR1
Pembroke, A1
Mysore, V1
al-Suwaid, AR1
Poshyachinda, M1
Buachum, V1
Mahasandana, S1
Shanks, GD1
Edstein, MD1
Suriyamongkol, V1
Timsaad, S1
Webster, HK1
Byrd, SR1
Gelber, RH1
Hutchinson, DB1
Whiteman, PD1
Farquhar, JA1
Carson, PE4
Cucinell, SA1
Rebert, C1
Clyde, D1
Willerson, D1
Rieckmann, KH1
Kass, L1
Frischer, H1
Bowman, JE1
Khaire, DS1
Magar, NG1
Glader, BE1
Conrad, ME1
Scott, GL1
Rasbridge, MR1
Onadeko, BO1
Bademosi, O1
McNamara, JV1
Eppes, RB2
Powell, RD2
Degowin, RL1
Gaetani, G1
Salvidio, E1
Pannacciulli, I1
Ajmar, F1
Paravidino, G1
Raper, AB1
Lewis, RA1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open Study on the Tolerability and Efficacy of the Combination Chlorproguanil-Dapsone+Artesunate Compared to Amodiaquine+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria in Rwandan Children[NCT00461578]800 participants Interventional2005-04-30Completed
A Multi-centre, Randomised, Double-blind, Double Dummy Study Comparing the Efficacy and Safety of Chlorproguanil-dapsone-artesunate Versus Artemether-lumefantrine in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria in Children and Adoles[NCT00344006]Phase 31,395 participants (Actual)Interventional2006-06-30Completed
A Multi-centre, Randomised, Double-blind Study to Compare the Efficacy and Safety of Chlorproguanil-dapsone-artesunate Versus Chlorproguanil-dapsone in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria in Children, Adolescents and Adults [NCT00371735]Phase 3900 participants (Actual)Interventional2006-04-30Completed
Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295]Phase 349 participants (Actual)Interventional2007-09-05Completed
Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients[NCT01836614]Phase 1/Phase 20 participants (Actual)Interventional2015-01-31Withdrawn (stopped due to Study was closed due to recommendations of performing a PK study first.)
Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869]91 participants (Actual)Interventional2011-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Delta Methemoglobin Blood Level

Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours

Interventionpercentage of methemoglobin in blood (Mean)
Prilocaine2.73
Lidocaine0.78
No Local Anesthetic0.76

Peak Methemoglobin Blood Levels

The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours

Interventionpercentage of methemoglobin in blood (Mean)
Prilocaine3.55
Lidocaine1.63
No Local Anesthetic1.60

Time to Peak Methemoglobin Blood Levels

The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours

Interventionminutes (Mean)
Prilocaine62.73
Lidocaine57.50
No Local Anesthetic29.50

Reviews

3 reviews available for dapsone and Glucosephosphate Dehydrogenase Deficiency

ArticleYear
G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications.
    British journal of haematology, 2014, Volume: 164, Issue:4

    Topics: Anemia, Hemolytic; Animals; Antimalarials; Dapsone; Female; Glucosephosphate Dehydrogenase Deficienc

2014
Alpha-1-antitrypsin deficiency-associated panniculitis: a case report.
    Dermatology online journal, 2014, Jan-15, Volume: 20, Issue:1

    Topics: alpha 1-Antitrypsin Deficiency; Biopsy; Colchicine; Contraindications; Dapsone; Erythema; Female; Gl

2014
Sulfonamides and sulfones in dermatologic therapy.
    International journal of dermatology, 1981, Volume: 20, Issue:2

    Topics: Animals; Chancroid; Conjunctivitis, Inclusion; Dapsone; Dermatitis Herpetiformis; Erythrocytes; Gluc

1981

Trials

6 trials available for dapsone and Glucosephosphate Dehydrogenase Deficiency

ArticleYear
Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Antimalarials; Cohort Studies; Dapsone; Double-Blind Method; Drug Combinations; Female; Genotype; Gl

2015
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
    PloS one, 2008, Volume: 3, Issue:12

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combina

2008
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
    Malaria journal, 2011, Aug-17, Volume: 10

    Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug

2011
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
    Malaria journal, 2011, Aug-17, Volume: 10

    Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug

2011
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
    Malaria journal, 2011, Aug-17, Volume: 10

    Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug

2011
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
    Malaria journal, 2011, Aug-17, Volume: 10

    Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug

2011
Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria.
    Malaria journal, 2012, Jul-10, Volume: 11

    Topics: Africa South of the Sahara; Anemia, Hemolytic; Antimalarials; Artemisinins; Artesunate; Case-Control

2012
Efficacy of WHO regimens in the management of leprosy patients with G6PD deficiency.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Glucosephosphate Dehydro

1999
Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border.
    The American journal of tropical medicine and hygiene, 1992, Volume: 46, Issue:6

    Topics: Blood Cells; Cambodia; Dapsone; Doxycycline; Drug Therapy, Combination; Drug Tolerance; Glucosephosp

1992

Other Studies

32 other studies available for dapsone and Glucosephosphate Dehydrogenase Deficiency

ArticleYear
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
    Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1

    Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur

2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
    Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1

    Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur

2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
    Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1

    Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur

2022
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
    Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1

    Topics: Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methemoglobinemia; Ur

2022
Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model.
    The Journal of pharmacology and experimental therapeutics, 2023, Volume: 386, Issue:3

    Topics: Animals; Dapsone; Erythrocytes; Glucose; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Human

2023
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43

    Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy;

2013
Dapsone hypersensitivity syndrome not related to G6PD deficiency.
    BMJ case reports, 2015, Dec-18, Volume: 2015

    Topics: Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Dapsone; Diagnosis, Differential; Dru

2015
The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.
    Lancet (London, England), 2010, Aug-28, Volume: 376, Issue:9742

    Topics: Anemia, Hemolytic; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Glucosephosphate Dehy

2010
Prevalence of G6PD deficiency in a large cohort of HIV-infected patients.
    The Journal of infection, 2010, Volume: 61, Issue:5

    Topics: Adult; Aged; Anemia, Hemolytic; Anti-Infective Agents; Black or African American; Cohort Studies; Da

2010
High prevalence of Dapsone-induced oxidant hemolysis in North American SCT recipients without glucose-6-phosphate-dehydrogenase deficiency.
    Bone marrow transplantation, 2012, Volume: 47, Issue:3

    Topics: Adult; Anti-Infective Agents; Dapsone; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehy

2012
[Lip cyanosis in dapsone therapy: should the dosage be reduced?].
    MMW Fortschritte der Medizin, 2012, Apr-05, Volume: 154, Issue:6

    Topics: Cyanosis; Dapsone; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Glucosephosphat

2012
Pharmacogenomic biomarkers in dermatologic drugs.
    The Journal of dermatological treatment, 2013, Volume: 24, Issue:6

    Topics: Androstenes; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chloroquine; Cytochrome P-450 CYP2C19; Cytoc

2013
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
    Blood, 2012, Nov-15, Volume: 120, Issue:20

    Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child

2012
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
    Blood, 2012, Nov-15, Volume: 120, Issue:20

    Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child

2012
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
    Blood, 2012, Nov-15, Volume: 120, Issue:20

    Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child

2012
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone.
    Blood, 2012, Nov-15, Volume: 120, Issue:20

    Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child

2012
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
    Medicine, 2004, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi

2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
    Medicine, 2004, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi

2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
    Medicine, 2004, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi

2004
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
    Medicine, 2004, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chi

2004
Is dapsone safe?
    International journal of dermatology, 1981, Volume: 20, Issue:2

    Topics: Anemia, Hemolytic; Dapsone; Glucosephosphate Dehydrogenase Deficiency; Humans; Leprosy

1981
Interactions of glucose-6-phosphate dehydrogenase deficiency with drug acetylation and hydroxylation reactions.
    The Journal of laboratory and clinical medicine, 1981, Volume: 97, Issue:6

    Topics: Acetylation; Animals; Dapsone; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione;

1981
Pharmacogenetic interactions in G6PD deficiency and development of an in vitro test to predict a drug's hemolytic potential.
    Progress in clinical and biological research, 1981, Volume: 55

    Topics: Animals; Dapsone; Drug Evaluation, Preclinical; Erythrocytes; Glucosephosphate Dehydrogenase Deficie

1981
Haemoglobinuria after a single dose treatment with dapsone and pyrimethamine for falciparum malaria in a patient with glucose-6-phosphate dehydrogenase deficiency.
    Tropical and geographical medicine, 1981, Volume: 33, Issue:4

    Topics: Child, Preschool; Dapsone; Drug Combinations; Glucosephosphate Dehydrogenase; Glucosephosphate Dehyd

1981
Screening for glucose-6-phosphate dehydrogenase deficiency prior to dapsone therapy.
    Clinical and experimental dermatology, 1994, Volume: 19, Issue:3

    Topics: Adolescent; Anemia, Hemolytic; Contraindications; Dapsone; Female; Glucosephosphate Dehydrogenase De

1994
Haemolytic side effects of DFD in normal and G-6-PD deficient Thais.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1978, Volume: 61, Issue:8

    Topics: Adult; Dapsone; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Middle Aged; Thailand

1978
Glucose-6-phosphate dehydrogenase deficiency.
    The New England journal of medicine, 1991, Jun-13, Volume: 324, Issue:24

    Topics: Acetaminophen; Dapsone; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans

1991
Effect of dapsone on haemoglobin concentration in patients with leprosy.
    Leprosy review, 1991, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Dapsone; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglob

1991
Agranulocytosis associated with maloprim: review of cases.
    Human toxicology, 1986, Volume: 5, Issue:4

    Topics: Adult; Agranulocytosis; Antimalarials; Dapsone; Dose-Response Relationship, Drug; Drug Combinations;

1986
Hemolysis due to inherited erythrocyte enzyme deficiencies.
    Annals of the New York Academy of Sciences, 1968, Jul-31, Volume: 151, Issue:2

    Topics: Age Factors; Asia, Southeastern; Dapsone; Erythrocytes; Genetics, Population; Glucose; Glucosephosph

1968
Clinical pharmacology of diformyldapsone.
    Journal of clinical pharmacology, 1974, Volume: 14, Issue:1

    Topics: Chloroquine; Dapsone; Drug Therapy, Combination; Erythrocytes; Formaldehyde; Glucosephosphate Dehydr

1974
The chemoprophylactic use of diformyl diaminodiphenyl sulfone (DFD) in falciparum malaria.
    The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:2

    Topics: Adult; Anopheles; Antimalarials; Blood Cell Count; Chloroquine; Dapsone; Drug Resistance, Microbial;

1972
Haemolytic effects of DDS in leprosy patients.
    The Indian journal of medical research, 1972, Volume: 60, Issue:10

    Topics: Adult; Anemia, Hemolytic; Dapsone; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency;

1972
Hemolysis by diphenylsulfones: comparative effects of DDS and hydroxylamine-DDS.
    The Journal of laboratory and clinical medicine, 1973, Volume: 81, Issue:2

    Topics: Amitrole; Animals; Ascorbic Acid; Catalase; Cell Survival; Chromium Isotopes; Dapsone; Erythrocytes;

1973
The in vitro action of dapsone and its derivatives on normal and G6PD-deficient red cells.
    British journal of haematology, 1973, Volume: 24, Issue:3

    Topics: Acetylcholinesterase; Adenosine Triphosphate; Cell Membrane; Dapsone; Erythrocytes; Glucose; Glucose

1973
Glucose-6-phosphate dehydrogenase deficiency and intravascular haemolysis.
    Irish journal of medical science, 1974, Volume: 143, Issue:4

    Topics: Adolescent; Adult; Anemia, Hemolytic; Aspirin; Dapsone; Female; Glucosephosphate Dehydrogenase Defic

1974
The effects of para-aminobenzoic acid on the hemolytic effects of 4, 4'-diaminodiphenylsulfone.
    Military medicine, 1966, Volume: 131, Issue:9

    Topics: Adult; Aminobenzoates; Black or African American; Dapsone; Glucosephosphate Dehydrogenase Deficiency

1966
The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency.
    Bulletin of the World Health Organization, 1966, Volume: 35, Issue:2

    Topics: Adult; Black or African American; Dapsone; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Hum

1966
Absence of hemolytic effects of L-DOPA on transfused G6PD-deficient erythrocytes.
    Experientia, 1970, Volume: 26, Issue:7

    Topics: Blood Transfusion; Chromium Isotopes; Dapsone; Dihydroxyphenylalanine; Erythrocytes; Favism; Female;

1970
A commentary on the anti-sickling effect of the phenothiazine drugs.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1968, Volume: 62, Issue:1

    Topics: Anemia, Sickle Cell; Child; Dapsone; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glucoseph

1968
Experience with promazine in sickle cell disease.
    The West African medical journal and Nigerian practitioner, 1968, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Dapsone; Female; Glucosephosphate D

1968