dapsone has been researched along with Erythema Nodosum in 60 studies
Erythema Nodosum: An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
Excerpt | Relevance | Reference |
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"Patients with borderline-lepromatous (BL) or fully lepromatous (LL) leprosy were treated in the sanitarium for approximately 1 year with oral rifampin (600 mg daily) or with oral dapsone (100 mg daily)." | 9.04 | Rifampin therapy of lepromatous leprosy. ( , 1975) |
"Six male patients of lepromatous leprosy with erythema nodosum leprosum reaction (ENL) reactions diagnosed clinically and by slit skin smear were treated with aspirin and clofazimine." | 7.83 | A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases. ( Sharma, PK; Singh, DK, 2016) |
"The basal level of blood ascorbic acid was studied in 70 cases of polar leprosy." | 7.67 | A study of blood ascorbic acid in leprosy. ( Bajaj, AK; Gupta, SC; Kumar, P; Singh, PA; Sinha, SN, 1984) |
"Isotretinoin has revolutionized the treatment of severe acne unresponsive to oral antibiotics." | 5.30 | Acne fulminans and erythema nodosum during isotretinoin therapy responding to dapsone. ( Lear, JT; Smith, AG; Tan, BB, 1997) |
"Patients with borderline-lepromatous (BL) or fully lepromatous (LL) leprosy were treated in the sanitarium for approximately 1 year with oral rifampin (600 mg daily) or with oral dapsone (100 mg daily)." | 5.04 | Rifampin therapy of lepromatous leprosy. ( , 1975) |
"A comparison of clofazimine and dapsone in the management of untreated lepromatous leprosy showed no significant differences between the two drugs in terms of morphological and bacterial indices." | 5.03 | Controlled clinical trial of clofazimine in untreated lepromatous leprosy. ( Jeevaratnam, A; Karat, AB; Karat, S; Rao, PS, 1971) |
" The patient responded well to fluoroquinolone, rifampicin and clofazimine, with however, the occurrence of erythema nodosum leprosum." | 4.82 | [Histoid leprosy with erythema nodosum leprosum]. ( Alioua, Z; Benomar, S; Boudi, O; Bouzidi, A; Elhaouri, M; Ghfir, M; Sbai, M; Sedrati, OL, 2003) |
"Six male patients of lepromatous leprosy with erythema nodosum leprosum reaction (ENL) reactions diagnosed clinically and by slit skin smear were treated with aspirin and clofazimine." | 3.83 | A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases. ( Sharma, PK; Singh, DK, 2016) |
"Changes in hemoglobin (HGB) and serum albumin (SA) concentration associated with the onset of symptomatic erythema nodosum leprosum (ENL) were studied by comparing the values obtained on the day thalidomide or prednisone therapy commenced, with each patients' preceding values." | 3.71 | Decreases in mean hemoglobin and serum albumin values in erythema nodosum leprosum and lepromatous leprosy. ( Rea, TH, 2001) |
"The basal level of blood ascorbic acid was studied in 70 cases of polar leprosy." | 3.67 | A study of blood ascorbic acid in leprosy. ( Bajaj, AK; Gupta, SC; Kumar, P; Singh, PA; Sinha, SN, 1984) |
"Oral zinc sulfate was tried in Eight cases of recurrent Erythema Nodosum Leprosum." | 3.66 | Oral zinc in recurrent Erythema Nodosum Leprosum reaction. ( Bumb, RA; Mangal, HN; Mathur, NK, 1983) |
" Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy." | 3.66 | Lucio's phenomenon and diffuse nonnodular lepromatous leprosy. ( Levan, NE; Rea, TH, 1978) |
" Reactive episodes continue to be a serious complication, but the availability of thalidomide to control erythema nodosum leprosum has markedly improved the prognosis." | 3.65 | The diagnosis and treatment of leprosy. ( Jacobson, RR; Trautman, JR, 1976) |
"No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients." | 2.68 | Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997) |
"Lepromatous leprosy is associated with a high bacillary load and poor cellular immune response." | 1.56 | Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment. ( Bidari-Zerehpoosh, F; Bizaval, Z; Mozafari, N; Niknejad, N; Robati, RM, 2020) |
"Isotretinoin has revolutionized the treatment of severe acne unresponsive to oral antibiotics." | 1.30 | Acne fulminans and erythema nodosum during isotretinoin therapy responding to dapsone. ( Lear, JT; Smith, AG; Tan, BB, 1997) |
" ENL was also more frequent in regimens C and D and was not prevented by CLO in the dosage used." | 1.27 | Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions. ( Coussens, L; Groenen, G; Janssens, L; Kayembe, T; Nollet, E; Pattyn, SR, 1986) |
"Only in lepromatous cases was complete ageusia seen (9." | 1.27 | Electrogustometry in Hansen's disease (study of 225 cases). ( Chaturvedi, VN; Jain, SK; Raizada, RM; Rathi, SS, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 41 (68.33) | 18.7374 |
1990's | 8 (13.33) | 18.2507 |
2000's | 4 (6.67) | 29.6817 |
2010's | 6 (10.00) | 24.3611 |
2020's | 1 (1.67) | 2.80 |
Authors | Studies |
---|---|
Robati, RM | 1 |
Mozafari, N | 1 |
Bidari-Zerehpoosh, F | 1 |
Niknejad, N | 1 |
Bizaval, Z | 1 |
Sharma, PK | 1 |
Singh, DK | 1 |
Tavares Rodrigues, F | 1 |
Pereira Cardozo, MR | 1 |
da Costa Nery, JA | 1 |
Song, JS | 1 |
Halim, K | 1 |
Vleugels, RA | 1 |
Merola, JF | 1 |
Yuchua-Guillen, A | 1 |
Dofitas, BL | 1 |
Chakma, JK | 1 |
Malaviya, GN | 1 |
Girdhar, A | 1 |
Hussein, S | 1 |
Desenfants, A | 1 |
Huguon, E | 1 |
Polfrit, Y | 1 |
Crouzat, M | 1 |
Rouleau, V | 1 |
Chassot, V | 1 |
Besson-Leaud, L | 1 |
Missotte, I | 1 |
Crawford, CL | 1 |
SCHALLER, KF | 1 |
Alioua, Z | 1 |
Sbai, M | 1 |
Elhaouri, M | 1 |
Bouzidi, A | 1 |
Boudi, O | 1 |
Ghfir, M | 1 |
Benomar, S | 1 |
Sedrati, OL | 1 |
Anderson, R | 2 |
Waters, MF | 4 |
Sinha, SN | 1 |
Gupta, SC | 1 |
Bajaj, AK | 1 |
Singh, PA | 1 |
Kumar, P | 1 |
Mathur, NK | 2 |
Bumb, RA | 2 |
Mangal, HN | 2 |
Sharma, ML | 1 |
Girdhar, BK | 1 |
Desikan, KV | 1 |
Mshana, RN | 1 |
Haregewoin, A | 1 |
Belehu, A | 1 |
Imkamp, FM | 2 |
Gatner, EM | 1 |
Dutta, RK | 2 |
Naik, SS | 2 |
Gurnani, S | 1 |
Sampaio, EP | 1 |
Malta, AM | 1 |
Sarno, EN | 1 |
Kaplan, G | 1 |
de Carsalade, GY | 1 |
Wallach, D | 1 |
Spindler, E | 1 |
Pennec, J | 1 |
Cottenot, F | 1 |
Flageul, B | 1 |
Tan, BB | 1 |
Lear, JT | 1 |
Smith, AG | 1 |
Gálvez, J | 1 |
López-Domínguez, JM | 1 |
Navarro, A | 1 |
Creagh, R | 1 |
Casado, JL | 1 |
Chinchón Lara, I | 1 |
Vides, EA | 1 |
Cabrera, A | 1 |
Ahern, KP | 1 |
Levis, WR | 1 |
Manandhar, R | 1 |
LeMaster, JW | 1 |
Roche, PW | 1 |
Petering, H | 1 |
Kiehl, P | 1 |
Vogelbruch, M | 1 |
Sticht-Groh, V | 1 |
Kapp, A | 1 |
Werfel, T | 1 |
Rea, TH | 3 |
Sehgal, VN | 2 |
Rege, VL | 1 |
Mascarenhas, MF | 1 |
Lieberman, J | 1 |
Gelber, RH | 1 |
Pearson, JM | 3 |
Rees, RJ | 1 |
McDougall, AC | 1 |
Leiker, DL | 1 |
Levan, NE | 1 |
Ganapati, R | 1 |
Shah, MH | 1 |
Shirsat, LS | 1 |
Gaitonde, BB | 1 |
Jacobson, RR | 2 |
Trautman, JR | 3 |
Ekambaram, V | 1 |
Venkatachari, S | 1 |
Lim, SD | 2 |
Kiszkiss, DF | 2 |
Choi, YS | 2 |
Gajl-Peczalska, K | 1 |
Good, RA | 2 |
Somorin, AO | 1 |
Chaudary, AK | 1 |
Mahajan, DM | 1 |
Bedi, BS | 1 |
Cellona, RV | 1 |
Fajardo, TT | 1 |
Kim, DI | 1 |
Hah, YM | 1 |
Ramasoota, T | 1 |
Sampattavanich, S | 1 |
Carrillo, MP | 1 |
Abalos, RM | 1 |
dela Cruz, EC | 1 |
Ito, T | 1 |
Patki, AH | 1 |
Garraud, O | 1 |
Ribierre, O | 1 |
Bach, MA | 1 |
Aitken, IW | 1 |
Groenen, G | 1 |
Janssens, L | 1 |
Kayembe, T | 1 |
Nollet, E | 1 |
Coussens, L | 1 |
Pattyn, SR | 1 |
Rathi, SS | 1 |
Chaturvedi, VN | 1 |
Raizada, RM | 1 |
Jain, SK | 1 |
Helmy, HS | 3 |
Selby, RC | 1 |
Gottlieb, LS | 1 |
Southgate, MT | 1 |
Shepard, CC | 1 |
Tolentino, JG | 1 |
McRae, DH | 1 |
Karat, AB | 1 |
Jeevaratnam, A | 1 |
Karat, S | 1 |
Rao, PS | 1 |
Schulz, EJ | 1 |
4 reviews available for dapsone and Erythema Nodosum
Article | Year |
---|---|
[Histoid leprosy with erythema nodosum leprosum].
Topics: Adult; Clofazimine; Dapsone; Erythema Nodosum; Fluoroquinolones; Histiocytes; Humans; Leprostatic Ag | 2003 |
The immunopharmacology of antileprosy agents.
Topics: Antigens, Bacterial; Clofazimine; Dapsone; Erythema Nodosum; Humans; Immune Tolerance; Immunity, Cel | 1983 |
The management of reactions in leprosy.
Topics: Dapsone; Dermatitis; Erythema Nodosum; Female; Humans; Leprosy; Neuritis; Pregnancy | 1987 |
Neurosurgical aspects of leprosy.
Topics: Abscess; Adolescent; Adult; Aged; Brain; Carpal Tunnel Syndrome; Child; Dapsone; Demyelinating Disea | 1974 |
11 trials available for dapsone and Erythema Nodosum
Article | Year |
---|---|
Intermittent rifampicin therapy in lepromatous leprosy.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Clinical Trials as Topic; Dapsone; Doubl | 1980 |
Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Humans; Interferon-gamma; Leprost | 1996 |
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial; | 1997 |
Effect of zafirlukast on leprosy reactions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Clofazimine; Cohort Studies; D | 1999 |
Clinical trial of DADDS in lepromatous leprosy.
Topics: Adolescent; Adult; Clinical Trials as Topic; Dapsone; Erythema Nodosum; Female; Humans; Injections, | 1976 |
Rifampin therapy of lepromatous leprosy.
Topics: Acetamides; Animals; Clinical Trials as Topic; Dapsone; Drug Administration Schedule; Erythema Nodos | 1975 |
Joint chemotherapy trials in lepromatous leprosy conducted in Thailand, the Philippines, and Korea.
Topics: Adolescent; Adult; Animals; Biopsy; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; | 1990 |
Treatment of moderately severe erythema nodosum leprosum with clofazimine--a controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Benzenesulfonates; Clinical Trials as Topic; Dapsone; Erythe | 1971 |
The relationship of dapsone (DDS) therapy to erythema nodosum leprosum. Is it direct or indirect?
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dapsone; Drug Resistance, Micr | 1974 |
The therapeutic effect of 4,4'-diacetyldiamino-diphenylsulfone (DADDS) in leprosy.
Topics: Adult; Biopsy; Body Weight; Clinical Trials as Topic; Dapsone; Erythema Nodosum; Female; Humans; Inj | 1968 |
Controlled clinical trial of clofazimine in untreated lepromatous leprosy.
Topics: Adult; Anti-Inflammatory Agents; Body Weight; Clinical Trials as Topic; Costs and Cost Analysis; Dap | 1971 |
45 other studies available for dapsone and Erythema Nodosum
Article | Year |
---|---|
Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment.
Topics: Clofazimine; Dapsone; Disease Progression; Drug Therapy, Combination; Erythema Nodosum; Humans; Lepr | 2020 |
A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clofazimine; Dapsone; Drug Therapy, Combina | 2016 |
Widespread Dermatophytosis in a Patient Treated for Leprosy Type II Reactional State after MDT/WHO-MB Release.
Topics: Antifungal Agents; Brazil; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromato | 2018 |
Dapsone for treatment of erythema nodosum.
Topics: Adult; Anti-Infective Agents; Dapsone; Erythema Nodosum; Female; Humans; Male | 2016 |
Atypical Hansen's disease presenting as florid verrucous plaques on the lower extremities: a case report.
Topics: Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Glucocorticoids; Humans; | 2012 |
Florid reactive periostitis ossificans of long bones and digits associated with reaction in a patient with leprosy.
Topics: Adolescent; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous | 2012 |
[Leprosy with an unusual course].
Topics: Anemia, Hemolytic; Child; Dapsone; Disease Progression; Drug Therapy, Combination; Erythema Nodosum; | 2012 |
The schizophrenic career of a "monster drug".
Topics: Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy; Leprosy, Lepromatous; Nervous System | 2003 |
THE USE OF TRIAMCINOLONE IN THE TREATMENT OF SEVERE LEPRA REACTIONS.
Topics: Dapsone; Erythema Nodosum; Humans; Leprosy; Triamcinolone | 1963 |
The treatment of leprosy.
Topics: Adult; Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Ethionamide; Hum | 1983 |
A study of blood ascorbic acid in leprosy.
Topics: Ascorbic Acid; Dapsone; Erythema Nodosum; Humans; Leprosy; Skin Ulcer; Socioeconomic Factors | 1984 |
Oral zinc as an adjunct to dapsone in lepromatous leprosy.
Topics: Adult; Dapsone; Erythema Nodosum; Female; Humans; Leprosy; Male; Middle Aged; Zinc | 1984 |
Oral zinc in recurrent Erythema Nodosum Leprosum reaction.
Topics: Administration, Oral; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Fema | 1983 |
Thymus-dependent lymphocytes in leprosy. II. Effect of chemotherapy on T-lymphocyte subpopulations.
Topics: Antibodies, Monoclonal; Dapsone; Erythema Nodosum; Humans; Leprosy; Lymphocyte Activation; Mycobacte | 1982 |
Possible incompatibility of dapsone with clofazimine in the treatment of patients with erythema nodosum leprosum.
Topics: Clofazimine; Dapsone; Erythema Nodosum; Female; Humans; Leprosy; Male | 1982 |
Clofazimine and dapsone--a combination therapy in erythema nodosum leprosum syndrome.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Female; Humans | 1980 |
Serum lysozyme in leprosy.
Topics: Adolescent; Adult; Aged; Dapsone; Erythema Nodosum; Female; Humans; Leprosy; Male; Middle Aged; Mura | 1980 |
Acne fulminans and erythema nodosum during isotretinoin therapy responding to dapsone.
Topics: Acne Vulgaris; Adolescent; Anti-Infective Agents; Dapsone; Erythema Nodosum; Humans; Isotretinoin; K | 1997 |
[Patient with Hansen disease and lepromatous reaction with predominant neural involvement].
Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Ma | 1998 |
Risk factors for erythema nodosum leprosum.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Clofazimine; Cohor | 1999 |
[Chemotherapy-induced erythema nodosum leprosum: successful treatment with thalidomide].
Topics: Adult; Dapsone; Dermatologic Agents; Drug Therapy, Combination; Erythema Nodosum; Follow-Up Studies; | 2001 |
Decreases in mean hemoglobin and serum albumin values in erythema nodosum leprosum and lepromatous leprosy.
Topics: Anemia; Dapsone; Erythema Nodosum; Hemoglobins; Humans; Leprostatic Agents; Leprosy, Lepromatous; Pr | 2001 |
Pattern of reactions in leprosy: a clinical appraisal.
Topics: Acute Disease; Adolescent; Adult; Child; Dapsone; Edema; Erythema Nodosum; Female; Humans; Leprosy; | 1977 |
Serum angiotensin-converting enzyme in leprosy and coccidioidomycosis.
Topics: Coccidioidomycosis; Dapsone; Drug Administration Schedule; Erythema Nodosum; Humans; Infarction; Lep | 1977 |
Dapsone alone compared with dapsone plus rifampicin in short-term therapy of lepromatous leprosy.
Topics: Dapsone; Drug Therapy, Combination; Erythema Nodosum; Female; Humans; Leprosy; Malaysia; Male; Mycob | 1977 |
[Chemotherapy of leprosy. I. Sulfones and sulfonamides].
Topics: Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Erythema Nodosum; Humans; Leprostati | 1979 |
A study of patients with erythema nondosum leprosum syndrome.
Topics: Adult; Dapsone; Erythema Nodosum; Female; Humans; Leprosy; Male; Middle Aged | 1979 |
Srategy of leprosy control.
Topics: BCG Vaccine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy; Population Surveillance | 1978 |
Lucio's phenomenon and diffuse nonnodular lepromatous leprosy.
Topics: Adult; Dapsone; Erythema Nodosum; Female; Humans; Ischemia; Leprosy; Lymphopenia; Male; Middle Aged; | 1978 |
The diagnosis and treatment of leprosy.
Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Immunotherapy; Leprosy; Recurrence; Rifampin | 1976 |
Treatment of Hansen's disease.
Topics: Chloroquine; Clofazimine; Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Humans; Leprosy; Pr | 1976 |
A trial of long-acting sulphonamide R.O. 4-4393 (fanasil) in treatment of cases of lepromatous leprosy with repeated E.N.L.
Topics: Dapsone; Erythema Nodosum; Humans; Leprosy; Sulfonamides | 1976 |
Immunodeficiency in leprosy.
Topics: Agglutination Tests; B-Lymphocytes; Blood Transfusion; Body Temperature; Cytotoxicity Tests, Immunol | 1975 |
Erythema nodosum leprosum in Nigeria.
Topics: Adolescent; Child; Dapsone; Erythema Nodosum; Humans; Leprosy; Male; Nigeria | 1975 |
Type II (ENL) reaction in histoid leprosy in a child.
Topics: Adolescent; Dapsone; Erythema Nodosum; Humans; Leprosy, Lepromatous; Male | 1991 |
Dapsone and erythema nodosum leprosum.
Topics: Dapsone; Erythema Nodosum; Humans; Leprosy, Lepromatous | 1989 |
A follow up of T-cell subsets and of anti-M. leprae antibody titer as measured by the FLA-ABS test in Melanesian leprosy patients under polychemotherapy.
Topics: Adolescent; Adult; Antibodies, Bacterial; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Er | 1986 |
Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions.
Topics: Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Erythema Nodosum; Ethionamide; | 1986 |
Electrogustometry in Hansen's disease (study of 225 cases).
Topics: Adolescent; Adult; Ageusia; Clofazimine; Dapsone; Erythema Nodosum; Facial Paralysis; Female; Humans | 1986 |
Standardized schemes for steroid treatment in ENL and reversal reactions.
Topics: Adrenal Cortex Hormones; Dapsone; Erythema Nodosum; Humans; Leprosy; Prednisone | 1985 |
Thymus-dependent lymphocytes of peripheral blood in leprosy patients.
Topics: Adult; Aged; Animals; Blood Cell Count; Clofazimine; Dapsone; Erythema Nodosum; Erythrocytes; Humans | 1974 |
Acute adenopathy in a young man.
Topics: Adult; Animals; Dapsone; Diagnosis, Differential; Erythema Nodosum; Granuloma; Guinea Pigs; Humans; | 1973 |
The effect of stopping dapsone treatment for two months and then restarting it in full dosage in patients with moderately severe erythema nodosum leprosum.
Topics: Dapsone; Erythema Nodosum; Humans; Leprosy; Placebos | 1973 |
Forty-four months' experience in the treatment of leprosy with clofazimine (Lamprene (Geigy)).
Topics: Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Female; Humans; Leprosy; Neuritis; Phenazines | 1971 |
The management of leprosy and its complications.
Topics: Amyloidosis; Dapsone; Erythema Nodosum; Humans; Leprosy; Neuritis; Tuberculosis | 1965 |