Page last updated: 2024-10-25

dapsone and Brain Ischemia

dapsone has been researched along with Brain Ischemia in 4 studies

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"In this study, the authors sought to define the differences in the incidence of delayed cerebral ischemia (DCI) between patients treated with dapsone and those treated with placebo."9.51Neuroprotective effect of dapsone in patients with aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled clinical trial. ( Balcázar-Padrón, JC; Díaz-Ruíz, A; García-Pastor, C; Nathal, E; Navarro-Garcia de Llano, JP; Rios, C; Rodríguez-Hernandez, LA; Tristán-López, L, 2022)
" We have shown that dapsone acts as an antioxidant, antiinflammatory and antiapoptotic agent after brain Ischemia reperfusion (I/R) in rats; however, its therapeutic efficacy, measured by imaging has not been characterized."7.83Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats. ( Diaz-Ruiz, A; Heras-Romero, Y; Mendez-Armenta, M; Mondragón-Lozano, R; Nava-Ruiz, C; Ortiz-Plata, A; Osorio-Rico, L; Ríos, C; Roldan-Valadez, E, 2016)
"In this study, the authors sought to define the differences in the incidence of delayed cerebral ischemia (DCI) between patients treated with dapsone and those treated with placebo."5.51Neuroprotective effect of dapsone in patients with aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled clinical trial. ( Balcázar-Padrón, JC; Díaz-Ruíz, A; García-Pastor, C; Nathal, E; Navarro-Garcia de Llano, JP; Rios, C; Rodríguez-Hernandez, LA; Tristán-López, L, 2022)
" Rats were dosed either with dapsone (12."5.35Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. ( Diaz-Ruiz, A; Montes, S; Nava-Ruiz, C; Orozco-Suarez, S; Ortiz-Plata, A; Pérez-Neri, I; Perez-Severiano, F; Ríos, C; Salgado-Ceballos, H; Zavala, C, 2008)
" We have shown that dapsone acts as an antioxidant, antiinflammatory and antiapoptotic agent after brain Ischemia reperfusion (I/R) in rats; however, its therapeutic efficacy, measured by imaging has not been characterized."3.83Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats. ( Diaz-Ruiz, A; Heras-Romero, Y; Mendez-Armenta, M; Mondragón-Lozano, R; Nava-Ruiz, C; Ortiz-Plata, A; Osorio-Rico, L; Ríos, C; Roldan-Valadez, E, 2016)
" Rats were dosed either with dapsone (12."1.35Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. ( Diaz-Ruiz, A; Montes, S; Nava-Ruiz, C; Orozco-Suarez, S; Ortiz-Plata, A; Pérez-Neri, I; Perez-Severiano, F; Ríos, C; Salgado-Ceballos, H; Zavala, C, 2008)
"Dapsone-treated animals showed a reduction of 93% (9."1.32Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats. ( Nader-Kawachi, J; Nava-Ruiz, C; Ríos, C; Rodriguez-Payán, AJ, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
García-Pastor, C1
Navarro-Garcia de Llano, JP1
Balcázar-Padrón, JC1
Tristán-López, L1
Rios, C4
Díaz-Ruíz, A3
Rodríguez-Hernandez, LA1
Nathal, E1
Roldan-Valadez, E1
Ortiz-Plata, A2
Mondragón-Lozano, R1
Heras-Romero, Y1
Mendez-Armenta, M1
Osorio-Rico, L1
Nava-Ruiz, C3
Zavala, C1
Montes, S1
Salgado-Ceballos, H1
Orozco-Suarez, S1
Pérez-Neri, I1
Perez-Severiano, F1
Nader-Kawachi, J1
Rodriguez-Payán, AJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295]Phase 349 participants (Actual)Interventional2007-09-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for dapsone and Brain Ischemia

ArticleYear
Neuroprotective effect of dapsone in patients with aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled clinical trial.
    Neurosurgical focus, 2022, Volume: 52, Issue:3

    Topics: Adolescent; Adult; Aged; Brain Ischemia; Dapsone; Female; Humans; Male; Middle Aged; Neuroprotective

2022

Other Studies

3 other studies available for dapsone and Brain Ischemia

ArticleYear
Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats.
    Brain research, 2016, 09-01, Volume: 1646

    Topics: Animals; Brain; Brain Ischemia; Dapsone; Magnetic Resonance Imaging; Male; Neuroprotective Agents; N

2016
Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats.
    Journal of neuroscience research, 2008, Nov-15, Volume: 86, Issue:15

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Ischemia; Caspase 3; Caspase 9; Ch

2008
Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats.
    Brain research, 2004, Mar-05, Volume: 999, Issue:2

    Topics: Animals; Brain Infarction; Brain Ischemia; Dapsone; Disease Models, Animal; Dose-Response Relationsh

2004