dapsone has been researched along with Brain Ischemia in 4 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the authors sought to define the differences in the incidence of delayed cerebral ischemia (DCI) between patients treated with dapsone and those treated with placebo." | 9.51 | Neuroprotective effect of dapsone in patients with aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled clinical trial. ( Balcázar-Padrón, JC; Díaz-Ruíz, A; García-Pastor, C; Nathal, E; Navarro-Garcia de Llano, JP; Rios, C; Rodríguez-Hernandez, LA; Tristán-López, L, 2022) |
| " We have shown that dapsone acts as an antioxidant, antiinflammatory and antiapoptotic agent after brain Ischemia reperfusion (I/R) in rats; however, its therapeutic efficacy, measured by imaging has not been characterized." | 7.83 | Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats. ( Diaz-Ruiz, A; Heras-Romero, Y; Mendez-Armenta, M; Mondragón-Lozano, R; Nava-Ruiz, C; Ortiz-Plata, A; Osorio-Rico, L; Ríos, C; Roldan-Valadez, E, 2016) |
| "In this study, the authors sought to define the differences in the incidence of delayed cerebral ischemia (DCI) between patients treated with dapsone and those treated with placebo." | 5.51 | Neuroprotective effect of dapsone in patients with aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled clinical trial. ( Balcázar-Padrón, JC; Díaz-Ruíz, A; García-Pastor, C; Nathal, E; Navarro-Garcia de Llano, JP; Rios, C; Rodríguez-Hernandez, LA; Tristán-López, L, 2022) |
| " Rats were dosed either with dapsone (12." | 5.35 | Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. ( Diaz-Ruiz, A; Montes, S; Nava-Ruiz, C; Orozco-Suarez, S; Ortiz-Plata, A; Pérez-Neri, I; Perez-Severiano, F; Ríos, C; Salgado-Ceballos, H; Zavala, C, 2008) |
| " We have shown that dapsone acts as an antioxidant, antiinflammatory and antiapoptotic agent after brain Ischemia reperfusion (I/R) in rats; however, its therapeutic efficacy, measured by imaging has not been characterized." | 3.83 | Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats. ( Diaz-Ruiz, A; Heras-Romero, Y; Mendez-Armenta, M; Mondragón-Lozano, R; Nava-Ruiz, C; Ortiz-Plata, A; Osorio-Rico, L; Ríos, C; Roldan-Valadez, E, 2016) |
| " Rats were dosed either with dapsone (12." | 1.35 | Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. ( Diaz-Ruiz, A; Montes, S; Nava-Ruiz, C; Orozco-Suarez, S; Ortiz-Plata, A; Pérez-Neri, I; Perez-Severiano, F; Ríos, C; Salgado-Ceballos, H; Zavala, C, 2008) |
| "Dapsone-treated animals showed a reduction of 93% (9." | 1.32 | Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats. ( Nader-Kawachi, J; Nava-Ruiz, C; Ríos, C; Rodriguez-Payán, AJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| García-Pastor, C | 1 |
| Navarro-Garcia de Llano, JP | 1 |
| Balcázar-Padrón, JC | 1 |
| Tristán-López, L | 1 |
| Rios, C | 4 |
| Díaz-Ruíz, A | 3 |
| Rodríguez-Hernandez, LA | 1 |
| Nathal, E | 1 |
| Roldan-Valadez, E | 1 |
| Ortiz-Plata, A | 2 |
| Mondragón-Lozano, R | 1 |
| Heras-Romero, Y | 1 |
| Mendez-Armenta, M | 1 |
| Osorio-Rico, L | 1 |
| Nava-Ruiz, C | 3 |
| Zavala, C | 1 |
| Montes, S | 1 |
| Salgado-Ceballos, H | 1 |
| Orozco-Suarez, S | 1 |
| Pérez-Neri, I | 1 |
| Perez-Severiano, F | 1 |
| Nader-Kawachi, J | 1 |
| Rodriguez-Payán, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295] | Phase 3 | 49 participants (Actual) | Interventional | 2007-09-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for dapsone and Brain Ischemia
| Article | Year |
|---|---|
Neuroprotective effect of dapsone in patients with aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Dapsone; Female; Humans; Male; Middle Aged; Neuroprotective | 2022 |
3 other studies available for dapsone and Brain Ischemia
| Article | Year |
|---|---|
Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats.
Topics: Animals; Brain; Brain Ischemia; Dapsone; Magnetic Resonance Imaging; Male; Neuroprotective Agents; N | 2016 |
Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Ischemia; Caspase 3; Caspase 9; Ch | 2008 |
Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats.
Topics: Animals; Brain Infarction; Brain Ischemia; Dapsone; Disease Models, Animal; Dose-Response Relationsh | 2004 |