Page last updated: 2024-10-25

dapsone and Autoimmune Thrombocytopenia

dapsone has been researched along with Autoimmune Thrombocytopenia in 35 studies

Research Excerpts

ExcerptRelevanceReference
"This report describes a case of methemoglobinemia in association with dapsone therapy."7.73Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura. ( Roberts, WD; Schiff, DE; Sue, YJ, 2006)
"This report describes a case of methemoglobinemia in association with dapsone therapy."3.73Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura. ( Roberts, WD; Schiff, DE; Sue, YJ, 2006)
"5-(2-Pyridylsulfonyl)-2-thiazolamine (2) was effective both in mitomycin C (MMC)-induced thrombocytopenia and in an animal model of idiopathic thrombocytopenic purpura (ITP)."3.70Synthesis and effects of novel thiazole derivatives against thrombocytopenia. ( Manda, T; Matsuo, M; Nishigaki, F; Ogino, T; Sawada, M; Seki, N; Sudo, Y; Tsuji, K, 1998)
"Dapsone is an antibacterial sulfonamide with anti-inflammatory property, which showed therapeutic activity in patients with immune thrombocytopenia (ITP); the activity in patients who showed refractoriness to rituximab is unknown."2.77Dapsone salvage therapy for adult patients with immune thrombocytopenia relapsed or refractory to steroid and rituximab. ( Chiozzotto, M; Fanin, R; Marin, L; Puglisi, S; Volpetti, S; Zaja, F, 2012)
"Eight patients with idiopathic thrombocytopenic purpura (ITP) refractory to corticosteroids were given oral diaminodiphenyl sulfone (DDS) (75 mg to 150 mg/day)."2.69[Diaminodiphenyl sulfone therapy for refractory idiopathic thrombocytopenic purpura--long-term effectiveness and possible mechanisms]. ( Chiba, S; Hirasawa, A; Kawabuchi, Y; Nishikawa, T; Sato, T; Wakabayashi, Y, 1999)
"With prolonged life expectancy, immune thrombocytopenia (ITP) is frequent in elderly people."2.53How we manage immune thrombocytopenia in the elderly. ( Godeau, B; Mahévas, M; Michel, M, 2016)
"Dapsone is an inexpensive drug with a well-established safety profile."2.49Dapsone for primary immune thrombocytopenia in adults and children: an evidence-based review. ( Gooneratne, L; Rodrigo, C, 2013)
"Chronic Immune Thrombocytopenic Purpura (cITP) has become a field of multiple therapeutic assays."2.45[Treatment of chronic immune thrombocytopenic purpura. Looking for something better. Review]. ( Diez-Ewald, M; Vizcaíno, G; Vizcaíno-Carruyo, J, 2009)
" Side effects of steroids prohibits their long-term use and patients often have to be switched to other agents."1.51Is dapsone still relevant in immune thrombocytopenia in resource limited settings? ( Dalal, P; Gulia, M; Gupta, M; Tahlan, A, 2019)
"Many patients with immune thrombocytopenia (ITP) may require special attention and long-term treatment."1.48Efficacy and tolerability of old and new drugs used in the treatment of immune thrombocytopenia: Results from a long-term observation in clinical practice. ( Aboud, N; Depré, F; Mayer, B; Salama, A, 2018)
" Side effects occurred in 31% (n = 13) of patients, and required dapsone withdrawal in 22% (n = 9) or dosage reduction in 10% (n = 4) of the cases."1.46Efficacy and safety of dapsone as second line therapy for adult immune thrombocytopenia: A retrospective study of 42 patients. ( Audia, S; Berthier, S; Bonnotte, B; Estève, C; Guilhem, A; Leguy-Seguin, V; Nicolas, B; Samson, M, 2017)
"Dapsone is a safe and cheap second-line therapy for ITP with a response rate of about 50% (majority being CR)."1.42Dapsone for immune thrombocytopenic purpura in children and adults. ( Patel, AP; Patil, AS, 2015)
"Dapsone has been shown to be effective in treating immune thrombocytopenic purpura (ITP) in adults."1.38Dapsone treatment in a girl with severe chronic thrombocytopenic purpura. Does it work? Do not touch it! ( Nocerino, A; Passone, E; Pusiol, A; Tenore, A, 2012)
" Dapsone-related adverse events were mild and promptly reversed by treatment withdrawal."1.35Efficacy and safety of dapsone as a second-line treatment in non-splenectomized adults with immune thrombocytopenic purpura. ( Annichino-Bizzacchi, JM; De Paula, EV; Fabri, DR; Orsi, FL; Ozelo, MC; Vancine-Califani, SM, 2008)
"Dapsone was continued in 20/33 responders for a median of 12."1.30Dapsone for chronic autoimmune thrombocytopenic purpura: a report of 66 cases. ( Bierling, P; Durand, JM; Godeau, B; Kaplanski, G; Oksenhendler, E; Roudot-Thoraval, F; Schaeffer, A; Tennezé, A, 1997)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (25.71)18.2507
2000's9 (25.71)29.6817
2010's14 (40.00)24.3611
2020's3 (8.57)2.80

Authors

AuthorsStudies
Tsuji, K1
Ogino, T1
Seki, N1
Sawada, M1
Sudo, Y1
Nishigaki, F2
Manda, T2
Matsuo, M1
Dalal, P1
Gulia, M1
Gupta, M1
Tahlan, A1
Bm, S1
Toshniwal, M1
Bhattacharya, M1
Jakkal, D1
Bartakke, SP1
Sampagar, AA1
Reddy, NA1
Kangle, R1
Colella, MP1
Orsi, FA1
Alves, ECF1
Delmoro, GF1
Yamaguti-Hayakawa, GG1
de Paula, EV2
Annichino-Bizzacchi, JM2
Estève, C1
Samson, M1
Guilhem, A1
Nicolas, B1
Leguy-Seguin, V2
Berthier, S2
Bonnotte, B3
Audia, S3
Depré, F1
Aboud, N1
Mayer, B1
Salama, A1
Rodrigo, C1
Gooneratne, L1
Patel, AP1
Patil, AS1
Oo, T1
Hill, QA2
Sauvetre, G1
MahÉvas, M2
Limal, N1
Guillaud, C1
Khellaf, M1
Bierling, P4
Languille, L1
Delbos, F1
Noizat-Pirenne, F1
Michel, M2
Godeau, B6
Ali, M1
Islam, MS1
Rahman, MH1
Islam, MM1
Anis, MA1
Vancine-Califani, SM1
Ozelo, MC1
Orsi, FL1
Fabri, DR1
Varghese, L1
Viswabandya, A2
Mathew, AJ1
Vizcaíno, G1
Diez-Ewald, M1
Vizcaíno-Carruyo, J1
Lakomy, D1
Guy, J1
Aho, S1
Lorcerie, B1
Zaja, F1
Marin, L1
Chiozzotto, M1
Puglisi, S1
Volpetti, S1
Fanin, R1
Pusiol, A1
Nocerino, A1
Passone, E1
Tenore, A1
Treppendahl, MB1
Nielsen, OJ1
Damodar, S1
George, B1
Mathews, V1
Chandy, M1
Srivastava, A1
Schiff, DE1
Roberts, WD1
Sue, YJ1
Litton, G1
Hernández, F1
Linares, M2
Colomina, P2
Pastor, E2
Cerveró, A2
Pérez, A1
Perella, M1
Oksenhendler, E2
Durand, JM1
Roudot-Thoraval, F1
Tennezé, A1
Kaplanski, G1
Schaeffer, A1
Radaelli, F1
Calori, R1
Goldaniga, M1
Guggiari, E1
Luciano, A1
Tsujimoto, S1
Inami, M1
Matsumoto, S1
Naoe, Y1
Kawamura, I1
Shimomura, K1
Hirasawa, A1
Sato, T1
Kawabuchi, Y1
Nishikawa, T1
Chiba, S1
Wakabayashi, Y1
Le Louët, H1
Ruivart, M1
Duche, JC1
Lush, R1
Iland, H1
Peat, B1
Young, G1
Kurata, Y1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295]Phase 349 participants (Actual)Interventional2007-09-05Completed
Prospective Multicenter Randomized Open-label Controlled Trial Assessing Efficacy and Safety of DAPSone as a Second-line Option in Adult Immune Thrombocytopenia[NCT02627417]Phase 3216 participants (Anticipated)Interventional2015-12-31Recruiting
Randomized, Double Blinded, Placebo-controlled Trial to Assess the Preventive Effects of Cetylpyridinium Chloride on Sarcopenia[NCT02575235]Early Phase 1100 participants (Actual)Interventional2015-10-01Completed
Randomized, Double Blinded, Placebo-controlled Trial to Assess the Preventive Effects of Cetylpyridinium Chloride on Sarcopenia: An Exploratory Pilot Study[NCT02297997]Early Phase 165 participants (Actual)Interventional2014-11-13Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for dapsone and Autoimmune Thrombocytopenia

ArticleYear
Dapsone for primary immune thrombocytopenia in adults and children: an evidence-based review.
    Journal of thrombosis and haemostasis : JTH, 2013, Volume: 11, Issue:11

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Child; Clinical Trials as Topic; Dapsone; Evide

2013
How does dapsone work in immune thrombocytopenia? Implications for dosing.
    Blood, 2015, Jun-04, Volume: 125, Issue:23

    Topics: Anti-Infective Agents; Dapsone; Female; Humans; Male; Purpura, Thrombocytopenic, Idiopathic

2015
How we manage immune thrombocytopenia in the elderly.
    British journal of haematology, 2016, Volume: 173, Issue:6

    Topics: Aged; Aged, 80 and over; Danazol; Dapsone; Disease Management; Female; Humans; Immunoglobulins, Intr

2016
[Treatment of chronic immune thrombocytopenic purpura. Looking for something better. Review].
    Investigacion clinica, 2009, Volume: 50, Issue:1

    Topics: Adrenal Cortex Hormones; Antigens, Human Platelet; Autoantibodies; Benzoates; Blood Platelets; Clini

2009
[New development in the treatment of idiopathic thrombocytopenic purpura].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2000, Jun-10, Volume: 89, Issue:6

    Topics: Antibodies, Monoclonal; CD40 Ligand; Dapsone; Humans; Laparoscopy; Membrane Glycoproteins; Purpura,

2000

Trials

3 trials available for dapsone and Autoimmune Thrombocytopenia

ArticleYear
Dapsone salvage therapy for adult patients with immune thrombocytopenia relapsed or refractory to steroid and rituximab.
    American journal of hematology, 2012, Volume: 87, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Contraindications; Dan

2012
Dapsone for autoimmune thrombocytopenic purpura.
    American journal of hematology, 1993, Volume: 44, Issue:1

    Topics: Adult; Aged; Dapsone; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet

1993
[Diaminodiphenyl sulfone therapy for refractory idiopathic thrombocytopenic purpura--long-term effectiveness and possible mechanisms].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1999, Volume: 40, Issue:10

    Topics: Administration, Oral; Adult; Dapsone; Dose-Response Relationship, Drug; Female; Humans; Leprostatic

1999

Other Studies

27 other studies available for dapsone and Autoimmune Thrombocytopenia

ArticleYear
Synthesis and effects of novel thiazole derivatives against thrombocytopenia.
    Bioorganic & medicinal chemistry letters, 1998, Sep-22, Volume: 8, Issue:18

    Topics: Animals; Autoantibodies; Blood Platelets; Dapsone; Disease Models, Animal; Dose-Response Relationshi

1998
Is dapsone still relevant in immune thrombocytopenia in resource limited settings?
    BMJ case reports, 2019, Dec-19, Volume: 12, Issue:12

    Topics: Adult; Dapsone; Diagnosis, Differential; Gingival Hemorrhage; Humans; India; Male; Medically Underse

2019
Combination Therapy of Azathioprine+ Dapsone as Effective Second Line Agents for the Treatment of Chronic Immune Thrombocytopenic Purpura.
    The Journal of the Association of Physicians of India, 2020, Volume: 68, Issue:1

    Topics: Anti-Infective Agents; Azathioprine; Combined Modality Therapy; Dapsone; Humans; Immunosuppressive A

2020
Dapsone Induced Agranulocytosis and Hemolytic Anemia in Immune Thrombocytopenic Purpura.
    Indian journal of pediatrics, 2020, Volume: 87, Issue:10

    Topics: Agranulocytosis; Anemia, Hemolytic; Dapsone; Humans; Purpura; Purpura, Thrombocytopenic; Purpura, Th

2020
A retrospective analysis of 122 immune thrombocytopenia patients treated with dapsone: Efficacy, safety and factors associated with treatment response.
    Journal of thrombosis and haemostasis : JTH, 2021, Volume: 19, Issue:9

    Topics: Dapsone; Humans; Purpura, Thrombocytopenic, Idiopathic; Remission Induction; Retrospective Studies;

2021
Efficacy and safety of dapsone as second line therapy for adult immune thrombocytopenia: A retrospective study of 42 patients.
    PloS one, 2017, Volume: 12, Issue:10

    Topics: Adult; Dapsone; Humans; Purpura, Thrombocytopenic, Idiopathic; Retrospective Studies

2017
Efficacy and tolerability of old and new drugs used in the treatment of immune thrombocytopenia: Results from a long-term observation in clinical practice.
    PloS one, 2018, Volume: 13, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Benzoates; Child; Child, Preschool; Combin

2018
Dapsone for immune thrombocytopenic purpura in children and adults.
    Platelets, 2015, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dapsone; Erythrocyte Indices; Female; Follow-Up St

2015
Disappointing response to dapsone as second line therapy for primary ITP: a case series.
    Annals of hematology, 2015, Volume: 94, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dapsone; Female; Humans; Male; Middle Aged; Purpura, Thr

2015
Cutaneous rash and dapsone-induced hypersensitivity syndrome a common manifestation in adult immune thrombocytopenia. Presentation and outcome in 16 cases.
    American journal of hematology, 2015, Volume: 90, Issue:10

    Topics: Adult; Anti-Infective Agents; Dapsone; Drug Hypersensitivity; Exanthema; Female; Humans; Male; Purpu

2015
Is there still a place for "old therapies" in the management of immune thrombocytopenia?
    La Revue de medecine interne, 2016, Volume: 37, Issue:1

    Topics: Benzoates; Danazol; Dapsone; Humans; Hydrazines; Hydroxychloroquine; Immunoglobulins, Intravenous; P

2016
Response of Dapsone in Refractory Chronic Immune Thrombocytopenia.
    Mymensingh medical journal : MMJ, 2016, Volume: 25, Issue:4

    Topics: Dapsone; Humans; Platelet Count; Prospective Studies; Purpura, Thrombocytopenic, Idiopathic; Treatme

2016
Efficacy and safety of dapsone as a second-line treatment in non-splenectomized adults with immune thrombocytopenic purpura.
    Platelets, 2008, Volume: 19, Issue:7

    Topics: Adolescent; Adult; Aged; Cohort Studies; Dapsone; Drug-Related Side Effects and Adverse Reactions; F

2008
Dapsone, danazol, and intrapartum splenectomy in refractory ITP complicating pregnancy.
    Indian journal of medical sciences, 2008, Volume: 62, Issue:11

    Topics: Anti-Inflammatory Agents; Cesarean Section; Danazol; Dapsone; Dexamethasone; Estrogen Antagonists; F

2008
[Treatment of immune thrombocytopenia: a retrospective study of 40 patients].
    La Revue de medecine interne, 2010, Volume: 31, Issue:5

    Topics: Adult; Aged; Anti-Infective Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived;

2010
Dapsone treatment in a girl with severe chronic thrombocytopenic purpura. Does it work? Do not touch it!
    Minerva pediatrica, 2012, Volume: 64, Issue:5

    Topics: Adolescent; Blood Platelets; Dapsone; Female; Humans; Intracranial Hemorrhages; Platelet Count; Purp

2012
[Idiopathic thrombocytopenic purpura. A retrospective evaluation of 68 patients].
    Ugeskrift for laeger, 2004, Sep-20, Volume: 166, Issue:39

    Topics: Adult; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Azathioprine; Cyclophospha

2004
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chronic Disease; Dapsone; Drug Evaluation;

2005
Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura.
    Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:6

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Mur

2006
Refractory idiopathic thrombocytopenic purpura treated with the soluble tumor necrosis factor receptor etanercept.
    American journal of hematology, 2008, Volume: 83, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Bacterial Agents; Colchicine; Combined Modality

2008
Dapsone for refractory chronic idiopathic thrombocytopenic purpura.
    British journal of haematology, 1995, Volume: 90, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Dapsone; Female; Humans; Middle Aged; P

1995
Dapsone for idiopathic thrombocytopenic purpura.
    American journal of hematology, 1994, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Aged; Dapsone; Female; Humans; Male; Middle Aged; Purpura, Thrombocytopenic, Idio

1994
Dapsone for chronic autoimmune thrombocytopenic purpura: a report of 66 cases.
    British journal of haematology, 1997, Volume: 97, Issue:2

    Topics: Adult; Chronic Disease; Dapsone; Female; Humans; Male; Middle Aged; Platelet Count; Purpura, Thrombo

1997
Adult refractory chronic idiopathic thrombocytopenic purpura: can dapsone be proposed as second-line therapy?
    British journal of haematology, 1999, Volume: 104, Issue:3

    Topics: Aged; Chronic Disease; Dapsone; Female; Humans; Male; Middle Aged; Purpura, Thrombocytopenic, Idiopa

1999
Effects of a novel pyridylsulphonyl thiazole derivative, FR115092, on autoimmune and mitomycin C-induced thrombocytopenia in mice.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoimmunity; Blood Platelets; Bon

1999
Lack of relevance of the acetylator status on dapsone response in chronic autoimmune thrombocytopenic purpura.
    American journal of hematology, 1999, Volume: 62, Issue:4

    Topics: Acetylation; Arylamine N-Acetyltransferase; Dapsone; Female; Humans; Male; Middle Aged; Phenotype; P

1999
Successful use of dapsone in refractory pregnancy-associated idiopathic thrombocytopenic purpura.
    Australian and New Zealand journal of medicine, 2000, Volume: 30, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dapsone; Female; Glucocorticoids; Humans; Immunoglob

2000