dapi has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
DAPI: RN given refers to parent cpd.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Western blot of lysates from FTLD-TDP frontal cortex and TDP-43-positive SALS spinal cord revealed decreased levels of OPTN protein compared to controls (p < 0." | 1.37 | Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders. ( Al-Sarraj, S; Hortobágyi, T; King, A; Nishimura, AL; Rogelj, B; Seelaar, H; Shaw, CE; Troakes, C; van Swieten, JC; Vance, C, 2011) |
| " The possible toxic factor(s) and the exact mode of action (e." | 1.33 | Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro. ( Anneser, JM; Borasio, GD; Chahli, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeong, SY | 1 |
| Rathore, KI | 1 |
| Schulz, K | 1 |
| Ponka, P | 1 |
| Arosio, P | 1 |
| David, S | 1 |
| Hortobágyi, T | 1 |
| Troakes, C | 1 |
| Nishimura, AL | 1 |
| Vance, C | 1 |
| van Swieten, JC | 1 |
| Seelaar, H | 1 |
| King, A | 1 |
| Al-Sarraj, S | 1 |
| Rogelj, B | 1 |
| Shaw, CE | 1 |
| Anneser, JM | 1 |
| Chahli, C | 1 |
| Borasio, GD | 1 |
3 other studies available for dapi and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Aldehydes; Amyotrophic Lateral Sclerosis; Animals; Body Weight; Cation Transport Protei | 2009 |
Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Brain; Cell Cycle Proteins; DNA-Binding Prot | 2011 |
Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Cell Count; Cell Death; Cells, Cultured; Cerebrospinal | 2006 |