dapi has been researched along with Alzheimer Disease in 22 studies
DAPI: RN given refers to parent cpd.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The majority of neuritic plaques are decorated by IgG." | 2.74 | Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden. ( Bernreuther, C; Ferrer, I; Glatzel, M; Kellner, A; Matschke, J; Moch, H, 2009) |
| "DAPI was positive in 3R/4R (3-repeat/4-repeat) tau deposits in Alzheimer's disease, myotonic dystrophy, and neurodegeneration with brain iron accumulation, and in 4R tau deposits in corticobasal degeneration, but negative in 4R tau deposits in frontotemporal dementia with parkinsonism-17 and progressive supranuclear palsy." | 1.48 | 4',6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits. ( Kinoshita, E; Li, C; Maruyama, H; Matsubara, T; Matsumoto, M; Shrestha, T; Takahashi, T, 2018) |
| "To investigate whether Alzheimer's disease is associated with changes in the absolute cell numbers of ageing brains, we used the isotropic fractionator, a novel technique designed to determine the absolute cellular composition of brain regions." | 1.39 | Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles. ( Andrade-Moraes, CH; Carvalho, LR; Castro-Fonseca, E; da Silva, CG; Ferretti-Rebustini, RE; Gomes, BV; Grinberg, LT; Guimarães, DM; Jacob-Filho, W; Leite, RE; Lent, R; Oliveira, LM; Oliveira-Pinto, AV; Parente-Bruno, DR; Pasqualucci, CA; Polichiso, L; Rodriguez, RD; Szczupak, D, 2013) |
| "The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss." | 1.36 | The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease. ( Bae, JS; Carter, JE; Jin, HK; Lee, H; Lee, HJ; Lee, JK; Sakamoto, T; Shin, JW, 2010) |
| "Ibuprofen-treated transgenic mice showed a significant decrease in intraneuronal oligomeric Abeta and hyperphosphorylated tau (AT8) immunoreactivity in the hippocampus." | 1.35 | Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. ( Carreras, I; Dedeoglu, A; Hossain, L; Jenkins, BG; Klein, WL; Kowall, NW; LaFerla, FM; McKee, AC; Oddo, S; Ryu, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Mabrouk, R | 1 |
| Gotkiewicz, M | 1 |
| Rauramaa, T | 1 |
| Tanila, H | 1 |
| Wee, M | 1 |
| Chegini, F | 1 |
| Power, JHT | 1 |
| Majd, S | 1 |
| Li, C | 1 |
| Takahashi, T | 1 |
| Shrestha, T | 1 |
| Kinoshita, E | 1 |
| Matsubara, T | 1 |
| Matsumoto, M | 1 |
| Maruyama, H | 1 |
| Andrade-Moraes, CH | 1 |
| Oliveira-Pinto, AV | 1 |
| Castro-Fonseca, E | 1 |
| da Silva, CG | 1 |
| Guimarães, DM | 1 |
| Szczupak, D | 1 |
| Parente-Bruno, DR | 1 |
| Carvalho, LR | 1 |
| Polichiso, L | 1 |
| Gomes, BV | 1 |
| Oliveira, LM | 1 |
| Rodriguez, RD | 1 |
| Leite, RE | 1 |
| Ferretti-Rebustini, RE | 1 |
| Jacob-Filho, W | 1 |
| Pasqualucci, CA | 1 |
| Grinberg, LT | 1 |
| Lent, R | 1 |
| Pisa, D | 1 |
| Alonso, R | 1 |
| Juarranz, A | 1 |
| Rábano, A | 1 |
| Carrasco, L | 1 |
| Zarrouk, A | 1 |
| Lizard, G | 1 |
| Sadallah, M | 1 |
| Labat-Gest, V | 1 |
| Tempia, F | 1 |
| Li, L | 1 |
| Rasul, I | 1 |
| Liu, J | 1 |
| Zhao, B | 1 |
| Tang, R | 1 |
| Premont, RT | 1 |
| Suo, WZ | 1 |
| Xuan, AG | 1 |
| Luo, M | 1 |
| Ji, WD | 1 |
| Long, DH | 1 |
| Kellner, A | 1 |
| Matschke, J | 1 |
| Bernreuther, C | 1 |
| Moch, H | 1 |
| Ferrer, I | 1 |
| Glatzel, M | 1 |
| Bailey, JA | 1 |
| Lahiri, DK | 1 |
| Lee, HJ | 1 |
| Lee, JK | 1 |
| Lee, H | 1 |
| Shin, JW | 1 |
| Carter, JE | 1 |
| Sakamoto, T | 1 |
| Jin, HK | 1 |
| Bae, JS | 1 |
| Pérez-González, R | 1 |
| Antequera, D | 1 |
| Vargas, T | 1 |
| Spuch, C | 1 |
| Bolós, M | 1 |
| Carro, E | 1 |
| Taghavi, A | 1 |
| Nasir, S | 1 |
| Pickhardt, M | 1 |
| Heyny-von Haussen, R | 1 |
| Mall, G | 1 |
| Mandelkow, E | 1 |
| Mandelkow, EM | 1 |
| Schmidt, B | 1 |
| Wu, CK | 1 |
| Thal, L | 1 |
| Pizzo, D | 1 |
| Hansen, L | 1 |
| Masliah, E | 1 |
| Geula, C | 1 |
| Campbell, WA | 1 |
| Yang, H | 1 |
| Zetterberg, H | 1 |
| Baulac, S | 1 |
| Sears, JA | 1 |
| Liu, T | 1 |
| Wong, ST | 1 |
| Zhong, TP | 1 |
| Xia, W | 1 |
| Simard, AR | 1 |
| Soulet, D | 1 |
| Gowing, G | 1 |
| Julien, JP | 1 |
| Rivest, S | 1 |
| Page, G | 1 |
| Rioux Bilan, A | 1 |
| Ingrand, S | 1 |
| Lafay-Chebassier, C | 1 |
| Pain, S | 1 |
| Perault Pochat, MC | 1 |
| Bouras, C | 1 |
| Bayer, T | 1 |
| Hugon, J | 1 |
| Leroy, K | 1 |
| Yilmaz, Z | 1 |
| Brion, JP | 1 |
| Clifford, PM | 1 |
| Zarrabi, S | 1 |
| Siu, G | 1 |
| Kinsler, KJ | 1 |
| Kosciuk, MC | 1 |
| Venkataraman, V | 1 |
| D'Andrea, MR | 1 |
| Dinsmore, S | 1 |
| Nagele, RG | 1 |
| Marksteiner, J | 1 |
| Humpel, C | 1 |
| McKee, AC | 1 |
| Carreras, I | 1 |
| Hossain, L | 1 |
| Ryu, H | 1 |
| Klein, WL | 1 |
| Oddo, S | 1 |
| LaFerla, FM | 1 |
| Jenkins, BG | 1 |
| Kowall, NW | 1 |
| Dedeoglu, A | 1 |
1 trial available for dapi and Alzheimer Disease
| Article | Year |
|---|---|
Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antigens, CD; Antigens, | 2009 |
21 other studies available for dapi and Alzheimer Disease
| Article | Year |
|---|---|
DAPI (4',6-diamidino-2-phenylindole) Stains Compact Amyloid Plaques.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Coloring Agents; Humans; Indoles; Plaque, Amyloid | 2022 |
Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Autopsy; Brain; Cell Nucleolus; F | 2018 |
4',6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Fluorescent Dyes; Frontotemporal Dementia; Humans | 2018 |
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain; Cell Count; Female; Humans; | 2013 |
Direct visualization of fungal infection in brains from patients with Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antibodies, Fungal; Brain; Candida glabrata; Disease Models, Animal; Fem | 2015 |
DNA and neutral lipid contents of peripheral cells as predictive biomarkers of mild cognitive impairment and Alzheimer's disease: Highlights on the interest of a cytomic approach for the characterization of dementia.
Topics: Alzheimer Disease; Azo Compounds; Biomarkers; Cell Nucleus; Cognitive Dysfunction; DNA; Flow Cytomet | 2015 |
Propagation of Neuronal Damage to Embryonic Grafts Transplanted in the Hippocampus of Murine Models of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid; Animals; Astrocytes; Cell Count; Dendritic Spines; Disease Models, Anima | 2015 |
Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice.
Topics: Alzheimer Disease; Animals; Axons; Blotting, Western; Disease Models, Animal; Female; Fluoroimmunoas | 2009 |
Effects of engrafted neural stem cells in Alzheimer's disease rats.
Topics: Alzheimer Disease; Animals; Bromodeoxyuridine; Cell Differentiation; Disease Models, Animal; Embryo, | 2009 |
A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer's disease.
Topics: Actins; Adenosine Triphosphate; Alzheimer Disease; Animals; Cell Enlargement; Cell Survival; Cells, | 2010 |
The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Behavior, Animal | 2010 |
Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Proliferation; Cells, Cultured; Cer | 2011 |
N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Brain; Female; Humans; Hydrazines; Indo | 2011 |
Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease.
Topics: Acetylcholine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Antigens, CD; Antigens, Differenti | 2005 |
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Topics: Alzheimer Disease; Animals; Animals, Genetically Modified; Apoptosis; Blotting, Northern; Blotting, | 2006 |
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Bone | 2006 |
Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Ac | 2006 |
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cell Nucleus; Dendrites; Epitopes; Female; Fluorescent D | 2007 |
Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Bra | 2007 |
Beta-amyloid expression, release and extracellular deposition in aged rat brain slices.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Prot | 2008 |
Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.
Topics: Adenosine Triphosphatases; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; | 2008 |