dapagliflozin and Diabetes-Mellitus

dapagliflozin has been researched along with Diabetes-Mellitus* in 2 studies

Other Studies

2 other study(ies) available for dapagliflozin and Diabetes-Mellitus

Article	Year
Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by 'click chemistry'. Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1 Novel analogs of SGLT2 inhibitors containing the 1,2,3-triazole motif were designed and synthesized for urinary glucose excretion evaluation. The C-glucosides with triazole aglycone can be easily constructed by click chemistry. Most of the synthesized compounds increased urinary glucose excretion and demonstrated inhibition of glucose transport. Topics: Amino Acid Motifs; Animals; Biological Transport; Chemistry, Pharmaceutical; Click Chemistry; Diabetes Mellitus; Drug Design; Drug Evaluation, Preclinical; Glucose; Humans; Models, Chemical; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Time Factors; Triazoles	2012
Exploration of SAR regarding glucose moiety in novel C-aryl glucoside inhibitors of SGLT2. Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2 In order to investigate SAR regarding glucose moiety in novel C-aryl glucoside SGLT2 inhibitors containing a thiazole motif, a series of chemical modifications on glucose was conducted to explore potential utility as a suitable replacement of glucose per se. Among the compounds prepared, deshydroxy 29 (IC(50)=7.01nM) demonstrated the best in vitro inhibitory activity against SGLT2 in this series to date. But, none of the compounds were better than the parent molecule 5 (IC(50)=1.75nM). Topics: Diabetes Mellitus; Glycosides; Humans; Hypoglycemic Agents; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiazoles	2011

Article

Year

Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by 'click chemistry'.

Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

Novel analogs of SGLT2 inhibitors containing the 1,2,3-triazole motif were designed and synthesized for urinary glucose excretion evaluation. The C-glucosides with triazole aglycone can be easily constructed by click chemistry. Most of the synthesized compounds increased urinary glucose excretion and demonstrated inhibition of glucose transport.

Topics: Amino Acid Motifs; Animals; Biological Transport; Chemistry, Pharmaceutical; Click Chemistry; Diabetes Mellitus; Drug Design; Drug Evaluation, Preclinical; Glucose; Humans; Models, Chemical; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Time Factors; Triazoles

2012

Exploration of SAR regarding glucose moiety in novel C-aryl glucoside inhibitors of SGLT2.

Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2

In order to investigate SAR regarding glucose moiety in novel C-aryl glucoside SGLT2 inhibitors containing a thiazole motif, a series of chemical modifications on glucose was conducted to explore potential utility as a suitable replacement of glucose per se. Among the compounds prepared, deshydroxy 29 (IC(50)=7.01nM) demonstrated the best in vitro inhibitory activity against SGLT2 in this series to date. But, none of the compounds were better than the parent molecule 5 (IC(50)=1.75nM).

Topics: Diabetes Mellitus; Glycosides; Humans; Hypoglycemic Agents; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiazoles

2011