dantrolene and Spasm studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.

Research Excerpts

Excerpt	Relevance	Reference
"Seventy-seven patients with muscle spasticity secondary to central nervous system pathology were treated with dantrolene sodium for periods of up to two years."	9.04	Dantrolene sodium: long-term effects in patients with muscle spasticity. ( Joynt, RL, 1976)
"A case of severe muscle spasms relieved by oral administration of dantrolene sodium is presented."	7.67	Treatment of muscle spasms with oral dantrolene sodium. ( Christian, JM, 1989)
" In a selected group of patients with external sphincter spasm diagnosed by concitant sphincter electromyography, cystometrography, and voiding cystourethrography, dantrolene sodium (Dantrium) therapy was instituted."	7.65	Use of dantrolene sodium in external sphincter spasm. ( Krane, RJ; Murdock, MM; Sax, D, 1976)
"Dantrolene sodium is a valuable tool in the management of spasticity due to hemiplegia."	5.25	Effect of dantrolene sodium on spasticity associated with hemiplegia. ( Ferguson, KL; Steinberg, FU, 1975)
"Seventy-seven patients with muscle spasticity secondary to central nervous system pathology were treated with dantrolene sodium for periods of up to two years."	5.04	Dantrolene sodium: long-term effects in patients with muscle spasticity. ( Joynt, RL, 1976)
"A case of severe muscle spasms relieved by oral administration of dantrolene sodium is presented."	3.67	Treatment of muscle spasms with oral dantrolene sodium. ( Christian, JM, 1989)
" In a selected group of patients with external sphincter spasm diagnosed by concitant sphincter electromyography, cystometrography, and voiding cystourethrography, dantrolene sodium (Dantrium) therapy was instituted."	3.65	Use of dantrolene sodium in external sphincter spasm. ( Krane, RJ; Murdock, MM; Sax, D, 1976)
"Its main symptoms are: painful muscle spasms, diarrhea, alopecia and skeletal abnormalities."	2.61	Treatment of Satoyoshi syndrome: a systematic review. ( de Cabo, C; Solera, J; Solís-García Del Pozo, J, 2019)
"The medicinal treatment of spasticity includes use of oral treatments (baclofène and tizanidine), botulinum toxin, intrathecal baclofène and local application of alcohol or phenol."	2.48	[Pharmacological treatment of spasticity in multiple sclerosis]. ( Heinzlef, O; Monteil-Roch, I, 2012)
"Dantrolene sodium is a valuable tool in the management of spasticity due to hemiplegia."	1.25	Effect of dantrolene sodium on spasticity associated with hemiplegia. ( Ferguson, KL; Steinberg, FU, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (82.35)	18.7374
1990's	2 (5.88)	18.2507
2000's	2 (5.88)	29.6817
2010's	2 (5.88)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Solís-García Del Pozo, J	1
de Cabo, C	1
Solera, J	1
Heinzlef, O	1
Monteil-Roch, I	1
DeLisa, JA	1
Little, J	1
Taricco, M	1
Adone, R	1
Pagliacci, C	1
Telaro, E	1
Sunohara, N	1
Burke, DJ	1
Joynt, RL	1
Basmajian, JV	2
Sheplan, L	1
Ishmael, C	1
Goldblatt, D	1
Horne, ML	1
Wilkie, OL	1
Schneider, R	1
Mitchell, D	1
Murdock, MM	1
Sax, D	1
Krane, RJ	1
Takeuchi, A	1
Kobayashi, I	1
Nagasawa, T	1
Nakazawa, T	1
Inui, S	1
Tolosa, ES	1
Soll, RW	1
Loewenson, RB	1
Denhoff, E	1
Feldman, S	1
Smith, MG	1
Litchman, H	1
Holden, W	1
Jonsson, B	2
Ladd, H	2
Afzelius-Frisk, I	1
Lindberg-Broman, AM	1
Steinberg, FU	1
Ferguson, KL	1
Dahllöf, AG	1
Nelson, JR	1
Schmidt, RT	1
Lee, RH	1
Spehlmann, R	1
Hetherington, N	1
Sailer, R	1
Hinrichs, B	1
Mantel, K	1
Christian, JM	1
Tidyman, M	1
Prichard, JG	1
Deamer, RL	1
Mac, N	1
Pedersen, E	1
Chyatte, SB	1
Haslam, RH	2
Walcher, JR	2
Lietman, PS	2
Kallman, CH	1
Mellits, ED	1
Monster, AW	2
Glass, A	1
Hannah, A	1
Herman, R	1
Meeks, S	1
McHenry, J	1

Article	Year
Treatment of Satoyoshi syndrome: a systematic review. Orphanet journal of rare diseases, 2019, 06-19, Volume: 14, Issue:1 Topics: Adrenal Cortex Hormones; Alopecia; Animals; Anticonvulsants; Bone and Bones; Dantrolene; Diarrhea; F	2019
[Pharmacological treatment of spasticity in multiple sclerosis]. Revue neurologique, 2012, Volume: 168 Suppl 3 Topics: Algorithms; Amines; Baclofen; Botulinum Toxins, Type A; Clonidine; Cyclohexanecarboxylic Acids; Dant	2012
Pharmacological interventions for spasticity following spinal cord injury. The Cochrane database of systematic reviews, 2000, Issue:2 Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Parasympatholytics; Spasm; Spina	2000
[Satoyoshi syndrome (disease)]. Ryoikibetsu shokogun shirizu, 2001, Issue:36 Topics: Alopecia; Dantrolene; Diagnosis, Differential; Diarrhea; Disease Progression; Humans; Muscle, Skelet	2001
Electromyographic investigation of spasticity and muscle spasm. Physiotherapy, 1976, Volume: 62, Issue:10 Topics: Animals; Dantrolene; Drug Evaluation; Electromyography; Humans; Muscle Spasticity; Neural Conduction	1976
Clinical assessment and pharmacologic therapy of spasticity. Archives of physical medicine and rehabilitation, 1974, Volume: 55, Issue:8 Topics: Achilles Tendon; Activities of Daily Living; Curare; Dantrolene; Diazepam; Electromyography; Gait; H	1974

Article	Year
Dantrolene sodium: long-term effects in patients with muscle spasticity. Archives of physical medicine and rehabilitation, 1976, Volume: 57, Issue:5 Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Dantrolene; Drug Evaluation; Female; Humans; Hyd	1976
Spasmolytic properties of dantrolene sodium: clinical evaluation. Military medicine, 1975, Volume: 140, Issue:1 Topics: Adult; Clinical Trials as Topic; Dantrolene; Drug Evaluation; Humans; Hydantoins; Male; Middle Aged;	1975
Letter: Treatment of spasticity in multiple sclerosis with dantrolene. JAMA, 1975, Sep-08, Volume: 233, Issue:10 Topics: Clinical Trials as Topic; Dantrolene; Humans; Hydantoins; Multiple Sclerosis; Placebos; Sodium; Spas	1975
Treatment of spastic cerebral-palsied children with sodium dantrolene. Developmental medicine and child neurology, 1975, Volume: 17, Issue:6 Topics: Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Dantrolene; Female; Humans; Hydan	1975
Dantrolene sodium: long-term effects in severe spasticity. Archives of physical medicine and rehabilitation, 1973, Volume: 54, Issue:7 Topics: Activities of Daily Living; Adolescent; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Ce	1973
Dantrolene sodium in children with spasticity. Archives of physical medicine and rehabilitation, 1974, Volume: 55, Issue:8 Topics: Administration, Oral; Adolescent; Brain Damage, Chronic; Child; Child, Preschool; Clinical Trials as	1974
Spasticity and the effect of dantrolene sodium. Archives of physical medicine and rehabilitation, 1974, Volume: 55, Issue:8 Topics: Adult; Ankle Joint; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Dose-Response R	1974
A comparison of dantrolene sodium and diazepam in the treatment of spasticity. Paraplegia, 1974, Volume: 12, Issue:3 Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam;	1974
Cooperative study for assessing the effects of a pharmacological agent on spasticity. American journal of physical medicine, 1973, Volume: 52, Issue:4 Topics: Adult; Aged; Analog-Digital Conversion; Cerebrovascular Disorders; Computers, Analog; Dantrolene; El	1973

Article	Year
Drugs to relieve spasticity. Drug and therapeutics bulletin, 1983, Jan-14, Volume: 21, Issue:1 Topics: Baclofen; Dantrolene; Diazepam; Humans; Parasympatholytics; Spasm	1983
Managing spasticity. American family physician, 1982, Volume: 26, Issue:3 Topics: Adult; Baclofen; Child, Preschool; Cold Temperature; Dantrolene; Diazepam; Female; Humans; Muscle Sp	1982
An approach to the treatment of spasticity. Drugs, 1975, Volume: 10, Issue:2 Topics: Adrenergic alpha-Antagonists; Baclofen; Brain Diseases; Dantrolene; Diazepam; Humans; Mephenesin; Mu	1975
Treatment of amyotrophic lateral sclerosis. Advances in neurology, 1977, Volume: 17 Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor	1977
Letter: Treatment of spasticity in multiple sclerosis with dantrolene. JAMA, 1976, Jan-19, Volume: 235, Issue:3 Topics: Dantrolene; Humans; Hydantoins; Multiple Sclerosis; Spasm	1976
Letter: Dantrolene deposited in connective tissue. JAMA, 1976, Mar-15, Volume: 235, Issue:11 Topics: Cornea; Dantrolene; Eye Manifestations; Humans; Hydantoins; Spasm	1976
Dantrolene hepatitis. JAMA, 1976, Apr-12, Volume: 235, Issue:15 Topics: Adult; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Dantrolene; Female; Humans; Hy	1976
Use of dantrolene sodium in external sphincter spasm. Urology, 1976, Volume: 8, Issue:2 Topics: Dantrolene; Female; Humans; Hydantoins; Male; Spasm; Urethra; Urethral Stricture; Urinary Bladder; U	1976
[Endocrinologic features and the effect of dantrolene sodium in a subject with recurrent muscle spasms (author's transl)]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1976, Aug-10, Volume: 65, Issue:8 Topics: Adrenal Glands; Adult; Dantrolene; Female; Humans; Hydantoins; Ovary; Spasm	1976
The effect of dantrium on spasticity of hemiplegic patients. Acta neurologica Scandinavica, 1975, Volume: 51, Issue:5 Topics: Adolescent; Adult; Aged; Dantrolene; Drug Evaluation; Hemiplegia; Humans; Hydantoins; Middle Aged; M	1975
Effect of dantrolene sodium on spasticity associated with hemiplegia. Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:2 Topics: Adult; Aged; Dantrolene; Fatigue; Follow-Up Studies; Gait; Hemiplegia; Humans; Hydantoins; Middle Ag	1975
The effect of Dantrium on spasticity in spinal cord injuries. Scandinavian journal of rehabilitation medicine, 1975, Volume: 7, Issue:2 Topics: Administration, Oral; Adult; Dantrolene; Disability Evaluation; Electromyography; Humans; Hydantoins	1975
Dantrolene sodium (Dantrium-Eaton) for relief of spasticity. The Western journal of medicine, 1975, Volume: 123, Issue:2 Topics: Dantrolene; Hydantoins; Spasm	1975
Treatment of spasticity in multiple sclerosis: comparison of dantrolene sodium and diazepam. Transactions of the American Neurological Association, 1975, Volume: 100 Topics: Dantrolene; Diazepam; Humans; Hydantoins; Multiple Sclerosis; Spasm	1975
Dantrolene. The Australian nurses' journal. Royal Australian Nursing Federation, 1992, Volume: 21, Issue:8 Topics: Dantrolene; Drug Interactions; Humans; Malignant Hyperthermia; Neuroleptic Malignant Syndrome; Spasm	1992
[Malignant hyperthermia in a child with acute lymphatic leukemia]. Der Anaesthesist, 1991, Volume: 40, Issue:5 Topics: Child, Preschool; Dantrolene; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Precursor Cell	1991
Treatment of muscle spasms with oral dantrolene sodium. Oral surgery, oral medicine, and oral pathology, 1989, Volume: 67, Issue:3 Topics: Administration, Oral; Adult; Dantrolene; Diazepam; Facial Pain; Female; Humans; Injections, Intraven	1989
Adjunctive use of dantrolene in severe tetanus. Anesthesia and analgesia, 1985, Volume: 64, Issue:5 Topics: Administration, Oral; Adult; Combined Modality Therapy; Dantrolene; Humans; Injections, Intravenous;	1985
Pharmacology of dantrolene sodium in children. Archives of physical medicine and rehabilitation, 1974, Volume: 55, Issue:8 Topics: Administration, Oral; Adolescent; Amines; Capsules; Child; Child, Preschool; Chronic Disease; Dantro	1974

dantrolene and Spasm

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