dantrolene has been researched along with Serotonin Syndrome in 5 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant hyperthermia is a hypermetabolic syndrome that appears in susceptible patients after exposure to certain anaesthetic drugs (succinylcholine, inhalation anaesthetics)." | 2.55 | Clinical protocol for the management of malignant hyperthermia. ( Alsina, E; Del Blanco, B; Domínguez, A; García, A; Guerrero, JL; Kollmann-Camaiora, A; Yepes, MJ, 2017) |
| "Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are uncommon but potentially life-threatening adverse reactions associated with psychotropic medications." | 2.48 | Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management. ( Perry, PJ; Wilborn, CA, 2012) |
| "Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are life-threatening adverse reactions caused by serotonergic antidepressants and neuroleptics, respectively." | 1.42 | Serotonin syndrome overlapping with neuroleptic malignant syndrome: A case report and approaches for differentially diagnosing the two syndromes. ( Nisijima, K, 2015) |
| "Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent." | 1.31 | Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nisijima, K | 2 |
| Kollmann-Camaiora, A | 1 |
| Alsina, E | 1 |
| Domínguez, A | 1 |
| Del Blanco, B | 1 |
| Yepes, MJ | 1 |
| Guerrero, JL | 1 |
| García, A | 1 |
| Héritier Barras, AC | 1 |
| Walder, B | 1 |
| Seeck, M | 1 |
| Perry, PJ | 1 |
| Wilborn, CA | 1 |
| Yoshino, T | 1 |
| Yui, K | 1 |
| Katoh, S | 1 |
2 reviews available for dantrolene and Serotonin Syndrome
| Article | Year |
|---|---|
Clinical protocol for the management of malignant hyperthermia.
Topics: Adolescent; Adult; Caffeine; Calcium Signaling; Child; Child, Preschool; Clinical Protocols; Critica | 2017 |
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.
Topics: Antipsychotic Agents; Dantrolene; Diagnosis, Differential; Humans; Muscle Relaxants, Central; Neurol | 2012 |
3 other studies available for dantrolene and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin syndrome overlapping with neuroleptic malignant syndrome: A case report and approaches for differentially diagnosing the two syndromes.
Topics: Antidepressive Agents, Tricyclic; Clinical Decision-Making; Cyproheptadine; Dantrolene; Depressive D | 2015 |
Serotonin syndrome following Methylene Blue infusion: a rare complication of antidepressant therapy.
Topics: Adenoma; Aged; Antidepressive Agents, Tricyclic; Clomipramine; Critical Care; Dantrolene; Drug Inter | 2010 |
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature | 2001 |