dantrolene has been researched along with Seizures in 16 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this two-phase study, 21 pediatric patients with epilepsy and spasticity were initially treated with dantrolene sodium suspension and, after a washout period, began a double-blind portion where one half received dantrolene sodium suspension and the other half received a placebo suspension." | 9.04 | Effect of dantrolene sodium on the incidence of seizures in children with spasticity. ( Nogen, AG, 1979) |
| "To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx)." | 7.71 | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. ( Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M, 2001) |
| "In this two-phase study, 21 pediatric patients with epilepsy and spasticity were initially treated with dantrolene sodium suspension and, after a washout period, began a double-blind portion where one half received dantrolene sodium suspension and the other half received a placebo suspension." | 5.04 | Effect of dantrolene sodium on the incidence of seizures in children with spasticity. ( Nogen, AG, 1979) |
| "To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx)." | 3.71 | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. ( Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M, 2001) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| " Dantrolene, a muscle contraction antagonist, and MI-65-S, a muscle spindle suppressant, significantly delayed THE." | 3.65 | Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method. ( Anderson, RJ; Britton, LW; Helke, CJ; Iadarola, MJ; Raines, A, 1976) |
| "TsTX caused electrographic seizure expressed by moderate or intense discharges and neuronal loss in hippocampal areas in all injected animals (n = 8)." | 1.32 | Dantrolene protects hippocampal cells from damage induced by TsTX, an alpha-scorpion toxin from Tityus serrulatus. ( Dorce, VA; Lebrun, I; Nencioni, AL, 2004) |
| "1S,3R-ACPD-induced seizures were antagonized by systemic administration of dantrolene, an inhibitor of intracellular calcium mobilization, but not by the ionotropic glutamate antagonists MK-801 or GYKI-52466." | 1.29 | Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. ( Fix, AS; McDonald, JW; Schoepp, DD; Tizzano, JP, 1993) |
| "Dantrolene sodium iv was administered for three days." | 1.29 | Neuroleptic malignant-like syndrome: a complication of acute organophosphate poisoning. ( Arai, T; Hatakenaka, S; Ochi, G; Tokuoka, H; Watanabe, K, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Royero, PX | 1 |
| Higa, GSV | 1 |
| Kostecki, DS | 1 |
| Dos Santos, BA | 1 |
| Almeida, C | 1 |
| Andrade, KA | 1 |
| Kinjo, ER | 1 |
| Kihara, AH | 1 |
| Tran, L | 1 |
| Athiraman, U | 1 |
| Rich, KM | 1 |
| Tempelhoff, R | 1 |
| Keshavarz, M | 1 |
| Fotouhi, M | 1 |
| Rasti, A | 1 |
| Nencioni, AL | 1 |
| Lebrun, I | 1 |
| Dorce, VA | 1 |
| Berg, M | 1 |
| Bruhn, T | 1 |
| Frandsen, A | 1 |
| Schousboe, A | 1 |
| Diemer, NH | 1 |
| McDonald, JW | 1 |
| Fix, AS | 1 |
| Tizzano, JP | 1 |
| Schoepp, DD | 1 |
| Ochi, G | 1 |
| Watanabe, K | 1 |
| Tokuoka, H | 1 |
| Hatakenaka, S | 1 |
| Arai, T | 1 |
| Borowicz, KK | 1 |
| Gasior, M | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Yang, L | 1 |
| Benardo, LS | 1 |
| Pelletier, MR | 1 |
| Wadia, JS | 1 |
| Mills, LR | 1 |
| Carlen, PL | 1 |
| Nagatomo, I | 1 |
| Hashiguchi, W | 1 |
| Tominaga, M | 1 |
| Akasaki, Y | 1 |
| Uchida, M | 1 |
| Takigawa, M | 1 |
| Raines, A | 1 |
| Helke, CJ | 1 |
| Iadarola, MJ | 1 |
| Britton, LW | 1 |
| Anderson, RJ | 1 |
| Feit, H | 1 |
| Nogen, AG | 1 |
| Denhoff, E | 1 |
| Feldman, S | 1 |
| Smith, MG | 1 |
| Litchman, H | 1 |
| Holden, W | 1 |
| Carrillo, E | 1 |
| Laorden, ML | 1 |
| Miralles, FS | 1 |
| Puig, MM | 1 |
2 trials available for dantrolene and Seizures
| Article | Year |
|---|---|
Effect of dantrolene sodium on the incidence of seizures in children with spasticity.
Topics: Adolescent; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Dant | 1979 |
Treatment of spastic cerebral-palsied children with sodium dantrolene.
Topics: Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Dantrolene; Female; Humans; Hydan | 1975 |
14 other studies available for dantrolene and Seizures
| Article | Year |
|---|---|
Ryanodine receptors drive neuronal loss and regulate synaptic proteins during epileptogenesis.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Hippocampus; Male; Neurons; Neuroprotective | 2020 |
Hyperventilation, Sympathetic and Metabolic Derangements After Endoscopic Third Ventriculostomy.
Topics: Acidosis; Adult; Antihypertensive Agents; Blood Pressure; Dantrolene; Diagnosis, Differential; Endos | 2017 |
Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice.
Topics: Animals; Anticonvulsants; Dantrolene; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Pentyl | 2016 |
Dantrolene protects hippocampal cells from damage induced by TsTX, an alpha-scorpion toxin from Tityus serrulatus.
Topics: Animals; Dantrolene; Electroencephalography; Hippocampus; Male; Microinjections; Neurons; Neuroprote | 2004 |
Kainic acid-induced seizures and brain damage in the rat: role of calcium homeostasis.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Diseases; Calcium; Calcium Channels; Dantrolene; | 1995 |
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain Injuries; Cell Nucleus; Corpu | 1993 |
Neuroleptic malignant-like syndrome: a complication of acute organophosphate poisoning.
Topics: Atropine; Cholinesterase Reactivators; Cholinesterases; Dantrolene; Female; Humans; Middle Aged; Mio | 1995 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Removal of superficial inhibition releases hyperexcitability in middle and deep horizontal slices from rat somatosensory neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dantrolene; Electric Stimulation; Excitatory Amino Ac | 1998 |
Seizure-induced cell death produced by repeated tetanic stimulation in vitro: possible role of endoplasmic reticulum calcium stores.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Death; Dantrolene; Electric Stimulation; Electropho | 1999 |
Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.
Topics: Animals; Brain; Brain Chemistry; Calcineurin; Calcium; Dantrolene; Disease Models, Animal; Dizocilpi | 2001 |
Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dantrolene; Electroshock; Gallamine Triethiodide; Hindlimb | 1976 |
A form of chorea that responds to dantrolene sodium.
Topics: Adult; Carbamazepine; Dantrolene; Female; Humans; Huntington Disease; Seizures | 1979 |
Dantrolene prevents hyperthermia induced seizures in rat pups.
Topics: Animals; Anticonvulsants; Dantrolene; Fever; Rats; Rats, Inbred Strains; Seizures | 1990 |