Page last updated: 2024-10-25

dantrolene and Rhabdomyolysis

dantrolene has been researched along with Rhabdomyolysis in 48 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.

Research Excerpts

ExcerptRelevanceReference
"Dantrolene sodium (Dantrium) has been used extensively for the treatment of myopathies in man and anecdotal evidence suggests it is of clinical benefit in the control of exercise-induced rhabdomyolysis (ER) in racehorses, although data to support this are currently lacking."9.10The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse. ( Edwards, JG; Newtont, JR; Pilsworth, RC; Ramzan, PH; Shepherd, MC, 2003)
"To determine the effect of oral administration of dantrolene sodium on serum creatine kinase (CK) activity after exercise in horses with recurrent exertional rhabdomyolysis (RER)."7.72Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysis. ( Finno, CJ; Godden, SM; McKenzie, EC; Murphy, MJ; Valberg, SJ, 2004)
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection."7.70Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998)
"A patient with recurrent attacks of exertional rhabdomyolysis and easy fatiguability was treated with dantrolene sodium."7.67Prevention of recurrent exertional rhabdomyolysis by dantrolene sodium. ( Haverkort-Poels, PJ; Joosten, EM; Ruitenbeek, W, 1987)
"Dantrolene has shown promising results in controlling muscle symptoms in individuals with ERM, however, its use in children remains poorly documented."5.91Oral Dantrolene Reduces Myalgia and Hyperckemia in a Child with RYR1-Related Exertional Myalgia/Rhabdomyolysis. ( Aschoff, CAM; de Lima Silva, EV; de Souza, CFM; Donis, KC; Machado, FRC; Poswar, FO; Saute, JAM; Simão Medeiros, L, 2023)
"Dantrolene is a ryanodine receptor antagonist and is used as an anti-inflammatory agent."5.62Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report. ( Chiba, N; Kinoshita, K; Matsuzaki, M; Mawatari, T; Mizuochi, M; Sakurai, A, 2021)
"Dystonia is of particular concern as a dystonic storm can ensue leading to rhabdomyolysis."5.56Recurrent Dystonic Crisis and Rhabdomyolysis Treated with Dantrolene in Two Patients with Aromatic L-Amino Acid Decarboxylase Deficiency. ( Horvath, G; Micallef, J; Salvarinova-Zivkovic, R; Stockler-Ipsiroglu, S; van Karnebeek, CD, 2020)
"Dantrolene sodium (Dantrium) has been used extensively for the treatment of myopathies in man and anecdotal evidence suggests it is of clinical benefit in the control of exercise-induced rhabdomyolysis (ER) in racehorses, although data to support this are currently lacking."5.10The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse. ( Edwards, JG; Newtont, JR; Pilsworth, RC; Ramzan, PH; Shepherd, MC, 2003)
" They include: (1) How much dantrolene should be available in facilities where volatile agents are not available or administered, and succinylcholine is only stocked on site for emergency purposes? (2) What defines masseter muscle rigidity? What is its relationship to MH, and how should it be managed when it occurs? (3) What is the relationship between MH susceptibility and heat- or exercise-related rhabdomyolysis? (4) What evidence-based interventions should be recommended to alleviate hyperthermia associated with MH? (5) After treatment of acute MH, how much dantrolene should be administered and for how long? What criteria should be used to determine stopping treatment with dantrolene? (6) Can patients with a suspected personal or family history of MH be safely anesthetized before diagnostic testing? This report describes the consensus process and the outcomes for each of the foregoing unanswered clinical questions."3.91Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia. ( Larach, MG; Litman, RS; Mayes, L; Shukry, M; Smith, VI; Theroux, MC; Watt, S; Wong, CA, 2019)
" Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50 mg."3.78Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene. ( Hawryluck, LA; Kraeva, N; Riazi, S; Russell, T; Steel, AC, 2012)
" Exposure of CASQ1-null mice to either 2% halothane or heat stress triggers lethal episodes characterized by whole-body contractures, elevated core temperature, and severe rhabdomyolysis, which are prevented by prior dantrolene administration."3.75Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice. ( Canato, M; Dainese, M; Dirksen, RT; Lyfenko, AD; Paolini, C; Protasi, F; Quarta, M; Reggiani, C, 2009)
" We present a detailed description of the case and also discuss the role of propofol and rhabdomyolysis."3.72A fatal case of malignant hyperthermia complicated by generalized compartment syndrome and rhabdomyolysis. ( Green, G, 2003)
"To determine the effect of oral administration of dantrolene sodium on serum creatine kinase (CK) activity after exercise in horses with recurrent exertional rhabdomyolysis (RER)."3.72Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysis. ( Finno, CJ; Godden, SM; McKenzie, EC; Murphy, MJ; Valberg, SJ, 2004)
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection."3.70Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998)
" Eight days later, he presented with a neuroleptic malignant syndrome following an injection of droperidol."3.70Malignant hyperthermia and neuroleptic malignant syndrome in a patient during treatment for acute asthma. ( Cardinaud, JP; Favier, JC; Gbikpi-Benissan, G; Gruson, D; Hilbert, G; Portel, L, 1999)
"To present a case of rhabdomyolysis which developed in a child with a known history of Duchenne's muscular dystrophy, following an anesthetic which included sevoflurane."3.70Rhabdomyolysis in association with Duchenne's muscular dystrophy. ( Nakajima, Y; Obata, R; Sato, S; Suzuki, A; Yasumi, Y, 1999)
" We report a case of this rare syndrome in a head injury patient associated with some unusual features: rhabdomyolysis with a high level of creatine kinase, the development of acute renal failure, the early use of continuous venovenous haemofiltration in treatment and rigidity that was refractory to conventional treatment with dantrolene and bromocriptine."3.69Neuroleptic malignant syndrome in a patient with head injury. ( Alted Lopez, E; Ambros Checa, A; Caballero Cubedo, R; Perez-Vela, JL; Sanchez Casado, M; Sanchez-Izquierdo Riera, JA, 1996)
"Binge drinking of alcohol, cocaine overdose, or overexertion can lead to rhabdomyolysis characterized by elevated creatine kinase (CK) and myoglobin in the serum, myoglobinuria, and muscle tenderness."3.69Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by ethanol, cocaine, and electrical stimulation in isolated fast and slow muscles of rat. ( Amaladevi, B; Bernstein, A; Grob, D; Herzlich, B; Namba, T; Pagala, M, 1997)
"Neuroleptic malignant syndrome is a rare but serious adverse effect of antipsychotic medication."2.37Neuroleptic malignant syndrome. ( Levenson, JL, 1985)
" Our aim was to investigate the occurrence of serious adverse effects and the adherence to oral dantrolene therapy."1.91Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability. ( Ibarra Moreno, CA; Jungbluth, H; Kraeva, N; Riazi, S; Voermans, NC; Zvaritch, E, 2023)
"Dantrolene has shown promising results in controlling muscle symptoms in individuals with ERM, however, its use in children remains poorly documented."1.91Oral Dantrolene Reduces Myalgia and Hyperckemia in a Child with RYR1-Related Exertional Myalgia/Rhabdomyolysis. ( Aschoff, CAM; de Lima Silva, EV; de Souza, CFM; Donis, KC; Machado, FRC; Poswar, FO; Saute, JAM; Simão Medeiros, L, 2023)
"Dantrolene is a ryanodine receptor antagonist and is used as an anti-inflammatory agent."1.62Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report. ( Chiba, N; Kinoshita, K; Matsuzaki, M; Mawatari, T; Mizuochi, M; Sakurai, A, 2021)
"Dystonia is of particular concern as a dystonic storm can ensue leading to rhabdomyolysis."1.56Recurrent Dystonic Crisis and Rhabdomyolysis Treated with Dantrolene in Two Patients with Aromatic L-Amino Acid Decarboxylase Deficiency. ( Horvath, G; Micallef, J; Salvarinova-Zivkovic, R; Stockler-Ipsiroglu, S; van Karnebeek, CD, 2020)
"The diagnosis of malignant hyperthermia (MH) susceptibility could be confirmed in the patient 4 months after the acute event by the in vitro contracture test and detection of the MH causative mutation p."1.48[Abortive course of malignant hyperthermia following preclinical induction of general anesthesia using succinylcholine]. ( Helf, D; Johannsen, S; Markus, CK; Schneiderbanger, D; Schuster, F, 2018)
"The cardiac arrhythmia was associated with hyperkalemia, metabolic acidosis, and myoglobulinemia."1.35Rhabdomyolysis after liver transplantation: a case report. ( Chen, CL; Chen, KH; Cheng, KW; Cheng, YF; Chiu, KW; Concejero, AM; Huang, CJ; Huang, TL; Jawan, B; Lin, CC; Liu, YW; Wang, CC; Wang, CS; Wang, SH, 2008)
"We report two cases of malignant hyperthermia-like syndrome associated with HHNS in adolescents."1.33Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus. ( Backeljauw, PF; Crimmins, NA; Kilbane, BJ; Mehta, S; Shanley, TP, 2006)
"With regards to the neuroleptic malignant syndrome dantrolenum and bromocriptin treatment were applied with the discontinuation of neuroleptic medication."1.29[Acute renal failure in neuroleptic malignant syndrome]. ( Rónai, L; Wagner, G, 1995)
"Exertional rhabdomyolysis is a myopathy of unknown pathophysiology."1.29Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis. ( Cordovez, G; Linares, N; López, JR; Terzic, A, 1995)
"Rhabdomyolysis is a clinical disorder arising from skeletal muscle injury."1.29The neuroleptic malignant syndrome and acute renal failure. ( Becker, BN; Ismail, N, 1994)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19905 (10.42)18.7374
1990's17 (35.42)18.2507
2000's11 (22.92)29.6817
2010's8 (16.67)24.3611
2020's7 (14.58)2.80

Authors

AuthorsStudies
Ibarra Moreno, CA1
Kraeva, N2
Zvaritch, E1
Jungbluth, H1
Voermans, NC2
Riazi, S2
de Lima Silva, EV1
Donis, KC1
Machado, FRC1
Simão Medeiros, L1
Aschoff, CAM1
de Souza, CFM1
Poswar, FO1
Saute, JAM1
Micallef, J1
Stockler-Ipsiroglu, S1
van Karnebeek, CD1
Salvarinova-Zivkovic, R1
Horvath, G1
Kajani, R1
Apramian, A1
Vega, A1
Ubhayakar, N1
Xu, P1
Liu, A1
Nakashima, K1
Matsunaga, Y1
Ohara, K1
Nie, M1
Chiba, N1
Matsuzaki, M1
Mawatari, T1
Mizuochi, M1
Sakurai, A1
Kinoshita, K1
Aldrich, K1
Velez-Irizarry, D1
Fenger, C1
Schott, M1
Valberg, SJ2
Wystub, N1
Heymel, S1
Fritzenwanger, M1
Schulze, PC1
Pfeifer, R1
Helf, D1
Schneiderbanger, D1
Markus, CK1
Johannsen, S1
Schuster, F1
Nelson, EP1
Dorlon, ME1
Szabo, TA1
Trollinger, JB1
Johnson-Mann, C1
Broderick, G1
Warters, RD1
Ashley, AL1
Litman, RS1
Smith, VI1
Larach, MG1
Mayes, L1
Shukry, M1
Theroux, MC1
Watt, S1
Wong, CA1
Xu, X1
Huang, CJ1
Chen, CL1
Wang, CS1
Cheng, KW1
Chen, KH1
Wang, CC1
Concejero, AM1
Cheng, YF1
Huang, TL1
Chiu, KW1
Wang, SH1
Lin, CC1
Liu, YW1
Jawan, B1
Dainese, M1
Quarta, M1
Lyfenko, AD1
Paolini, C1
Canato, M1
Reggiani, C1
Dirksen, RT1
Protasi, F1
Ginz, HF1
Levano, S1
Girard, T1
Urwyler, A1
Hamel, C1
Russell, T1
Steel, AC1
Hawryluck, LA1
Lappa, A1
Podestà, M1
Capelli, O1
Castagna, A1
Di Placido, G1
Alampi, D1
Semeraro, F1
Reingardiene, D1
Green, G1
Hollander, AS1
Olney, RC1
Blackett, PR1
Marshall, BA1
Edwards, JG1
Newtont, JR1
Ramzan, PH1
Pilsworth, RC1
Shepherd, MC1
McKenzie, EC1
Godden, SM1
Finno, CJ1
Murphy, MJ1
Poels, PJ1
Kluijtmans, LA1
van Engelen, BG1
Kilbane, BJ1
Mehta, S1
Backeljauw, PF1
Shanley, TP1
Crimmins, NA1
Wagner, G1
Rónai, L1
López, JR2
Linares, N1
Cordovez, G1
Terzic, A2
Rojas, B1
Gonzalez, MA1
Watson, JD1
Ferguson, C1
Hinds, CJ1
Skinner, R1
Coakley, JH1
Becker, BN1
Ismail, N1
Perez-Vela, JL1
Sanchez Casado, M1
Sanchez-Izquierdo Riera, JA1
Ambros Checa, A1
Caballero Cubedo, R1
Alted Lopez, E1
Dar, KJ1
McBrien, ME1
Pagala, M1
Amaladevi, B1
Bernstein, A1
Herzlich, B1
Namba, T1
Grob, D1
Montgomery, H1
Myerson, S1
Pollock, AN1
McKenzie, AJ1
Hodges, M1
Snoeck, MM1
Reeves, RK1
Stolp-Smith, KA1
Christopherson, MW1
Kasamatsu, Y1
Osada, M1
Ashida, K1
Azukari, K1
Yoshioka, K1
Ohsawa, A1
Portel, L1
Hilbert, G1
Gruson, D1
Favier, JC1
Gbikpi-Benissan, G1
Cardinaud, JP1
Obata, R1
Yasumi, Y1
Suzuki, A1
Nakajima, Y1
Sato, S1
Kozack, JK1
MacIntyre, DL1
Ramesh, V1
Gardner-Medwin, D1
Parr, MJ1
Willatts, SM1
Kaukonen, L1
Hoffman, RS1
Harioka, T1
Sone, T1
Toda, H1
Miyake, C1
Fox, AW1
Levenson, JL1
Materson, BJ1
Preston, RA1
Haverkort-Poels, PJ1
Joosten, EM1
Ruitenbeek, W1

Reviews

6 reviews available for dantrolene and Rhabdomyolysis

ArticleYear
[Neuroleptic malignant syndrome].
    Medicina (Kaunas, Lithuania), 2002, Volume: 38, Issue:1

    Topics: Acute Kidney Injury; Adult; Amantadine; Bromocriptine; Carbidopa; Contraindications; Dantrolene; Dia

2002
Fatal malignant hyperthermia-like syndrome with rhabdomyolysis complicating the presentation of diabetes mellitus in adolescent males.
    Pediatrics, 2003, Volume: 111, Issue:6 Pt 1

    Topics: Adolescent; Dantrolene; Diabetes Mellitus, Type 2; Fatal Outcome; Humans; Hyperglycemic Hyperosmolar

2003
Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place?
    Anaesthesia, 1993, Volume: 48, Issue:12

    Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Blood Coagulation Disorders; Dancing; Dantrolene;

1993
MDMA induced hyperthermia: report of a fatality and review of current therapy.
    Intensive care medicine, 1996, Volume: 22, Issue:9

    Topics: Acute Kidney Injury; Adolescent; Blood Coagulation Disorders; Dantrolene; Fatal Outcome; Fever; Hall

1996
Malignant hyperthermia.
    Physical therapy, 2001, Volume: 81, Issue:3

    Topics: Adult; Anesthesia; Child; Dantrolene; Exercise; Health Education; Heat Stroke; Humans; Malignant Hyp

2001
Neuroleptic malignant syndrome.
    The American journal of psychiatry, 1985, Volume: 142, Issue:10

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Bromocriptine; Child; Dantrol

1985

Trials

2 trials available for dantrolene and Rhabdomyolysis

ArticleYear
The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse.
    Equine veterinary journal, 2003, Volume: 35, Issue:7

    Topics: Administration, Oral; Animals; Creatine Kinase; Cross-Over Studies; Dantrolene; Double-Blind Method;

2003
Myoplasmic Ca2+ concentration during exertional rhabdomyolysis.
    Lancet (London, England), 1995, Feb-18, Volume: 345, Issue:8947

    Topics: Adult; Biopsy; Calcium; Dantrolene; Female; Humans; Intracellular Fluid; Male; Muscle, Skeletal; Phy

1995

Other Studies

40 other studies available for dantrolene and Rhabdomyolysis

ArticleYear
Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability.
    Anesthesia and analgesia, 2023, 03-01, Volume: 136, Issue:3

    Topics: Dantrolene; Drug-Related Side Effects and Adverse Reactions; Fatigue; Halothane; Humans; Malignant H

2023
Oral Dantrolene Reduces Myalgia and Hyperckemia in a Child with RYR1-Related Exertional Myalgia/Rhabdomyolysis.
    Journal of neuromuscular diseases, 2023, Volume: 10, Issue:6

    Topics: Child; Child, Preschool; Dantrolene; Humans; Muscles; Myalgia; Rhabdomyolysis; Ryanodine Receptor Ca

2023
Recurrent Dystonic Crisis and Rhabdomyolysis Treated with Dantrolene in Two Patients with Aromatic L-Amino Acid Decarboxylase Deficiency.
    Neuropediatrics, 2020, Volume: 51, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool;

2020
Neuroleptic malignant syndrome in a COVID-19 patient.
    Brain, behavior, and immunity, 2020, Volume: 88

    Topics: Acute Kidney Injury; Antipsychotic Agents; Betacoronavirus; Bromocriptine; C-Reactive Protein; Coron

2020
[Rhabdomyolysis during Perioperative Period after Cardiac Surgery].
    Kyobu geka. The Japanese journal of thoracic surgery, 2020, Volume: 73, Issue:12

    Topics: Cardiac Surgical Procedures; Dantrolene; Humans; Male; Malignant Hyperthermia; Middle Aged; Perioper

2020
Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report.
    European journal of medical research, 2021, Feb-08, Volume: 26, Issue:1

    Topics: Adult; COVID-19; Dantrolene; Humans; Male; Malignant Hyperthermia; Muscle Relaxants, Central; Rhabdo

2021
Pathways of calcium regulation, electron transport, and mitochondrial protein translation are molecular signatures of susceptibility to recurrent exertional rhabdomyolysis in Thoroughbred racehorses.
    PloS one, 2021, Volume: 16, Issue:2

    Topics: Animals; Calcium; Dantrolene; Disease Susceptibility; Electron Transport; Female; Genetic Predisposi

2021
[Prolonged neuroleptic malignant syndrome after Haloperidol injection].
    Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2018, Volume: 113, Issue:3

    Topics: Antipsychotic Agents; Dantrolene; Haloperidol; Humans; Male; Middle Aged; Neuroleptic Malignant Synd

2018
[Abortive course of malignant hyperthermia following preclinical induction of general anesthesia using succinylcholine].
    Der Anaesthesist, 2018, Volume: 67, Issue:4

    Topics: Anesthesia, General; Anesthetics, Intravenous; Dantrolene; Female; Fentanyl; Humans; Malignant Hyper

2018
Management of a Patient With a History of Nonanesthesia-Related Malignant Hyperthermia Undergoing Laparoscopic Cholecystectomy: A Case Report.
    A&A practice, 2018, Sep-01, Volume: 11, Issue:5

    Topics: Adult; Cholecystectomy, Laparoscopic; Dantrolene; Humans; Male; Malignant Hyperthermia; Muscle Relax

2018
TREATMENT OF SUSPECTED EXERTIONAL MYOPATHY USING DANTROLENE IN A COYOTE ( CANIS LATRANS).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2018, Volume: 49, Issue:2

    Topics: Animals; Animals, Zoo; Coyotes; Dantrolene; Female; Muscle Relaxants, Central; Muscular Diseases; Ph

2018
Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia.
    Anesthesia and analgesia, 2019, Volume: 128, Issue:4

    Topics: Consensus; Dantrolene; Drug Administration Schedule; Evidence-Based Medicine; Exercise; Humans; Mali

2019
Magnesium sulfate - An effective agent could delay the progression of fulminant malignant hyperthermia.
    Medical hypotheses, 2019, Volume: 124

    Topics: Anesthesia, General; Anesthetics; Calcium; Catecholamines; Dantrolene; Disease Progression; Fever; H

2019
Rhabdomyolysis after liver transplantation: a case report.
    Transplantation proceedings, 2008, Volume: 40, Issue:8

    Topics: Arrhythmias, Cardiac; Biliary Atresia; Child, Preschool; Dantrolene; Female; Humans; Liver Transplan

2008
Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:6

    Topics: Anesthetics; Animals; Caffeine; Calcium; Calcium-Binding Proteins; Calsequestrin; Central Nervous Sy

2009
Dantrolene for severe rhabdomyolysis in Staphylococcus aureus toxic shock syndrome.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:3

    Topics: Dantrolene; Humans; Male; Middle Aged; Rhabdomyolysis; Shock, Septic; Staphylococcal Infections

2012
Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene.
    Anaesthesia, 2012, Volume: 67, Issue:9

    Topics: Anesthetics, Inhalation; Antipsychotic Agents; Body Temperature; Caffeine; Central Nervous System St

2012
Successful treatment of a complicated case of neuroleptic malignant syndrome.
    Intensive care medicine, 2002, Volume: 28, Issue:7

    Topics: Administration, Oral; Adult; Antipsychotic Agents; Dantrolene; Disseminated Intravascular Coagulatio

2002
A fatal case of malignant hyperthermia complicated by generalized compartment syndrome and rhabdomyolysis.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:5

    Topics: Adult; Anesthetics, Intravenous; Compartment Syndromes; Dantrolene; Fatal Outcome; Hemorrhage; Human

2003
Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysis.
    American journal of veterinary research, 2004, Volume: 65, Issue:1

    Topics: Administration, Oral; Animals; Creatine Kinase; Cross-Over Studies; Dantrolene; Food Deprivation; Ho

2004
The effect of dantrolene sodium in Very Long Chain Acyl-CoA Dehydrogenase Deficiency.
    Neuromuscular disorders : NMD, 2005, Volume: 15, Issue:12

    Topics: Acyl-CoA Dehydrogenase, Long-Chain; Aged; Dantrolene; Female; Humans; Muscle Relaxants, Central; Rha

2005
Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2006, Volume: 7, Issue:2

    Topics: Adolescent; Black or African American; Butyryl-CoA Dehydrogenase; Child; Dantrolene; Diabetes Mellit

2006
[Acute renal failure in neuroleptic malignant syndrome].
    Orvosi hetilap, 1995, Oct-01, Volume: 136, Issue:40

    Topics: Acute Kidney Injury; Adult; Antipsychotic Agents; Bromocriptine; Dantrolene; Humans; Male; Muscle Re

1995
Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis.
    Pflugers Archiv : European journal of physiology, 1995, Volume: 430, Issue:2

    Topics: Animals; Calcium; Dantrolene; Horse Diseases; Horses; Microelectrodes; Muscle, Skeletal; Physical Ex

1995
The neuroleptic malignant syndrome and acute renal failure.
    Journal of the American Society of Nephrology : JASN, 1994, Volume: 4, Issue:7

    Topics: Acute Kidney Injury; Bromocriptine; Dantrolene; Diagnosis, Differential; Female; Fever; Humans; Midd

1994
Neuroleptic malignant syndrome in a patient with head injury.
    Intensive care medicine, 1996, Volume: 22, Issue:6

    Topics: Adolescent; Bromocriptine; Craniocerebral Trauma; Creatine Kinase; Dantrolene; Hemofiltration; Human

1996
Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by ethanol, cocaine, and electrical stimulation in isolated fast and slow muscles of rat.
    Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:1

    Topics: Animals; Cell Membrane Permeability; Cocaine; Creatine Kinase; Culture Techniques; Dantrolene; Elect

1997
3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") and associated hypoglycemia.
    The American journal of emergency medicine, 1997, Volume: 15, Issue:2

    Topics: Acute Disease; Adult; Dantrolene; Female; Fever; Hallucinogens; Humans; Hypoglycemia; Muscle Relaxan

1997
Propofol and malignant hyperthermia susceptibility.
    Anaesthesia and intensive care, 1997, Volume: 25, Issue:5

    Topics: Acidosis; Adolescent; Adult; Aged; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cause of Death; C

1997
Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure.
    Archives of physical medicine and rehabilitation, 1998, Volume: 79, Issue:3

    Topics: Adult; Baclofen; Catheters, Indwelling; Dantrolene; Disseminated Intravascular Coagulation; Equipmen

1998
Rhabdomyolysis after infection and taking a cold medicine in a patient who was susceptible to malignant hyperthermia.
    Internal medicine (Tokyo, Japan), 1998, Volume: 37, Issue:2

    Topics: Adult; Caffeine; Chlorpheniramine; Common Cold; Dantrolene; Halothane; Humans; In Vitro Techniques;

1998
Malignant hyperthermia and neuroleptic malignant syndrome in a patient during treatment for acute asthma.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:1

    Topics: Acute Disease; Adjuvants, Anesthesia; Adult; Anesthetics, Inhalation; Asthma; Bronchodilator Agents;

1999
Rhabdomyolysis in association with Duchenne's muscular dystrophy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1999, Volume: 46, Issue:6

    Topics: Acute Disease; Anesthetics, Inhalation; Child; Dantrolene; Humans; Male; Methyl Ethers; Muscle Relax

1999
Familial paroxysmal rhabdomyolysis: management of two cases of the non-exertional type.
    Developmental medicine and child neurology, 1992, Volume: 34, Issue:1

    Topics: Biopsy; Child, Preschool; Combined Modality Therapy; Creatine Kinase; Dantrolene; Fasting; Female; H

1992
Fatal theophylline poisoning with rhabdomyolysis. A potential role for dantrolene treatment.
    Anaesthesia, 1991, Volume: 46, Issue:7

    Topics: Acute Kidney Injury; Adult; Compartment Syndromes; Dantrolene; Drug Overdose; Humans; Male; Rhabdomy

1991
Cocaine.
    New York state journal of medicine, 1990, Volume: 90, Issue:1

    Topics: Acidosis; Ammonium Chloride; Bicarbonates; Cocaine; Dantrolene; Humans; Malignant Hyperthermia; Rhab

1990
Malignant hyperthermia in a hemodialysis patient.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:1

    Topics: Acidosis; Dantrolene; Female; Humans; Hyperkalemia; Intraoperative Complications; Malignant Hyperthe

1989
More on rhabdomyolysis associated with cocaine intoxication.
    The New England journal of medicine, 1989, Nov-02, Volume: 321, Issue:18

    Topics: Cocaine; Dantrolene; Humans; Rhabdomyolysis

1989
Myoglobinuria versus hemoglobinuria.
    Hospital practice (Office ed.), 1988, Oct-30, Volume: 23, Issue:10A

    Topics: Acute Kidney Injury; Alcoholism; Biopsy; Creatine Kinase; Dantrolene; Diagnosis, Differential; Hemog

1988
Prevention of recurrent exertional rhabdomyolysis by dantrolene sodium.
    Muscle & nerve, 1987, Volume: 10, Issue:1

    Topics: Dantrolene; Female; Humans; Middle Aged; Mitochondria, Muscle; Oxidative Phosphorylation; Physical E

1987