dantrolene has been researched along with Reperfusion Injury in 11 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene was reported to suppress ventricular fibrillation (VF) in failing hearts with acute myocardial infarction, but its antiarrhythmic efficacy in regional ischemia-reperfusion (IR) hearts remains debatable." | 7.81 | Effects of dantrolene on arrhythmogenicity in isolated regional ischemia-reperfusion rabbit hearts with or without pacing-induced heart failure. ( Chang, PC; Chou, CC; Lee, HL; Wen, MS; Wo, HT; Yeh, SJ, 2015) |
| "It was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury." | 7.74 | Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study. ( Aslan, A; Ayva, E; Buyukokuroglu, ME; Cekirdekci, A; Cemek, M; Demirkan, I; Emmiler, M; Kocogullari, CU; Sahin, O; Tur, L, 2008) |
| "The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under hypothermic conditions is unknown." | 3.88 | Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model. ( Chew, HC; Dhital, KK; Doyle, A; Gao, L; Hicks, M; Jabbour, A; Macdonald, PS; Qui, MR; Villanueva, JE, 2018) |
| "Dantrolene was reported to suppress ventricular fibrillation (VF) in failing hearts with acute myocardial infarction, but its antiarrhythmic efficacy in regional ischemia-reperfusion (IR) hearts remains debatable." | 3.81 | Effects of dantrolene on arrhythmogenicity in isolated regional ischemia-reperfusion rabbit hearts with or without pacing-induced heart failure. ( Chang, PC; Chou, CC; Lee, HL; Wen, MS; Wo, HT; Yeh, SJ, 2015) |
| "It was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury." | 3.74 | Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study. ( Aslan, A; Ayva, E; Buyukokuroglu, ME; Cekirdekci, A; Cemek, M; Demirkan, I; Emmiler, M; Kocogullari, CU; Sahin, O; Tur, L, 2008) |
| "Dantrolene is a ryanodine receptor and intracellular calcium antagonist." | 1.34 | Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10. ( López-Neblina, F; Toledo, AH; Toledo-Pereyra, LH; Walsh, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Prieto-Moure, B | 1 |
| Cejalvo-Lapeña, D | 1 |
| Belda-Antolí, M | 1 |
| Padrón-Sanz, C | 1 |
| Lloris-Cejalvo, JM | 1 |
| Lloris-Carsí, JM | 1 |
| Søfteland, JM | 1 |
| Oltean, M | 1 |
| Villanueva, JE | 1 |
| Gao, L | 1 |
| Chew, HC | 1 |
| Hicks, M | 1 |
| Doyle, A | 1 |
| Qui, MR | 1 |
| Dhital, KK | 1 |
| Macdonald, PS | 1 |
| Jabbour, A | 1 |
| Chou, CC | 1 |
| Lee, HL | 1 |
| Chang, PC | 1 |
| Wo, HT | 1 |
| Wen, MS | 1 |
| Yeh, SJ | 1 |
| Kocogullari, CU | 1 |
| Emmiler, M | 1 |
| Cemek, M | 1 |
| Sahin, O | 1 |
| Aslan, A | 1 |
| Ayva, E | 1 |
| Tur, L | 1 |
| Buyukokuroglu, ME | 1 |
| Demirkan, I | 1 |
| Cekirdekci, A | 1 |
| Boys, JA | 1 |
| Toledo, AH | 2 |
| Anaya-Prado, R | 1 |
| Lopez-Neblina, F | 2 |
| Toledo-Pereyra, LH | 2 |
| Phillis, JW | 1 |
| Diaz, FG | 1 |
| O'Regan, MH | 1 |
| Pilitsis, JG | 1 |
| Walsh, J | 1 |
| Wu, D | 1 |
| Chen, X | 1 |
| Ding, R | 1 |
| Qiao, X | 1 |
| Shi, S | 1 |
| Xie, Y | 1 |
| Hong, Q | 1 |
| Feng, Z | 1 |
| Klenerman, L | 1 |
| Lowe, NM | 1 |
| Miller, I | 1 |
| Fryer, PR | 1 |
| Green, CJ | 1 |
| Jackson, MJ | 1 |
| Nakayama, R | 1 |
| Yano, T | 1 |
| Ushijima, K | 1 |
| Abe, E | 1 |
| Terasaki, H | 1 |
1 review available for dantrolene and Reperfusion Injury
| Article | Year |
|---|---|
Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney.
Topics: Animals; Brain; Calcium; Cytoprotection; Dantrolene; Disease Models, Animal; Heart; Kidney; Liver; R | 2010 |
10 other studies available for dantrolene and Reperfusion Injury
| Article | Year |
|---|---|
Combination Therapy of Allopurinol and Dantrolene and Its Role In The Prevention of Experimental Ischemia Reperfusion Injury Of The Small Intestine.
Topics: Allopurinol; Animals; Dantrolene; Intestine, Small; Male; Rats; Rats, Wistar; Reperfusion Injury; Su | 2021 |
Intestinal Ischemia-Reperfusion Injury and Calcium Channel Blockers: Getting to the Core of the Problem.
Topics: Allopurinol; Calcium Channel Blockers; Dantrolene; Humans; Intestine, Small; Reperfusion Injury | 2021 |
Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model.
Topics: Animals; Cold Temperature; Cryopreservation; Dantrolene; Dietary Supplements; Heart; Hemodynamics; I | 2018 |
Effects of dantrolene on arrhythmogenicity in isolated regional ischemia-reperfusion rabbit hearts with or without pacing-induced heart failure.
Topics: Animals; Anti-Arrhythmia Agents; Dantrolene; Heart; Heart Failure; Heart Ventricles; Myocardial Infa | 2015 |
Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study.
Topics: Animals; Antioxidants; Aorta, Abdominal; Biomarkers; Constriction; Dantrolene; Disease Models, Anima | 2008 |
Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium Channels; Cerebral Cortex; Cyclosporine; Dantr | 2002 |
Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Calcium Channel Blockers; Dantr | 2007 |
Ischemia/reperfusion induce renal tubule apoptosis by inositol 1,4,5-trisphosphate receptor and L-type Ca2+ channel opening.
Topics: Animals; Antimycin A; Apoptosis; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels | 2008 |
Dantrolene sodium protects against experimental ischemia and reperfusion damage to skeletal muscle.
Topics: Animals; Cations; Dantrolene; Glutathione; In Vitro Techniques; Infusions, Intravenous; Ischemia; Mi | 1995 |
Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia.
Topics: Animals; Cell Death; Dantrolene; Dimethyl Sulfoxide; Extracellular Space; Glutamic Acid; Hippocampus | 2002 |