dantrolene has been researched along with Paraplegia in 15 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 70-year-old male developed eosinophilic pleurisy fifteen years after dantrolene sodium had been started for his spastic paraplegia due to spinocerebellar degeneration." | 7.73 | Eosinophilic pleurisy induced by dantrolene. ( Eguchi, K; Ishii, H; Kita, F; Kobayashi, K; Nagayama, M; Nishiumi, M; Tajiri, S; Tanigaki, T; Tokuoka, K; Urano, T, 2005) |
| " He had been treated for spastic paraplegia with dantrolene sodium for 28 months." | 7.71 | [Eosinophilic pleural effusion associated with dantrolene administration]. ( Asada, K; Chida, K; Inui, N; Kuwata, H; Matsuda, H; Miwa, S; Nakamura, H; Nakamura, Y; Nakano, H; Shirai, T; Suda, T; Suzuki, K; Yokomura, K, 2002) |
| "We describe two cases of an unusual acneiform eruption which occurred in middle aged women being treated with dantrolene for spasticity." | 7.66 | Acne induced by dantrolene. ( Kataria, M; Pembroke, AC; Saxena, SR; Zilkha, KD, 1981) |
| "A 70-year-old male developed eosinophilic pleurisy fifteen years after dantrolene sodium had been started for his spastic paraplegia due to spinocerebellar degeneration." | 3.73 | Eosinophilic pleurisy induced by dantrolene. ( Eguchi, K; Ishii, H; Kita, F; Kobayashi, K; Nagayama, M; Nishiumi, M; Tajiri, S; Tanigaki, T; Tokuoka, K; Urano, T, 2005) |
| " He had been treated for spastic paraplegia with dantrolene sodium for 28 months." | 3.71 | [Eosinophilic pleural effusion associated with dantrolene administration]. ( Asada, K; Chida, K; Inui, N; Kuwata, H; Matsuda, H; Miwa, S; Nakamura, H; Nakamura, Y; Nakano, H; Shirai, T; Suda, T; Suzuki, K; Yokomura, K, 2002) |
| "We describe two cases of an unusual acneiform eruption which occurred in middle aged women being treated with dantrolene for spasticity." | 3.66 | Acne induced by dantrolene. ( Kataria, M; Pembroke, AC; Saxena, SR; Zilkha, KD, 1981) |
| "A patient is reported who was on prolonged treatment with dantrolene for spastic paraplegia; he developed a malignant lymphoma which led to his death." | 3.66 | Dantrolene and lymphocytic lymphoma. ( Tucker, JS; Wan, HH, 1980) |
| "Dantrolene sodium was effective in controlling spasticity and improving function in 11 of 13 patients taking part in a 14-week double-blind crossover study." | 1.25 | Efficacy of dantrolene sodium in the treatment of spasticity. ( Chipman, M; Kaul, S; Lambie, M, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yokomura, K | 1 |
| Chida, K | 1 |
| Suda, T | 1 |
| Miwa, S | 1 |
| Nakano, H | 1 |
| Kuwata, H | 1 |
| Suzuki, K | 2 |
| Matsuda, H | 1 |
| Asada, K | 1 |
| Nakamura, Y | 1 |
| Inui, N | 1 |
| Shirai, T | 1 |
| Nakamura, H | 1 |
| Urano, T | 1 |
| Nishiumi, M | 1 |
| Tajiri, S | 1 |
| Ishii, H | 1 |
| Tanigaki, T | 1 |
| Kobayashi, K | 1 |
| Kita, F | 1 |
| Tokuoka, K | 1 |
| Nagayama, M | 1 |
| Eguchi, K | 1 |
| Chipman, M | 1 |
| Kaul, S | 1 |
| Lambie, M | 1 |
| Pembroke, AC | 1 |
| Saxena, SR | 1 |
| Kataria, M | 1 |
| Zilkha, KD | 1 |
| Wan, HH | 1 |
| Tucker, JS | 1 |
| Hall, AP | 2 |
| Lyburn, ID | 1 |
| Spears, FD | 1 |
| Riley, B | 1 |
| Gilman, TM | 1 |
| Segal, JL | 1 |
| Brunnemann, SR | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Miglietta, O | 1 |
| Pedersen, E | 1 |
| Harving, H | 1 |
| Klemar, B | 1 |
| van Laere, M | 1 |
| Leus, P | 1 |
| Mastelinck, C | 1 |
| Andrews, LG | 1 |
| Muzumdar, AS | 1 |
| Pinkerton, AC | 1 |
| Azouvi, P | 1 |
| Roby-Brami, A | 1 |
| Tougeron, A | 1 |
| Bussel, B | 1 |
| Herman, R | 1 |
| Freedman, W | 1 |
| Mayer, N | 1 |
1 review available for dantrolene and Paraplegia
| Article | Year |
|---|---|
Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity.
Topics: Adult; Animals; Cats; Cerebral Palsy; Chemical and Drug Induced Liver Injury; Child; Clinical Trials | 1977 |
2 trials available for dantrolene and Paraplegia
| Article | Year |
|---|---|
Metoclopramide increases the bioavailability of dantrolene in spinal cord injury.
Topics: Administration, Oral; Adult; Biological Availability; Cross-Over Studies; Dantrolene; Dopamine Antag | 1996 |
Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity.
Topics: Adult; Animals; Cats; Cerebral Palsy; Chemical and Drug Induced Liver Injury; Child; Clinical Trials | 1977 |
13 other studies available for dantrolene and Paraplegia
| Article | Year |
|---|---|
[Eosinophilic pleural effusion associated with dantrolene administration].
Topics: Adult; Dantrolene; Diagnosis, Differential; Eosinophilia; Humans; Male; Paraplegia; Pleural Effusion | 2002 |
Eosinophilic pleurisy induced by dantrolene.
Topics: Aged; Dantrolene; Eosinophilia; Humans; Male; Muscle Relaxants, Central; Paraplegia; Pleurisy; Radio | 2005 |
Efficacy of dantrolene sodium in the treatment of spasticity.
Topics: Activities of Daily Living; Adult; Cross-Over Studies; Dantrolene; Dose-Response Relationship, Drug; | 1974 |
Acne induced by dantrolene.
Topics: Acne Vulgaris; Adult; Dantrolene; Female; Humans; Male; Middle Aged; Muscle Spasticity; Paraplegia | 1981 |
Dantrolene and lymphocytic lymphoma.
Topics: Dantrolene; Humans; Liver Neoplasms; Lymphoma, Non-Hodgkin; Male; Middle Aged; Muscle Spasticity; Pa | 1980 |
An unusual case of Ecstasy poisoning.
Topics: Adult; Creatine Kinase; Dantrolene; Humans; Male; Muscle Relaxants, Central; N-Methyl-3,4-methylened | 1996 |
Ecstasy: creatinine kinase.
Topics: 3,4-Methylenedioxyamphetamine; Creatine Kinase; Dantrolene; Designer Drugs; Fever; Humans; Multiple | 1997 |
Effect of dantrolene sodium on muscle contraction.
Topics: Adolescent; Adult; Dantrolene; Humans; Hydantoins; Muscle Contraction; Paraplegia | 1977 |
Effect of dantrolene sodium on the spastic external urethral sphincter recorded by sphincterometry.
Topics: Dantrolene; Female; Humans; Hydantoins; Male; Muscle Spasticity; Muscles; Paraplegia; Pressure; Uret | 1978 |
[Effect of Dantrium on spasticity in paraplegic and tetraplegic patients (author's transl)].
Topics: Adolescent; Adult; Dantrolene; Drug Evaluation; Drug Tolerance; Female; Humans; Male; Middle Aged; M | 1978 |
Letter: Hallucinations associated with dantrolene sodium therapy.
Topics: Adult; Dantrolene; Hallucinations; Humans; Hydantoins; Male; Paraplegia; Psychoses, Substance-Induce | 1975 |
[Antispastic treatment of paraplegic patients].
Topics: Baclofen; Contracture; Dantrolene; Diazepam; Humans; Muscle Spasticity; Nursing Care; Paraplegia | 1988 |
Neurophysiologic mechanisms of hemiplegic and paraplegic spasticity: implications for therapy.
Topics: Ankle; Dantrolene; Diazepam; Electromyography; Hemiplegia; Humans; Knee; Motor Neurons; Muscle Relax | 1974 |