dantrolene has been researched along with Osteogenesis Imperfecta in 1 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two clinical myopathies are known to be associated with this membrane defect." | 2.36 | Etiology and pathophysiology of malignant hyperthermia. ( Denborough, MA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denborough, MA | 1 |
1 review available for dantrolene and Osteogenesis Imperfecta
| Article | Year |
|---|---|
Etiology and pathophysiology of malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Calcium; Cell Membrane; Dantrolene; Humans; Islets of Langerhans; M | 1979 |