dantrolene has been researched along with Nerve Degeneration in 5 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene has been investigated widely for its possible cytoprotective effects against cell damage in different tissue culture or animal models of diseases involving cytotoxicity induced by disruption of intracellular calcium homeostasis in pathogenesis." | 2.46 | The cytoprotective effects of dantrolene: a ryanodine receptor antagonist. ( Inan, S; Wei, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X | 1 |
| Tang, TS | 2 |
| Tu, H | 2 |
| Nelson, O | 2 |
| Pook, M | 1 |
| Hammer, R | 1 |
| Nukina, N | 1 |
| Bezprozvanny, I | 2 |
| Aslan, A | 1 |
| Cemek, M | 1 |
| Buyukokuroglu, ME | 1 |
| Altunbas, K | 1 |
| Bas, O | 1 |
| Yurumez, Y | 1 |
| Cosar, M | 1 |
| Liu, J | 1 |
| Herndon, E | 1 |
| Huynh, DP | 1 |
| Pulst, SM | 1 |
| Inan, S | 1 |
| Wei, H | 1 |
| Yoshida, I | 1 |
| Monji, A | 1 |
| Tashiro, K | 1 |
| Nakamura, K | 1 |
| Inoue, R | 1 |
| Kanba, S | 1 |
1 review available for dantrolene and Nerve Degeneration
| Article | Year |
|---|---|
The cytoprotective effects of dantrolene: a ryanodine receptor antagonist.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cytoprotection; Dantrolene; Homeostas | 2010 |
4 other studies available for dantrolene and Nerve Degeneration
| Article | Year |
|---|---|
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Topics: Adult; Animals; Animals, Genetically Modified; Ataxin-3; Brain; Calcium Signaling; Cells, Cultured; | 2008 |
Dantrolene can reduce secondary damage after spinal cord injury.
Topics: Animals; Antioxidants; Apoptosis; Cell Count; Dantrolene; Disease Models, Animal; Disease Progressio | 2009 |
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.
Topics: Animals; Ataxins; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Death; Cells, Cultured; | 2009 |
Depletion of intracellular Ca2+ store itself may be a major factor in thapsigargin-induced ER stress and apoptosis in PC12 cells.
Topics: Animals; Apoptosis; Calcium; Calcium Signaling; Chelating Agents; Dantrolene; Endoplasmic Reticulum; | 2006 |