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dantrolene and Myotonic Dystrophy

dantrolene has been researched along with Myotonic Dystrophy in 7 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Myotonic Dystrophy: Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.

Research Excerpts

ExcerptRelevanceReference
"The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy."7.66Effect of dantrolene sodium in myotonic dystrophy. ( Dal-Bianco, P; Mamoli, B; Zeitlhofer, K, 1983)
"Oral dantrolene was given during the first nine postoperative days."5.27[Oral dantrolene in a parturient with myotonic dystrophy and susceptibility to malignant hyperthermia]. ( Achilli-Cornesse, E; Houvenaeghel, M; Jullian-Papouin, H; Manelli, JC; Martin-Meyssonier, A, 1988)
"The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy."3.66Effect of dantrolene sodium in myotonic dystrophy. ( Dal-Bianco, P; Mamoli, B; Zeitlhofer, K, 1983)
"Dantrolene was administered to treat the hypermetabolic manifestations in 20 minutes after the identification of MH."1.62A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article. ( Baek, SJ; Doo, AR; Kim, DC; Yoo, SW, 2021)
"Dantrolene was used as it is accepted that the drug has a place in the control of spasticity and also causes muscle relaxation, whereas conventional muscle relaxants are unable to control myotonia of muscle origin."1.27Dantrolene sodium and dystrophia myotonica. ( Ellis, FR; Exley, KA; Ness, MA; Phillips, DC, 1984)
"Oral dantrolene was given during the first nine postoperative days."1.27[Oral dantrolene in a parturient with myotonic dystrophy and susceptibility to malignant hyperthermia]. ( Achilli-Cornesse, E; Houvenaeghel, M; Jullian-Papouin, H; Manelli, JC; Martin-Meyssonier, A, 1988)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19906 (85.71)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Yoo, SW1
Baek, SJ1
Kim, DC1
Doo, AR1
Phillips, DC1
Ellis, FR1
Exley, KA1
Ness, MA1
Mamoli, B1
Dal-Bianco, P1
Zeitlhofer, K1
Wruck, G1
Tryba, M1
Houvenaeghel, M1
Achilli-Cornesse, E1
Jullian-Papouin, H1
Martin-Meyssonier, A1
Manelli, JC1
Dawson, AD1
Duncan, BA1

Trials

1 trial available for dantrolene and Myotonic Dystrophy

ArticleYear
Letter: Dantrolene ineffective in myotonic dystrophy.
    Lancet (London, England), 1975, May-03, Volume: 1, Issue:7914

    Topics: Clinical Trials as Topic; Dantrolene; Drug Evaluation; Humans; Hydantoins; Male; Middle Aged; Myoton

1975

Other Studies

6 other studies available for dantrolene and Myotonic Dystrophy

ArticleYear
A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article.
    Medicine, 2021, Jun-11, Volume: 100, Issue:23

    Topics: Adolescent; Anesthesia, General; Dantrolene; Genetic Predisposition to Disease; Genetic Testing; Hum

2021
Dantrolene sodium and dystrophia myotonica.
    Anaesthesia, 1984, Volume: 39, Issue:6

    Topics: Adult; Anesthesia, General; Cholecystectomy; Dantrolene; Electromyography; Humans; Male; Muscles; My

1984
Effect of dantrolene sodium in myotonic dystrophy.
    European neurology, 1983, Volume: 22, Issue:1

    Topics: Adult; Dantrolene; Electromyography; Female; Humans; Male; Middle Aged; Muscle Contraction; Myotonic

1983
[Vecuronium in dystrophia myotonica (Curschmann-Steinert)].
    Der Anaesthesist, 1989, Volume: 38, Issue:5

    Topics: Adult; Dantrolene; Female; Humans; Laparotomy; Myotonic Dystrophy; Preanesthetic Medication; Vecuron

1989
[Oral dantrolene in a parturient with myotonic dystrophy and susceptibility to malignant hyperthermia].
    Annales francaises d'anesthesie et de reanimation, 1988, Volume: 7, Issue:5

    Topics: Administration, Oral; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Creati

1988
Dantrolene sodium and dystrophia myotonica.
    Anaesthesia, 1985, Volume: 40, Issue:6

    Topics: Atracurium; Dantrolene; Humans; Isoquinolines; Male; Middle Aged; Muscle Relaxants, Central; Myotoni

1985