dantrolene has been researched along with Myotonic Dystrophy in 7 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Myotonic Dystrophy: Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy." | 7.66 | Effect of dantrolene sodium in myotonic dystrophy. ( Dal-Bianco, P; Mamoli, B; Zeitlhofer, K, 1983) |
| "Oral dantrolene was given during the first nine postoperative days." | 5.27 | [Oral dantrolene in a parturient with myotonic dystrophy and susceptibility to malignant hyperthermia]. ( Achilli-Cornesse, E; Houvenaeghel, M; Jullian-Papouin, H; Manelli, JC; Martin-Meyssonier, A, 1988) |
| "The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy." | 3.66 | Effect of dantrolene sodium in myotonic dystrophy. ( Dal-Bianco, P; Mamoli, B; Zeitlhofer, K, 1983) |
| "Dantrolene was administered to treat the hypermetabolic manifestations in 20 minutes after the identification of MH." | 1.62 | A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article. ( Baek, SJ; Doo, AR; Kim, DC; Yoo, SW, 2021) |
| "Dantrolene was used as it is accepted that the drug has a place in the control of spasticity and also causes muscle relaxation, whereas conventional muscle relaxants are unable to control myotonia of muscle origin." | 1.27 | Dantrolene sodium and dystrophia myotonica. ( Ellis, FR; Exley, KA; Ness, MA; Phillips, DC, 1984) |
| "Oral dantrolene was given during the first nine postoperative days." | 1.27 | [Oral dantrolene in a parturient with myotonic dystrophy and susceptibility to malignant hyperthermia]. ( Achilli-Cornesse, E; Houvenaeghel, M; Jullian-Papouin, H; Manelli, JC; Martin-Meyssonier, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Yoo, SW | 1 |
| Baek, SJ | 1 |
| Kim, DC | 1 |
| Doo, AR | 1 |
| Phillips, DC | 1 |
| Ellis, FR | 1 |
| Exley, KA | 1 |
| Ness, MA | 1 |
| Mamoli, B | 1 |
| Dal-Bianco, P | 1 |
| Zeitlhofer, K | 1 |
| Wruck, G | 1 |
| Tryba, M | 1 |
| Houvenaeghel, M | 1 |
| Achilli-Cornesse, E | 1 |
| Jullian-Papouin, H | 1 |
| Martin-Meyssonier, A | 1 |
| Manelli, JC | 1 |
| Dawson, AD | 1 |
| Duncan, BA | 1 |
1 trial available for dantrolene and Myotonic Dystrophy
| Article | Year |
|---|---|
Letter: Dantrolene ineffective in myotonic dystrophy.
Topics: Clinical Trials as Topic; Dantrolene; Drug Evaluation; Humans; Hydantoins; Male; Middle Aged; Myoton | 1975 |
6 other studies available for dantrolene and Myotonic Dystrophy
| Article | Year |
|---|---|
A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article.
Topics: Adolescent; Anesthesia, General; Dantrolene; Genetic Predisposition to Disease; Genetic Testing; Hum | 2021 |
Dantrolene sodium and dystrophia myotonica.
Topics: Adult; Anesthesia, General; Cholecystectomy; Dantrolene; Electromyography; Humans; Male; Muscles; My | 1984 |
Effect of dantrolene sodium in myotonic dystrophy.
Topics: Adult; Dantrolene; Electromyography; Female; Humans; Male; Middle Aged; Muscle Contraction; Myotonic | 1983 |
[Vecuronium in dystrophia myotonica (Curschmann-Steinert)].
Topics: Adult; Dantrolene; Female; Humans; Laparotomy; Myotonic Dystrophy; Preanesthetic Medication; Vecuron | 1989 |
[Oral dantrolene in a parturient with myotonic dystrophy and susceptibility to malignant hyperthermia].
Topics: Administration, Oral; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Creati | 1988 |
Dantrolene sodium and dystrophia myotonica.
Topics: Atracurium; Dantrolene; Humans; Isoquinolines; Male; Middle Aged; Muscle Relaxants, Central; Myotoni | 1985 |