dantrolene has been researched along with Myocardial Ischemia in 3 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Calcium release from sarcoplasmic reticulum which is triggered by myocardial ischemia is mainly mediated by ryanodine receptors." | 8.12 | Dantrolene Induces Mitigation of Myocardial Ischemia-Reperfusion Injury by Ryanodine Receptor Inhibition. ( Dedeilias, P; Deftereos, S; Kotanidou, A; Papakonstantinou, NA; Papalois, A; Samiotis, I; Vasileiadis, I, 2022) |
| "To investigate the effect of dantrolene on energy metabolism in rats with myocardial ischemia-reperfusion." | 7.77 | [Effect of dantrolene on energy metabolism in rats with myocardial ischemia-reperfusion]. ( Cao, Y; Guo, YQ; Li, HD; Wang, LY; Yu, GY; Zhang, YJ; Zhao, XL, 2011) |
| " Calcium release from sarcoplasmic reticulum which is triggered by myocardial ischemia is mainly mediated by ryanodine receptors." | 4.12 | Dantrolene Induces Mitigation of Myocardial Ischemia-Reperfusion Injury by Ryanodine Receptor Inhibition. ( Dedeilias, P; Deftereos, S; Kotanidou, A; Papakonstantinou, NA; Papalois, A; Samiotis, I; Vasileiadis, I, 2022) |
| "To investigate the effect of dantrolene on energy metabolism in rats with myocardial ischemia-reperfusion." | 3.77 | [Effect of dantrolene on energy metabolism in rats with myocardial ischemia-reperfusion]. ( Cao, Y; Guo, YQ; Li, HD; Wang, LY; Yu, GY; Zhang, YJ; Zhao, XL, 2011) |
| "Dantrolene was protective at micromolar concentrations: tissue necrosis decreased to 21." | 1.31 | Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel. ( Ronca, G; Ronca-Testoni, S; Yu, G; Zucchi, R, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Samiotis, I | 1 |
| Papakonstantinou, NA | 1 |
| Dedeilias, P | 1 |
| Vasileiadis, I | 1 |
| Papalois, A | 1 |
| Deftereos, S | 1 |
| Kotanidou, A | 1 |
| Zhao, XL | 1 |
| Li, HD | 1 |
| Guo, YQ | 1 |
| Wang, LY | 1 |
| Cao, Y | 1 |
| Yu, GY | 1 |
| Zhang, YJ | 1 |
| Yu, G | 1 |
| Zucchi, R | 1 |
| Ronca-Testoni, S | 1 |
| Ronca, G | 1 |
3 other studies available for dantrolene and Myocardial Ischemia
| Article | Year |
|---|---|
Dantrolene Induces Mitigation of Myocardial Ischemia-Reperfusion Injury by Ryanodine Receptor Inhibition.
Topics: Animals; Calcium; Creatine Kinase; Dantrolene; Homeostasis; Myocardial Ischemia; Myocardial Reperfus | 2022 |
[Effect of dantrolene on energy metabolism in rats with myocardial ischemia-reperfusion].
Topics: Animals; Cardiotonic Agents; Dantrolene; Energy Metabolism; Male; Myocardial Ischemia; Myocardial Re | 2011 |
Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel.
Topics: Animals; Calcium; Dantrolene; Heart; Hemodynamics; Male; Myocardial Ischemia; Rats; Rats, Wistar; Ry | 2000 |