dantrolene has been researched along with Myasthenia Gravis in 3 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental autoimmune myasthenia gravis in rats was treated with dantrolene sodium (20 mg/kg/day) from 18th to 34th postinoculation day." | 7.66 | Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium. ( Matsubara, S; Okumura, S; Sakato, S; Takamori, M, 1983) |
| "Experimental autoimmune myasthenia gravis in rats was treated with dantrolene sodium (20 mg/kg/day) from 18th to 34th postinoculation day." | 3.66 | Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium. ( Matsubara, S; Okumura, S; Sakato, S; Takamori, M, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krarup, C | 1 |
| Takamori, M | 1 |
| Sakato, S | 1 |
| Matsubara, S | 1 |
| Okumura, S | 1 |
| Mora, CT | 1 |
| Eisenkraft, JB | 1 |
| Papatestas, AE | 1 |
1 review available for dantrolene and Myasthenia Gravis
| Article | Year |
|---|---|
Evoked responses in normal and diseased muscle with particular reference to twitch potentiation.
Topics: Action Potentials; Animals; Antibodies; Biomechanical Phenomena; Dantrolene; Elbow; Evoked Potential | 1983 |
2 other studies available for dantrolene and Myasthenia Gravis
| Article | Year |
|---|---|
Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium.
Topics: Animals; Autoimmune Diseases; Calcium; Dantrolene; Disease Models, Animal; Female; Membrane Potentia | 1983 |
Intravenous dantrolene in a patient with myasthenia gravis.
Topics: Adolescent; Anesthesia, General; Dantrolene; Disease Susceptibility; Drug Evaluation; Electromyograp | 1986 |