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dantrolene and Muscular Dystrophy, Duchenne

dantrolene has been researched along with Muscular Dystrophy, Duchenne in 3 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Uchimura, T1
Asano, T1
Nakata, T1
Hotta, A1
Sakurai, H1
Chamberlain, JS1
Kendall, GC1
Mokhonova, EI1
Moran, M1
Sejbuk, NE1
Wang, DW1
Silva, O1
Wang, RT1
Martinez, L1
Lu, QL1
Damoiseaux, R1
Spencer, MJ1
Nelson, SF1
Miceli, MC1

Other Studies

3 other studies available for dantrolene and Muscular Dystrophy, Duchenne

ArticleYear
A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs.
    Cell reports. Medicine, 2021, 06-15, Volume: 2, Issue:6

    Topics: Boron Compounds; Cell Differentiation; Collagen; Creatine; CRISPR-Cas Systems; Dantrolene; Dystrophi

2021
Genetics. A genetic intervention stands a skip away from clinical tests.
    Science (New York, N.Y.), 2012, Dec-14, Volume: 338, Issue:6113

    Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Dantrolene; Disease Models, Animal; Dys

2012
Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy.
    Science translational medicine, 2012, Dec-12, Volume: 4, Issue:164

    Topics: Animals; Cell Line; Dantrolene; Disease Models, Animal; Drug Synergism; Dystrophin; Exons; High-Thro

2012