dantrolene has been researched along with Muscle Relaxation in 15 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors examined the thesis that a dose of dantrolene producing 95 per cent of maximal muscle relaxation (ED95) would effectively prevent or treat malignant hyperthermia (MH)." | 3.66 | Dantrolene dose response in malignant hyperthermia-susceptible (MHS) swine: method to obtain prophylaxis and therapeusis. ( Flewellen, EH; Nelson, TE, 1980) |
| "Dantrolene failed to inhibit the caffeine- and CCh-induced contractions depending on intracellularly stored Ca." | 1.29 | Inhibitory effects of dantrolene on contractile responses in gastric smooth muscle of the rat. ( Ito, S; Nakazato, Y; Ohta, T; Satoh, K, 1994) |
| " Acute and chronic administration of Chlo (45 mg kg-1, i." | 1.28 | Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro. ( Okwuasaba, FK; Otubu, JA; Udoh, FV, 1990) |
| "Dantrolene has only a small effect on these responses which are larger in predominantly slow-twitch fibre preparations." | 1.26 | Does the sarcoplasmic reticulum achieve chemiosmotic equilibrium in relaxed muscle? ( Jeacocke, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murasawa, S | 1 |
| Iuchi, K | 1 |
| Sato, S | 1 |
| Noguchi-Yachide, T | 1 |
| Sodeoka, M | 1 |
| Yokomatsu, T | 1 |
| Dodo, K | 1 |
| Hashimoto, Y | 1 |
| Aoyama, H | 1 |
| Jeacocke, R | 1 |
| Patti, F | 1 |
| Maccagnano, C | 1 |
| Panico, AM | 1 |
| Giammona, G | 1 |
| Rampello, L | 1 |
| Reggio, A | 1 |
| Di Giorgio, RM | 1 |
| Nicoletti, F | 1 |
| Flewellen, EH | 1 |
| Nelson, TE | 1 |
| Satoh, K | 1 |
| Ohta, T | 1 |
| Ito, S | 1 |
| Nakazato, Y | 1 |
| Saito, S | 1 |
| Harada, M | 1 |
| Yamamoto, M | 1 |
| Takagi, H | 1 |
| Saito, K | 1 |
| Konno, Y | 1 |
| Fratea, S | 2 |
| Langeron, O | 2 |
| Lecarpentier, Y | 1 |
| Coriat, P | 2 |
| Riou, B | 2 |
| Rassier, DE | 1 |
| Tubman, LA | 1 |
| MacIntosh, BR | 1 |
| Coirault, C | 1 |
| Orliaguet, G | 1 |
| Takauji, M | 1 |
| Nagai, T | 1 |
| Takamori, M | 1 |
| Tsujihata, M | 1 |
| Mori, M | 1 |
| Hazama, R | 1 |
| Ide, Y | 1 |
| Gilai, A | 1 |
| Kirsch, GE | 1 |
| Eberstein, A | 1 |
| Goodgold, J | 1 |
| Okwuasaba, FK | 1 |
| Otubu, JA | 1 |
| Udoh, FV | 1 |
| Plötz, J | 1 |
| Braun, J | 1 |
1 trial available for dantrolene and Muscle Relaxation
| Article | Year |
|---|---|
[Serum myoglobin following intermittent administration of succinylcholine and the effect of dantrolene. Clinical studies of children in halothane anesthesia].
Topics: Anesthesia; Child; Dantrolene; Halothane; Humans; Muscle Relaxation; Myoglobin; Preanesthetic Medica | 1985 |
14 other studies available for dantrolene and Muscle Relaxation
| Article | Year |
|---|---|
Small-molecular inhibitors of Ca²⁺-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene.
Topics: Calcium; Crystallography, X-Ray; Cyclosporine; Cyclosporins; Dantrolene; Dose-Response Relationship, | 2012 |
Does the sarcoplasmic reticulum achieve chemiosmotic equilibrium in relaxed muscle?
Topics: 2,4-Dinitrophenol; Anaerobiosis; Animals; Calcium; Cattle; Cyanides; Dantrolene; Dinitrophenols; Mus | 1982 |
Effects of dantrolene sodium on gabaergic activity in spinal cord, corpus striatum, substantia nigra and cerebral cortex in rat.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Dantrolene; gamma-Aminobutyric Acid; Male; Muscle | 1981 |
Dantrolene dose response in malignant hyperthermia-susceptible (MHS) swine: method to obtain prophylaxis and therapeusis.
Topics: Animals; Dantrolene; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Lactates; | 1980 |
Inhibitory effects of dantrolene on contractile responses in gastric smooth muscle of the rat.
Topics: Animals; Caffeine; Calcium; Carbachol; Dantrolene; Dose-Response Relationship, Drug; In Vitro Techni | 1994 |
Muscle relaxant action of dantrolene sodium in rats.
Topics: 4-Aminopyridine; Animals; Caffeine; Dantrolene; Drug Interactions; Electric Stimulation; Injections, | 1993 |
In vitro effects of dantrolene on rat myocardium.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Dimethyl Sulfoxide; Energy Metabolism; Heart | 1997 |
Inhibition of Ca2+ release in rat atrophied gastrocnemius muscle.
Topics: Animals; Calcium; Dantrolene; Electric Stimulation; Female; Muscle Contraction; Muscle Relaxants, Ce | 1997 |
The effects of dantrolene on the contraction, relaxation, and energetics of the diaphragm muscle.
Topics: Animals; Cricetinae; Dantrolene; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contraction; M | 1999 |
Effect of dantrolene sodium on the inactivation of excitation-contraction coupling in frog skeletal muscle.
Topics: Animals; Anura; Calcium; Dantrolene; Hydantoins; In Vitro Techniques; Muscle Contraction; Muscle Rel | 1977 |
[Contraction-relaxation properties of experimental denervated and immobilized muscle: comparison with dystrophic muscle (author's transl)].
Topics: Action Potentials; Animals; Caffeine; Dantrolene; Humans; Immobilization; In Vitro Techniques; Isopr | 1978 |
Latency-relaxation in single muscle fibres.
Topics: Animals; Caffeine; Calcium; Dantrolene; Deuterium; In Vitro Techniques; Membrane Potentials; Muscle | 1978 |
Relief of myotonia by dantrolene in experimental myotonia.
Topics: Animals; Dantrolene; Disease Models, Animal; Hydantoins; Male; Muscle Contraction; Muscle Relaxation | 1978 |
Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro.
Topics: Animals; Caffeine; Calcium; Chloroquine; Dantrolene; Diaphragm; Electric Stimulation; Female; In Vit | 1990 |