dantrolene has been researched along with Muscle Disorders in 22 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two clinical myopathies are known to be associated with this membrane defect." | 2.36 | Etiology and pathophysiology of malignant hyperthermia. ( Denborough, MA, 1979) |
| "On dantrolene treatment, the patient became asymptomatic, and the ischemic test was performed without contracture." | 1.30 | Muscle phosphoglycerate mutase deficiency with tubular aggregates: effect of dantrolene. ( Clausen, T; Haller, RG; Schmalbruch, H; Vissing, J, 1999) |
| "Dantrolene has been recommended for use in horses at risk of developing postanesthetic myopathy." | 1.28 | Prophylactic use of dantrolene associated with prolonged postanesthetic recumbency in a horse. ( Boyd, CJ; Dyson, DH; Pascoe, PJ; Valverde, A, 1990) |
| "Malignant Hyperthermia is a specific potentially fatal condition which occurs in susceptible individuals in response to various triggering mechanisms, of which anesthetic agents have been found to be the most common offenders." | 1.27 | [Malignant neuroleptic syndrome and malignant hyperthermia--a comparison]. ( Hippius, H; Spiess-Kiefer, C, 1986) |
| "Dantrolene was only used in 32% of cases, and then at inadequate doses and very often too late; this probably explains the large number of treatment failures." | 1.27 | [Registration of peranesthetic cases of malignant hyperthermia in France. An update]. ( Jacquot, C; Kozak-Reiss, G; Krivosic-Horber, R; Laxenaire, MC; Lienhart, A; Nivoche, Y; Stieglitz, P, 1988) |
| "We describe a young man who experienced malignant hyperpyrexia, probably triggered by suxamethonium and/or enflurane during his second operation for an epigastric hernia." | 1.27 | Spinal block, after dantrolene pretreatment, for resection of a thigh muscle herniation in a young malignant hyperthermia susceptible man. ( Björkenheim, JM; Huopaniemi, T; Oikkonen, M; Paetau, A; Rosenberg, PH, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (54.55) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Magyar, ZÉ | 1 |
| Hevesi, J | 1 |
| Groom, L | 1 |
| Dirksen, RT | 1 |
| Almássy, J | 1 |
| Ashley, AL | 1 |
| Bokhari, MM | 1 |
| Spears, DA | 1 |
| Lai, PF | 1 |
| Si, D | 1 |
| Billia, F | 1 |
| Parker, JD | 1 |
| Al-Hesayen, AO | 1 |
| Azam, MA | 1 |
| Riazi, S | 1 |
| Nanthakumar, K | 1 |
| Plank, C | 1 |
| Hofmann, P | 1 |
| Gruber, M | 1 |
| Bollwein, G | 1 |
| Graf, BM | 1 |
| Zink, W | 1 |
| Metterlein, T | 1 |
| Hattori, H | 1 |
| Nagata, E | 1 |
| Oya, Y | 1 |
| Takahashi, T | 1 |
| Aoki, M | 1 |
| Ito, D | 1 |
| Suzuki, N | 1 |
| Krarup, C | 1 |
| Britt, BA | 1 |
| Ellis, FR | 1 |
| Guerin, JM | 1 |
| Denborough, MA | 2 |
| Kurien, T | 1 |
| Rajeev, KK | 1 |
| Abraham, OC | 1 |
| Archana, S | 1 |
| Cherian, AM | 1 |
| Langeron, O | 1 |
| Coirault, C | 1 |
| Fratea, S | 1 |
| Orliaguet, G | 1 |
| Coriat, P | 1 |
| Riou, B | 1 |
| Vissing, J | 1 |
| Schmalbruch, H | 1 |
| Haller, RG | 1 |
| Clausen, T | 1 |
| Sunohara, N | 1 |
| Burke, DJ | 1 |
| Dykes, MH | 1 |
| Valverde, A | 1 |
| Boyd, CJ | 1 |
| Dyson, DH | 1 |
| Pascoe, PJ | 1 |
| Spiess-Kiefer, C | 1 |
| Hippius, H | 1 |
| Jacquot, C | 1 |
| Stieglitz, P | 1 |
| Kozak-Reiss, G | 1 |
| Krivosic-Horber, R | 1 |
| Laxenaire, MC | 1 |
| Lienhart, A | 1 |
| Nivoche, Y | 1 |
| Eichhorn, JH | 1 |
| Oikkonen, M | 1 |
| Rosenberg, PH | 1 |
| Björkenheim, JM | 1 |
| Paetau, A | 1 |
| Huopaniemi, T | 1 |
5 reviews available for dantrolene and Muscle Disorders
| Article | Year |
|---|---|
Evoked responses in normal and diseased muscle with particular reference to twitch potentiation.
Topics: Action Potentials; Animals; Antibodies; Biomechanical Phenomena; Dantrolene; Elbow; Evoked Potential | 1983 |
Dantrolene.
Topics: Animals; Calcium; Dantrolene; Humans; In Vitro Techniques; Malignant Hyperthermia; Motor Neurons; Mu | 1984 |
The pathopharmacology of malignant hyperpyrexia.
Topics: Adenylate Kinase; Anesthesia, General; Animals; Blood Platelets; Calcium; Catecholamines; Cats; Dant | 1980 |
[Satoyoshi syndrome (disease)].
Topics: Alopecia; Dantrolene; Diagnosis, Differential; Diarrhea; Disease Progression; Humans; Muscle, Skelet | 2001 |
Etiology and pathophysiology of malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Calcium; Cell Membrane; Dantrolene; Humans; Islets of Langerhans; M | 1979 |
1 trial available for dantrolene and Muscle Disorders
| Article | Year |
|---|---|
Evaluation of a muscle relaxant: dantrolene sodium (Dantrium).
Topics: Activities of Daily Living; Administration, Oral; Adult; Age Factors; Animals; Child; Clinical Trial | 1975 |
16 other studies available for dantrolene and Muscle Disorders
| Article | Year |
|---|---|
Function of a mutant ryanodine receptor (T4709M) linked to congenital myopathy.
Topics: Adenosine Triphosphate; Animals; Cytoplasm; Dantrolene; Mice; Muscular Diseases; Myotonia Congenita; | 2023 |
TREATMENT OF SUSPECTED EXERTIONAL MYOPATHY USING DANTROLENE IN A COYOTE ( CANIS LATRANS).
Topics: Animals; Animals, Zoo; Coyotes; Dantrolene; Female; Muscle Relaxants, Central; Muscular Diseases; Ph | 2018 |
Safety of Chronic Cardiac Ryanodine Receptor Modulation: A 10-Year Experience.
Topics: Aged; Calcium Channel Blockers; Dantrolene; Electrocardiography; Female; Heart Diseases; Humans; Mal | 2018 |
Modification of Bupivacaine-Induced Myotoxicity with Dantrolene and Caffeine In Vitro.
Topics: Anesthetics, Local; Animals; Annexins; Bupivacaine; Caffeine; Central Nervous System Stimulants; Dan | 2016 |
A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene.
Topics: Adolescent; Asian People; Dantrolene; Dysferlin; Female; Heterozygote; Humans; Male; Membrane Protei | 2007 |
Malignant hyperpyrexia.
Topics: Adult; Anesthesia, General; Animals; Calcium; Child; Dantrolene; Heat Exhaustion; Humans; Malignant | 1984 |
Update in neuroleptic malignant syndrome.
Topics: Dantrolene; Humans; Muscular Diseases; Syndrome | 1983 |
Management of neuroleptic malignant syndrome--a series of eight cases.
Topics: Adolescent; Adult; Bromocriptine; Carbidopa; Dantrolene; Dopamine Agents; Drug Combinations; Female; | 1993 |
Effects of dantrolene on the diaphragm muscle of the normal and myopathic hamster.
Topics: Animals; Cricetinae; Culture Techniques; Dantrolene; Diaphragm; Dose-Response Relationship, Drug; Me | 1998 |
Muscle phosphoglycerate mutase deficiency with tubular aggregates: effect of dantrolene.
Topics: Adult; Dantrolene; Exercise; Humans; Male; Microscopy, Electron; Muscles; Muscular Diseases; Phospho | 1999 |
An approach to the treatment of spasticity.
Topics: Adrenergic alpha-Antagonists; Baclofen; Brain Diseases; Dantrolene; Diazepam; Humans; Mephenesin; Mu | 1975 |
Prophylactic use of dantrolene associated with prolonged postanesthetic recumbency in a horse.
Topics: Animals; Dantrolene; Horse Diseases; Horses; Male; Malignant Hyperthermia; Muscular Diseases; Postop | 1990 |
[Malignant neuroleptic syndrome and malignant hyperthermia--a comparison].
Topics: Adult; Amantadine; Bromocriptine; Calcium; Cross-Sectional Studies; Dantrolene; Female; Humans; Ion | 1986 |
[Registration of peranesthetic cases of malignant hyperthermia in France. An update].
Topics: Adolescent; Adult; Anesthetics; Child; Child, Preschool; Dantrolene; Female; France; Humans; Infant; | 1988 |
Malignant hyperthermia revisited.
Topics: Biopsy; Dantrolene; Disease Susceptibility; Humans; Malignant Hyperthermia; Muscular Diseases; Surge | 1988 |
Spinal block, after dantrolene pretreatment, for resection of a thigh muscle herniation in a young malignant hyperthermia susceptible man.
Topics: Adolescent; Adult; Anesthesia, Spinal; Child; Dantrolene; Disease Susceptibility; Herniorrhaphy; Hum | 1987 |