dantrolene has been researched along with Muscle Contraction in 238 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1 The effects of dantrolene on twitch and tetanic force development were determined in soleus and gastrocnemius muscle of euthyroid, hypothyroid, and hyperthyroid rats." | 7.67 | Effects of dantrolene on force development in slow- and fast-twitch muscle of euthyroid, hypothyroid, and hyperthyroid rats. ( Everts, ME; van Hardeveld, C, 1987) |
| "Experimental autoimmune myasthenia gravis in rats was treated with dantrolene sodium (20 mg/kg/day) from 18th to 34th postinoculation day." | 7.66 | Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium. ( Matsubara, S; Okumura, S; Sakato, S; Takamori, M, 1983) |
| "The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy." | 7.66 | Effect of dantrolene sodium in myotonic dystrophy. ( Dal-Bianco, P; Mamoli, B; Zeitlhofer, K, 1983) |
| "Where malignant hyperthermia has developed patients have been successfully treated with further dantrolene therapy." | 6.37 | Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. ( Chaffman, MO; Sorkin, EM; Ward, A, 1986) |
| " radix isolates, which are responsible for the antispasmodic effect of SKT, did not inhibit the twitch contraction in contrast to dantrolene sodium, a direct-acting peripheral muscle relaxant, indicating that the mechanisms of muscle contraction of SKT and dantrolene in skeletal muscle differ." | 3.81 | Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca2+ release in rat skeletal muscle. ( Fukutake, M; Kaifuchi, N; Kase, Y; Kushida, H; Nishimura, H; Omiya, Y, 2015) |
| "Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia." | 3.80 | Pharyngeal spasticity due to dantrolene. ( Amorelli, V; Avantaggiato, P; Clementi, E; Galbiati, S; Lanfranchi, M; Locatelli, F; Pozzi, M; Radice, S; Rizzi, G; Strazzer, S; Tufarulo, L, 2014) |
| " Caffeine, a sarcoplasmic reticulum (SR) Ca2+-releasing agent, at a concentration that does not cause muscle contractions or decreases in high-energy phosphates, led to an approximately 2-fold increase in 2-deoxyglucose (2-DG) uptake in isolated split soleus muscles." | 3.73 | Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle. ( Geiger, PC; Han, DH; Holloszy, JO; Wright, DC, 2005) |
| "Bifunctional dantrolene derivatives have been synthesized as probes for radioisotope-free photoaffinity labeling with the aim of elucidating the molecular mechanism of skeletal muscle contraction." | 3.73 | Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle. ( Aoyama, H; Endo, M; Hiramatsu, T; Hosoya, T; Ikemoto, T; Ohmae, T; Suzuki, M, 2005) |
| "Ryanodine receptors (RyRs), intracellular calcium release channels essential for skeletal and cardiac muscle contraction, are also expressed in various types of smooth muscle cells." | 3.73 | Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. ( Du, W; Eu, JP; Meissner, G; Rosenberg, PB; Stiber, JA, 2005) |
| "Binge drinking of alcohol, cocaine overdose, or overexertion can lead to rhabdomyolysis characterized by elevated creatine kinase (CK) and myoglobin in the serum, myoglobinuria, and muscle tenderness." | 3.69 | Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by ethanol, cocaine, and electrical stimulation in isolated fast and slow muscles of rat. ( Amaladevi, B; Bernstein, A; Grob, D; Herzlich, B; Namba, T; Pagala, M, 1997) |
| "1 The effects of dantrolene on twitch and tetanic force development were determined in soleus and gastrocnemius muscle of euthyroid, hypothyroid, and hyperthyroid rats." | 3.67 | Effects of dantrolene on force development in slow- and fast-twitch muscle of euthyroid, hypothyroid, and hyperthyroid rats. ( Everts, ME; van Hardeveld, C, 1987) |
| "Experimental autoimmune myasthenia gravis in rats was treated with dantrolene sodium (20 mg/kg/day) from 18th to 34th postinoculation day." | 3.66 | Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium. ( Matsubara, S; Okumura, S; Sakato, S; Takamori, M, 1983) |
| "The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy." | 3.66 | Effect of dantrolene sodium in myotonic dystrophy. ( Dal-Bianco, P; Mamoli, B; Zeitlhofer, K, 1983) |
| " Dantrolene, a muscle contraction antagonist, and MI-65-S, a muscle spindle suppressant, significantly delayed THE." | 3.65 | Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method. ( Anderson, RJ; Britton, LW; Helke, CJ; Iadarola, MJ; Raines, A, 1976) |
| "1-[5-(5-Chloro-2-pyrimidinyl)furfurylidene]amino-hydantoin, a structural analog of the skeletal muscle contraction antagonist dantrolene, was synthesized and found to have no skeletal muscle relaxant activity." | 3.65 | 5-chloro-2-pyrimidinyl analog of dantrolene. ( Ellis, KO; Schwan, TJ, 1975) |
| "Halothane-induced contractures in isolated muscle fibers from swine susceptible to malignant hyperthermia (MHS) were significantly less when fibers were incubated in KRB plus 6." | 3.65 | Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle. ( Anderson, IL; Jones, EW, 1976) |
| "Exertional heat stroke (EHS) and malignant hyperthermia (MH) are life-threatening conditions, triggered by different environmental stimuli that share several clinical symptoms and pathophysiological features." | 2.66 | Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture. ( Laitano, O; Leon, LR; Murray, KO, 2020) |
| "Malignant hyperthermia is a hypermetabolic syndrome that appears in susceptible patients after exposure to certain anaesthetic drugs (succinylcholine, inhalation anaesthetics)." | 2.55 | Clinical protocol for the management of malignant hyperthermia. ( Alsina, E; Del Blanco, B; Domínguez, A; García, A; Guerrero, JL; Kollmann-Camaiora, A; Yepes, MJ, 2017) |
| "In this article the pathophysiology of malignant hyperthermia, its signs, symptoms and treatment as well as safe anesthetic agents for individuals susceptible to malignant hyperthermia are discussed." | 2.42 | [Malignant hyperthermia]. ( Glahn, KP, 2003) |
| "The association of malignant hyperthermia-like reactions with other neuromuscular disorders requires the collaboration of several clinical disciplines to achieve a timely recognition of this still life-threatening disorder." | 2.42 | [Malignant hyperthermia]. ( Kress, HG; Zeitlhofer, J; Zimprich, F, 2003) |
| "Where malignant hyperthermia has developed patients have been successfully treated with further dantrolene therapy." | 2.37 | Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. ( Chaffman, MO; Sorkin, EM; Ward, A, 1986) |
| "Two clinical myopathies are known to be associated with this membrane defect." | 2.36 | Etiology and pathophysiology of malignant hyperthermia. ( Denborough, MA, 1979) |
| " Dose-response curves for the 5-HT-induced contraction (from 0." | 1.62 | The combination of dantrolene and nimodipine effectively reduces 5-HT-induced vasospasms in diabetic rats. ( Crespo, MJ; García, L; Morales, M; Román, M, 2021) |
| "In all malignant hyperthermia susceptible animals, the inhaled administration of halothane 0." | 1.37 | Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. ( Becker, S; Burmester, S; Gerbershagen, MU; Kröner, L; Lenz, D; Schütte, JK; Starosse, A; Wappler, F, 2011) |
| "Malignant hyperthermia is a pharmacogenetic disease of skeletal muscle in which a life-threatening, hypermetabolic syndrome is induced by exposure of susceptible patients to halogenated general anaesthetics and/or succinylcholine." | 1.35 | Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle. ( Carmo, PL; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2008) |
| "Dantrolene treatment was sufficient to reduce twitch amplitude by 25%." | 1.34 | Dantrolene, like fatigue, has a length-dependent effect on submaximal force-length relationships of rat gastrocnemius muscle. ( Campbell, JJ; Maclntosh, BR; MacNaughton, MB, 2007) |
| "Susceptibility to malignant hyperthermia is inherited as an autosomal dominant disorder and is associated with myopathies." | 1.33 | [Malignant hyperthermia--a hereditary and potentially life-threatening condition]. ( Aasly, J; Haugen, T; Müller, CR; Toft, M, 2005) |
| "Dantrolene was found to inhibit thymol-stimulated calcium efflux from heavy SR vesicles by 44 +/- 10% (n = 3) at 12 microM." | 1.31 | Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers. ( Collet, C; Csernoch, L; Jacquemond, V; Jona, I; Kovács, L; Sárközi, S; Szegedi, C; Szentesi, P, 2001) |
| "Porcine malignant hyperthermia (MH) can be triggered by administration of certain serotonin2 receptor agonists." | 1.30 | Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene. ( Fiege, M; Köchling, A; Lambrecht, W; Scholz, J; Schulte am Esch, J; von Richthofen, V; Wappler, F, 1997) |
| "Caffeine contractures were induced after K(+)-conditioning of skeletal muscles from pigs and mice." | 1.29 | Modulation of caffeine contractures in mammalian skeletal muscles by variation of extracellular potassium. ( Gallant, EM; Lentz, LR; Taylor, SR, 1995) |
| "Two cases of possible clinical malignant hyperthermia are described." | 1.29 | Clinical variability of possible malignant hyperthermia as revealed by two cases. ( Bendixen, D; Knudsen, F; Nielsen, J; Ording, H; Poulsen, TD, 1994) |
| "Pretreatment with pancuronium produced right and downward shift of ethanol induced contraction." | 1.29 | On mechanism of action of ethanol-induced contraction of frog rectus abdominis. ( Kela, AK; Mehta, SC; Mehta, VL; Sharma, AK; Srivastava, AK, 1994) |
| "Dantrolene failed to inhibit the caffeine- and CCh-induced contractions depending on intracellularly stored Ca." | 1.29 | Inhibitory effects of dantrolene on contractile responses in gastric smooth muscle of the rat. ( Ito, S; Nakazato, Y; Ohta, T; Satoh, K, 1994) |
| "Pretreatment with thapsigargin abolished agonist-induced 45Ca2+ efflux in both cell types." | 1.29 | Agonist-activated, ryanodine-sensitive, IP3-insensitive Ca2+ release channels in longitudinal muscle of intestine. ( Kuemmerle, JF; Makhlouf, GM; Murthy, KS, 1994) |
| "1." | 1.28 | W-7, a calmodulin antagonist, and contracture of malignant hyperthermia susceptible skeletal muscle. ( Holland, M; Lee, JC; Williams, JH, 1992) |
| "Until our malignant hyperthermia diagnostic center was opened, such tests could not be performed in Israel." | 1.28 | [In vitro diagnosis of malignant hyperpyrexia syndrome]. ( Eldar, I; Glauber, V; Goldberg, G; Perel, A, 1991) |
| " Acute and chronic administration of Chlo (45 mg kg-1, i." | 1.28 | Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro. ( Okwuasaba, FK; Otubu, JA; Udoh, FV, 1990) |
| "Malignant Hyperthermia is a specific potentially fatal condition which occurs in susceptible individuals in response to various triggering mechanisms, of which anesthetic agents have been found to be the most common offenders." | 1.27 | [Malignant neuroleptic syndrome and malignant hyperthermia--a comparison]. ( Hippius, H; Spiess-Kiefer, C, 1986) |
| " In the second part of the study, dogs received identical dosage sequences, but verapamil preceded dantrolene administration." | 1.27 | Effects of dantrolene and verapamil on atrioventricular conduction and cardiovascular performance in dogs. ( Althaus, JS; Durbin, CG; Fisher, NA; Lynch, C; Veselis, RA, 1986) |
| "The effects of an induced malignant hyperthermia (MH) crisis have been studied in the intact pig." | 1.27 | In vivo induced malignant hyperthermia in pigs. I. Physiological and biochemical changes and the influence of dantrolene sodium. ( Crul, JF; de Bruyn, CH; Gielen, MJ; Oerlemans, FT; van Bennekom, CA; Verburg, MP, 1984) |
| "Nifedipine was less effective." | 1.27 | Contractile inactivation in frog skeletal muscle fibers. The effects of low calcium, tetracaine, dantrolene, D-600, and nifedipine. ( Bolaños, P; Caputo, C, 1987) |
| "Dantrolene sodium is a muscle relaxant used in the treatment of spasticity." | 1.26 | The effect of dantrolene sodium on rat skeletal muscle in relation to the plasma concentration. ( Meyler, WJ; Mols-Thurkow, I; Sargo, S; Scaf, AH; Wesseling, H, 1979) |
| "Malignant hyperthermia is an inherited muscular disorder and a cause of sudden death in afflicted patients." | 1.26 | Malignant hyperthermia. A potentially fatal syndrome in orthopaedic patients. ( Barak, AJ; Connolly, JF; Jardon, OM; Wingard, DW, 1979) |
| " Dantrolene sodium, verapamil and nifedipine were able to shift the dose-response curves of calcium in potassium-polarized rabbit jejunum to the right and pA2 values were found to be 4." | 1.26 | Effect of dantrolene sodium on the contractility of rabbit jejunum in vitro. ( Dehpour, AR; Mahmoudian, M; Mofakham, S, 1981) |
| "Dantrolene has only a small effect on these responses which are larger in predominantly slow-twitch fibre preparations." | 1.26 | Does the sarcoplasmic reticulum achieve chemiosmotic equilibrium in relaxed muscle? ( Jeacocke, R, 1982) |
| "2." | 1.26 | The effect of dantrolene sodium on intrafusal muscle fibres in the rat soleus muscle. ( Leslie, GC; Part, NJ, 1981) |
| "Dantrolene pre-treatment results in no significant change in the response of normalized MEPP frequency to tetanus at stimulation rates of both 25 and 100 Hz." | 1.26 | The effect of dantrolene on tetanic potentiation of MEPP frequency in EGTA containing salines. ( Publicover, SJ, 1982) |
| " the dose-response curve on rat diaphragm was flatter." | 1.26 | The effects of dantrolene sodium on cardiac and skeletal muscle in rats. ( Agoston, S; Meyler, MJ; Wesseling, H, 1976) |
| "Caffeine contracture was partially inhibited by dantrolene and was almost unchanged by it in potassium-depolarized muscele fiber." | 1.25 | Effect of dantrolene sodium on excitation-contraction coupling in frog skeletal muscle. ( Nagai, T; Takahashi, N; Takauji, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 152 (63.87) | 18.7374 |
| 1990's | 46 (19.33) | 18.2507 |
| 2000's | 24 (10.08) | 29.6817 |
| 2010's | 12 (5.04) | 24.3611 |
| 2020's | 4 (1.68) | 2.80 |
| Authors | Studies |
|---|---|
| Dwivedi, R | 1 |
| Drumm, BT | 1 |
| Griffin, CS | 1 |
| Dudem, S | 1 |
| Bradley, E | 1 |
| Alkawadri, T | 1 |
| Martin, SL | 1 |
| Sergeant, GP | 1 |
| Hollywood, MA | 1 |
| Thornbury, KD | 1 |
| Laitano, O | 1 |
| Murray, KO | 1 |
| Leon, LR | 1 |
| Román, M | 1 |
| García, L | 1 |
| Morales, M | 1 |
| Crespo, MJ | 1 |
| Uchimura, T | 1 |
| Asano, T | 1 |
| Nakata, T | 1 |
| Hotta, A | 1 |
| Sakurai, H | 1 |
| Murayama, T | 1 |
| Kurebayashi, N | 1 |
| Ishigami-Yuasa, M | 1 |
| Mori, S | 1 |
| Suzuki, Y | 1 |
| Akima, R | 1 |
| Ogawa, H | 1 |
| Suzuki, J | 1 |
| Kanemaru, K | 1 |
| Oyamada, H | 1 |
| Kiuchi, Y | 1 |
| Iino, M | 1 |
| Kagechika, H | 1 |
| Sakurai, T | 1 |
| Nelson, TE | 6 |
| Locatelli, F | 1 |
| Pozzi, M | 1 |
| Avantaggiato, P | 1 |
| Lanfranchi, M | 1 |
| Tufarulo, L | 1 |
| Amorelli, V | 1 |
| Rizzi, G | 1 |
| Radice, S | 1 |
| Galbiati, S | 1 |
| Clementi, E | 1 |
| Strazzer, S | 1 |
| Kaifuchi, N | 1 |
| Omiya, Y | 2 |
| Kushida, H | 1 |
| Fukutake, M | 1 |
| Nishimura, H | 1 |
| Kase, Y | 2 |
| Kollmann-Camaiora, A | 1 |
| Alsina, E | 1 |
| Domínguez, A | 1 |
| Del Blanco, B | 1 |
| Yepes, MJ | 1 |
| Guerrero, JL | 1 |
| García, A | 1 |
| Ikemoto, T | 5 |
| Hosoya, T | 5 |
| Takata, K | 1 |
| Aoyama, H | 5 |
| Hiramatsu, T | 4 |
| Onoe, H | 1 |
| Suzuki, M | 5 |
| Endo, M | 6 |
| Robertson, AP | 1 |
| Clark, CL | 1 |
| Martin, RJ | 1 |
| Kolnes, AJ | 1 |
| Ingvaldsen, A | 1 |
| Bolling, A | 1 |
| Stuenaes, JT | 1 |
| Kreft, M | 1 |
| Zorec, R | 1 |
| Shepherd, PR | 1 |
| Jensen, J | 1 |
| Urwyler, A | 1 |
| Schütte, JK | 1 |
| Becker, S | 1 |
| Burmester, S | 1 |
| Starosse, A | 1 |
| Lenz, D | 1 |
| Kröner, L | 1 |
| Wappler, F | 3 |
| Gerbershagen, MU | 1 |
| MacIntosh, BR | 5 |
| Glumpak, JJ | 1 |
| MacNaughton, MB | 2 |
| Rassier, DE | 4 |
| Dahan, D | 1 |
| Ducret, T | 1 |
| Quignard, JF | 1 |
| Marthan, R | 2 |
| Savineau, JP | 2 |
| Estève, E | 1 |
| Lee, KK | 1 |
| Yuzurihara, M | 1 |
| Kobayashi, H | 1 |
| Kihara, Y | 3 |
| Wooldridge, AA | 1 |
| Eades, SC | 1 |
| Hosgood, GL | 1 |
| Moore, RM | 1 |
| Terada, S | 1 |
| Muraoka, I | 1 |
| Tabata, I | 1 |
| Büyükokuroğlu, ME | 1 |
| Göçer, F | 1 |
| Açikel, M | 1 |
| Gepdiremen, A | 1 |
| Glahn, KP | 1 |
| Zimprich, F | 1 |
| Kress, HG | 1 |
| Zeitlhofer, J | 1 |
| Germinario, E | 1 |
| Esposito, A | 1 |
| Megighian, A | 1 |
| Midrio, M | 1 |
| Betto, R | 1 |
| Danieli-Betto, D | 1 |
| Bagni, MA | 2 |
| Colombini, B | 2 |
| Geiger, P | 2 |
| Berlinguer Palmini, R | 2 |
| Cecchi, G | 3 |
| Colomo, F | 2 |
| Nasledov, GA | 2 |
| Katina, IE | 2 |
| Kobzeva, MA | 1 |
| Wright, DC | 1 |
| Geiger, PC | 1 |
| Holloszy, JO | 2 |
| Han, DH | 1 |
| Ohmae, T | 1 |
| Du, W | 1 |
| Stiber, JA | 1 |
| Rosenberg, PB | 1 |
| Meissner, G | 1 |
| Eu, JP | 1 |
| Haugen, T | 1 |
| Toft, M | 1 |
| Müller, CR | 1 |
| Aasly, J | 1 |
| Zhitnikova, IuV | 1 |
| Ono, T | 1 |
| Maekawa, K | 1 |
| Watanabe, S | 1 |
| Oka, H | 1 |
| Kuboki, T | 1 |
| Campbell, JJ | 1 |
| Maclntosh, BR | 1 |
| Sudo, RT | 3 |
| Carmo, PL | 1 |
| Trachez, MM | 1 |
| Zapata-Sudo, G | 1 |
| Middleton, E | 1 |
| Drzewiecki, G | 1 |
| Triggle, D | 1 |
| Røed, A | 5 |
| Gerald, MC | 1 |
| Meldrum, MJ | 1 |
| Skau, KA | 1 |
| Publicover, SJ | 1 |
| Mancinelli, L | 1 |
| Fanò, G | 1 |
| Ferroni, L | 1 |
| Secca, T | 1 |
| Dolcini, BM | 1 |
| Krarup, C | 2 |
| Blanck, TJ | 1 |
| Gruener, RP | 1 |
| Young, RR | 1 |
| Delwaide, PJ | 1 |
| Leslie, GC | 3 |
| Part, NJ | 3 |
| Takamori, M | 2 |
| Sakato, S | 1 |
| Matsubara, S | 2 |
| Okumura, S | 1 |
| Hui, CS | 3 |
| Kovács, L | 2 |
| Schümperli, RA | 1 |
| Szücs, G | 1 |
| Piazzesi, G | 1 |
| Ekelund, MC | 2 |
| Flewellen, EH | 3 |
| Jones, WP | 1 |
| Arens, JF | 1 |
| Wagner, DL | 1 |
| Fukushima, K | 1 |
| Aoki, T | 2 |
| Ishikawa, J | 1 |
| Britt, BA | 1 |
| Scott, E | 1 |
| Frodis, W | 1 |
| Clements, MJ | 1 |
| Endrenyi, L | 1 |
| Verburg, MP | 1 |
| Oerlemans, FT | 1 |
| van Bennekom, CA | 1 |
| Gielen, MJ | 1 |
| de Bruyn, CH | 1 |
| Crul, JF | 1 |
| Ayyat, FM | 1 |
| Lloyd, LK | 1 |
| Kuhlemeier, KV | 1 |
| Jami, L | 1 |
| Murthy, KS | 2 |
| Petit, J | 1 |
| Zytnicki, D | 1 |
| Mamoli, B | 1 |
| Dal-Bianco, P | 1 |
| Zeitlhofer, K | 1 |
| Halsall, PJ | 2 |
| Ellis, FR | 2 |
| Lograno, MD | 3 |
| Conte Camerino, D | 2 |
| Cioce, AM | 1 |
| Dibartolomec, MR | 1 |
| Anderson, IL | 2 |
| Rawstron, RE | 1 |
| Dunlop, DJ | 1 |
| Yagi, S | 1 |
| Tamai, Y | 2 |
| Oba, T | 5 |
| Hotta, K | 4 |
| Hatae, J | 1 |
| Ohba, M | 1 |
| Kawata, H | 1 |
| Denborough, MA | 9 |
| Sullivan, JS | 1 |
| Galloway, GJ | 1 |
| Lüllmann, H | 1 |
| Schramm, U | 1 |
| Jeacocke, R | 1 |
| Takauji, M | 5 |
| Tsutsu-ura, M | 2 |
| Nagai, T | 5 |
| Mitolo-Chieppa, D | 1 |
| Cagnazzo, F | 1 |
| Megna, GF | 1 |
| Oriowo, MA | 1 |
| Gronert, GA | 4 |
| Thompson, RL | 1 |
| Onofrio, BM | 1 |
| Mahmoudian, M | 1 |
| Dehpour, AR | 2 |
| Mofakham, S | 1 |
| Felice-Johnson, J | 1 |
| Sudds, T | 1 |
| Bennett, G | 1 |
| Parmiggiani, F | 1 |
| Stein, RB | 1 |
| Wendt, IR | 1 |
| Barclay, JK | 1 |
| Rymer, WZ | 1 |
| Hasan, Z | 1 |
| Okumura, F | 1 |
| Crocker, BD | 1 |
| Rosenberg, H | 2 |
| Lambert, W | 1 |
| Harris, JD | 1 |
| Benson, GS | 1 |
| Lee, C | 1 |
| Durant, NN | 1 |
| Au, E | 1 |
| Katz, RL | 1 |
| Kuemmerle, JF | 1 |
| Makhlouf, GM | 1 |
| Herlofson, BB | 1 |
| Gallant, EM | 3 |
| Lentz, LR | 1 |
| Taylor, SR | 4 |
| Tajkhorshid, E | 1 |
| Alimian, M | 1 |
| Behbahani, NR | 1 |
| Lenzen, C | 1 |
| Roewer, N | 1 |
| Köchling, A | 2 |
| Steinfath, M | 1 |
| Scholz, J | 2 |
| Schulte am Esch, J | 2 |
| Bendixen, D | 1 |
| Poulsen, TD | 1 |
| Knudsen, F | 1 |
| Nielsen, J | 1 |
| Ording, H | 1 |
| Straeter-Knowlen, IM | 1 |
| Marks, SL | 1 |
| Speth, RC | 1 |
| Wirth, W | 1 |
| Knowlen, GG | 1 |
| Orón, JD | 1 |
| Cortijo, J | 4 |
| Perpiñá, M | 3 |
| Morcillo, EJ | 4 |
| Kela, AK | 1 |
| Sharma, AK | 1 |
| Mehta, SC | 1 |
| Mehta, VL | 1 |
| Srivastava, AK | 1 |
| Satoh, K | 1 |
| Ohta, T | 2 |
| Ito, S | 2 |
| Nakazato, Y | 1 |
| Ecker-Schlipf, B | 1 |
| Fletcher, JE | 3 |
| Tripolitis, L | 1 |
| Beech, J | 1 |
| Nasu, T | 2 |
| Oosako, H | 2 |
| Shibata, H | 1 |
| Gonzalez De La Fuente, P | 1 |
| Owen, VJ | 1 |
| Taske, NL | 1 |
| Lamb, GD | 1 |
| Pagala, M | 1 |
| Amaladevi, B | 1 |
| Bernstein, A | 1 |
| Herzlich, B | 1 |
| Namba, T | 1 |
| Grob, D | 1 |
| Hopkinson, KC | 3 |
| Jong, DS | 1 |
| Stroffekova, K | 1 |
| Heiny, JA | 1 |
| Tubman, LA | 2 |
| Oh, ST | 1 |
| Yedidag, E | 1 |
| Conklin, JL | 1 |
| Martin, M | 1 |
| Bielefeldt, K | 1 |
| Etgen, GJ | 1 |
| Fryburg, DA | 1 |
| Gibbs, EM | 1 |
| von Richthofen, V | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury[NCT00223873] | 30 participants | Interventional | 2002-11-30 | Completed | |||
| Perioperative Accuracy of the Raiing Wireless Axillary Thermometer[NCT02756910] | 80 participants (Actual) | Observational | 2016-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Accuracy, defined as the true difference between reference and iThermonitor temperature. The esophageal temperature will be the core temperature reference during surgery.~The primary outcome measure is the proportion of iThermonitor measurements for a patient that are within 0.5° C of the reference will be calculated, and this proportion (median, quartiles, 95% CI) will be summarized across patients.~The Secondary outcome measure are bias and 95% CIs determined by repeated-measures Bland-Altman analysis.~For each patient the average difference between the iThermometer and the reference temperature will be calculated. Patient iThermonitor measurements will be regressed on patient reference measurements to assess the Pearson correlation and 95% CI between iThermonitor and reference and to estimate the bias (slope) of device versus reference." (NCT02756910)
Timeframe: From 1 to 3 hours after induction of anesthesia
| Intervention | celsius (Mean) |
|---|---|
| Surgery Patients >1.5 Hrs | 0.14 |
13 reviews available for dantrolene and Muscle Contraction
| Article | Year |
|---|---|
Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture.
Topics: Anesthetics; Calcium; Calcium Channel Blockers; Dantrolene; Heat Stroke; Humans; Malignant Hyperther | 2020 |
Clinical protocol for the management of malignant hyperthermia.
Topics: Adolescent; Adult; Caffeine; Calcium Signaling; Child; Child, Preschool; Clinical Protocols; Critica | 2017 |
[Malignant hyperthermia].
Topics: Anesthetics, Inhalation; Dantrolene; Diagnosis, Differential; Genetic Predisposition to Disease; Hum | 2003 |
[Malignant hyperthermia].
Topics: Adult; Biopsy; Child; Dantrolene; Humans; Injections, Intravenous; Malignant Hyperthermia; Muscle Co | 2003 |
Evoked responses in normal and diseased muscle with particular reference to twitch potentiation.
Topics: Action Potentials; Animals; Antibodies; Biomechanical Phenomena; Dantrolene; Elbow; Evoked Potential | 1983 |
Malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Cold Temperature; Creatine Kinase; Dantrolene; Disease Susceptibility; H | 1983 |
The pathopharmacology of malignant hyperpyrexia.
Topics: Adenylate Kinase; Anesthesia, General; Animals; Blood Platelets; Calcium; Catecholamines; Cats; Dant | 1980 |
Etiology and pathophysiology of malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Calcium; Cell Membrane; Dantrolene; Humans; Islets of Langerhans; M | 1979 |
Excitation-contraction coupling.
Topics: Action Potentials; Animals; Caffeine; Calcium; Dantrolene; Deuterium; Electric Stimulation; Formalde | 1976 |
Contractile activation in skeletal muscle.
Topics: Action Potentials; Animals; Caffeine; Calcium; Cell Membrane Permeability; Dantrolene; Formaldehyde; | 1975 |
Studies of the halothane-cooling contractures of skeletal muscle.
Topics: Anesthetics, Local; Animals; Calcium; Cold Temperature; Dantrolene; Halothane; Humans; Muscle Contra | 1987 |
Malignant hyperthermia.
Topics: Action Potentials; Adult; Animals; Child; Counseling; Dantrolene; Humans; Malignant Hyperthermia; Mu | 1986 |
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.
Topics: Animals; Calcium; Central Nervous System; Dantrolene; Endocrine Glands; Heat Exhaustion; Humans; Kin | 1986 |
5 trials available for dantrolene and Muscle Contraction
| Article | Year |
|---|---|
[Evaluation of the mechanism determining the painful symptomatology after proctological interventions].
Topics: Adult; Aged; Anal Canal; Analgesics; Dantrolene; Double-Blind Method; Female; Hemorrhoids; Humans; M | 1988 |
Spasticity and the effect of dantrolene sodium.
Topics: Adult; Ankle Joint; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Dose-Response R | 1974 |
A comparison of dantrolene sodium and diazepam in the treatment of spasticity.
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam; | 1974 |
Cooperative study for assessing the effects of a pharmacological agent on spasticity.
Topics: Adult; Aged; Analog-Digital Conversion; Cerebrovascular Disorders; Computers, Analog; Dantrolene; El | 1973 |
The effect of dantrolene sodium on spasticity in multiple sclerosis.
Topics: Adult; Aged; Dantrolene; Evaluation Studies as Topic; Female; Humans; Hydantoins; Male; Middle Aged; | 1973 |
220 other studies available for dantrolene and Muscle Contraction
| Article | Year |
|---|---|
Excitatory cholinergic responses in mouse primary bronchial smooth muscle require both Ca
Topics: Animals; Bronchi; Calcium; Cholinergic Agents; Dantrolene; Mice; Muscle Contraction; Muscle, Smooth; | 2023 |
The combination of dantrolene and nimodipine effectively reduces 5-HT-induced vasospasms in diabetic rats.
Topics: Animals; Calcium Channel Blockers; Dantrolene; Diabetes Mellitus, Experimental; Drug Therapy, Combin | 2021 |
A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs.
Topics: Boron Compounds; Cell Differentiation; Collagen; Creatine; CRISPR-Cas Systems; Dantrolene; Dystrophi | 2021 |
Efficient High-Throughput Screening by Endoplasmic Reticulum Ca
Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Line; Dantrolene; Endoplasmic Reticulum; | 2018 |
Malignant Hyperthermia: From the OR to the Sidelines.
Topics: Anesthesia; Animals; Caffeine; Dantrolene; Humans; Malignant Hyperthermia; Muscle Contraction; Ryano | 2018 |
Pharyngeal spasticity due to dantrolene.
Topics: Baclofen; Child; Dantrolene; Deglutition Disorders; Drug Therapy, Combination; Humans; Male; Muscle | 2014 |
Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca2+ release in rat skeletal muscle.
Topics: Animals; Calcium Signaling; Dantrolene; Drug Combinations; Drug Evaluation, Preclinical; Drugs, Chin | 2015 |
Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.
Topics: Animals; Blood Glucose; Calcium; Dantrolene; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyglucose | 2009 |
Levamisole and ryanodine receptors. I: A contraction study in Ascaris suum.
Topics: Animals; Anthelmintics; Ascaris suum; Caffeine; Calcium; Cholinergic Agonists; Dantrolene; Furylfura | 2010 |
Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles.
Topics: Animals; Caffeine; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Gluc | 2010 |
Malignant hyperthermia: presymptomatic screening and treatment 2011.
Topics: Anesthetics, Inhalation; Animals; Dantrolene; Halothane; Humans; Malignant Hyperthermia; Muscle Cont | 2011 |
Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs.
Topics: Animals; Biomarkers; Chemistry, Pharmaceutical; Dantrolene; Disease Models, Animal; Halothane; Hemod | 2011 |
Pattern of summation with fatigue and inhibition of calcium release in rat muscle.
Topics: Animals; Calcium; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Female; Models | 2011 |
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantr | 2012 |
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
Topics: Animals; Animals, Outbred Strains; Chalcone; Chalcones; Coumarins; Dantrolene; Disease Models, Anima | 2013 |
[(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle.
Topics: Animals; Biological Transport; Calcium; Dantrolene; Iodine Radioisotopes; Mice; Muscle Contraction; | 2002 |
In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus.
Topics: Acepromazine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics, Opioid; Animals; Area | 2002 |
Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle.
Topics: Animals; Calcium; Dantrolene; In Vitro Techniques; Indicators and Reagents; Mice; Muscle Contraction | 2003 |
Changes in [Ca2+]i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle.
Topics: Aminacrine; Animals; Biological Transport; Caffeine; Calcium; Dantrolene; Fura-2; Glucose; Hypoxia; | 2003 |
In vitro effects of dantrolene sodium and verapamil on noradrenaline-induced contractions of rabbit aorta and their interactions.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dantrolene; Dose-Response Relationship, Drug; In | 2002 |
Effects of modulators of sarcoplasmic Ca2+ release on the development of skeletal muscle fatigue.
Topics: Animals; Caffeine; Calcium; Cardiac Myosins; Central Nervous System Stimulants; Dantrolene; Electrop | 2004 |
Non-cross-bridge calcium-dependent stiffness in frog muscle fibers.
Topics: Animals; Calcium; Calcium Signaling; Dantrolene; Deuterium Oxide; Diacetyl; Elasticity; Gallopamil; | 2004 |
Force response to stretches in activated frog muscle fibres at low tension.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Deuterium Oxide; Gallopamil; Isometric Contr | 2003 |
[Functioning of the electromechanical connection in the course of the contracture contraction].
Topics: Acetylcholine; Animals; Biomechanical Phenomena; Calcium Channel Blockers; Dantrolene; In Vitro Tech | 2004 |
Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle.
Topics: Aminoimidazole Carboxamide; Animals; Biological Transport; Caffeine; Calcium; Calcium Channel Blocke | 2005 |
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle.
Topics: Animals; Calcium; Dantrolene; Drug Design; In Vitro Techniques; Mice; Molecular Structure; Muscle Co | 2005 |
Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.
Topics: Animals; Brain; Bronchi; Calcium; Carbachol; Cell Membrane; Cell Nucleus; Cholinergic Agonists; Dant | 2005 |
[Malignant hyperthermia--a hereditary and potentially life-threatening condition].
Topics: Adult; Dantrolene; Female; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Maligna | 2005 |
[Changes in the electromechanical activity in the course of tetanic contraction].
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Dantrolene; Electrophysiol | 2005 |
Muscle contraction accelerates IL-6 mRNA expression in the rat masseter muscle.
Topics: Animals; Carrageenan; Cyclophilin A; Dantrolene; Electric Stimulation; Inflammation Mediators; Inter | 2007 |
Dantrolene, like fatigue, has a length-dependent effect on submaximal force-length relationships of rat gastrocnemius muscle.
Topics: Animals; Calcium; Dantrolene; Electric Stimulation; Female; Isometric Contraction; Muscle Contractio | 2007 |
Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle.
Topics: Animals; Dantrolene; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Imidazoles; In Vitro Tec | 2008 |
Effects of smooth muscle calcium antagonists on human basophil histamine release.
Topics: Basophils; Calcium; Dantrolene; Gallic Acid; Gallopamil; Histamine Release; Humans; Muscle Contracti | 1981 |
Caffeine-induced blockade of neuromuscular transmission and its reversal by dantrolene sodium.
Topics: Animals; Caffeine; Calcium; Choline; Dantrolene; Electrophysiology; Extracellular Space; Female; Mal | 1982 |
Biphasic amphetamine effects on skeletal muscle contractions: noncholinergic mechanisms.
Topics: Amantadine; Animals; Dantrolene; Dextroamphetamine; In Vitro Techniques; Male; Muscle Contraction; M | 1982 |
The effect of dantrolene on tetanic potentiation of MEPP frequency in EGTA containing salines.
Topics: Animals; Dantrolene; Egtazic Acid; Electric Stimulation; Ethylene Glycols; Ion Channels; Membrane Po | 1982 |
Evidence for an inotropic positive action of cGMP during excitation-contraction coupling in frog sartorius muscle.
Topics: Animals; Calcium; Cyclic GMP; Dantrolene; Dibutyryl Cyclic GMP; Muscle Contraction; Muscles; Rana es | 1983 |
Dantrolene does not block calcium pulse-induced calcium release from a putative calcium channel in sarcoplasmic reticulum from malignant hyperthermia and normal pig muscle.
Topics: Animals; Caffeine; Calcium; Dantrolene; Halothane; Ion Channels; Malignant Hyperthermia; Muscle Cont | 1984 |
Drug therapy: spasticity (first of two parts).
Topics: Baclofen; Dantrolene; Diazepam; Humans; Motor Neurons; Muscle Contraction; Muscle Spasticity; Muscle | 1981 |
The effect of dantrolene sodium on intrafusal muscle fibres in the rat soleus muscle.
Topics: Action Potentials; Animals; Dantrolene; Female; In Vitro Techniques; Motor Neurons, Gamma; Muscle Co | 1981 |
Therapeutic approach to experimental autoimmune myasthenia gravis by dantrolene sodium.
Topics: Animals; Autoimmune Diseases; Calcium; Dantrolene; Disease Models, Animal; Female; Membrane Potentia | 1983 |
Differential properties of two charge components in frog skeletal muscle.
Topics: Animals; Dantrolene; Hypertonic Solutions; Kinetics; Membrane Potentials; Models, Biological; Muscle | 1983 |
Pharmacological studies of charge movement in frog skeletal muscle.
Topics: Animals; Dantrolene; Hypertonic Solutions; Membrane Potentials; Muscle Contraction; Muscles; Rana te | 1983 |
Comparison of birefringence signals and calcium transients in voltage-clamped cut skeletal muscle fibres of the frog.
Topics: Animals; Birefringence; Caffeine; Calcium; Dantrolene; In Vitro Techniques; Membrane Potentials; Mus | 1983 |
The development of the force-velocity relation in normal and dantrolene-treated frog single muscle fibres.
Topics: Animals; Calcium; Dantrolene; Kinetics; Muscle Contraction; Rana esculenta; Sarcoplasmic Reticulum; | 1983 |
The influence of dantrolene, diazepam, pentobarbital and 4-aminopyridine on shortening induced depression in isolated muscle fibres of the frog.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Dantrolene; Diazepam; Muscle Contraction; Muscles | 1983 |
Dantrolene dose response in awake man: implications for management of malignant hyperthermia.
Topics: Adult; Central Nervous System; Dantrolene; Female; Hand; Hemodynamics; Humans; Kinetics; Male; Malig | 1983 |
[Dantrolene sodium-induced depression of skeletal muscle tension and its antagonists].
Topics: Aminopyridines; Animals; Cevanes; Dantrolene; Germine Acetates; In Vitro Techniques; Muscle Contract | 1983 |
The action of dantrolene sodium on individual fast and slow motor units of the rat anaesthetized with urethane.
Topics: Anesthesia; Animals; Dantrolene; Hindlimb; Muscle Contraction; Rats; Rats, Inbred Strains; Reaction | 1984 |
Dantrolene--in vitro studies in malignant hyperthermia susceptible (MHS) and normal skeletal muscle.
Topics: Animals; Caffeine; Calcium; Dantrolene; Dose-Response Relationship, Drug; Drug Interactions; Humans; | 1984 |
In vivo induced malignant hyperthermia in pigs. I. Physiological and biochemical changes and the influence of dantrolene sodium.
Topics: Adenosine; Adenosine Triphosphate; Adenylate Kinase; Animals; Creatine; Dantrolene; Inosine Monophos | 1984 |
Effect of skeletal muscle relaxants on bladder smooth muscle.
Topics: Acetylcholine; Animals; Baclofen; Dantrolene; Diazepam; Humans; In Vitro Techniques; Muscle Contract | 1984 |
Action of dantrolene sodium on single motor units of cat muscle in vivo.
Topics: Action Potentials; Animals; Cats; Dantrolene; Depression, Chemical; Electric Stimulation; Motor Neur | 1983 |
Effect of dantrolene sodium in myotonic dystrophy.
Topics: Adult; Dantrolene; Electromyography; Female; Humans; Male; Middle Aged; Muscle Contraction; Myotonic | 1983 |
The control of muscle contracture by the action of dantrolene on the sarcolemma.
Topics: Animals; Caffeine; Dantrolene; Diaphragm; Dinitrophenols; Dose-Response Relationship, Drug; Halothan | 1983 |
Depressant effect of active shortening in the anterior byssus retractor muscle of Mytilus edulis.
Topics: Animals; Bivalvia; Caffeine; Culture Media; Dantrolene; Electric Stimulation; Muscle Contraction; Mu | 1983 |
[Stimulating effects of sodium dantrolene on smooth muscle organs].
Topics: Animals; Dantrolene; Dose-Response Relationship, Drug; Esophagus; Female; Guinea Pigs; Ileum; Male; | 1983 |
Screening for malignant hyperthermia susceptibility.
Topics: Caffeine; Dantrolene; Halothane; Humans; Malignant Hyperthermia; Mass Screening; Muscle Contraction; | 1980 |
Mechanism of action of dantrolene sodium, a peripherally acting muscle relaxant.
Topics: Action Potentials; Animals; Calcium; Contractile Proteins; Dantrolene; Electrophysiology; Muscle Con | 1982 |
Effect of dantrolene sodium on skeletal muscles and stretch reflexes.
Topics: Animals; Calcium; Cats; Dantrolene; Kinetics; Muscle Contraction; Muscles; Reflex, Stretch; Sarcopla | 1982 |
Study on tubular transient current and mechanical activation in skeletal muscle of frog.
Topics: Animals; Anura; Dantrolene; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscles; P | 1980 |
Effects of dantrolene sodium on the excitation-contraction coupling of the mammalian and amphibian cardiac muscle.
Topics: Action Potentials; Animals; Dantrolene; Guinea Pigs; Muscle Contraction; Muscles; Myocardial Contrac | 1980 |
Pharmacological dissection of charge movement in frog skeletal muscle fibers.
Topics: Animals; Calcium; Dantrolene; Kinetics; Movement; Muscle Contraction; Muscles; Rana temporaria; Sarc | 1982 |
Clodanolene sodium and malignant hyperpyrexia.
Topics: Animals; Dantrolene; Imidazoles; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Mu | 1982 |
A comparison of the effect of dantrolene upon the contractile response of different heart muscles and of a skeletal muscle preparation.
Topics: Animals; Anura; Cats; Dantrolene; Guinea Pigs; In Vitro Techniques; Mice; Muscle Contraction; Myocar | 1982 |
Does the sarcoplasmic reticulum achieve chemiosmotic equilibrium in relaxed muscle?
Topics: 2,4-Dinitrophenol; Anaerobiosis; Animals; Calcium; Cattle; Cyanides; Dantrolene; Dinitrophenols; Mus | 1982 |
The activation and inactivation in biphasic potassium contractures in frog single twitch muscle fibers.
Topics: Animals; Dantrolene; Dose-Response Relationship, Drug; In Vitro Techniques; Lincomycin; Muscle Contr | 1982 |
Effects of dantrolene sodium on the contractile properties of isolated guinea-pig pyeloureter.
Topics: Animals; Barium; Barium Compounds; Chlorides; Dantrolene; Drug Interactions; Female; Guinea Pigs; Hi | 1982 |
Differential effect of verapamil on noradrenaline, carbachol, tyramine and 5-hydroxytryptamine induced contractions of the rat anococcygeus muscle.
Topics: Animals; Calcium; Carbachol; Dantrolene; Drug Interactions; In Vitro Techniques; Male; Muscle Contra | 1982 |
Human malignant hyperthermia: awake episodes and correction by dantrolene.
Topics: Adenosine Triphosphate; Adult; Caffeine; Dantrolene; Fatigue; Female; Halothane; Humans; In Vitro Te | 1980 |
Effect of dantrolene sodium on the contractility of rabbit jejunum in vitro.
Topics: Animals; Caffeine; Calcium; Dantrolene; Female; In Vitro Techniques; Jejunum; Male; Muscle Contracti | 1981 |
Influence of temperature and external Ca2+ concentration upon dantrolene action on excitation-contraction coupling in frog skeletal muscle.
Topics: Animals; Calcium; Dantrolene; In Vitro Techniques; Maximum Allowable Concentration; Membrane Potenti | 1981 |
The effect of dantrolene on the enhancement and diminution of tension evoked by staircase and by tetanus in rat muscle.
Topics: Action Potentials; Animals; Dantrolene; Female; Kinetics; Male; Muscle Contraction; Muscles; Rats; R | 1981 |
Malignant hyperthermia: current perspectives.
Topics: Creatine Kinase; Dantrolene; Humans; Malignant Hyperthermia; Muscle Contraction | 1981 |
The action of dantrolene sodium on rat fast and slow muscle in vivo.
Topics: Animals; Dantrolene; Electric Stimulation; Female; Motor Neurons; Muscle Contraction; Muscle Spastic | 1981 |
Nonlinear summation of contractions in cat muscles. II. Later facilitation and stiffness changes.
Topics: Animals; Calcium; Cats; Dantrolene; Electric Stimulation; In Vitro Techniques; Muscle Contraction; M | 1981 |
Effects of dantrolene on the energetics of fast- and slow-twitch muscles of the mouse.
Topics: Animals; Body Temperature Regulation; Calcium; Dantrolene; Dose-Response Relationship, Drug; Energy | 1980 |
Absence of force-feedback regulation in soleus muscle of the decerebrate cat.
Topics: Animals; Cats; Dantrolene; Decerebrate State; Electromyography; Feedback; Mechanoreceptors; Muscle C | 1980 |
Site of the muscle cell abnormality in swine susceptible to malignant hyperpyrexia.
Topics: Acetylcholine; Animals; Caffeine; Dantrolene; Halothane; In Vitro Techniques; Malignant Hyperthermia | 1980 |
Dantrolene and caffeine contracture test.
Topics: Adult; Caffeine; Dantrolene; Female; Humans; Malignant Hyperthermia; Muscle Contraction | 1980 |
Dantrolene and caffeine contracture test.
Topics: Adult; Caffeine; Dantrolene; Female; Humans; Malignant Hyperthermia; Muscle Contraction | 1980 |
Effect of dantrolene sodium on canine bladder contractility.
Topics: Acetylcholine; Animals; Dantrolene; Dogs; Female; In Vitro Techniques; Muscle Contraction; Muscle, S | 1980 |
Reversal of dantrolene sodium-induced depression of skeletal muscle in the cat.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium Chloride; Cats; Cevanes; Dantrolene; Electromyogra | 1981 |
Biphasic potassium contractures in frog single twitch muscle fibers and effects of various agents on the contractures.
Topics: Animals; Calcium; Dantrolene; In Vitro Techniques; Lincomycin; Manganese; Muscle Contraction; Potass | 1980 |
Agonist-activated, ryanodine-sensitive, IP3-insensitive Ca2+ release channels in longitudinal muscle of intestine.
Topics: Animals; Binding, Competitive; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Da | 1994 |
Inhibitory effects of HgCl2 on excitation-secretion coupling at the motor nerve terminal and excitation-contraction coupling in the muscle cell.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Caffeine; Calcium; Dantrolene; Diaphragm; Electric Stimulat | 1994 |
Modulation of caffeine contractures in mammalian skeletal muscles by variation of extracellular potassium.
Topics: Animals; Caffeine; Dantrolene; Drug Synergism; Extracellular Space; Imidazoles; Mice; Muscle Contrac | 1995 |
Different calcium dependencies of contractile activity of prostatic and epididymal portions of rat vas deferens.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Electric Stimulation; Epididymis; Extracellu | 1995 |
Modulation of ryanodine-induced contractures in human skeletal muscle pretreated with dantrolene.
Topics: Adolescent; Adult; Calcium; Child; Dantrolene; Dose-Response Relationship, Drug; Female; Humans; Mal | 1995 |
Clinical variability of possible malignant hyperthermia as revealed by two cases.
Topics: Adolescent; Adult; Appendicitis; Combined Modality Therapy; Critical Care; Dantrolene; Heart Arrest; | 1994 |
Effect of succinylcholine, diazepam, and dantrolene on the urethral pressure profile of anesthetized, healthy, sexually intact male cats.
Topics: Anesthesia, General; Animals; Cats; Dantrolene; Diazepam; Dose-Response Relationship, Drug; Male; Mu | 1994 |
Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs.
Topics: Adenosine; Animals; Bronchodilator Agents; Caffeine; Calcium; Culture Media; Dantrolene; Diaphragm; | 1993 |
On mechanism of action of ethanol-induced contraction of frog rectus abdominis.
Topics: Acetylcholine; Animals; Dantrolene; Drug Interactions; Ethanol; Hemicholinium 3; Muscle Contraction; | 1994 |
Inhibitory effects of dantrolene on contractile responses in gastric smooth muscle of the rat.
Topics: Animals; Caffeine; Calcium; Carbachol; Dantrolene; Dose-Response Relationship, Drug; In Vitro Techni | 1994 |
Excitation-contraction uncoupling in the rat diaphragm by 2,3-butanedione monoxime.
Topics: Animals; Calcium; Dantrolene; Diacetyl; Diaphragm; Drug Synergism; Electromyography; Female; In Vitr | 1993 |
[Malignant hyperthermia. Physiologic and genetic principles].
Topics: Animals; Calcium; Dantrolene; Energy Metabolism; Humans; Malignant Hyperthermia; Muscle Contraction; | 1993 |
Species difference in modulation of calcium release by Naja naja kaouthia snake venom cardiotoxin in terminal cisternae from human and equine skeletal muscle.
Topics: Animals; Calcium; Cobra Cardiotoxin Proteins; Dantrolene; Horses; In Vitro Techniques; Muscle Contra | 1993 |
Dantrolene blocks the tonic contractions to carbachol and histamine with smaller effects on the phasic due to release of intracellular Ca2+ in ileal longitudinal muscle.
Topics: Animals; Calcium; Carbachol; Dantrolene; Guinea Pigs; Histamine Antagonists; Ileum; Male; Muscle Con | 1995 |
Dantrolene blocks the tonic contraction and calcium influx evoked by K+ in ileal longitudinal smooth muscle.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Central Nervous System Stimulants; Dantrolene; | 1996 |
Effect of modulators of tyrosine kinase activity on agonist-induced contraction in the rat pulmonary vascular smooth muscle.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Arsenicals; Calcium; Dantrolene; Enzyme Inhibito | 1996 |
Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Genetic Predisposition to Disease; | 1997 |
Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by ethanol, cocaine, and electrical stimulation in isolated fast and slow muscles of rat.
Topics: Animals; Cell Membrane Permeability; Cocaine; Creatine Kinase; Culture Techniques; Dantrolene; Elect | 1997 |
Dantrolene and "ecstasy".
Topics: Calcium; Dantrolene; Hallucinogens; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Cont | 1997 |
A surface potential change in the membranes of frog skeletal muscle is associated with excitation-contraction coupling.
Topics: Animals; Calcium; Calcium Channel Blockers; Coloring Agents; Dantrolene; Membrane Potentials; Models | 1997 |
Inhibition of Ca2+ release in rat atrophied gastrocnemius muscle.
Topics: Animals; Calcium; Dantrolene; Electric Stimulation; Female; Muscle Contraction; Muscle Relaxants, Ce | 1997 |
Calcium release from intracellular stores and excitation-contraction coupling in intestinal smooth muscle.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Carbachol; Cell Compartmentation; Cells, Cultu | 1997 |
Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway.
Topics: 3-O-Methylglucose; Androstadienes; Animals; Calcium; Dantrolene; Dibutyryl Cyclic GMP; Enzyme Inhibi | 1997 |
Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene.
Topics: Adolescent; Adult; Amphetamines; Child; Child, Preschool; Dantrolene; Humans; Malignant Hyperthermia | 1997 |
The effects of the atypical antipsychotics clozapine, remoxipride and risperidone on the contractile characteristics of rat skeletal muscle in vitro.
Topics: Animals; Antipsychotic Agents; Caffeine; Clozapine; Dantrolene; Dose-Response Relationship, Drug; Dr | 1997 |
Rhabdomyolysis after infection and taking a cold medicine in a patient who was susceptible to malignant hyperthermia.
Topics: Adult; Caffeine; Chlorpheniramine; Common Cold; Dantrolene; Halothane; Humans; In Vitro Techniques; | 1998 |
Mechanical activity is necessary for the elimination of polyneuronal innervation of developing rat soleus muscles.
Topics: Acetylcholine; Animals; Axons; Dantrolene; Electric Stimulation; Hindlimb; In Vitro Techniques; Moto | 1998 |
Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle.
Topics: Animals; Caffeine; Calcium; Chlorophenols; Cresols; Dantrolene; Electric Stimulation; Male; Membrane | 1998 |
Effects of dantrolene on the diaphragm muscle of the normal and myopathic hamster.
Topics: Animals; Cricetinae; Culture Techniques; Dantrolene; Diaphragm; Dose-Response Relationship, Drug; Me | 1998 |
Staircase in mammalian muscle without light chain phosphorylation.
Topics: Animals; Dantrolene; Female; Muscle Contraction; Muscle Relaxants, Central; Muscle, Skeletal; Muscul | 1999 |
The effects of dantrolene on the contraction, relaxation, and energetics of the diaphragm muscle.
Topics: Animals; Cricetinae; Dantrolene; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contraction; M | 1999 |
Length dependence of staircase potentiation: interactions with caffeine and dantrolene sodium.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Dantrolene; Drug Synergism; Electric Stimulati | 2000 |
Effects of dantrolene on rat diaphragm muscle during postnatal maturation.
Topics: Aging; Animals; Animals, Newborn; Biomechanical Phenomena; Dantrolene; Diaphragm; Muscle Contraction | 2001 |
Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers.
Topics: Animals; Calcium; Calcium Channels, L-Type; Dantrolene; Dose-Response Relationship, Drug; Female; In | 2001 |
Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres.
Topics: Animals; Calcium; Clofibric Acid; Dantrolene; Dose-Response Relationship, Drug; In Vitro Techniques; | 2001 |
Oxygen uptake of canine whole body and hind limb with hypocapnic alkalosis.
Topics: Alkalosis; Animals; Blood; Calcium; Calcium Chloride; Carbon Dioxide; Citrates; Dantrolene; Dogs; El | 1977 |
Some antagonists of dantrolene sodium on the isolated diaphragm muscle of the rat.
Topics: Animals; Caffeine; Calcimycin; Dantrolene; Diaphragm; Electric Stimulation; Epinephrine; Female; Hyd | 1977 |
Effects of dantrolene sodium on isolated skeletal, smooth and cardiac muscle of the guinea-pig.
Topics: Animals; Dantrolene; Guinea Pigs; Hydantoins; In Vitro Techniques; Muscle Contraction; Muscle, Smoot | 1977 |
Effects of verapamil on excitation-contraction coupling in frog sartorius muscle.
Topics: Animals; Anura; Caffeine; Calcium; Dantrolene; Drug Interactions; Electric Stimulation; Hydrogen-Ion | 1978 |
Proceedings: Effect of dantrolene sodium on skeletal muscle contractions.
Topics: Aequorin; Animals; Anura; Biological Transport, Active; Calcium; Calcium Radioisotopes; Contracture; | 1975 |
Effect of dantrolene sodium on excitation-contraction coupling in frog skeletal muscle.
Topics: Action Potentials; Adenosine Triphosphatases; Animals; Caffeine; Calcium; Dantrolene; Hydantoins; In | 1975 |
Action of dantrolene sodium in spasticity with low dependence on fusimotor drive.
Topics: Adult; Aged; Dantrolene; Drug Evaluation; Female; Humans; Hydantoins; Male; Middle Aged; Motor Activ | 1976 |
Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dantrolene; Electroshock; Gallamine Triethiodide; Hindlimb | 1976 |
Dissociation of excitation and contraction in skeletal muscle induced by deuterium oxide and dantrolene-sodium.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Anura; Caffeine; Calcium; Dantrolene; De | 1977 |
The mechanism of neuromuscular fatigue. A study of mammalian muscle using excitation-contraction uncoupling.
Topics: Action Potentials; Animals; Dantrolene; Electric Stimulation; Glycerol; Methods; Muscle Contraction; | 1975 |
Excitation-contraction uncoupling. The effect of hyperosomolar glycerol solution and antrolene sodium on mammalian muscle in vitro.
Topics: Action Potentials; Animals; Dantrolene; Diaphragm; Dose-Response Relationship, Drug; Glycerol; Hydan | 1975 |
Effects of 4-aminopyridine on the excitation-contraction coupling in frog and rat skeletal muscle.
Topics: Action Potentials; Aminopyridines; Animals; Anura; Caffeine; Dantrolene; Electric Stimulation; Membr | 1979 |
Calcium movements in relation to muscle contraction.
Topics: Animals; Anura; Calcium; Dantrolene; In Vitro Techniques; Light; Muscle Contraction; Muscles; Rana t | 1979 |
The mechanism of action of dantrolene sodium.
Topics: Animals; Anura; Biomechanical Phenomena; Calcimycin; Dantrolene; Drug Interactions; Electric Stimula | 1977 |
Excitation-contraction coupling in single muscle fibers and the calcium channel in sarcoplasmic reticulum.
Topics: Animals; Calcimycin; Calcium; Dantrolene; Electric Stimulation; In Vitro Techniques; Ion Channels; M | 1978 |
Dantrolene and A13187 ionophore: specific action on calcium channels revealed by the aequorin method.
Topics: Aequorin; Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Cytosol; Dantrolene; Hydantoins; In V | 1979 |
The effect of dantrolene sodium on rat skeletal muscle in relation to the plasma concentration.
Topics: Animals; Dantrolene; Dose-Response Relationship, Drug; Half-Life; Hydantoins; Kinetics; Male; Muscle | 1979 |
Rationale for dantrolene vs. procainamide for treatment of malignant hyperthermia.
Topics: Animals; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Halothane; Hy | 1979 |
Effects of dantrolene sodium on respiratory and other muscles and on respiratory parameters in the anaesthetised cat.
Topics: Acetylcholine; Airway Resistance; Animals; Cats; Dantrolene; Diaphragm; Female; Hydantoins; Lung Com | 1979 |
Malignant hyperthermia. A potentially fatal syndrome in orthopaedic patients.
Topics: Adult; Animals; Child, Preschool; Dantrolene; Female; Genes, Dominant; Humans; Male; Malignant Hyper | 1979 |
A screening test for the malignant hyperpyrexia phenotype using suxamethonium-induced contracture of muscle treated with caffeine and its inhibition by dantrolene.
Topics: Adolescent; Adult; Caffeine; Child; Dantrolene; Drug Synergism; Humans; Malignant Hyperthermia; Midd | 1979 |
Relationship between plasma concentration and effect of dantrolene sodium in man.
Topics: Adult; Dantrolene; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Male; Muscle Con | 1979 |
Does prior dantrolene affect the in vitro diagnosis of malignant hyperthermia susceptibility?
Topics: Animals; Biopsy; Caffeine; Dantrolene; Drug Interactions; Halothane; In Vitro Techniques; Malignant | 1979 |
[Simulation of K-contracture curve in smooth muscle (author's transl)].
Topics: Animals; Calcium; Colon; Dantrolene; Female; Guinea Pigs; In Vitro Techniques; Male; Models, Biologi | 1979 |
[The effect of sodium dantrolene on the detrusor urinae muscle of the bladder isolated from guinea pigs].
Topics: Acetylcholine; Animals; Dantrolene; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; | 1979 |
Effect of dantrolene sodium on muscle contraction.
Topics: Adolescent; Adult; Dantrolene; Humans; Hydantoins; Muscle Contraction; Paraplegia | 1977 |
Inhibitory action of dantrolene sodium on the activation of excitation-contraction coupling in frog skeletal muscle.
Topics: Animals; Anura; Calcium; Dantrolene; Hydantoins; In Vitro Techniques; Muscle Contraction; Muscles; P | 1977 |
Effect of dantrolene sodium on the inactivation of excitation-contraction coupling in frog skeletal muscle.
Topics: Animals; Anura; Calcium; Dantrolene; Hydantoins; In Vitro Techniques; Muscle Contraction; Muscle Rel | 1977 |
Dantrolene sodium: effects on smooth muscle.
Topics: Animals; Calcium; Dantrolene; Guinea Pigs; Hydantoins; Ileum; In Vitro Techniques; Male; Muscle Cont | 1978 |
The effects of glycerol detubulation, of manganese ions, of dantrolene and of nitrate ions on the responses of isolated chronically denervated soleus muscles of the mouse to acetylcholine.
Topics: Acetylcholine; Animals; Dantrolene; Drug Interactions; Glycerol; Hydantoins; In Vitro Techniques; Ma | 1978 |
Reversible effect of dantrolene sodium on twitch tension of rat skeletal muscle.
Topics: Animals; Dantrolene; Hydantoins; In Vitro Techniques; Muscle Contraction; Rats; Time Factors | 1978 |
[Contraction-relaxation properties of experimental denervated and immobilized muscle: comparison with dystrophic muscle (author's transl)].
Topics: Action Potentials; Animals; Caffeine; Dantrolene; Humans; Immobilization; In Vitro Techniques; Isopr | 1978 |
Transient effect of intracellular dantrolene on E--C coupling in skeletal muscle.
Topics: Action Potentials; Animals; Anura; Calcium; Dantrolene; Hydantoins; In Vitro Techniques; Membrane Po | 1978 |
Latency-relaxation in single muscle fibres.
Topics: Animals; Caffeine; Calcium; Dantrolene; Deuterium; In Vitro Techniques; Membrane Potentials; Muscle | 1978 |
Relief of myotonia by dantrolene in experimental myotonia.
Topics: Animals; Dantrolene; Disease Models, Animal; Hydantoins; Male; Muscle Contraction; Muscle Relaxation | 1978 |
A comparison of the effects of sodium thiocyanate and dantrolene sodium on a mammalian isolated skeletal muscle.
Topics: Animals; Caffeine; Dantrolene; Electric Stimulation; Female; Hydantoins; Male; Mice; Mice, Inbred BA | 1977 |
Dantrium--torque induced motion ("TIM"). Analysis in normal subjects.
Topics: Adult; Dantrolene; Female; Humans; Hydantoins; Male; Muscle Contraction; Muscle Spasticity | 1977 |
Drug treatment of malignant hyperpyrexia.
Topics: Caffeine; Calcium; Dantrolene; Humans; Hydantoins; Malignant Hyperthermia; Muscle Contraction; Muscl | 1977 |
[Effects of dantrolene sodium on some types of visceral muscles (author's transl)].
Topics: Animals; Caffeine; Colon; Dantrolene; Electric Stimulation; Esophagus; Guinea Pigs; Hydantoins; In V | 1977 |
Effect of dantrolene sodium on excitation-contraction coupling of frog toe muscle.
Topics: Animals; Caffeine; Cold Temperature; Dantrolene; Electric Stimulation; Electrophysiology; Hydantoins | 1976 |
Effect of dantrolene sodium upon the activity of the hind leg muscle of the cat with local tetanus.
Topics: Action Potentials; Animals; Cats; Dantrolene; Hindlimb; Hydantoins; Motor Neurons; Muscle Contractio | 1976 |
The effects of dantrolene sodium on cardiac and skeletal muscle in rats.
Topics: Animals; Dantrolene; Depression, Chemical; Diaphragm; Electric Stimulation; Female; Heart Rate; Hyda | 1976 |
Effects of intravenous dantrolene sodium on respiratory and cardiovascular functions.
Topics: Animals; Blood Pressure; Body Temperature; Dantrolene; Depression, Chemical; Dogs; Female; Heart Rat | 1976 |
Electron microscopic studies of the T-system--the effects of hyperosmolar glycerol and dantrolene sodium on mammalian muscles.
Topics: Animals; Dantrolene; Glycerol; Hydantoins; In Vitro Techniques; Muscle Contraction; Muscles; Rats; S | 1976 |
A comparison of skeletal, cardiac, and smooth muscle actions of dantrolene sodium--a skeletal muscle relaxant.
Topics: Animals; Dantrolene; Dogs; Electric Stimulation; Hemodynamics; Hydantoins; In Vitro Techniques; Male | 1976 |
Letter: Dantrolene sodium and "skinned" muscle fibres.
Topics: Animals; Anura; Calcium; Dantrolene; Hydantoins; Muscle Contraction; Muscles | 1975 |
5-chloro-2-pyrimidinyl analog of dantrolene.
Topics: Animals; Chlorine; Dantrolene; Dose-Response Relationship, Drug; Hydantoins; In Vitro Techniques; Mi | 1975 |
The effect of dantrium on spasticity of hemiplegic patients.
Topics: Adolescent; Adult; Aged; Dantrolene; Drug Evaluation; Hemiplegia; Humans; Hydantoins; Middle Aged; M | 1975 |
Positional isomer of the muscle relaxant dantrolene.
Topics: Animals; Dantrolene; Dose-Response Relationship, Drug; Hydantoins; Muscle Contraction; Muscle Relaxa | 1975 |
The effect of Dantrium on spasticity in spinal cord injuries.
Topics: Administration, Oral; Adult; Dantrolene; Disability Evaluation; Electromyography; Humans; Hydantoins | 1975 |
Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle.
Topics: Animals; Caffeine; Calcium; Contracture; Dantrolene; Halothane; Hydantoins; In Vitro Techniques; Mal | 1976 |
W-7, a calmodulin antagonist, and contracture of malignant hyperthermia susceptible skeletal muscle.
Topics: Animals; Caffeine; Calcium; Calmodulin; Dantrolene; Drug Synergism; Halothane; Intercellular Signali | 1992 |
Partial inhibition of skeletal muscle contraction by dantrolene sodium and its modification with perchlorate and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Dantrolene sodium and fatigue of long duration.
Topics: Adult; Aged; Calcium; Dantrolene; Electromyography; Exercise; Female; Humans; Male; Middle Aged; Mus | 1992 |
Separate sites for the dantrolene-induced inhibition of contracture of the rat diaphragm preparation due to depolarization or to caffeine.
Topics: Animals; Caffeine; Dantrolene; Diaphragm; Dicumarol; Drug Interactions; Drug Synergism; Ethylmaleimi | 1991 |
[In vitro diagnosis of malignant hyperpyrexia syndrome].
Topics: Adult; Caffeine; Dantrolene; Female; Halothane; Hernia, Inguinal; Humans; In Vitro Techniques; Male; | 1991 |
The effect of azumolene on hypercontractility and sarcoplasmic reticulum Ca(2+)-dependent ATPase activity of malignant hyperpyrexia-susceptible porcine skeletal muscle.
Topics: Animals; Caffeine; Calcium-Transporting ATPases; Dantrolene; Halothane; Imidazoles; Malignant Hypert | 1991 |
Skeletal muscle staircase response with fatigue or dantrolene sodium.
Topics: Analysis of Variance; Animals; Calcium Channels; Dantrolene; Female; Muscle Contraction; Muscles; My | 1991 |
Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea.
Topics: Acetylcholine; Albuterol; Animals; Caffeine; Calcium; Dantrolene; Female; Guinea Pigs; Indomethacin; | 1991 |
[Condition to produce oscillation after twitch shortening in the bullfrog geniohyoid muscle].
Topics: Animals; Caffeine; Dantrolene; Elasticity; Microbial Collagenase; Muscle Contraction; Neck Muscles; | 1990 |
Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction.
Topics: 3-O-Methylglucose; Adenosine Triphosphate; Aminacrine; Animals; Biological Transport, Active; Caffei | 1991 |
Malignant hyperthermia in dogs.
Topics: Animals; Biopsy; Caffeine; Crosses, Genetic; Dantrolene; Dog Diseases; Dogs; Female; Halothane; Hear | 1991 |
Multiple-pulse stimulation and dantrolene in malignant hyperthermia.
Topics: Adult; Dantrolene; Disease Susceptibility; Electric Stimulation; Electromyography; Female; Humans; L | 1990 |
Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro.
Topics: Animals; Caffeine; Calcium; Chloroquine; Dantrolene; Diaphragm; Electric Stimulation; Female; In Vit | 1990 |
Effect of dantrolene sodium in isolated guinea-pig trachea.
Topics: Acetylcholine; Animals; Caffeine; Calcium Chloride; Cell Membrane; Dantrolene; Female; Guinea Pigs; | 1990 |
Inhibitory action of dantrolene on Ca-induced Ca2+ release from sarcoplasmic reticulum in guinea pig skeletal muscle.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Caffeine; Calcium; Cold Temperature; Dantrolen | 1990 |
[Malignant neuroleptic syndrome and malignant hyperthermia--a comparison].
Topics: Adult; Amantadine; Bromocriptine; Calcium; Cross-Sectional Studies; Dantrolene; Female; Humans; Ion | 1986 |
Effects of new 4-aminopyridine derivatives on neuromuscular transmission and on smooth muscle contractility.
Topics: Aminopyridines; Animals; Botulinum Toxins; Chemical Phenomena; Chemistry, Physical; Dantrolene; Guin | 1989 |
Effects of the sulphydryl inhibitor N-ethyl-maleimide on the phrenic nerve and diaphragm muscle of the rat.
Topics: Action Potentials; Animals; Calcium; Dantrolene; Diaphragm; Electric Stimulation; Ethylmaleimide; Fe | 1989 |
Myosin light chain phosphorylation and tension potentiation in mouse skeletal muscle.
Topics: Animals; Chemical Phenomena; Chemistry; Dantrolene; Electric Stimulation; Female; Isometric Contract | 1989 |
Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle.
Topics: Caffeine; Dantrolene; Diltiazem; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Mal | 1989 |
Malignant hyperthermia: effects of halothane on the surface membrane.
Topics: Action Potentials; Animals; Dantrolene; Halothane; Malignant Hyperthermia; Membrane Potentials; Musc | 1989 |
Effect of diltiazem and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible porcine skeletal muscle.
Topics: Animals; Caffeine; Dantrolene; Diltiazem; Dose-Response Relationship, Drug; Halothane; In Vitro Tech | 1989 |
Dependency of histamine induced phasic and tonic contractions on intracellular and extracellular calcium in guinea pig tracheal smooth muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Dantrolene; Guinea Pigs; Histamine; In Vitro Techniques; | 1989 |
The effects of fructose 1,6-diphosphate, caffeine and dantrolene sodium on suxamethonium-induced contractures in denervated rat skeletal muscle.
Topics: Animals; Caffeine; Dantrolene; Female; Fructosediphosphates; Hexosediphosphates; Muscle Contraction; | 1988 |
The spasmogenic effect of caffeine in trachealis isolated from control and actively sensitized guinea-pigs.
Topics: Animals; Caffeine; Calcium; Dantrolene; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, | 1988 |
Contracture induction by snake venom cardiotoxin in skeletal muscle from humans and rats.
Topics: Animals; Calcium; Cobra Cardiotoxin Proteins; Culture Media; Dantrolene; Dose-Response Relationship, | 1987 |
Similar inhibitory effects of dantrolene sodium on twitch tension and on silver ion-induced contracture in skeletal muscle.
Topics: Animals; Caffeine; Dantrolene; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle | 1987 |
Contractile inactivation in frog skeletal muscle fibers. The effects of low calcium, tetracaine, dantrolene, D-600, and nifedipine.
Topics: Animals; Calcium; Dantrolene; Gallopamil; Membrane Potentials; Muscle Contraction; Muscles; Nifedipi | 1987 |
Effect of antispastic drugs on rapid force generation of spastic muscle.
Topics: Adult; Aged; Baclofen; Dantrolene; Electromyography; Hemiplegia; Humans; Male; Middle Aged; Muscle C | 1986 |
Comparison of the skeletal muscle relaxant properties of Portulaca oleracea extracts with dantrolene sodium and methoxyverapamil.
Topics: Animals; Caffeine; Dantrolene; Gallopamil; In Vitro Techniques; Muscle Contraction; Neuromuscular De | 1987 |
Effects of dantrolene on force development in slow- and fast-twitch muscle of euthyroid, hypothyroid, and hyperthyroid rats.
Topics: Animals; Dantrolene; Electric Stimulation; Hyperthyroidism; Hypothyroidism; Male; Muscle Contraction | 1987 |
Use of dantrolene plus multiple pulses to detect stress-susceptible porcine muscle.
Topics: Animals; Calcium; Dantrolene; Electric Stimulation; Malignant Hyperthermia; Muscle Contraction; Musc | 1986 |
Halothane-cooling contractures of mammalian muscles.
Topics: Anesthetics, Local; Animals; Caffeine; Calcium; Cold Temperature; Dantrolene; Dose-Response Relation | 1986 |
Physiological and ultrastructural studies on the mechanism of stretch-induced contractile activation in rabbit cerebral artery smooth muscle.
Topics: Animals; Biomechanical Phenomena; Calcium; Calcium Channel Blockers; Cerebral Arteries; Dantrolene; | 1986 |
In vitro muscle contractures induced by halothane and suxamethonium. I: The rat diaphragm.
Topics: Animals; Dantrolene; Diaphragm; Drug Synergism; Halothane; In Vitro Techniques; Indomethacin; Male; | 1986 |
Effects of dantrolene and verapamil on atrioventricular conduction and cardiovascular performance in dogs.
Topics: Animals; Dantrolene; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Heart Conduction System | 1986 |
In vitro responses of cat skeletal muscle to halothane and caffeine.
Topics: Animals; Caffeine; Cats; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Halotha | 1985 |
Verapamil is not a therapeutic adjunct to dantrolene in porcine malignant hyperthermia.
Topics: Anesthesia, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Dantrolene; Drug Synergism; Hal | 1985 |
Rapid cooling contracture in frog striated muscles treated with chlorpromazine and haloperidol.
Topics: Animals; Caffeine; Chlorpromazine; Cold Temperature; Dantrolene; Haloperidol; Muscle Contraction; Mu | 1985 |
Modification by dantrolene, procaine and suxamethonium of caffeine-induced changes in aequorin luminescence transients and twitch tensions of directly-stimulated diaphragm muscle of mouse.
Topics: Aequorin; Animals; Caffeine; Calcium; Dantrolene; Diaphragm; Drug Interactions; Electric Stimulation | 1985 |
[Determination of intracellular free calcium concentration, in vivo, in swine susceptible to malignant hyperthermia syndrome].
Topics: Animals; Calcium; Dantrolene; Halothane; Malignant Hyperthermia; Membrane Potentials; Muscle Contrac | 1985 |
Mechanism of control of skeletal-muscle contraction by dantrolene sodium.
Topics: Action Potentials; Administration, Oral; Animals; Anura; Binding Sites; Caffeine; Calcium; Cats; Dan | 1974 |
Dantrolene sodium: effects on crustacean muscle.
Topics: Animals; Axons; Brachyura; Dantrolene; Electric Conductivity; Electric Stimulation; In Vitro Techniq | 1974 |
Site of action of dantrolene in frog sartorius muscle.
Topics: Acetates; Analysis of Variance; Animals; Anura; Caffeine; Calcium; Calcium Radioisotopes; Chelating | 1974 |
Effect of dantrolene sodium on calcium movements in single muscle fibres.
Topics: Animals; Calcium; Dantrolene; Electric Stimulation; Ethylene Glycols; Evoked Potentials; In Vitro Te | 1974 |
Dantrolene, a direct acting skeletal muscle relaxant.
Topics: Animals; Blood Pressure; Cats; Cholinesterase Inhibitors; Dantrolene; Decamethonium Compounds; Dogs; | 1973 |
A quantitative electromyographic study of the effects of dantrolene sodium on skeletal muscle in normal subjects.
Topics: Action Potentials; Administration, Oral; Dantrolene; Electromyography; Humans; Hydantoins; Male; Mus | 1974 |
A comparative study of dantrolene sodium and other skeletal muscle relaxants with the Straub tail mouse.
Topics: Anesthetics, Local; Animals; Chlordiazepoxide; Chlorpromazine; Dantrolene; Diazepam; Gallamine Triet | 1974 |
Dantrolene sodium for treatment of spasticity.
Topics: Dantrolene; Humans; Hydantoins; Muscle Contraction; Muscle Relaxants, Central; Muscle Spasticity | 1974 |
Dantrolene sodium: its effect on extrafusal muscle fibers.
Topics: Animals; Ankle Joint; Calcium; Cats; Dantrolene; Electromyography; Electrophysiology; Femur; Humans; | 1974 |