dantrolene has been researched along with Metabolic Acidosis in 14 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant hyperthermia is defined in the International Classification of Diseases as a progressive life-threatening hyperthermic reaction occurring during general anaesthesia." | 1.62 | Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists. ( Dalay, S; Girard, T; Hopkins, PM; Jenkins, B; McGrady, E; Patteril, M; Thacker, A, 2021) |
| "After achieving predefined malignant hyperthermia criteria, standardised therapy was initiated; dantrolene sodium suspension (5 mg kg(-1)) was administered and the injection was repeated after 24 min." | 1.39 | 3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia. ( Becker, S; Gerbershagen, MU; Oldewurtel, C; Richard, A; Schäfer, U; Schütte, JK; Singler, P; Starosse, A; Wappler, F, 2013) |
| "The type and mechanisms of these arrhythmias have never been explored and were the aim of the present work." | 1.35 | Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II. ( Becerra, R; Copello, JA; Dedman, JR; Diaz-Sylvester, PL; Kaetzel, MA; Mattiazzi, A; Mundiña-Weilenmann, C; Palomeque, J; Rinaldi, G; Said, M; Vittone, L, 2008) |
| "Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions." | 1.32 | Is there a link between malignant hyperthermia and exertional heat illness? ( Brandom, B; Bunger, R; Deuster, P; Muldoon, S, 2004) |
| "The true incidence of malignant hyperthermia is unknown, but the frequency has been estimated as high as 1/14,000 anesthetic events." | 1.26 | Malignant hyperthermia. ( Nissen, RL; Yonkers, AJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Hopkins, PM | 1 |
| Girard, T | 1 |
| Dalay, S | 1 |
| Jenkins, B | 1 |
| Thacker, A | 1 |
| Patteril, M | 1 |
| McGrady, E | 1 |
| Tran, L | 1 |
| Athiraman, U | 1 |
| Rich, KM | 1 |
| Tempelhoff, R | 1 |
| Said, M | 1 |
| Becerra, R | 1 |
| Palomeque, J | 1 |
| Rinaldi, G | 1 |
| Kaetzel, MA | 1 |
| Diaz-Sylvester, PL | 1 |
| Copello, JA | 1 |
| Dedman, JR | 1 |
| Mundiña-Weilenmann, C | 1 |
| Vittone, L | 1 |
| Mattiazzi, A | 1 |
| Schütte, JK | 1 |
| Schäfer, U | 1 |
| Becker, S | 1 |
| Oldewurtel, C | 1 |
| Starosse, A | 1 |
| Singler, P | 1 |
| Richard, A | 1 |
| Wappler, F | 1 |
| Gerbershagen, MU | 1 |
| Muldoon, S | 1 |
| Deuster, P | 1 |
| Brandom, B | 1 |
| Bunger, R | 1 |
| Nissen, RL | 1 |
| Yonkers, AJ | 1 |
| Schulte-Sasse, U | 1 |
| Eberlein, HJ | 1 |
| Mayzner-Zawadzka, E | 1 |
| Neff, SP | 1 |
| Futter, ME | 1 |
| Anderson, BJ | 1 |
| Pollock, AN | 1 |
| McKenzie, AJ | 1 |
| Hodges, M | 1 |
| Snoeck, MM | 1 |
| Gronert, GA | 1 |
| Milde, JH | 1 |
| Theye, RA | 1 |
| Kaukonen, L | 1 |
| Hoffman, RS | 1 |
| Harioka, T | 1 |
| Sone, T | 1 |
| Toda, H | 1 |
| Miyake, C | 1 |
2 reviews available for dantrolene and Metabolic Acidosis
| Article | Year |
|---|---|
[Malignant hyperthermia].
Topics: Acidosis; Anesthesia, Inhalation; Anesthetics; Body Temperature Regulation; Calcium; Cell Membrane P | 1983 |
[Experimental malignant hyperthermia].
Topics: Acidosis; Animals; Calcium; Cell Membrane Permeability; Dantrolene; Malignant Hyperthermia; Muscles; | 1980 |
12 other studies available for dantrolene and Metabolic Acidosis
| Article | Year |
|---|---|
Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists.
Topics: Acidosis; Body Temperature; Calcium; Carbon Dioxide; Compartment Syndromes; Dantrolene; Disseminated | 2021 |
Hyperventilation, Sympathetic and Metabolic Derangements After Endoscopic Third Ventriculostomy.
Topics: Acidosis; Adult; Antihypertensive Agents; Blood Pressure; Dantrolene; Diagnosis, Differential; Endos | 2017 |
JSA guideline for the management of malignant hyperthermia crisis 2016.
Topics: Acidosis; Anesthetics, Inhalation; Body Temperature; Calcium; Carbon Dioxide; Dantrolene; Humans; Hy | 2017 |
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Topics: Acidosis; Action Potentials; Animals; Arrhythmias, Cardiac; Benzylamines; Calcium; Calcium-Binding P | 2008 |
3,4-Methylenedioxymethamphetamine induces a hyperthermic and hypermetabolic crisis in pigs with and without a genetic disposition for malignant hyperthermia.
Topics: Acidosis; Animals; Dantrolene; Fatty Acids, Nonesterified; Fever; Genetic Predisposition to Disease; | 2013 |
Is there a link between malignant hyperthermia and exertional heat illness?
Topics: Acidosis; Adolescent; Child; Dantrolene; Fatal Outcome; Genetic Predisposition to Disease; Heat Exha | 2004 |
Malignant hyperthermia.
Topics: Acidosis; Bicarbonates; Calcium; Creatine Kinase; Dantrolene; Diuretics; Fever; Humans; Malignant Hy | 1982 |
Fatal outcome after propofol sedation in children.
Topics: Acidosis; Arrhythmias, Cardiac; Cardiac Output, Low; Cause of Death; Child; Creatine Kinase; Dantrol | 1997 |
Propofol and malignant hyperthermia susceptibility.
Topics: Acidosis; Adolescent; Adult; Aged; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cause of Death; C | 1997 |
Role of sympathetic activity in porcine malignant hyperthermia.
Topics: Acidosis; Acidosis, Respiratory; Anesthesia, Conduction; Anesthesia, Spinal; Animals; Catecholamines | 1977 |
Cocaine.
Topics: Acidosis; Ammonium Chloride; Bicarbonates; Cocaine; Dantrolene; Humans; Malignant Hyperthermia; Rhab | 1990 |
Malignant hyperthermia in a hemodialysis patient.
Topics: Acidosis; Dantrolene; Female; Humans; Hyperkalemia; Intraoperative Complications; Malignant Hyperthe | 1989 |