dantrolene has been researched along with Lassitude in 6 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene sodium is a valuable tool in the management of spasticity due to hemiplegia." | 5.25 | Effect of dantrolene sodium on spasticity associated with hemiplegia. ( Ferguson, KL; Steinberg, FU, 1975) |
| "Five patients with McArdle's disease entered a double-blind, placebo-controlled, cross-over study of dantrolene sodium." | 2.67 | Dantrolene sodium does influence the second-wind phenomenon in McArdle's disease. Electrophysiological evidence during exercise in a double-blind placebo-controlled, cross-over study in 5 patients. ( Braakhekke, JP; Joosten, EM; Poels, PJ; Stegeman, DF, 1990) |
| "Baclofen is the treatment of choice for spasticity and is usually given in doses of 30 to 80 mg/day, although higher doses may be used." | 2.37 | Multiple sclerosis. Current concepts in management. ( Giesser, B, 1985) |
| "Dantrolene median dose was 50 (25-400) and 200 (25-400) mg·day -1 in responders and nonresponders, respectively." | 1.91 | Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability. ( Ibarra Moreno, CA; Jungbluth, H; Kraeva, N; Riazi, S; Voermans, NC; Zvaritch, E, 2023) |
| "Dantrolene (3 mg/kg) was administered slowly into an antecubital vein, and blood samples were withdrawn from the other arm at 5 and 25 minutes after infusion." | 1.29 | Clinical effects of intravenously administered dantrolene. ( Iaizzo, PA; Quinlan, JG; Wedel, DJ, 1995) |
| "Dantrolene sodium is a valuable tool in the management of spasticity due to hemiplegia." | 1.25 | Effect of dantrolene sodium on spasticity associated with hemiplegia. ( Ferguson, KL; Steinberg, FU, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ibarra Moreno, CA | 1 |
| Kraeva, N | 1 |
| Zvaritch, E | 1 |
| Jungbluth, H | 1 |
| Voermans, NC | 1 |
| Riazi, S | 1 |
| Gronert, GA | 1 |
| Thompson, RL | 1 |
| Onofrio, BM | 1 |
| Wedel, DJ | 1 |
| Quinlan, JG | 1 |
| Iaizzo, PA | 1 |
| Steinberg, FU | 1 |
| Ferguson, KL | 1 |
| Poels, PJ | 1 |
| Braakhekke, JP | 1 |
| Joosten, EM | 1 |
| Stegeman, DF | 1 |
| Giesser, B | 1 |
1 review available for dantrolene and Lassitude
| Article | Year |
|---|---|
Multiple sclerosis. Current concepts in management.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Baclofen; Dantrolene; Fatigue; Gastrointestina | 1985 |
1 trial available for dantrolene and Lassitude
| Article | Year |
|---|---|
Dantrolene sodium does influence the second-wind phenomenon in McArdle's disease. Electrophysiological evidence during exercise in a double-blind placebo-controlled, cross-over study in 5 patients.
Topics: Adult; Creatine Kinase; Dantrolene; Double-Blind Method; Electromyography; Exercise Test; Fatigue; F | 1990 |
4 other studies available for dantrolene and Lassitude
| Article | Year |
|---|---|
Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability.
Topics: Dantrolene; Drug-Related Side Effects and Adverse Reactions; Fatigue; Halothane; Humans; Malignant H | 2023 |
Human malignant hyperthermia: awake episodes and correction by dantrolene.
Topics: Adenosine Triphosphate; Adult; Caffeine; Dantrolene; Fatigue; Female; Halothane; Humans; In Vitro Te | 1980 |
Clinical effects of intravenously administered dantrolene.
Topics: Adult; Dantrolene; Dizziness; Fatigue; Female; Humans; Infusions, Intravenous; Male; Malignant Hyper | 1995 |
Effect of dantrolene sodium on spasticity associated with hemiplegia.
Topics: Adult; Aged; Dantrolene; Fatigue; Follow-Up Studies; Gait; Hemiplegia; Humans; Hydantoins; Middle Ag | 1975 |