dantrolene has been researched along with Ischemic Attack, Transient in 5 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene." | 1.31 | Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. ( Kindy, MS; Mattson, MP; Yu, J; Zhu, H, 2000) |
| "Dantrolene has been shown to block the increase in free intracellular calcium ion stimulated by either NMDA or glutamate." | 1.29 | [Effects of dantrolene on histological and behavioral outcome in rat CA1 hippocampus after global transient cerebral ischemia]. ( Kamiyama, Y; Shiraishi, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Djuricic, B | 1 |
| Röhn, G | 1 |
| Paschen, W | 1 |
| Hossmann, KA | 1 |
| Shiraishi, M | 1 |
| Kamiyama, Y | 1 |
| Zhang, L | 1 |
| Andou, Y | 1 |
| Masuda, S | 1 |
| Mitani, A | 1 |
| Kataoka, K | 1 |
| Mattson, MP | 1 |
| Zhu, H | 1 |
| Yu, J | 1 |
| Kindy, MS | 1 |
| Nakayama, R | 1 |
| Yano, T | 1 |
| Ushijima, K | 1 |
| Abe, E | 1 |
| Terasaki, H | 1 |
5 other studies available for dantrolene and Ischemic Attack, Transient
| Article | Year |
|---|---|
Calcium activity and post-ischemic suppression of protein synthesis.
Topics: Animals; Calcimycin; Calcium; Dantrolene; Female; Hippocampus; In Vitro Techniques; Ischemic Attack, | 1995 |
[Effects of dantrolene on histological and behavioral outcome in rat CA1 hippocampus after global transient cerebral ischemia].
Topics: Animals; Dantrolene; Hippocampus; Ischemic Attack, Transient; Male; Rats; Rats, Sprague-Dawley | 1995 |
Dantrolene protects against ischemic, delayed neuronal death in gerbil brain.
Topics: Animals; Brain; Carotid Arteries; Cell Death; Dantrolene; Gerbillinae; Hippocampus; Injections, Intr | 1993 |
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
Topics: Alzheimer Disease; Animals; Apoptosis; Blood Pressure; Calcium; Carbon Dioxide; Cell Hypoxia; Cells, | 2000 |
Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia.
Topics: Animals; Cell Death; Dantrolene; Dimethyl Sulfoxide; Extracellular Space; Glutamic Acid; Hippocampus | 2002 |