dantrolene has been researched along with Injuries, Spinal Cord in 24 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe a new case of eosinophilic pleural effusion induced by dantrolene chronic administration." | 8.82 | Dantrolene and pleural effusion: case report and review of literature. ( Calmels, P; Fayolle-Minon, I; Gautheron, V; Lê-Quang, B; Valayer-Chaléat, E, 2004) |
| "To describe a new case of eosinophilic pleural effusion induced by dantrolene chronic administration." | 4.82 | Dantrolene and pleural effusion: case report and review of literature. ( Calmels, P; Fayolle-Minon, I; Gautheron, V; Lê-Quang, B; Valayer-Chaléat, E, 2004) |
| "Forty patients, whose ages varied from 4 to 65 years, presenting skeletal muscle spascitiy as sequel of cerebral palsy, spinovertebral trauma and cerebral vascular diseases were treated with Dantrium (dantrolene sodium), a drug muscle relaxing." | 3.65 | [Sodium dantrolene (dantrium) in the treatment of neurogenic muscular spasm]. ( Alvarenga, H; Araújo Leitão, RE; Couto, B; Figuereido, HB; Gomes Marleide, M; Melo Reis, CH, 1976) |
| "In the groups with spinal cord trauma, the positive control group (PC) was given no treatment, the MS group was treated with methylprednisolone, the MS/DS group was treated with methylprednisolone and dantrolene, and the DS group was treated with dantrolene alone." | 1.40 | Effects of methylprednisolone, dantrolene, and their combination on experimental spinal cord injury. ( Alves, EG; Caldeira, FM; Costa, PM; Fukushima, FB; Lavor, MS; Melo, EG; Oliveira, KM; Rosado, IR; Silva, CM, 2014) |
| "Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after SCI." | 1.37 | The ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats. ( Caldeira, F; Gomes, M; Melo, E; Serakides, R; Torres, B, 2011) |
| "Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after brain injury in several animal models of neurological disorders." | 1.36 | Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats. ( Bertagnolli, AC; Caldeira, FM; de Marco Viott, A; de Melo, EG; de Oliveira, KM; Fukushima, FB; Gomes, MG; Gomes, MV; Serakides, R; Torres, BB, 2010) |
| "Motor point blocks may partially dampen spasticity in selected muscles of some patients." | 1.26 | Management of spasticity in spinal cord injury. ( Merritt, JL, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keles, I | 1 |
| Bozkurt, MF | 1 |
| Aglamis, E | 1 |
| Fidan, AF | 1 |
| Ceylan, C | 1 |
| Karalar, M | 1 |
| Coban, S | 1 |
| Denk, B | 1 |
| Buyukokuroglu, ME | 2 |
| Martins, BC | 1 |
| Torres, BBJ | 1 |
| de Oliveira, KM | 2 |
| Lavor, MS | 2 |
| Osório, CM | 1 |
| Fukushima, FB | 3 |
| Rosado, IR | 2 |
| de Melo, EG | 2 |
| Alves, EG | 1 |
| Oliveira, KM | 1 |
| Silva, CM | 1 |
| Caldeira, FM | 2 |
| Costa, PM | 1 |
| Melo, EG | 1 |
| Aslan, A | 1 |
| Cemek, M | 1 |
| Altunbas, K | 1 |
| Bas, O | 1 |
| Yurumez, Y | 1 |
| Cosar, M | 1 |
| Javed, M | 1 |
| Bogdanov, A | 1 |
| Torres, BB | 1 |
| Gomes, MG | 1 |
| Serakides, R | 2 |
| de Marco Viott, A | 1 |
| Bertagnolli, AC | 1 |
| Gomes, MV | 1 |
| Torres, B | 1 |
| Caldeira, F | 1 |
| Gomes, M | 1 |
| Melo, E | 1 |
| Lê-Quang, B | 1 |
| Calmels, P | 1 |
| Valayer-Chaléat, E | 1 |
| Fayolle-Minon, I | 1 |
| Gautheron, V | 1 |
| Taricco, M | 2 |
| Pagliacci, MC | 1 |
| Telaro, E | 2 |
| Adone, R | 2 |
| Roberts, MH | 1 |
| Wright, V | 1 |
| Delaney, JF | 1 |
| Winnem, M | 1 |
| Dahlin, PA | 1 |
| Merritt, JL | 1 |
| Hackler, RH | 1 |
| Broecker, BH | 1 |
| Klein, FA | 1 |
| Brady, SM | 1 |
| Khorasani, A | 1 |
| Peruzzi, WT | 1 |
| Gilman, TM | 1 |
| Segal, JL | 1 |
| Brunnemann, SR | 1 |
| Pagliacci, C | 1 |
| Elovic, E | 1 |
| Thorell, WE | 1 |
| Leibrock, LG | 1 |
| Agrawal, SK | 1 |
| Couto, B | 1 |
| Figuereido, HB | 1 |
| Araújo Leitão, RE | 1 |
| Alvarenga, H | 1 |
| Gomes Marleide, M | 1 |
| Melo Reis, CH | 1 |
| Jonsson, B | 1 |
| Ladd, H | 1 |
| Dahllöf, AG | 1 |
| Glass, A | 1 |
| Hannah, A | 1 |
| Monster, AW | 1 |
| Herman, R | 1 |
| Meeks, S | 1 |
| McHenry, J | 1 |
4 reviews available for dantrolene and Injuries, Spinal Cord
| Article | Year |
|---|---|
Dantrolene and pleural effusion: case report and review of literature.
Topics: Dantrolene; Female; Humans; Middle Aged; Muscle Relaxants, Central; Muscle, Skeletal; Nitrofurantoin | 2004 |
Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Muscle Spasticity; Randomized Co | 2006 |
Pharmacological interventions for spasticity following spinal cord injury.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Parasympatholytics; Spasm; Spina | 2000 |
Principles of pharmaceutical management of spastic hypertonia.
Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant | 2001 |
4 trials available for dantrolene and Injuries, Spinal Cord
| Article | Year |
|---|---|
[Treatment of spasticity with dantrolene sodium].
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Dantrolene; Female; Humans; Male; Middle Aged; Mu | 1980 |
Metoclopramide increases the bioavailability of dantrolene in spinal cord injury.
Topics: Administration, Oral; Adult; Biological Availability; Cross-Over Studies; Dantrolene; Dopamine Antag | 1996 |
A comparison of dantrolene sodium and diazepam in the treatment of spasticity.
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam; | 1974 |
Cooperative study for assessing the effects of a pharmacological agent on spasticity.
Topics: Adult; Aged; Analog-Digital Conversion; Cerebrovascular Disorders; Computers, Analog; Dantrolene; El | 1973 |
16 other studies available for dantrolene and Injuries, Spinal Cord
| Article | Year |
|---|---|
Protective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study.
Topics: Animals; Antioxidants; Dantrolene; Disease Models, Animal; Lipid Peroxidation; Methylprednisolone; M | 2019 |
Association of riluzole and dantrolene improves significant recovery after acute spinal cord injury in rats.
Topics: Animals; Apoptosis; Dantrolene; Drug Combinations; Drug Synergism; Male; Neuroprotective Agents; Rat | 2018 |
Effects of methylprednisolone, dantrolene, and their combination on experimental spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Dantrolene; Disease Models, Animal; Drug Therapy, Comb | 2014 |
Dantrolene can reduce secondary damage after spinal cord injury.
Topics: Animals; Antioxidants; Apoptosis; Cell Count; Dantrolene; Disease Models, Animal; Disease Progressio | 2009 |
Oral dantrolene and severe respiratory failure in a patient with chronic spinal cord injury.
Topics: Administration, Oral; Chronic Disease; Dantrolene; Humans; Male; Middle Aged; Muscle Relaxants, Cent | 2010 |
Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats.
Topics: Analysis of Variance; Animals; Antigens, Nuclear; Apoptosis; Caspase 3; Cell Count; Dantrolene; Immu | 2010 |
The ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats.
Topics: Animals; Cystitis; Dantrolene; Disease Models, Animal; Hemorrhage; Male; Neuroprotective Agents; Rat | 2011 |
Drugs or physical therapy in rehabilitation?
Topics: Analgesics; Baclofen; Dantrolene; Diazepam; Humans; Physical Therapy Modalities; Rheumatic Diseases; | 1983 |
Medical treatment of spasticity.
Topics: Baclofen; Dantrolene; Diazepam; Humans; Injections, Spinal; Mephenesin; Muscle Relaxants, Central; M | 1980 |
Re: present urological treatment of spinal cord injury patients.
Topics: Baclofen; Dantrolene; Humans; Spinal Cord Injuries; Urinary Bladder, Neurogenic | 1982 |
Management of spasticity in spinal cord injury.
Topics: Baclofen; Benzodiazepines; Dantrolene; Humans; Muscle Spasticity; Phenothiazines; Spinal Cord Injuri | 1981 |
A clinical experience with dantrolene sodium for external urinary sphincter hypertonicity in spinal cord injured patients.
Topics: Adolescent; Adult; Dantrolene; Humans; Middle Aged; Muscle Hypertonia; Spinal Cord Injuries; Urinati | 1980 |
Dantrolene treatment for abrupt intrathecal baclofen withdrawal.
Topics: Adult; Baclofen; Dantrolene; Fever; Humans; Male; Muscle Spasticity; Spinal Cord Injuries; Substance | 1995 |
Role of RyRs and IP3 receptors after traumatic injury to spinal cord white matter.
Topics: Action Potentials; Animals; Boron Compounds; Caffeine; Calcium; Calcium Channels; Calcium-Binding Pr | 2002 |
[Sodium dantrolene (dantrium) in the treatment of neurogenic muscular spasm].
Topics: Adolescent; Adult; Aged; Cerebral Palsy; Cerebrovascular Disorders; Child; Child, Preschool; Dantrol | 1976 |
The effect of Dantrium on spasticity in spinal cord injuries.
Topics: Administration, Oral; Adult; Dantrolene; Disability Evaluation; Electromyography; Humans; Hydantoins | 1975 |