dantrolene has been researched along with Hypertension, Pulmonary in 3 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we aimed to investigate whether direct pharmacological intervention in the RV muscle with dantrolene (DAN), a stabilizer of the cardiac ryanodine receptor (RyR2), has a protective effect against RV dysfunction and arrhythmia in a monocrotaline (MCT)-induced PAH rat model." | 4.12 | Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension. ( Fujii, S; Fukuda, M; Kato, T; Kobayashi, S; Mikawa, M; Nakamura, Y; Nawata, J; Oda, T; Okamura, T; Okuda, S; Suetomi, T; Tanaka, S; Uchinoumi, H; Yamamoto, T; Yano, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, S | 1 |
| Yamamoto, T | 1 |
| Mikawa, M | 1 |
| Nawata, J | 1 |
| Fujii, S | 1 |
| Nakamura, Y | 1 |
| Kato, T | 1 |
| Fukuda, M | 1 |
| Suetomi, T | 1 |
| Uchinoumi, H | 1 |
| Oda, T | 1 |
| Okuda, S | 1 |
| Okamura, T | 1 |
| Kobayashi, S | 1 |
| Yano, M | 1 |
| Huang, Y | 1 |
| Lei, C | 1 |
| Xie, W | 1 |
| Yan, L | 1 |
| Wang, Y | 1 |
| Yuan, S | 1 |
| Wang, J | 1 |
| Zhao, Y | 1 |
| Wang, Z | 1 |
| Yang, X | 1 |
| Qin, X | 1 |
| Fang, Q | 1 |
| Fang, L | 1 |
| Guo, X | 1 |
| Dahan, D | 1 |
| Ducret, T | 1 |
| Quignard, JF | 1 |
| Marthan, R | 1 |
| Savineau, JP | 1 |
| Estève, E | 1 |
3 other studies available for dantrolene and Hypertension, Pulmonary
| Article | Year |
|---|---|
Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
Topics: Animals; Arrhythmias, Cardiac; Dantrolene; Disease Models, Animal; Hypertension, Pulmonary; Male; Mo | 2022 |
Oxidation of Ryanodine Receptors Promotes Ca
Topics: Animals; Calcium; Dantrolene; Hypertension, Pulmonary; Male; Oxidation-Reduction; Rats; Rats, Spragu | 2021 |
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantr | 2012 |