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dantrolene and Hypertension, Pulmonary

dantrolene has been researched along with Hypertension, Pulmonary in 3 studies

Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
"Here, we aimed to investigate whether direct pharmacological intervention in the RV muscle with dantrolene (DAN), a stabilizer of the cardiac ryanodine receptor (RyR2), has a protective effect against RV dysfunction and arrhythmia in a monocrotaline (MCT)-induced PAH rat model."4.12Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension. ( Fujii, S; Fukuda, M; Kato, T; Kobayashi, S; Mikawa, M; Nakamura, Y; Nawata, J; Oda, T; Okamura, T; Okuda, S; Suetomi, T; Tanaka, S; Uchinoumi, H; Yamamoto, T; Yano, M, 2022)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Tanaka, S1
Yamamoto, T1
Mikawa, M1
Nawata, J1
Fujii, S1
Nakamura, Y1
Kato, T1
Fukuda, M1
Suetomi, T1
Uchinoumi, H1
Oda, T1
Okuda, S1
Okamura, T1
Kobayashi, S1
Yano, M1
Huang, Y1
Lei, C1
Xie, W1
Yan, L1
Wang, Y1
Yuan, S1
Wang, J1
Zhao, Y1
Wang, Z1
Yang, X1
Qin, X1
Fang, Q1
Fang, L1
Guo, X1
Dahan, D1
Ducret, T1
Quignard, JF1
Marthan, R1
Savineau, JP1
Estève, E1

Other Studies

3 other studies available for dantrolene and Hypertension, Pulmonary

ArticleYear
Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
    Heart rhythm, 2022, Volume: 19, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Dantrolene; Disease Models, Animal; Hypertension, Pulmonary; Male; Mo

2022
Oxidation of Ryanodine Receptors Promotes Ca
    Hypertension (Dallas, Tex. : 1979), 2021, Volume: 77, Issue:1

    Topics: Animals; Calcium; Dantrolene; Hypertension, Pulmonary; Male; Oxidation-Reduction; Rats; Rats, Spragu

2021
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Nov-01, Volume: 303, Issue:9

    Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantr

2012