dantrolene has been researched along with Hyperkalemia in 10 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additionally, we discuss the use of dantrolene in dinitrophenol poisoning and question whether current Toxbase/UK National Poison Information Service treatment guidelines regarding the indication and dosing of this drug, the only relatively specific treatment in dinitrophenol poisoning presently recommended, could be revised." | 5.36 | 'Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you'. ( Narasimhaiah, R; Siegmueller, C, 2010) |
| " The initial reaction was successfully treated with dantrolene, but during the following days the patient developed several compartment syndromes requiring fasciotomies." | 3.72 | A fatal case of malignant hyperthermia complicated by generalized compartment syndrome and rhabdomyolysis. ( Green, G, 2003) |
| "Malignant hyperthermia is defined in the International Classification of Diseases as a progressive life-threatening hyperthermic reaction occurring during general anaesthesia." | 1.62 | Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists. ( Dalay, S; Girard, T; Hopkins, PM; Jenkins, B; McGrady, E; Patteril, M; Thacker, A, 2021) |
| " Additionally, we discuss the use of dantrolene in dinitrophenol poisoning and question whether current Toxbase/UK National Poison Information Service treatment guidelines regarding the indication and dosing of this drug, the only relatively specific treatment in dinitrophenol poisoning presently recommended, could be revised." | 1.36 | 'Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you'. ( Narasimhaiah, R; Siegmueller, C, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hopkins, PM | 1 |
| Girard, T | 1 |
| Dalay, S | 1 |
| Jenkins, B | 1 |
| Thacker, A | 1 |
| Patteril, M | 1 |
| McGrady, E | 1 |
| Siegmueller, C | 1 |
| Narasimhaiah, R | 1 |
| Green, G | 1 |
| Yoganathan, T | 1 |
| Casthely, PA | 1 |
| Lamprou, M | 1 |
| Saltzman, LS | 1 |
| Kates, RA | 1 |
| Corke, BC | 1 |
| Norfleet, EA | 1 |
| Heath, KR | 1 |
| Amiel, I | 1 |
| Nivoche, Y | 1 |
| Harioka, T | 1 |
| Sone, T | 1 |
| Toda, H | 1 |
| Miyake, C | 1 |
| Jenkins, LC | 1 |
| Scoates, PJ | 1 |
| San Juan, AC | 1 |
| Wong, KC | 1 |
| Port, JD | 1 |
| Rubin, AS | 1 |
| Zablocki, AD | 1 |
2 reviews available for dantrolene and Hyperkalemia
| Article | Year |
|---|---|
[Treatment of malignant hyperthermia crisis during anesthesia].
Topics: Anesthesia, General; Arrhythmias, Cardiac; Dantrolene; Humans; Hyperkalemia; Malignant Hyperthermia; | 1989 |
Anaesthetic implications of calcium channel blockers.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Asthma; Calcium; Calcium Channel Bloc | 1985 |
8 other studies available for dantrolene and Hyperkalemia
| Article | Year |
|---|---|
Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists.
Topics: Acidosis; Body Temperature; Calcium; Carbon Dioxide; Compartment Syndromes; Dantrolene; Disseminated | 2021 |
'Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you'.
Topics: 2,4-Dinitrophenol; Adult; Calcium Gluconate; Dantrolene; Emergency Treatment; Fatal Outcome; Humans; | 2010 |
A fatal case of malignant hyperthermia complicated by generalized compartment syndrome and rhabdomyolysis.
Topics: Adult; Anesthetics, Intravenous; Compartment Syndromes; Dantrolene; Fatal Outcome; Hemorrhage; Human | 2003 |
Dantrolene-induced hyperkalemia in a patient treated with diltiazem and metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Corona | 1988 |
Hyperkalemia and cardiovascular collapse after verapamil and dantrolene administration in swine.
Topics: Animals; Dantrolene; Drug Evaluation, Preclinical; Drug Interactions; Electric Stimulation; Heart Ar | 1984 |
Malignant hyperthermia in a hemodialysis patient.
Topics: Acidosis; Dantrolene; Female; Humans; Hyperkalemia; Intraoperative Complications; Malignant Hyperthe | 1989 |
Hyperkalemia after dantrolene and verapamil-dantrolene administration in dogs.
Topics: Animals; Blood Pressure; Calcium; Cardiac Output; Dantrolene; Dogs; Drug Interactions; Heart Rate; H | 1988 |
Hyperkalemia, verapamil, and dantrolene.
Topics: Colectomy; Colonic Neoplasms; Coronary Disease; Dantrolene; Drug Interactions; Humans; Hyperkalemia; | 1987 |