dantrolene has been researched along with Heat Stroke in 15 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Heat Stroke: A condition caused by the failure of body to dissipate heat in an excessively hot environment or during PHYSICAL EXERTION in a hot environment. Contrast to HEAT EXHAUSTION, the body temperature in heat stroke patient is dangerously high with red, hot skin accompanied by DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy." | 7.72 | Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management. ( Kerwin, RW; Osborne, S; Sainz-Fuertes, R, 2004) |
| "Several authors have shown that dantrolene may be effective in the treatment of heat stroke patients." | 7.70 | Dantrolene and recovery from heat stroke. ( Epstein, Y; Horowitz, M; Moran, D; Wiener, M, 1999) |
| "To evaluate the effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke." | 7.69 | Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke. ( Conway, EE; Rubin, DH; Singer, LP; Zuckerman, GB, 1997) |
| "Dantrolene was also found to be effective in reducing the extent of HS signs when given as pretreatment in an animal model." | 6.43 | Clinical review: Treatment of heat stroke: should dantrolene be considered? ( Cohen-Sivan, Y; Epstein, Y; Hadad, E; Heled, Y, 2005) |
| "A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy." | 3.72 | Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management. ( Kerwin, RW; Osborne, S; Sainz-Fuertes, R, 2004) |
| "Several authors have shown that dantrolene may be effective in the treatment of heat stroke patients." | 3.70 | Dantrolene and recovery from heat stroke. ( Epstein, Y; Horowitz, M; Moran, D; Wiener, M, 1999) |
| "To evaluate the effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke." | 3.69 | Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke. ( Conway, EE; Rubin, DH; Singer, LP; Zuckerman, GB, 1997) |
| "Exertional heat stroke (EHS) and malignant hyperthermia (MH) are life-threatening conditions, triggered by different environmental stimuli that share several clinical symptoms and pathophysiological features." | 2.66 | Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture. ( Laitano, O; Leon, LR; Murray, KO, 2020) |
| "Dantrolene was also found to be effective in reducing the extent of HS signs when given as pretreatment in an animal model." | 2.43 | Clinical review: Treatment of heat stroke: should dantrolene be considered? ( Cohen-Sivan, Y; Epstein, Y; Hadad, E; Heled, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 11 (73.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Laitano, O | 1 |
| Murray, KO | 1 |
| Leon, LR | 1 |
| McNamara, R | 1 |
| Ryan, D | 1 |
| McCarthy, G | 1 |
| Kerwin, RW | 1 |
| Osborne, S | 1 |
| Sainz-Fuertes, R | 1 |
| Hadad, E | 2 |
| Rav-Acha, M | 1 |
| Heled, Y | 2 |
| Epstein, Y | 3 |
| Moran, DS | 1 |
| Hausfater, P | 1 |
| Cohen-Sivan, Y | 1 |
| Gaig, C | 1 |
| Martí, MJ | 1 |
| Tolosa, E | 1 |
| Gómez-Choco, MJ | 1 |
| Amaro, S | 1 |
| Smith, JE | 1 |
| Moreau, TP | 1 |
| Deeter, M | 1 |
| Duffy, MR | 1 |
| Ferguson, C | 1 |
| Bouchama, A | 1 |
| Dehbi, M | 1 |
| Chaves-Carballo, E | 1 |
| Zuckerman, GB | 1 |
| Singer, LP | 1 |
| Rubin, DH | 1 |
| Conway, EE | 1 |
| Duthie, DJ | 1 |
| Moran, D | 1 |
| Wiener, M | 1 |
| Horowitz, M | 1 |
| Kozack, JK | 1 |
| MacIntyre, DL | 1 |
8 reviews available for dantrolene and Heat Stroke
| Article | Year |
|---|---|
Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture.
Topics: Anesthetics; Calcium; Calcium Channel Blockers; Dantrolene; Heat Stroke; Humans; Malignant Hyperther | 2020 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 4: in patients with classic heat stroke does adding treatment with dantrolene improve outcome?
Topics: Dantrolene; Emergency Treatment; Heat Stroke; Humans; Male; Middle Aged; Muscle Relaxants, Central; | 2008 |
Heat stroke : a review of cooling methods.
Topics: Animals; Body Temperature Regulation; Cryotherapy; Dantrolene; Gastric Lavage; Heat Stroke; Humans; | 2004 |
Clinical review: Treatment of heat stroke: should dantrolene be considered?
Topics: Chemical and Drug Induced Liver Injury; Dantrolene; Female; Fever; Half-Life; Heat Stroke; Humans; H | 2005 |
Cooling methods used in the treatment of exertional heat illness.
Topics: Body Temperature; Cold Temperature; Controlled Clinical Trials as Topic; Dantrolene; Heat Stroke; Hu | 2005 |
Heatstroke--predictable, preventable, treatable.
Topics: Dantrolene; Heat Stroke; Hot Temperature; Humans; Physical Exertion; Risk Factors | 2005 |
Cooling and hemodynamic management in heatstroke: practical recommendations.
Topics: Adult; Aged; Aged, 80 and over; Dantrolene; Heat Stroke; Hemodynamics; Humans; Hydrotherapy; Hypothe | 2007 |
Malignant hyperthermia.
Topics: Adult; Anesthesia; Child; Dantrolene; Exercise; Health Education; Heat Stroke; Humans; Malignant Hyp | 2001 |
7 other studies available for dantrolene and Heat Stroke
| Article | Year |
|---|---|
Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.
Topics: Adult; Antipsychotic Agents; Clozapine; Dantrolene; Heat Stroke; Humans; Male; Muscle Relaxants, Cen | 2004 |
Dantrolene and heatstroke: a good molecule applied in an unsuitable situation.
Topics: Dantrolene; Environment; France; Heat Stroke; Humans; Hypothermia, Induced; Malignant Hyperthermia; | 2005 |
Parkinsonism-hyperpyrexia syndrome not related to antiparkinsonian treatment withdrawal during the 2003 summer heat wave.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Dantrolene; Diagnosis, Differential; Female; Fever of Unk | 2005 |
Role of dantrolene in treatment of heat stroke associated with Ecstasy ingestion.
Topics: Dantrolene; Hallucinogens; Heat Stroke; Humans; Muscle Relaxants, Central; N-Methyl-3,4-methylenedio | 2007 |
Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke.
Topics: Animals; Body Temperature; Cardiovascular System; Dantrolene; Disease Models, Animal; Fluid Therapy; | 1997 |
Heat-related illness.
Topics: Climate; Dantrolene; Heat Stroke; Humans; Male; Muscle Relaxants, Central; Physical Exertion | 1998 |
Dantrolene and recovery from heat stroke.
Topics: Analysis of Variance; Animals; Body Temperature; Body Temperature Regulation; Dantrolene; Disease Mo | 1999 |