dantrolene has been researched along with Heat Collapse in 21 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dantrolene has also been used successfully in the treatment of a few cases of heat stroke and the neuroleptic malignant syndrome--both of which have many similarities to malignant hyperthermia." | 6.37 | Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. ( Chaffman, MO; Sorkin, EM; Ward, A, 1986) |
| "We present the case of a 35-year-old man who developed symptoms of the neuroleptic malignant syndrome (NMS) after taking prescribed, moderately high, therapeutic doses of haloperidol." | 3.67 | Neuroleptic malignant syndrome. ( Lucid, EJ; Martin, ML; Walker, RW, 1985) |
| "Treatment with dantrolene sodium at the dose used, did not prove beneficial to patients with heatstroke." | 2.67 | Ineffectiveness of dantrolene sodium in the treatment of heatstroke. ( Bouchama, A; Cafege, A; Devol, EB; el-Assil, K; Labdi, O; Seraj, M, 1991) |
| "Dantrolene has also been used successfully in the treatment of a few cases of heat stroke and the neuroleptic malignant syndrome--both of which have many similarities to malignant hyperthermia." | 2.37 | Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. ( Chaffman, MO; Sorkin, EM; Ward, A, 1986) |
| "Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions." | 1.32 | Is there a link between malignant hyperthermia and exertional heat illness? ( Brandom, B; Bunger, R; Deuster, P; Muldoon, S, 2004) |
| "Dantrolene is an expensive drug and justification for its routine use in HS remains to be evaluated." | 1.28 | Is dantrolene effective in heat stroke patients? ( Channa, AB; Kadiwal, GH; Saddique, AA; Samarkandi, AH; Seraj, MA; Shaikh, MH, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (66.67) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muldoon, S | 1 |
| Deuster, P | 1 |
| Brandom, B | 1 |
| Bunger, R | 1 |
| Paasuke, RT | 1 |
| Bismuth, C | 1 |
| de Rohan-Chabot, P | 1 |
| Goulon, M | 1 |
| Raphael, JC | 1 |
| Ellis, FR | 1 |
| Knochel, JP | 1 |
| Denborough, MA | 1 |
| Lydiatt, JS | 1 |
| Hill, GE | 1 |
| Watson, JD | 1 |
| Ferguson, C | 1 |
| Hinds, CJ | 1 |
| Skinner, R | 1 |
| Coakley, JH | 1 |
| Larner, AJ | 1 |
| Orser, B | 1 |
| Bouchama, A | 1 |
| Cafege, A | 1 |
| Devol, EB | 1 |
| Labdi, O | 1 |
| el-Assil, K | 1 |
| Seraj, M | 1 |
| Denborough, M | 2 |
| Channa, AB | 1 |
| Seraj, MA | 1 |
| Saddique, AA | 1 |
| Kadiwal, GH | 1 |
| Shaikh, MH | 1 |
| Samarkandi, AH | 1 |
| Sewell, DD | 1 |
| Jeste, DV | 1 |
| Gibb, WR | 1 |
| Lees, AJ | 1 |
| Baum, J | 1 |
| Ward, A | 1 |
| Chaffman, MO | 1 |
| Sorkin, EM | 1 |
| Amsterdam, JT | 1 |
| Syverud, SA | 1 |
| Barker, WJ | 1 |
| Bills, GR | 1 |
| Goltra, DD | 1 |
| Armao, JC | 1 |
| Hedges, JR | 1 |
| Guzé, BH | 1 |
| Baxter, LR | 1 |
| Martin, ML | 1 |
| Lucid, EJ | 1 |
| Walker, RW | 1 |
5 reviews available for dantrolene and Heat Collapse
| Article | Year |
|---|---|
Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place?
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Blood Coagulation Disorders; Dancing; Dantrolene; | 1993 |
Neuroleptic malignant syndrome: a review.
Topics: Bromocriptine; Dantrolene; Diagnosis, Differential; Heat Exhaustion; Humans; Neuroleptic Malignant S | 1989 |
The neuroleptic malignant syndrome--a review.
Topics: Animals; Antipsychotic Agents; Catatonia; Dantrolene; Diagnosis, Differential; Heat Exhaustion; Huma | 1985 |
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.
Topics: Animals; Calcium; Central Nervous System; Dantrolene; Endocrine Glands; Heat Exhaustion; Humans; Kin | 1986 |
Current concepts. Neuroleptic malignant syndrome.
Topics: Amantadine; Basal Ganglia Diseases; Bromocriptine; Catatonia; Dantrolene; Diagnosis, Differential; D | 1985 |
1 trial available for dantrolene and Heat Collapse
| Article | Year |
|---|---|
Ineffectiveness of dantrolene sodium in the treatment of heatstroke.
Topics: Dantrolene; Double-Blind Method; Female; Heat Exhaustion; Humans; Length of Stay; Male; Middle Aged | 1991 |
15 other studies available for dantrolene and Heat Collapse
| Article | Year |
|---|---|
Is there a link between malignant hyperthermia and exertional heat illness?
Topics: Acidosis; Adolescent; Child; Dantrolene; Fatal Outcome; Genetic Predisposition to Disease; Heat Exha | 2004 |
Drugs, heat stroke and dantrolene.
Topics: Antipsychotic Agents; Dantrolene; Heat Exhaustion; Humans; Phenothiazines; Syndrome | 1984 |
Dantrolene--a new therapeutic approach to the neuroleptic malignant syndrome.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Dantrolene; Haloperidol; Heat Exhaustion; Humans; Hyperte | 1984 |
Malignant hyperpyrexia.
Topics: Adult; Anesthesia, General; Animals; Calcium; Child; Dantrolene; Heat Exhaustion; Humans; Malignant | 1984 |
Treatment of heat stroke.
Topics: Dantrolene; Evaluation Studies as Topic; Heat Exhaustion; Humans | 1983 |
Heat stroke and malignant hyperpyrexia.
Topics: Adult; Dantrolene; Heat Exhaustion; Humans; Male; Malignant Hyperthermia | 1982 |
Treatment of heat stroke with dantrolene.
Topics: Adult; Dantrolene; Heat Exhaustion; Humans; Injections, Intravenous; Male | 1981 |
Dantrolene for exertional heatstroke.
Topics: Calcium; Dantrolene; Heat Exhaustion; Humans; Physical Exertion | 1992 |
Dantrolene sodium and heatstroke.
Topics: Dantrolene; Drug Evaluation; Heat Exhaustion; Humans | 1992 |
Severe heat stroke in an experienced athlete.
Topics: Dantrolene; Heat Exhaustion; Humans; Sports Medicine | 1990 |
Is dantrolene effective in heat stroke patients?
Topics: Body Temperature Regulation; Body Weight; Dantrolene; Female; Heat Exhaustion; Humans; Male; Middle | 1990 |
Fatal thermal injury.
Topics: Dantrolene; Heat Exhaustion; Humans; Malignant Hyperthermia; Neuroleptic Malignant Syndrome | 1989 |
[Heat stroke. Therapeutic considerations in a case].
Topics: Combined Modality Therapy; Critical Care; Dantrolene; Dopamine; Emergencies; Flecainide; Heat Exhaus | 1986 |
Dantrolene sodium for treatment of heatstroke victims: lack of efficacy in a canine model.
Topics: Animals; Creatine Kinase; Creatinine; Dantrolene; Disease Models, Animal; Dogs; Heat Exhaustion; Hem | 1986 |
Neuroleptic malignant syndrome.
Topics: Adult; Basal Ganglia Diseases; Bromocriptine; Dantrolene; Diagnosis, Differential; Haloperidol; Heat | 1985 |